Category Archives: Education

MicroRNAs Emerged Early in Evolution

New Research Shows MicroRNAs Emerged Early in Evolution

“MicroRNAs have been available to regulate and shape gene expression as far back as we can go in animal evolution—they might even predate animals,” says Bartel, a leader in the discovery and functional study of microRNAs. “They might have helped to usher in the era of multi-cellular animal life.”

First discovered in 1993, microRNAs are strands of RNA that are 21-24 nucleotides in length. They dampen gene expression by intercepting messenger RNA before it can turn the cellular crank that translates a gene into a protein. Earlier, Bartel’s research team showed that each microRNA can regulate the expression of hundreds of genes.

The ability of microRNAs to silence gene expression likely evolved from a more ancient defense against viruses, bacteria, and other mobile genetic elements that can mutate host DNA.
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The scientists determined that the starlet sea anemone has both microRNAs and piRNAs. In addition, the anemone makes proteins resembling those that interact with these small RNAs in humans. Both types of small RNA were also found in the sponge. The third target of their search, Trichoplax, did not contain any microRNAs, though Bartel suspects they may have existed in ancestral forms and later disappeared.

$400 Million More for Harvard and MIT

$400 million endowment for the Broad Institute of Harvard and MIT

“Today the Broad Institute is the world’s leading genomics and biomedical institute, and we’re now making a $600 million bet that the Broad will be the place where the greatest scientific discoveries take place,” Eli Broad said at today’s ceremony.
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In its short history, the Broad Institute’s accomplishments include cataloging and identifying genetic risk factors for diseases such as type 2 diabetes and autism; discovering new therapeutic targets for cancer, malaria, and other diseases; and applying genomic tools to better understand and treat human pathogens like tuberculosis.
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The Broads’ gift is the largest to support biomedical research at a university anywhere in the world. The Broads initially invested $100 million in 2003 as a way to test the institute’s new approach to biomedical research. By 2005, the Broad Institute had already made significant accomplishments and progress, and the Broads invested a second $100 million. Their endowment of $400 million today will allow the Broad Institute to transition to a permanent, non-profit 501(c)(3) organization with both Harvard and MIT still at the heart of it, continuing to help govern the institute.

Many countries would love to create a world class center of biomedical research. And several are trying. Boston sure seems to be staking a claim that it will be one of those centers of excellence. The economic benefits of that to Boston will be huge.

Carbon Nanotechnology in an 17th Century Damascus Sword

Carbon nanotechnology in an 17th century Damascus sword

Wootz, with its especially high carbon content of about 1.5%, should have been useless for sword-making. Nonetheless, the resulting sabres showed a seemingly impossible combination of hardness and malleability.
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Amazingly, they found that the steel contained carbon nanotubes, each one just slightly larger than half a nanometre. Ten million could fit side by side on the head of a thumbtack.
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It isn’t clear how ancient blacksmiths produced these nanotubes, but the researchers believe that the key to this process lay with small traces of metals in the wootz including vanadium, chromium, manganese, cobalt and nickel. Alternating hot and cold phases during manufacture caused these impurities to segregate out into planes. From there, they would have acted as catalysts for the formation of the carbon nanotubes, which in turn would have promoted the formation of the cementite nanowires.
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By gradually refining their blade-making skills, these blacksmiths of centuries past were using nanotechnology at least 400 years before it became the scientific buzzword of the twenty-first century.

Wind Power Provided Over 1% of Global Electricity in 2007

graph of global installed wind power capacity

Data from World Wind Energy Association, for installed Mega Watts of global wind power capacity in 2007. 19,696 MW of capacity were added in 2007, bringing the total to 93,849 MW. Europe accounts for 61% of installed capacity, Germany accounts for 24% and the USA 18%.

The graph shows the top 10 producers (with the exceptions of Denmark and Portugal) and includes Japan (which is 13th).

New Neurons are Needed for New Memories

New neurons are needed for new memories

Around 15 years ago, researchers discovered that the adult rodent brain contains discrete populations of stem cells which continue to divide and produce new cells throughout life. This discovery was an important one, as it overturned a persistent dogma in neuroscience which held that the adult mammalian brain cannot regenerate.
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This study shows that inhibiting neurogenesis has strikingly different consequences in two distinct regions of the brain. In the olfactory bulb, it leads to significant shrinkage but apparently does not alter smell-related behaviour. In the hippocampus, the effect on structure is not so marked, but it is clear that newly-generated neurons are necessary for the processes of learning and memory. Exactly how the new cells contribute to memory formation is still unknown.

More interesting stuff. Related: How The Brain Rewires Itself – Scientists Witness the Birth of a Brain Cell – New Neurons in Old Brains – No Sleep, No New Brain Cells

Tidal Turbine Farms to Power 40,000 Homes

Scotland Plans World’s First Tidal Turbine Farms

Scottish Power Renewables will apply for planning permission next year to build the two farms in Northern Ireland’s seabed. The turbines will be manufactured in Scotland in an intentional boost to the country’s green-collar job market. The 98-foot structures have been tested to operate in water as deep as 328 feet, and they spin slow enough to allow marine life to avoid the 66-foot blades.
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New York City installed its first turbine for their tidal power farm earlier this month, but the Scottish plan differs in that the farms will be located in the open sea, not a river or straight.

Project aims to harness sea power

Projects on the firth could be operational by 2020… The Scottish and Irish sites would host up to 60 of the turbines – 20 at each site – generating 60 megawatts of power for up to 40,000 homes.

Foreign Cells Outnumber Human Cells in Our Bodies

This is one of those area I find very interesting: People Have More Bacterial Cells than Human Cells. Colin Nickerson has written an interesting article on the topic: Of microbes and men

Scientists estimate that 90 percent of the cells contained in the human body belong to nonhuman organisms – mostly bacteria, but also a smattering of fungi and other eensy entities. Some 100 trillion microbes nestle in niches from our teeth to our toes.

But what’s setting science on its heels these days is not the boggling numbers of bugs so much as the budding recognition that they are much more than casual hitchhikers capable of causing disease. They may be so essential to well-being that humans couldn’t live without them.

In this emerging view, humans and their microbes – or, as some biologists playfully put it, microbes and their attached humans – have evolved together to form an extraordinarily complex ecosystem.

The understanding of the complex interaction is something I came to through reading on the overuse of antibiotics. And the more I read the more interesting it gets.

“We can’t take nutrition properly without bacteria. We can’t fight bad germs without good germs,” he said. “It may turn out that secretions from bacteria affect not only long-term health, but hour-by-hour moods – could a person’s happiness depend on his or her bugs? It’s possible. Our existences are so incredibly intertwined.”

However, in the opinion of some researchers, this strange union may be headed for trouble because of profligate use of antibiotics and antiseptic lifestyles that deter the transfer of vital strains of bacteria that have swarmed in our systems at least since early humans ventured out of Africa.

Bonobo Research

Chimps ‘are people, too’

In a private facility just outside Des Moine, Iowa , primatologist Sue Savage-Rumbaugh is conducting an experiment that has lasted 26 years. She’s been rearing a small group of apes as if they are people, to see what happens.

Her results appear to be spectacular, at least to writer Danny Wallace: “Kanzi asked me for a present. I gave him the free toothbrush kit from my flight over. He brushed his teeth. We bonded.”
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Victoria: “This experiment is the first definite evidence that chimpanzees can pass on ideas to each other. That is the basis of culture.”
Danny: “So, are they people then?”
Victoria: “No.”

In Budongo National Park, Uganda. Katie Slocombe from St Andrews University is studying vocalisations with wild chimps…
Katie: “Chimps produce an incredibly wide range of sounds. It appears that they may have a rudimentary language.”
Danny: “So, are they people then?
Katie: “No”

More Mysterious Space Phenomenon

One of the things I really hope this blog helps accomplish is to show how science progresses (which explains why I use that tag so often, 3rd most, other popular tags: animals (most used), engineers 2nd, fun and webcasts tied for 4th).

Science is a process of continual learning as curiosity leads us to seek better understanding. On a small scale this can mean a person learning more about knowledge already understood by others. But it also means the scientific community facing new questions and coming up with new explanations for the new questions raised by observations (and testing those new explanations…). Mysterious New ‘Dark Flow’ Discovered in Space

Patches of matter in the universe seem to be moving at very high speeds and in a uniform direction that can’t be explained by any of the known gravitational forces in the observable universe. Astronomers are calling the phenomenon “dark flow.” The stuff that’s pulling this matter must be outside the observable universe, researchers conclude.
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They discovered that the clusters were moving nearly 2 million mph (3.2 million kph) toward a region in the sky between the constellations of Centaurus and Vela. This motion is different from the outward expansion of the universe (which is accelerated by the force called dark energy).

“We found a very significant velocity, and furthermore, this velocity does not decrease with distance, as far as we can measure,” Kashlinsky told SPACE.com. “The matter in the observable universe just cannot produce the flow we measure.”

The Glove – Engineering Coolness

photo of The Glove - core control

Cool invention helps tired players bounce back

The device, called the Glove and invented by two Stanford biologists, is used by the Niners during games and at practice for players’ health. But its applications are far broader: from treating stroke and heart attack victims to allowing soldiers to remain in the field longer under intense heat.

It’s also a proven athletic performance enhancer – billed as better than steroids without any ill effects.

“We use the Glove primarily for health reasons,” said Dan Garza, the 49ers’ medical director. “But outside of sports, it has potential for a lot of exciting things. This technology is a much more effective way of cooling the core temperature than what we would typically do – misting, fanning, cold towels, fluids.”

The Glove works by cooling the body from inside out, rather than conventional approaches that cool from outside in. The device creates an airtight seal around the wrist, pulls blood into the palm of the hand and cools it before returning it to the heart and to overheated muscles and organs. The palm is the ideal place for rapid cooling because blood flow increases to the hands (and feet and face) as body temperature rises.

“These are natural mammalian radiators,” said Dennis Grahn, who invented the device with Stanford colleague Craig Heller.

Cool, you can buy your own for only $2,000 🙂 (The Glove used to be called Core Control) High resolution image. Related: Research on Reducing Hamstring Injuries – The Science of the Football Swerve – Randomization in Sports – posts on science and athletics