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One-Factor-at-a-Time Versus Designed Experiments by Veronica Czitrom:

The advantages of designed experiments over [One Factor at a Time] OFAT experiments are illustrated using three real engineering OFAT experiments, and showing how in each case a designed experiment would have been better. This topic is important because many scientists and engineers continue to perform OFAT experiments.

I still remember, as a child, asking what my father was going to be teaching the company he was going to consult with for a few days. He said he was going to teach them about using designed factorial experiments. I said, but you explained that to me and I am just a kid? How can you be teaching adults that? Didn’t they learn it in school? The paper provides some examples showing why OFAT experimentation is not as effective as designed multi-factor experiments.

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