Category Archives: Students

Items for students and others, interested in learning about science and engineering and the application of science in our lives. We post many of the general interest items here.

Education is Opportunity

Google, Gates, Indian Diaspora Bet on Children by Andy Mukherjee

Yogi Patel, a retired chemical engineer and motel owner from Dallas, was nearing the end of his presentation about the need to tackle illiteracy in India when he put up a slide showing a thumb impression: his dad’s. “I’ve never needed anyone to tell me just how important education is,” Patel said last weekend to a gathering of the Indian diaspora in Singapore. “I’ve seen it in my own life.”

Born into a poor, illiterate family in the western Indian state of Gujarat, Patel was lucky to break free of the poverty trap. Several people from his community had prospered in East Africa. They supported his studies.
…
at 30 U.S. cents per child per year, the basic math, reading and writing skills required to help young learners retain their interest in education and keep them from dropping out of school are ridiculously cheap. It’s also critical enough to have caught the attention not just of wealthy Indian communities overseas but also of the Menlo Park, California-based William and Flora Hewlett Foundation and the Bill & Melinda Gates Foundation.

Together, the two charities offered to help 10 million students for three years by pledging $9 million last year to Read India, an initiative of Pratham, a Mumbai-based not-for- profit organization for which Patel is a fund-raiser. Google.org, the philanthropic arm of Google Inc., chipped in last month with a $2 million grant to help fund Pratham’s annual survey of the qualitative aspects of primary education in India.

Funding Medical Research

Cheap, ‘safe’ drug kills most cancers

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar.

Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis’s experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died

The University of Alberta is raising funds to further the research. Some look at this and indite a funding system that does not support research for human health unless there is profit to be made. Much of the blame seems to go to profit focused drug companies. I can see room for some criticism. But really I think the criticism is misplaced.

The organizations for which curing cancer is the partial aim (rather than making money) say government (partial aim or public health…), public universities (partial aim of science research or medical research…), foundations, cancer societies, private universities… should fund such efforts, if they have merit. Universities have huge research budgets. Unfortunately many see profit as their objective and research as the means to the objective (based on their actions not their claims). These entities with supposedly noble purposes are the entities I blame most, not profit focused companies (though yes, if they claim an aim of health care they I would blame them too).

Now I don’t know what category this particular research falls into. Extremely promising or a decent risk that might work just like hundreds or thousands of other possibilities. But lets look at several possibilities. Some others thoughts on where it falls: Dichloroacetate to enter clinical trials in cancer patients, from a previous post here – Not a Cancer Cure Yet, The dichloroacetate (DCA) cancer kerfuffle, CBC’s ‘The Current’ on dichloroacetate (DCA), Dichloroacetate (DCA) Phase II Trial To Begin (“Like hundreds (if not, thousands) of compounds being tested to treat cancer, DCA was shown by Michelakis’ group earlier this year to slow the growth of human lung tumors in a preclinical rodent model.”).
Continue reading →

Your Inner Fish

photo of Neil Shubin

Your Inner Fish: A Journey into the 3.5-Billion-Year History of the Human Body by Neil Shubin. A great piece from the University of Chicago, Fish out of Water, provides a good preview to the book:

What are the leading causes of death in humans? Four of the top ten causes—heart disease, diabetes, obesity, and stroke – have some sort of genetic basis and, likely, a historical one. Much of the difficulty is almost certainly due to our having a body built for an active animal but the lifestyle of a spud.
…
The problem is that the brain stem originally controlled breathing in fish; it has been jerry-rigged to work in mammals… This works well in fish, but it is a lousy arrangement for mammals.
…
The example from microbes is not unique. Judging by the Nobel Prizes awarded in medicine and physiology in the past 13 years, I should have called this book Your Inner Fly, Your Inner Worm, or Your Inner Yeast. Pioneering research on flies won the 1995 Nobel Prize in medicine for uncovering a set of genes that builds bodies in humans and other animals. Nobels in medicine in 2002 and 2006 went to people who made significant advances in human genetics and health by studying an insignificant-looking little worm (C. elegans). Similarly, in 2001, elegant analyses of yeast (including baker’s yeast) and sea urchins won the Nobel in medicine for increasing our understanding of some of the basic biology of all cells. These are not esoteric discoveries made on obscure and unimportant creatures. These discoveries on yeast, flies, worms, and, yes, fish tell us about how our own bodies work, the causes of many of the diseases we suffer, and ways we can develop tools to make our lives longer and healthier.

Two of my more controversial posts have been: Evolution is Fundamental to Science and Understanding the Evolution of Human Beings by Country. Evolution is not controversial scientifically. Just as gravity is not. Obviously this understanding is far from universal however.

But it is just a matter of time: similar to Galileo Galilei and heliocentric cosmology. See: Galileo’s Battle for the Heavens – Copernican System – Galileo). We now sit maybe 100 years after Galileo’s death (based on the evidence available in support of each scientific theory). At some point the evidence is accepted and life continues. Though I must admit it, I find it a bit disappointing how long it is taking for some people to accept the evidence of evolution. But I probably need to learn to be more patient – I have been told that more than once. All I can do is try to help present some small amount of the great work so many scientists have done to advance our knowledge. And here I am talking about evolution – for the 28% of those in the USA that couldn’t provide the answer that earth revolves around the sun, in 1998, well, they need much more help than I can provide.

YouTube Access Denied

Millions of users around the globe could not access YouTube for a couple hours yesterday. Why?

Well to understand, we need to start with how you normally connect to a web site. You click on a link to youtube.com. Your ISP looks up the internet address for youtube.com by looking at internet routing tables. Each domain has a name server that provides the IP address for where it should be found (for example, an IP address that shows youtube.com is 208.65.153.238).

Well what happened in this case is Pakistan decided to prevent anyone in Pakistan from accessing YouTube because the government didn’t like some video. The way Pakistan decided to accomplish this was to update their routing table to just direct all traffic that was meant to go to YouTube to a phony address which would then return nothing.

Why did many outside of Pakistan lose access to YouTube? Well their version of the routing table leaked out of Pakistan through PCCW (large internet provider), Then other internet providers adopted the incorrect information, until many around the globe were being directed to the wrong place.

You might find it amazing the routing system could allow such a thing to happen – it doesn’t seem very secure. You are right, that it doesn’t seem very sensible. When the internet was created some protocols were established that made sense then but don’t necessarily make sense for what the internet has become.

The problem was fixed when Google’s YouTube engineers contacted PCCW to inform them of the problem and have them correct it. I think if it was my site instead, I would have had difficulty figure out what was going on 🙂 Once PCCW corrected their routing tables the fixed flowed through the system and everyone was able to see the great stuff like Marissa Mayer discussing Innovation at Google.

I would imagine Internet2 (well on its way to a computer near you) and IPv6 will take not be so venerable to such a mistake.

Bacteria Can Transfer Genes to Other Bacteria

From page 115 of Good Gems, Bad Germs:

Microbiologists of the 1950’s did not appreciate the stunning extent to which bacteria swap genes… In 1959 Japanese hospitals experience outbreaks of multidrug-resistant bacterial dysentery. The shigella bacteria, which caused the outbreaks, were shrugging off four different classes of previously effective antibiotics: sulfonamides, streptomycins, chloramphenicols, and tetracyclines… In fact, the Japanese researches found it quite easy to transfer multidrug resistance from E. coli to shingella and back again simply by mixing resistant and susceptible strains together in a test tube.

Car Powered Using Compressed Air

car powered using compressed air

Jules Verne predicted cars would run on air. The Air Car (link broken, so it was removed) is making that a reality. The car is powered by compressed air which certainly seems like an interesting idea. Air car ready for production (link broken, so it was removed, sigh, when will site stop failing the web so badly?):

Refueling is simple and will only take a few minutes. That is, if you live nearby a gas station with custom air compressor units. The cost of a fill up is approximately $2.00. If a driver doesn’t have access to a compressor station, they will be able to plug into the electrical grid and use the car’s built-in compressor to refill the tank in about 4 hours.

The car is said to have a driving range of 125 miles so by my calculation it would cost about 1.6 cents per mile. A car that gets 31 mpg would use 4 gallons to go 124 miles. At $3 a gallon for gas, the cost is $12 for fuel or about 9.7 cents per mile. I didn’t notice anything about maintenance costs. I don’t see any reason why the Air Car would cost more to maintain than a normal car.

The air car was named one of Time magazine’s best inventions of the 2007.

Five-seat concept car runs on air

An engineer has promised that within a year he will start selling a car that runs on compressed air, producing no emissions at all in town. The OneCAT will be a five-seater with a fibre-glass body, weighing just 350kg and could cost just over Â£2,500.
…
Tata is the only big firm he’ll license to sell the car – and they are limited to India. For the rest of the world he hopes to persuade hundreds of investors to set up their own factories, making the car from 80% locally-sourced materials.
…
“Imagine we will be able to save all those components traveling the world and all those transporters.” He wants each local factory to sell its own cars to cut out the middle man and he aims for 1% of global sales – about 680,000 per year. Terry Spall from the Institution of Mechanical Engineers says: “I really hope he succeeds. It is a really brave experiment in producing a sustainable car.”

Virus Engineered To Kill Deadly Brain Tumors

Yale Lab Engineers Virus That Can Kill Deadly Brain Tumors

A laboratory-engineered virus that can find its way through the vascular system and kill deadly brain tumors has been developed by Yale School of Medicine researchers, it was reported this week in the Journal of Neuroscience.

Each year 200,000 people in the United States are diagnosed with a brain tumor, and metastatic tumors and glioblastomas make up a large part of these tumors. There currently is no cure for these types of tumors, and they generally result in death within months.
…
“Three days after inoculation, the tumors were completely or almost completely infected with the virus and the tumor cells were dying or dead,” van den Pol said. “We were able to target different types of cancer cells. Within the same time frame, normal mouse brain cells or normal human brain cells transplanted into mice were spared. This underlines the virus’ potential therapeutic value against multiple types of brain cancers.”

Pretty cool. Too bad these press releases never quite live up to the initial promise. Still this one is very cool, if it can succeed in helping even a small percentage of people it will be a great breakthrough. It is also just cool – using a virus to kill tumors – how cool is that?

Scientists Search for Clues To Bee Mystery

Honey Bees Give Clues on Virus Spread by Carl Zimmer

Now, as farmers wait anxiously to see if the honeybees will suffer again this spring, the true cause of CCD remains murky. Skeptics have raised many reasons to doubt that Australian viruses are to blame. In Australia, bees that get Israeli acute paralytic virus don’t get sick, and the country has had no reports of CCD. And in places where honeybee colonies are collapsing — Greece, Poland, Spain — there are no imported Australian bees. These are not the sort of patterns you’d expect, the skeptics say, if Australian viruses were killing American bees.
…
Whether scientists look inside a honeybee or look at the entire biosphere, nature is proving to be awesomely intricate. In the oceans and the soil, metagenomics is revealing millions of different kinds of microbes, with an almost inconceivable diversity of viruses shuttling between them, carrying genes from host to host. But we have almost no idea how these menageries work together, either in the biosphere or inside a host like a honeybee — or a human. Many of the microbes that metagenomics is revealing are entirely new to science. As genetic databases fill with DNA sequences from millions of new species, our scientific wisdom lags far behind.

How true. Watching as scientists try to work out what is going on with Colony Collapse Disorder is a great lesson in how scientists search for answers. As I stated earlier much of science is not about simple obvious truths but a search through confusing signs to try and determine what is going on. Answering why, is not always so easy as it appears when someone has already found the answer and posted it online.

Bats Are Dying in North-East USA

Vet College scientists aid investigation of why bats in Northeast are mysteriously dying By Krishna Ramanujan

Bat specialists from the New York State Department of Conservation (NYSDEC) have found 15 sites, up from four discovered last year, with sick bats: one in Massachusetts, two in Vermont and 12 in New York between Albany and Watertown. To help diagnose the problem, NYSDEC scientists are sending samples to Beth Buckles, assistant professor of biomedical sciences in Cornell’s College of Veterinary Medicine.

The affected bats are mostly little brown bats (Myotis lucifugus), among the most common North American bats. Other affected bats include the endangered Indiana bat (Myotis Sodalis), the northern long-eared bat (Myotis septentrionalis) and the eastern pipistrelle (Perimyotis subflavus). The bats live year round in the general area of study and usually hibernate each winter in the same caves.

Buckles and colleagues are conducting postmortem exams of organs and tissues and testing for signs of inflammation, bacteria, viruses and toxins. So far, the researchers do not yet know what is causing the massive casualties, Buckles said. “We have some good leads. We are continuing to look for infectious causes and are developing protocols to assess the bats’ metabolic states. They may not have enough fat to make it through the winter,” she said.

Many of the sick bats have a white fungus growing on their faces, are very thin and are congregating near to the cave entrances, a habit of ill bats. But it is “unprecedented” to find so many sick bats grouped near cave entrances, said Buckles. In two caves the researchers studied last year — that together had an estimated 18,000 bats — up to 97 percent died. The caves found this year may hold between 150,000 and 200,000 bats, many of them sick.

Related: Nectar-Feeding Bats – Bye Bye Bees

Electron Filmed for the First Time

Now it is possible to see a movie of an electron. The movie shows how an electron rides on a light wave after just having been pulled away from an atom. This is the first time an electron has ever been filmed. Previously it has been impossible to photograph electrons since their extremely high velocities have produced blurry pictures. In order to capture these rapid events, extremely short flashes of light are necessary, but such flashes were not previously available.

With the use of a newly developed technology for generating short pulses from intense laser light, so-called attosecond pulses, scientists at the Lund University Faculty of Engineering in Sweden have managed to capture the electron motion for the first time. “It takes about 150 attoseconds for an electron to circle the nucleus of an atom. An attosecond is 10-18 seconds long, or, expressed in another way: an attosecond is related to a second as a second is related to the age of the universe,” says Johan Mauritsson, an assistant professor in atomic physics at the Faculty of Engineering, Lund University.

Scientists also hope to find out more about what happens with the rest of the atom when an inner electron leaves it, for instance how and when the other electrons fill in the gap that is created. “What we are doing is pure basic research. If there happen to be future applications, they will have to be seen as a bonus,” adds Johan Mauritsson. The length of the film corresponds to a single oscillation of the light, but the speed has then been ratcheted down considerably so that we can watch it. The filmed sequence shows the energy distribution of the electron and is therefore not a film in the usual sense.

Photo: Experimental results obtained in helium at an intensity of 1:2 x 1013 W=c/m2 are shown. The results are
distinctively different from those taken in argon (Fig. 1).With this higher intensity, more momentum is transferred to the electrons, and in combination with the lower initial energy, some electrons return to the atomic potential for further interaction. In the first panel, we compare the experimental results (right) with theoretical calculations (left) obtained for the same conditions.
Continue reading →