Author Archives: curiouscat

What Happens If the Overuse of Antibiotics Leads to Them No Longer Working?

Antibiotics have been a miraculous tool to keep up healthy. Like vaccines this full value of this tool is wasted if it is used improperly. Vaccines value is wasted when they are not used enough. Antibiotics lose potency when they are overused. The overuse of anti-biotics on humans is bad (especially the huge amount of just lazy, not scientific use). But the massive overuse in livestock is much worse, it seems to me.

The health system in the USA is broken in a huge way in which it is broken is the failure to address creating systemic behavior that promotes human health and instead just treating illness. It is much better to avoid a situation where we breed super bugs and then try to treat those super bugs that have evolved to be immune to the antibiotics we have to use.

When antibiotics no longer work

While the source of the current salmonella outbreak remains murky, we can reasonably speculate about the genesis of the bug’s drug-resistance: the reportedly endemic overuse of antibiotics by the agricultural industry.

Drugs are given to livestock for multiple reasons. An obvious one is for the treatment of diseases. When livestock are sick, veterinarians administer a significant dosage in hopes of eliminating the animal’s affliction. Another reason is preventative. Animals in close quarters are more susceptible to infection, so farmers will often administer medicine to healthy animals in order to nip anything nasty in the bud. Most controversially, though, members of the agricultural industry use antibiotics for the express purpose of promoting livestock growth.

It’s a well-known, if not entirely intuitive, fact that healthy animals who are fed small, or “sub-therapeutic,” doses of antibiotics will wind up larger than their unmedicated counterparts. In many such cases, these drugs are given to livestock through their feed or water, and without the prescription or oversight of a veterinarian, according to Dr. Gail Hansen, a senior officer at the Pew Campaign on Human Health and Industrial Farming.

An estimated 80 percent of all antibiotics in the U.S. are given to food-producing livestock, according to the FDA. And approximately 83 percent of that medicine is “administered flock- or herd-wide at low levels for non-therapeutic purposes, such as growth promotion and routine disease prevention,” according to a lawsuit filed against the FDA in May. These figures could have very real consequences for public health, because the Catch-22 of this antibiotic abandon is the widespread development of drug-resistant bacteria, colloquially referred to as “super-bugs.”
…
In 2006, the European Union banned all use of antibiotics on livestock for growth promotion. And the U.S. Senate will consider similar legislation this year. Sen. Dianne Feinstein, D-Calif., reintroduced the “Preservation of Antibiotics for Medical Treatment Act” last month, which would significantly rein in agricultural drug use, and strictly prohibit the application of sub-therapeutic doses of drugs that have benefits for humans.

Still, the agricultural industry disputes data about its use of antibiotics and the rise of super-bugs, and it has aggressively fought efforts to legislate the matter. As a result, it’s hard to tell how far the legislation might proceed.

The end of the era of antibiotics

How did this happen? The driving forces are Darwin and human carelessness. Bacteria are constantly evolving, adapting to the changing conditions they face. Antibiotics usually kill bacteria. But sometimes a bacteria will develop a biological defense – particularly if too small a dose is used.
…
Antibiotics require a prescription in America, but our nation is still very much a part of the problem. Patients routinely demand these drugs, and doctors acquiesce, for respiratory infections and other ailments that will not respond to antibiotics because they are caused by a virus. We use soap with antimicrobial agents when regular soap does equally well. And we allow farmers to feed antibiotics to livestock in horrifying amounts, not to treat illnesses but to make farming more efficient.

The Potential Role of Concentrated Animal Feeding Operations in Infectious Disease Epidemics and Antibiotic Resistance

This working group, which was part of the Conference on Environmental Health Impacts of Concentrated Animal Feeding Operations: Anticipating Hazards—Searching for Solutions, considered the state of the science around these issues and concurred with the World Health Organization call for a phasing-out of the use of antimicrobial growth promotants for livestock and fish production. We also agree that all therapeutic antimicrobial agents should be available only by prescription for human and veterinary use.

Antibiotic Resistance in Livestock: More at Risk Than Steak
Continue reading →

MIT Engineering Design Workshop for Boston High School Students

This summer, a few dozen Boston-area high school students chose to spend their mornings toiling away with a variety of materials to create working marvels of engineering in the Engineering Design Workshop, a month-long program that gives teenagers a hands-on experience with the joys and challenges of engineering.

None of the activities are prescribed; instead, students take part in brainstorming sessions on the first day, and things develop from there. Typically, the “counselors” — a mix of undergraduate and graduate students from MIT and other local universities — present a few ideas, and the high school students decide which projects they’d most like to work on. I really like the idea of involving the college students.

This year, the 22 students divided themselves into five projects: a modified Razor scooter, equipped with a motor and brakes; a sound system of giant tower speakers; remote-controlled “anything” (which ended up including cars, fish, birds and even a flying turtle); a mosaic tiger meticulously assembled from pieces of stained glass; and an electric cello.

Each student is allotted $100 to spend on materials for his or her group’s project; this way, projects that attract more students have a larger budget to work with. Counselors help them purchase supplies online and work with them on the construction from the ground up.

There are probably thousands of similar type activities throughout the year to help engage students in engineering. I think it is great, but we need to do more. We need to let young students know what they are missing. If people know the wonders of engineering and choose something else for their career path, that is fine. It is a shame when people don’t get to decide, because they never experience what engineering has to offer.

Read the full press release.

Science is at its best when curious people are just trying to find things out

Brian Cox has a new television show, Wonders Of The Universe (a co-production of the BBC, the Discovery Channel, and the Science Channel), that looks like it will be wonderful. I would love more great shows on science. BBC has done some great stuff, so has PBS and the Discovery channel. I’ll be exploring what kind of access those channels have provided over the internet in the next year. I hope it is good. I was going to link to the web site for the show but the first 2 videos I tried to click on to view they wouldn’t show, so I don’t see the point in linking – hopefully eventually people that care about promoting science will make decisions to use the internet sensibly).

Interview of Professor Brian Cox

That’s a very important point about scientific discovery in general. Most scientists are interested in just looking at the universe, looking at nature. I don’t think there are many great discoveries that you can point to that were the result of someone wanting to find the answer to a particular question. If you look back at Einstein or Newton, you find that people are fascinated often by the smallest things, actually. In terms of Einstein, cosmology—which is a real part of the way the universe evolved, the way the universe began, the Big Bang—all that stuff came from Einstein really just being interested in the speed of light. He was just interested. It was a question he’d always asked. He’d always wondered about how light travels. It’s a useful lesson, in general, not only to the theories, but that science is at its best when curious people are just trying to find things out.
…
There’s a very famous quote from [Alexander] Fleming, when he discovered penicillin, he said something like, “On September something 1928, I didn’t expect to wake up and revolutionize medicine.” He woke up playing around with little bits of mold in his kitchen, basically. He was just interested in moldy things. [Laughs.] And he revolutionized everybody’s life. Everybody. Virtually everybody who is over the age of about 40 or 50 is alive today because of antibiotics. Virtually everybody would have died if it hadn’t been for that. And it wasn’t someone trying to discover antibiotics that did it. It was someone exploring nature. So, the argument, “Couldn’t we just spend our money making everybody’s lives better?” We are doing that. That’s what exploration actually does.

The Sun is a Miasma of Incandescent Plasma

They Might be Giants once again provide an enjoyable view into the wonders of science. Previously they published the video, The Sun is a Mass of Incandescent Gas. They published an updated video, a couple years ago, which captures the best current understanding based on the scientific inquiry process: Why Does the Sun Really Shine? (The Sun is a Miasma of Incandescent Plasma).

I really do love, They Might be Giants. Even before their focus on science I enjoyed their music. But they have done wonders with all their recent work. Go Giants. Get their DVD: Here Comes Science.

Their previous video, The Sun is a Mass of Incandescent Gas, Continue reading →

Wesley the Owl: Love Story of an Owl and His Girl

This story begins on Valentine’s Day in 1985 when biologist Stacey O’Brien meets a four-day-old baby barn owl in a fateful encounter that would turn into an astonishing 19-year saga. With nerve damage in one wing, the owlet’s ability to fly was forever compromised and he had no hope of surviving on his own in the wild. A young assistant in the owl laboratory at Caltech, O’Brien promised to care for the helpless owlet and give him a permanent home. O’Brien’s heartfelt memoir of life with this wild bird, Wesley the Owl: The Remarkable Love Story of an Owl and His Girl recounts their dramatic, and often humorous, life together.

For almost two decades, O’Brien studied Wesley and his strange habits intensively and providing a mice-only diet. With a heart-shaped face and outsized personality that belied his 18-inch stature, the gorgeous white-and-gold Wesley fascinated everyone he met, and touched many lives. Stacey and Wesley’s bond was especially deep; O’Brien discovered that owls are highly sentient beings with individual personalities, subtle emotions, and a playful nature that can also turn fiercely loyal and protective.

Cool fact: “While we hear in two dimensions, owls hear in three.” Owls can detect a mouse heartbeat under three feet of snow.
Related: Friday Fun: Cat and Owl Playing – Bird Brain (smart crows) – Using Barn Owls for Bilogical Pest Control in Israel
Continue reading →

Evolution in New York City Wildlife

Evolution Right Under Our Noses by Carl Zimmer

White-footed mice, stranded on isolated urban islands, are evolving to adapt to urban stress. Fish in the Hudson have evolved to cope with poisons in the water. Native ants find refuge in the median strips on Broadway. And more familiar urban organisms, like bedbugs, rats and bacteria, also mutate and change in response to the pressures of the metropolis. In short, the process of evolution is responding to New York and other cities the way it has responded to countless environmental changes over the past few billion years. Life adapts.
…
Dr. Wirgin and his colleagues were intrigued to discover that the Hudson’s population of tomcod, a bottom-dwelling fish, turned out to be resistant to PCBs. “There was no effect on them at all,” Dr. Wirgin said, “and we wanted to know why.”

In March, he and his colleagues reported that almost all the tomcod in the Hudson share the same mutation in a gene called AHR2. PCBs must first bind to the protein encoded by AHR2 to cause damage. The Hudson River mutation makes it difficult for PCBs to grab onto the receptor, shielding the fish from the chemical’s harm.

The AHR2 mutation is entirely missing from tomcod that live in northern New England and Canada. A small percentage of tomcod in Long Island and Connecticut carry the mutation. Dr. Wirgin and his colleagues concluded that once PCBs entered the Hudson, the mutant gene spread quickly.

Carl Zimmer again does a good job of explaining science in an engaging way. It is interesting to learn about science and evolution in urban environments. Lots of life manages to survive the challenges of urban life and it is interesting to learn what scientists are finding about that life.

How Algorithms Shape our World

Our modern world is influenced greatly by algorithms. As computing power allowed incredibly complex calculation we have taken advantage of that and used algorithms to find solutions to our desires. Great things are done but we also find ourselves getting into trouble occasionally as we develop these algorithm.

EZ-Builder Robot Control Software

You can get EZ-Builder Robot Control Software and try this out yourself.

Not a programmer? No problem! The EZ-Builder application allows non-programmers to easily build robots using advanced functions of the EZ-B Robot Controller. It is a Microsoft Windows application that gives you remote and scripting control of your custom robot design. Within the application, you add Controls that mimic your robot’s configuration. There are many controls for speakers, iRobot Roomba, HBridge, Servos, Cameras, Voice Recognition, Joysticks and more! There is even an easy scripting language so you may create short animations, interactions or initialization routines for your robot.
…
Using a Dremel, hot glue gun, screw drivers and various other tools, you can begin modifying the toy shell to fit your servos. For wheels or mobility, use continuous rotation modified servos. For arms and neck, use a standard servo. To allow your robot to see for object detection, use a Sharp IR Distance Sensor or a HC-SR04 Ultrasonic Ping Sensor.

Great Projects From First Google Science Fair Finalists

15 finalists (from 3 different age groups – 13-14 years old, 15-16 and 17-18) were selected. 11 finalists were from the USA and 1 each from Singapore, Canada, India and South Africa. These examples of what can be done with imagination, effort and a scientific mindset is great.

The grand prize winner, Shree Boseer’s project:

Each year, over 21,000 women are diagnosed with ovariancancer – the 5th leading cause of cancer-related deaths in women in the United States. One of the most common drugs usedin ovarian cancer chemotherapy is cisplatin, a platinum-based chemotherapy treatment. While the drug affects ordinary cells, the significantly higher replication frequency of cancer cells causes cisplatin to have a greater impact in malignant cells. However, cancer cells often develop resistance to cisplatin, rendering the treatment ineffective. To improve the efficiency of cisplatin treatment, this research sought to determine whether AMP kinase, an energy protein of cell, plays a role in the development of cisplatin resistance. Studies with various techniques showed a significant difference on cell death caused by cisplatin insensitive and resistant ovarian cancer cells when AMPK was inhibited,suggesting that AMPK plays a role in the development of resistance. This work,in addition to offering a new treatment regime, also furthers our understanding of ovarian cancer and cancers in general.

This is a great project and the experience for the students is wonderful. Still I do think the prizes should be much larger given all the large corporations involved. Get involved with the next Google Science fair.

Google Science Fair 2011 Projects semi finalists – Intel Science and Engineering Fair 2009 Webcasts – Hats off to the winners of the inaugural Google Science Fair – President Obama Speaks on Getting Students Excited About Science and Engineering
Continue reading →

Cambrian Explosion Song

via Smithsonian’s Surprising Science:

What does a music teacher do when he ends up teaching science? He teaches about evolution and the geologic timeline with music, of course, and that’s what Canadian elementary school teacher John Palmer did. He originally played “Cambrian Explosion” as a rock/hip hop creation in class but has since recorded an acoustic version. (The trio is called Brighter Lights, Thicker Glasses and consists of Palmer on the guitar/vocals, Michael Dunn on the dobro and Brian Samuels [from UBC civil engineering department] on the cello.)

The video was filmed in the Beaty Biodiversity Museum (Canada) atrium with the blue whale exhibit in the background.