One-Factor-at-a-Time Versus Designed Experiments by Veronica Czitrom:
I still remember, as a child, asking what my father was going to be teaching the company he was going to consult with for a few days. He said he was going to teach them about using designed factorial experiments. I said, but you explained that to me and I am just a kid? How can you be teaching adults that? Didn’t they learn it in school? The paper provides some examples showing why OFAT experimentation is not as effective as designed multi-factor experiments.
Related: Design of Experiments articles – Statistics for Experimenters (2nd Edition) – Design of Experiments blog posts

