Author Archives: curiouscat

Robot with Biological Brain

Life for Warwick’s robot began when his team at the University of Reading spread rat neurons onto an array of electrodes. After about 20 minutes, the neurons began to form connections with one another. “It’s an innate response of the neurons,” says Warwick, “they try to link up and start communicating.”

For the next week the team fed the developing brain a liquid containing nutrients and minerals. And once the neurons established a network sufficiently capable of responding to electrical inputs from the electrode array, they connected the newly formed brain to a simple robot body consisting of two wheels and a sonar sensor.
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At first, the young robot spent a lot of time crashing into things. But after a few weeks of practice, its performance began to improve as the connections between the active neurons in its brain strengthened. “This is a specific type of learning, called Hebbian learning,” says Warwick, “where, by doing something habitually, you get better at doing it.”
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“It’s fun just looking at it as a robot life form, but I think it may also contribute to a better understanding of how our brain works,” he says. Studying the ways in which his robot learns and stores memories in its brain may provide new insights into neurological disorders like Alzheimer’s disease.

CDC: Reduce Salt in Your Diet

USA Center for Disease Control: Application of Lower Sodium Intake Recommendations for Adults, 1999-2006 study

In 2005-2006, an estimated 29% of U.S. adults had hypertension (i.e., high blood pressure), and another 28% had prehypertension. The estimated average intake of sodium for those in the United States over 2 years old was 3,436 mg/day while the U.S. Department of Health and Human Services and U.S. Department of Agriculture recommended adults should consume no more than 2,300 mg/day of sodium (equal to approximately 1 tsp of salt), but those in specific groups (i.e., all persons with hypertension, all middle-aged and older adults, and all blacks) should consume no more than 1,500 mg/day of sodium (69% of U.S. adults should consume no more than !,500 mg/day). There is substantial evidence linking greater sodium intake to higher blood pressure.

Sodium reduction is recommended for persons with hypertension and as a first line of intervention for persons with prehypertension. Public health actions to reduce sodium intake likely will include reducing the sodium content of processed foods; encouraging consumption of more low-sodium foods, such as fruits and vegetables; and providing more relevant information about sodium in food labeling.

The current daily percentage value for sodium in the nutrition facts panel of packaged foods is based on a previous federal guideline of 2,400 mg/day and is likely to mislead the majority of consumers, for whom the 1,500 mg/day limit is applicable.

Cardiac Cath Lab: Innovation on Site

Photo of John Cooke at the Cardiac Catheterisation Labs at St. Thomas’ hospital in London

I manage several blogs on several topics that are related. Often blog posts stay firmly in the domain of one blog of the other. Occasionally the topic blurs the lines between the various blogs (which I like). This post ties directly to my Curious Cat Management Improvement Blog. The management principles I believe in are very similar to engineering principles (no surprise given this blog). And actual observation in situ is important – to understand fully the situation and what would be helpful. Management relying on reports instead of seeing things in action results in many poor decisions. And engineers doing so also results in poor decisions.

Getting to Gemba – a day in the Cardiac Cath Lab by John Cooke

I firmly believe that it is impossible to innovate effectively without a clear understanding of the context and usage of your final innovation. Ideally, I like to “go to gemba“, otherwise known as the place where the problem exists, so I can dig for tacit knowledge and observe unconscious behaviours.
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I didn’t disgrace myself and I’ve been invited back for another day or so. What did I learn that I didn’t know before? The key things I learnt were:

the guide wire isn’t just a means of steering the catheter into place as I thought. It is a functional tool in it’s own right
Feel is really critical to the cardiologist
There is a huge benefit in speeding up procedures in terms of patient wellbeing and lab efficiency
Current catheter systems lack the level of detection capability and controllability needed for some more complex PCIs (Percutaneous Cardiac Interventions)

The whole experience reminded me that in terms of innovation getting to gemba is critical. When was the last time you saw your products in use up-close and personal?

Long Term ADHD Drug Benefits Questioned

Debate Over Drugs For ADHD Reignites by Shankar Vedantam

New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months. The study also indicated that long-term use of the drugs can stunt children’s growth.
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One principal scientist in the study, psychologist William Pelham, said that the most obvious interpretation of the data is that the medications are useful in the short term but ineffective over longer periods but added that his colleagues had repeatedly sought to explain away evidence that challenged the long-term usefulness of medication. When their explanations failed to hold up, they reached for new ones, Pelham said.
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Peter Jensen, one of Pelham’s fellow researchers, responded that Pelham was biased against the use of drugs and was substituting his personal opinion for science.

Jensen said Pelham was the only member of the team of researchers who took away “the silly message” that the study raised questions about the long-term utility of drugs, but interviews and e-mails show that Pelham was not alone.
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In a telephone interview, Jensen denied that the researchers had misled the public, pointing out that some children getting the drugs did do better over the long term. Looking at overall results was not as useful as studying how particular groups of children fared, he said.

Jensen and another co-author, L. Eugene Arnold at Ohio State University, who are both psychiatrists, emphasized the importance of individualizing treatment — and warned parents against abruptly terminating drug therapy.

The subgroup analysis found that children in homes that were socially and economically stable did the same in the long term with or without medication. Children from troubled or deprived backgrounds slid backward as soon as the intensive therapy stopped and they went back to their communities. About one-third — those with the least impairment to begin with — continued to improve over the long term.

Jensen and co-author Benedetto Vitiello at the NIMH said drugs may not have shown an overall long-term benefit because the quality of routine care that children received may have been inferior to the care they got during the initial part of the study. Jensen said the take-home message is that community care needs improvement.

I have said I believe we too frequently reach for drug solutions. In the right situations drugs are wonderful tools. But they also have consequences and risks and it seems to me those negatives are given far too little weight.

Friday Fun: Duck and Dog Playing

Another fun example of inter-species animal play.

Personal Robots Being Developed in Japan

Robots Lend a Hand in Japan by Tony McNicol

The most numerous, and certainly the most high-profile, service robots in Japan are for entertainment. Ever since 2000 when Honda amazed the world with its walking humanoid Asimo, other Japanese companies have been fast on their heels. Notable examples include Mitsubishi’s lemon yellow home helper Wakamaru, Toyota’s trumpet-playing humanoid, and Murata Manufacturing’s bicycle-riding robot. Although such impressive PR robots are too expensive to sell, Japan also has popular home entertainment robots. The best known to date is Sony’s robot pooch Aibo, which was produced between 1999 and 2006.
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Another potential role for service robots is dealing with Japan’s imminent demographic crisis. A low birthrate and unrivalled longevity mean the number of elderly Japanese will increase dramatically over the coming decades. In the absence of mass immigration (which Japan has been keen to avoid) a severe shortage of caregivers seems inevitable. Some people believe robots are the answer. Takanori Shibata, a senior research scientist at the National Institute of Advanced Industrial Science and Technology, says that robot caregivers can be divided into physical service and mental service robots. The former are designed to help with tasks such as washing or carrying elderly people, although given the limitations of current technology, not to mention safety concerns, they are still quite a long way from commercialization.

Mental service robots on the other hand are already here. One of the best known is Paro, an interactive robot seal designed by Shibata himself. The sophisticated robot can remember its name and change its behavior depending on how it is treated. It has been extensively tested in homes for elderly people and in hospitals. In 2002 the Guinness Book of Records named Paro as “the world’s most therapeutic robot.” The robot reminds patients of the pets or children they once cared for, says Shibata. “Paro is a kind of trigger to provoke something in the mind of the owner,” he suggests. About 1,000 of the robots, which cost about 3,000 dollars, have been produced since 2004. Overseas sales will begin shortly.

The effective use of personal robots finally seems to be fairly close at hand. Undoubtedly the initial attempts will seem limited. See Clayton Christsen’s ideas on disruptive innovation for an understanding of how I think the adoption will play out. Robots will be poor substitutes for other alternatives but as we experiment with how to make them effective we will figure out niches for which they work well. It is hard to predict what will happen but my feeling is we may finally be a the point where real uses of personal robots stat to take hold and then the growth may surprise us.

Image of the Common Cold Virus

image created by Dr. Jean-Yves Sgro, Institute for Molecular Virology, University of Wisconsin-Madison, from published X-ray data. larger image

Sequences capture the code of the common cold

Conducted by teams at the University of Maryland School of Medicine, UW-Madison and the J. Craig Venter Institute, the work to sequence and analyze the cold virus genomes lays a foundation for understanding the virus, its evolution and three-dimensional structure and, most importantly, for exposing vulnerabilities that could lead to the first effective cold remedies.

“We’ve had bits and pieces of these things for a long time,” says Ann Palmenberg, of UW-Madison’s Institute for Molecular Virology and the lead author of the new study. “Now, we have the full genome sequences and we can put them into evolutionary perspective.”

As its name implies, the common cold is an inescapable, highly contagious pathogen. Humans are constantly exposed to cold viruses, and each year adults may endure two to four infections, while schoolchildren can catch as many as 10 colds.

“We know a lot about the common cold virus,” Palmenberg explains, “but we didn’t know how their genomes encoded all that information. Now we do, and all kinds of new things are falling out.”
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The newly sequenced viruses also show, says Palmenberg, why it is unlikely we will ever have an effective, all-purpose cold vaccine: The existing reservoir of viruses worldwide is huge and, according to the new study, they have a tendency to swap genetic sequences when cells are infected by more than one virus, a phenomenon that can lead to new virus strains and clinical manifestations.
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The ability of different cold virus strains to swap genes and make entirely new strains was thought to be impossible, notes Claire M. Fraser-Liggett, a co-author of the new study and director of the Institute for Genome Sciences and professor of medicine and microbiology at the University of Maryland School of Medicine. “There is the possibility that this could lead to the emergence of a new rhinovirus strain with fairly dramatic properties,” says Fraser-Liggett.

Solving the Mystery of the Vanishing Bees

As I have mentioned before the Colony Collapse Disorder (CCD) investigations have been a great view into the scientific inquiry process. Solving the Mystery of the Vanishing Bees:

a survey our team conducted in the spring of 2007 revealed that a fourth of U.S. beekeepers had suffered similar losses and that more than 30 percent of all colonies had died. The next winter the die-off resumed and expanded, hitting 36 percent of U.S. beekeepers. Reports of large losses also surfaced from Australia, Brazil, Canada, China, Europe and other regions. More recent data are not available yet, but some beekeepers say they have seen their colonies collapse this winter, too.
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Our collaboration has ruled out many potential causes for CCD and found many possible contributing factors. But no single culprit has been identified. Bees suffering from CCD tend to be infested with multiple pathogens, including a newly discovered virus, but these infections seem secondary or opportunistic much the way pneumonia kills a patient with AIDS. The picture now emerging is of a complex condition that can be triggered by different combinations of causes. There may be no easy remedy to CCD. It may require taking better care of the environment and making long-term changes to our beekeeping and agricultural practices.

Value of Prostate Cancer Screening Questioned by Two Studies

Ben Goldacre, in his bad science blog, again takes on journalist’s articles of health research in: Venal, misleading, pathetic, dangerous, stupid, and busted

1410 men would need to be screened to prevent one death. For each death prevented, 48 people would need to be treated: and prostate cancer treatment has a high risk of very serious side effects like impotence and incontinence. These figures are not hard to find: they are in the summary of the research paper.

For complex risk decisions like screening, it has been shown in three separate studies that patients, doctors, and NHS purchasing panels make more rational decisions about treatments and screening programmes when they are given the figures as real numbers, as I did above, instead of percentages. I’m not saying that PSA screening is either good or bad: I am saying that people deserve the figures in the clearest form possible so they can make their own mind up.
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So newspapers ignore one half of the evidence, and they fail to explain the other half properly.
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They can also link directly and transparently to scientific papers, which mainstream media still refuses to do. Journalists insist that we need professionals to mediate and explain science. From today’s story, their self belief seems truly laughable.

He also says some journalists got it right including the Washington Post in, Prostate Cancer Screening May Not Reduce Deaths:

The PSA blood test, which millions of men undergo each year, did not lower the death toll from the disease in the first decade of a U.S. government-funded study involving more than 76,000 men, researchers reported yesterday. The second study, released simultaneously, was a European trial involving more than 162,000 men that did find fewer deaths among those tested. But the reduction was relatively modest and the study showed that the tests resulted in a large number of men undergoing needless, often harmful treatment.

I think it is true that most people need help having science mediated to some extent. But he is also right that those doing so need to do better. And also everyone needs to learn about science to understand the choices they personally and politically (for policy issues) need to make decisions on. Being scientifically illiterate is dangerous.

Image of Viral Coat

image of exterior of virus - made up of 5 million atoms

High-energy X-ray diffraction was used to pinpoint some 5 million atoms in the protective protein coat of the PsV-F virus. The coat’s symmetrical features are shared by hundreds of viruses. The red and yellow sections illustrate how building blocks of four proteins come together to form the spherical shell.

The image reveals the structure of a type of protein coat shared by hundreds of known viruses containing double-stranded RNA genomes. The image was painstakingly created from hundreds of high-energy X-ray diffraction images and paints the clearest picture yet of the viruses’ genome-encasing shell called a “capsid.”

Viruses can reproduce themselves only by invading a host cell and highjacking its biochemical machinery. But when they invade, viruses need to seal off their genetic payload to prevent it from being destroyed by the cell’s protective mechanisms. Though there are more than 5,000 known viruses, including whole families that are marked by wide variations in genetic payload and other characteristics, most of them use either a helical or a spherical capsid.

“Spherical viruses like this have symmetry like a soccer ball or geodesic dome,” Pan said. “The whole capsid contains exactly 120 copies of a single protein.” Previous studies had shown that spherical capsids contain dozens of copies of the capsid protein, or CP, in an interlocking arrangement. The new research identified the sphere’s basic building block, a four-piece arrangement of CP molecules called a tetramer, which could also be building blocks for other viruses’ protein coats.

Full press release