Author Archives: curiouscat

Basic Concepts: List of Posts

Basic Concepts in Science: A list collects posts on basic science concepts. This is a great collection of posts, including:

Force, Energy and Fields
Genes and Prions
Correlation, Algorithm and Sets

Take some time to look through this interesting, educational and growing list of concepts explained by science bloggers.

Related: Science and Engineering Blogs

European Innovation Scoreboard

European Innovation Scoreboard (pdf)

The US and Japan are still ahead of the EU25 in terms of innovation performance, but the innovation gap between the EU25 and Japan, and in particular with the US is decreasing (see Figure II). The EU25 has improved its relative performance compared to the US in S&E graduates, tertiary education, business R&D, early-stage venture capital, medium-high and high-tech manufacturing employment, EPO patents, USPTO patents and community trademarks. The EU has improved its relative performance compared to Japan mostly in S&E graduates and broadband penetration rate.
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Sweden, Switzerland, Finland, Denmark, Japan and Germany are the innovation leaders, with SII scores well above that of the EU25 and the other countries…
The US, UK, Iceland, France, Netherlands, Belgium, Austria and Ireland are the innovation followers, with SII scores below those of the innovation leaders but above that of the EU25 and the other countries.

How to Deal with False Research Findings

The Science of Getting It Wrong: How to Deal with False Research Findings by JR Minkel adds to our recent spate of posts on drawing faulty conclutions from data (such as: Correlation is Not Causation, Cancer Deaths – Declining Trend?, Seeing Patterns Where None Exists, Karl Popper Webcast).

In his widely read 2005 PLoS Medicine paper, Ioannidis, a clinical and molecular epidemiologist, attempted to explain why medical researchers must frequently repeal past claims. In the past few years alone, researchers have had to backtrack on the health benefits of low-fat, high-fiber diets and the value and safety of hormone replacement therapy as well as the arthritis drug Vioxx, which was pulled from the market after being found to cause heart attacks and strokes in high-risk patients.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials—the gold standard of human research—were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

Among the most likely reasons for mistakes, he says: a lack of coordination by researchers and biases such as tending to only publish results that mesh with what they expected or hoped to find. Interestingly, Ioannidis predicted that more researchers in the field are not necessarily better—especially if they are overly competitive and furtive, like the fractured U.S. intelligence community, which failed to share information that might have prevented the September 11, 2001, terrorist strikes on the World Trade Center and the Pentagon.

But Ioannidis left out one twist: The odds that a finding is correct increase every time new research replicates the same result, according to a study published in the current PLoS Medicine.

$60 Million in Grants for Universities

HHMI Invites Colleges to Compete for Grants to Strengthen Undergraduate Research, Mentoring, Computational Skills:

Institutions are invited to compete based on their proven records in preparing undergraduates for graduate education in science and for careers in scientific research and medicine. In the past, the top 200 colleges were invited to apply. This year, to increase the pool of applicants, the Institute invited the 226 colleges with the highest percentage of graduates, including underrepresented minorities, who go on to graduate or medical school. For the first time, invited institutions include a Native American tribal college.

A panel of leading scientists and educators will review the applications and make recommendations to the HHMI undergraduate science education grants staff. Awards will be announced in May 2008.

Through its Undergraduate Science Education Program, HHMI has awarded $235.8 million in grants to 126 colleges throughout the United States and Puerto Rico since 1988, part of $693 million in grants for undergraduate science education that the Institute has awarded to institutions of higher education, including research and doctoral universities. HHMI is the largest private supporter of science education in the United States.

This is a huge amount of money that can do a great deal of good.

Editorial: Engineers of the Future

Engineers of the future:

Technology education programs at all grade levels seek to afford students opportunities to tinker, to discover how things work, and to explore the designed world. At the elementary school level, students may learn about simple machines designed for specific tasks or about the basics of electricity by actually building simple circuits. In middle school, students may explore concepts in more detail, perhaps by designing and building a model of a bridge or a gliding aircraft. In high school, students may have opportunities to design an affordable home, take something apart to see how it works, or design and build a robot that would be used for a rescue mission or some other specific purpose. All of these experiences are related to the processes of engineering.

This is the type of learning that can enhance a future engineer’s experience, but also the type that cannot be included in the typical upper grade level math or science classroom for one main reason: math and science teachers generally do not have the time and may not have the interest or expertise needed for in-depth study of technology.

The editorial makes a good point. As import and primary science and math education are they are not enough. Effort to create an environment where students can experiment and use their hands and minds to solve problems is incredibly valuable. Teaching in this way is not as simple as it might seem, see example below for some ideas and resources that can help create these type of learning institutions.

Examples: Middle School Engineers – k-12 Engineering Education – Engineering is Elementary – Colorado Science Teacher of the Year – Building minds by building robots – Leadership Initiatives for Teaching and Technology – Engineering Education Program for k-12 – Project Lead The Way – k-12 science and engineering posts

Medical Study: Antioxidant Supplements Don’t Extend Life

Antioxidant Supplements Don’t Extend Life Span, Study Finds

Representatives of the vitamin industry, as well as some other researchers, disputed the findings, criticizing the study for, among other things, including people who were already sick. People tend to take vitamins to stay healthy, they said.

“There’s a large body of data that shows that antioxidant supplementation is beneficial,” said Andrew Shao of the Council for Responsible Nutrition, an industry group. “The message to the average consumer is: Don’t pay attention to this. This doesn’t apply to you. You can go ahead and continue taking your antioxidant supplements in addition to the other things you do in your life to stay healthy.”

But Gluud and his colleagues defended the findings, saying that the study used careful methods developed by the internationally respected Cochrane Collaboration, an independent nonprofit effort to methodically assess medical claims. The analysis included many large studies involving healthy people, and the increased risk was clear after accounting for factors that could confuse the findings, Gluud said.

Tracking Changes in Individual Molecules

Watching a Biological Jigsaw Puzzle Come Together

Scientists have recorded the action involved in assembling telomerase, an enzyme used by cells to protect their genes during the potentially dangerous process of DNA replication. Using a sophisticated technique for tracking structural changes in individual molecules in real time, they have revealed how three of the protein and RNA components of the enzyme come together, altering their shapes along the way to ensure that the next piece will fit.
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In these more complicated systems, it’s much harder to guess what is going on in the assembly process. But by directly watching things as they happen, this sort of powerful approach will give a lot of new insights.

Very cool stuff. It just keeps coming doesn’t it?

Economic Gains from Science

Gaze into future for state’s economy:

For policymakers, that means: Invest in the state’s educational system, especially the University of Wisconsin System, and use tax policy to encourage investors to supply the money to make business ideas grow.
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TomoTherapy, 10 years old, already employs 500 people. Co-founded by two UW-Madison professors, it was financially backed by investment groups in Madison, Milwaukee and California. The next step may be to follow Madison-area high-tech businesses Third Wave and Sonic Foundry into the public stock market.

GenTel, employing 17, started at University Research Park, has moved to Fitchburg and plans to open an office in North Carolina. The company has found additional financing from investors, including groups in Madison and Appleton. Aruna sprouted from brainpower and research at the University of Georgia, but it licenses human em bryonic stem cell technology from the Wisconsin Alumni Research Foundation. Because UW-Madison is a hotbed of stem cell research, moving its jobs and income to Wisconsin would make sense.

Saving Mankind

Hollywood got it wrong, this is how you stop an apocalyptic asteroid:

Rather than Hollywood’s preferred option, engineers are trying to develop unmanned rockets that can land on space rocks and use the asteroids’ own material to propel them into a safer orbit.
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“It is like throwing rocks out of a rowing boat on a lake. The rocks go in one direction and the boat is slowly pushed in the other under the laws of physics,” said John Olds, the chief executive of SpaceWorks, the firm behind the scheme. “Over several months we think we can make the difference between a hit and a miss.” Astronomers fear that a 400-yard wide asteroid will pass dangerously close to the Earth within 30 years. Typically, one the size of a football pitch strikes every 100 years or so, and it is also almost 100 years since the last major impact which caused an explosion equivalent to a 15 megaton nuclear bomb in Tunguska, Siberia on June 30, 1908.

Fighting Elephant Poaching With Science

DNA Technology Leads Scientists to Locations of Elephant Poaching:

The illegal trade in elephant ivory continues unabated despite the fact that it was banned by international convention in 1989. In an effort to hunt down poachers who slaughter thousands of elephants a year for the animals’ tusks, scientists have turned to DNA technology to narrow the search.
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But to pinpoint the precise origin of the tusks can tell authorities where elephants are being slaughtered and which routes are being used to transport the illegal tusks. Armed with this information, the enforcement authorities would find it easier to track down poachers.
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Wasser led a group of researchers who performed a DNA analysis on 67 tusks confiscated in the 2002 Singapore seizure. The genetic material was compared to an existing database of elephant DNA. The researchers determined with near “100 percent accuracy” that the poached elephants came from the savanna within a narrow band of Southern Africa — possibly extending from Mozambique to Angola — with Zambia at its center.

Excellent use of science to gain knowledge which can help determine where best to put effort to counteract poaching.