Author Archives: curiouscat

$60 Million in Grants for Undergraduate Science Education

The Howard Hughes Medical Institute (HHMI) is challenging colleges and universities to think creatively about how they educate future scientists, science teachers, and a scientifically-literate public. The Institute has invited 215 undergraduate-focused colleges and universities from across the country to apply for a total of $60 million in science education grants. I am very happy that HHMI continues to help provide support for science education.

Sadly USA government leaders (local and national) have chosen to cut the importance they place on science education over the last few decades we have coasted on the gains we made in the 1960s and 1970s. That is no way to succeed. Thankfully a few foundations, with HHMI probably leading the way, and some great schools have kept the USA in a leadership position, but that leadership shrinks each year. And at the primary and secondary school level the USA dropped far back in the pack decades ago for science eduction The top countries in primary and secondary science education are now Finland, Hong Kong and Korea.

Since 1988, the Howard Hughes Medical Institute has awarded $820 million to 264 colleges and universities to support science education. Those grants have generally been awarded through two separate but complementary efforts, one aimed at undergraduate-focused institutions and the other at research universities. HHMI support has enabled more than 80,000 students nationwide to work in research labs and developed programs that have helped 95,000 K-12 teachers learn how to teach science more effectively.

The new grants will range from $800,000 to $1.6 million over four years for individual institutions and up to $4.8 million over four years for those applying jointly.

The biggest change in the new 2012 competition is the requirement that applicants focus on a single educational goal that unites their proposed science education program. In the past, HHMI’s grants have allowed applicants to submit projects in four categories: student research, faculty development, curriculum and laboratory development, and outreach. Although schools were not expected to put forward a program in every category, Asai notes the modular design of the grant competition often led schools to “check the boxes” rather than encouraging them to think strategically about how these activities can help them reach an overarching science education objective.
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Hardware Hacker Challenge Invitation

Calling all Inventors, Makers and Hackers. This is a fun idea for a hacker invitation. Teams decode the invitation embedded in hardware to reveal their password for an invitation to the creation event.

Google Art Project – View Art from the Hermitage, the Met…

Google Art Project lets you view art from the Hermitage, Van Gogh Museum, the Met, Tate Britain, National Gallery and more museums around the world. The site lets you navigate the museum (similar to Google street view) and zoom in for very close looks at the the works of art.

The image above is a close up view of the Birth of Venus by Sandro Botticelli. In the lower right of the image you can see the portion of the painting that this view is zoomed into.

You can create your own artwork collects, which is a cute feature. Unfortunately it is tied to the still incredibly broken Google ideas on social Internet applications. I find it amazing that a company that does so many things so well, can have such continuously bad ideas about social applications.

Cat Allergy Vaccine Created

McMaster University researchers have developed aÂ vaccine which successfully treats people with anÂ allergy to cats. Traditionally, frequent allergy shots have been considered the most effective way to bring relief — other than getting rid of the family pet — for the 8 to 10% of the population allergic to cats.

Both options, may now be avoided thanks to the work of immunologistÂ Mark LarchÃ©, professor at theÂ Michael G. DeGroote School of Medicine andÂ Canada Research Chair in Allergy & Immune Tolerance.

Building on research he’s conducted for the past 10 years in Canada and Britain, LarchÃ© and his research team have developed a vaccine which is effective and safe with almost no side effects. The research is published in a the January 2011 issue of theÂ Journal of Allergy & Clinical Immunology, a leading journal in the allergy field.

The researchers took one protein (molecule) that cats secrete on their fur which causes the majority of allergic problems. Using blood samples from 100 patient volunteers allergic to cats, they deconstructed the molecule and identified short regions within the protein which activate T-cells (helper cells that fight infection) in the immune system.

Using the amino acid code for the whole protein, researchers made synthetic versions of these regions. For the cat allergy vaccine, they found seven peptides (strings of amino acids). “And those synthetic peptides are what we mix together to make the vaccine,” said LarchÃ©. “We picked the peptides that would work in as much of the population as possible.”

Known as “peptide immunotherapy,” a low dose of the vaccine is given into the skin. Initially, four to eight doses a year may be required, but the side effects of the traditional allergy shots do not arise, LarchÃ© said. The optimal dose will be determined in phase three clinical trials which are getting underway with a much larger group of cat allergy sufferers.

The development of a vaccine to treat people allergic to cats is the first in a line of vaccines developed withÂ Adiga Life Sciences, a company established at McMaster in 2008. It is a joint venture between McMaster University Circassia Ltd., a UK-based biotech company.

Adiga and McMaster are now collaborating on research into the use of peptide immunotherapy for house dust mite, ragweed, grass, birch tree and moulds

Votizen is Looking for Software Engineers

Link broken by pointy haired boss at Votizen, so I removed it. This phb behavior will make those of us who link to websites hesitant to trust anything Votizen posts will stay around 🙁

A nice presentation on why software engineers should work at Votizen.

Google Summer of Code is Accepting Application Now

Google Summer of Code 2011 is accepting applications. This is a great initiative I have highlighted previously: Google Summer of Code 2009, Google Summer of Code 2008. The deadline for applications is April 8th.

Google Summer of Code is a program that offers student developers stipends to write code for various open source projects. The program has brought together over 4,500 students with over 300 open source projects, to create millions of lines of code. Participants (including students and mentors) have represented over 85 countries. The program, which kicked off in 2005, is now in its seventh year.

Participating organizations include: R Project for Statistical Computing, Debian Project, WordPress and the Marine Biological Laboratory. (9 of the 175 participating organizations list Ruby as part of their project :-).

For 2010 the effort had a budget of $5,000,000 and accepted 1026 students partnering with 150 Open Source organizations. This year they plan on 1,150 – 1,200 student positions. For 2007 they had 6,200 applications and 7,000 in 2008. I don’t see any data on applicants for 2009.

As for the application it should include the following: your project proposal, why you’d like to execute on this particular project, and the reason you’re the best individual to do so. Your proposal should also include details of your academic, industry, and/or open source development experience, and other details as you see fit. An explanation of your development methodology is a good idea, as well.

Bleeding Heart Flowers

photo of some bleeding heart flowers

One the first flowers to bloom in my yard this year are some bleeding heart flowers (shown the photo). If I remember right, I planted them last year. I love perennials: I just plant them once and then get to keep enjoying them. I also find that some plants that are supposedly annuals seem to keep coming back (I think the plant must just manage to hang on, even if they often don’t, and so are called annuals). I enjoy gardening a bit, but don’t really spend enough time to know much about it. I just do as much as I feel like – and often am so busy that amounts to not much.

Also known as Lamprocapnos spectabilis they are a rhizomatous perennial plant native to eastern Asia from Siberia south to Japan.

New Analysis of Primordial Soup Experiment Half a Century Later

Open access paper: Primordial synthesis of amines and amino acids in a 1958 Miller H₂S-rich spark discharge experiment

Archived samples from a previously unreported 1958 Stanley Miller electric discharge experiment containing hydrogen sulfide (H₂S) were recently discovered and analyzed using high-performance liquid chromatography and time-of-flight mass spectrometry. We report here the detection and quantification of primary amine-containing compounds in the original sample residues, which were produced via spark discharge using a gaseous mixture of H₂S, CH₄, NH₃, and CO₂. A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples.

The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordial environments. The relative yield of some amino acids, in particular the isomers of aminobutyric acid, are the highest ever found in a spark discharge experiment.

The simulated primordial conditions used by Miller may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H₂S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H₂S may have played an important role in prebiotic reactions in early solar system environments.

Amazing Webcast of the Aurora Borealis

The Aurora from Terje Sorgjerd on Vimeo.

Norwegian landscape photographer Terje Sorgjerd spent a week capturing one of the biggest aurora borealis shows in recent years. He shot the video in and around Kirkenes and Pas National Park bordering Russia at temperatures around -25 Celsius.

Aurora are caused by the collision of charged particles and the Earth’s magnetic field. Aurora Borealis is Latin for northern lights. An aurora is usually observed at night and typically occurs in the ionosphere. The lights are commonly visible between 60 and 72 degrees north and south latitudes, which place them in a ring just within the Arctic and Antarctic polar circles.

Auroras result from emissions of photons in the Earth’s upper atmosphere, above 80 km (50 miles), from ionized nitrogen atoms regaining an electron, and oxygen and nitrogen atoms returning from an excited state to ground state. They are ionized or excited by the collision of solar wind particles being funneled down and accelerated along the Earth’s magnetic field lines; excitation energy is lost by the emission of a photon of light, or by collision with another atom or molecule. Oxygen emissions give off a green or reddish hue, depending on the amount of energy. Nitrogen emissions give off a blue (if the atom regains and electron after it has been ionized) or red hue (if returning to the ground state from an excited state).

Auroras are associated with the solar wind, a flow of ions continuously flowing outward from the Sun. The Earth’s magnetic field traps these particles, many of which travel toward the poles where they are accelerated toward Earth. Collisions between these ions and atmospheric atoms and molecules cause energy releases in the form of auroras appearing in large circles around the poles. Auroras are more frequent and brighter during the intense phase of the solar cycle when coronal mass ejections increase the intensity of the solar wind.

11 Year Old Using Design of Experiments

This reminds me of great times I had experimenting with my father when I was a kid. Though, to be honest, Sarah is much more impressive than I was.

Catapulting to Success with Design of Experiments

Sarah Flexman with her trebuchet at the Storm the Castle science challenge in North Carolina.

At the end of 2010, Sarah had decided to take part in Storm the Castle, one of the events offered in the statewide science Olympiad competition. This particular challenge was to design, build and launch a model trebuchet, which is a medieval-style catapult for hurling heavy stones…

Here’s Sarah’s whole process: She built the trebuchet, tested it, used JMP for DOE during optimization, changed the hook angle and sling to improve performance, did more tests, entered this new data, reran the model, and made her final prediction graphs. The variables in her DOE were string length, counterweight and projectile weight, and she optimized for distance – that is, how far the projectile would go.

“Rather than doing 125 tests because we have three variables with five levels each, DOE found a way for us to perform only 26 tests and get approximately the same results. I typed in the results, ran the model and used the JMP Profiler. I understood how the variables predicted the outcome and found several patterns,” she explained.
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“I hadn’t done any building like that. The whole day was fun. It was a very open learning environment. You were experimenting with things you had never done before. I would definitely do it again,” Sarah said. And she will – next year.

I have collected quite a few design of experiments resources, for those who are interested in learning more. Here is a nice webcast by brother: Combinatorial Testing – The Quadrant of Massive Efficiency Gains, discussing the incredibly efficiency designed combinatorial testing (very similar ideas to design of experiments) can provide.