Category Archives: Engineering

Printing Bone, Muscle and More

A Pittsburgh-based research team has created and used an innovative ink-jet system to print “bio-ink” patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells.

The custom-built ink-jet printer, developed at Carnegie Mellon’s Robotics Institute, can deposit and immobilize growth factors in virtually any design, pattern or concentration, laying down patterns on native extracellular matrix-coated slides (such as fibrin). These slides are then placed in culture dishes and topped with muscle-derived stem cells (MDSCs). Based on pattern, dose or factor printed by the ink-jet, the MDSCs can be directed to differentiate down various cell-fate differentiation pathways (e.g. bone- or muscle-like).

“This system provides an unprecedented means to engineer replacement tissues derived from muscle stem cells,” said Johnny Huard, professor of orthopedic surgery at the University of Pittsburgh School of Medicine and director of the Stem Cell Research Center at Children’s Hospital of UPMC. Huard has long-standing research findings that show how muscle-derived stem cells (MDSCs) from mice can repair muscle in a model for Duchenne Muscular Dystrophy, improve cardiac function following heart failure, and heal large bone and articular cartilage defects.

Weiss and Campbell, along with graduate student Eric Miller, previously demonstrated the use of ink-jet printing to pattern growth factor “bio-inks” to control cell fates. For their current research, they teamed with Phillippi, Huard and biologists of the Stem Cell Research Center at Children’s Hospital to gain experience in using growth factors to control differentiation in populations of MDSCs from mice.

The team envisions the ink-jet technology as potentially useful for engineering stem cell-based therapies for repairing defects where multiple tissues are involved, such as joints where bone, tendon, cartilage and muscle interface. Patients afflicted with conditions like osteoarthritis might benefit from these therapies, which incorporate the needs of multiple tissues and may improve post-treatment clinical outcomes.

The long-term promise of this new technology could be the tailoring of tissue-engineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are combining the versatile ink-jet system with advanced real-time live cell image analysis developed at the Robotics Institute and Molecular Biosensor and Imaging Center to further understand how stem cells differentiate into bone, muscle and other cell types.

Graduate Engineering and Professional Education @UMichigan

Dilbert’s bosses broke the video link (so I removed it) – not a good sign that they will succeed in my eyes. If they can’t follow basic web usability guidelines it doesn’t make me want to spend time on them.

Engineering TV is a site with lots of good webcasts for engineers: “by engineers for engineers! Focused on technical B2B engineering topics”. In the embedded webcast Dr. Ann Marie Sastry, Director of the Energy Systems Engineering Program at the University of Michigan, discusses a collaboration between GM and the University of Michigan in the Interdisciplinary Graduate Engineering and Professional Education Programs. This is a good example of university and business collaboration.

Engineering a Better Football

The football (soccer ball) for the 2010 FIFA World Cup features completely new, ground-breaking technology. Eight 3-D spherically formed panels are moulded together, harmoniously enveloping the inner carcass. The result is an energetic unit combined with perfect roundness.

Aero grooves create the clearly visible profile on the ball’s surface. The Grip’n’Groove profile circles around the entire ball in an optimal aerodynamic way. The integrated grooves provide unmatched flight characteristics, making this the most stable and most accurate Adidas football. The ground breaking performance features have been confirmed in comprehensive comparison tests at Loughborough University in England and countless checks in wind tunnel and the Adidas football laboratory in Scheinfeld, Germany.

The process, shown in the video, for manufacturing the footballs is way more complicate than I thought it would be.

How the Practice and Instruction of Engineering Must Change

Chief Scientist for the Rocky Mountain Institute and MacArthur Fellow, Amory Lovins, describes how small gains in efficiency at the consumption point can trigger gains that are magnitudes larger at higher levels and discusses how engineering must be practiced and taught fundamentally different.

Bionic Vision

Micro Machines and Opto-Electronics on a Contact Lense

Fiction now meets reality with prototype contact lenses developed by Babak Parviz at the University of Washington, in Seattle. Dr. Parviz’s prototype lenses can be used as biosensors to display body chemistry or as a heads up display (HUD). Powered by radio waves and 330 microwatts of power from a loop antenna that picks up power beamed from nearby radio sources, future versions will also be able to harvest power from a cell phone.

In his early 2008 lab tests, rabbits safely wore contact lenses with metal connectors for electronic circuits. The prototype lenses contained an electric circuit as well as red light-emitting diodes for a display. The lenses were tested on rabbits for up to 20 minutes and the animals showed no adverse effects.
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Contact lenses as replacements for smart phone displays — even to monitor blood glucose levels — might best be done while not operating heavy equipment. “The true promise of this research is not just the actual system we end up making, whether it’s a display, a biosensor, or both,” comments Dr. Parviz. “We already see a future in which the humble contact lens becomes a real platform, like the iPhone is today, with lots of developers contributing their ideas and inventions. As far as we’re concerned, the possibilities extend as far as the eye can see, and beyond.”

Monkey Bridge

Monkey see Monkey do

When you visit Diani Beach, Kenya’s version the Florida keys, look up and you’ll see 20 rope bridges swinging over the highway – what’s that little bulge with a tail? Before you flash by, you will realise that it’s a monkey sitting up there. Yes it’s watching you! And then, a burst of action as an entire troop of black and white might start galloping across the wildly swaying bridge!
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Being naturally shy, the colobus initially stared at the bridges gadgets with disdain until the more inquisitive and daring Sykes monkey began to see the logic. Once the Sykes and even vervet monkeys started using the bridges, the colobus followed suit, and are now very comfortable with their arboreal walkways.

Zubbles – Get Your Colored Bubbles

photo of blue colored bubble.

I first posted on this in 2005: Colored Bubbles. Now you can order your own via Zubbles. Colored Bubbles Have Landed (and Popped and Vanished)

Having solved the colored bubble dilemma, we spent most of 2006 trying to refine our dyes and the manufacturing process. We had invented several completely new dyes and a few derivatives of existing dyes. But the manufacturing process was long, tedious and expensive. It took three days just to make a few grams of each dye. It quickly became apparent that we needed to radically streamline the production process in order to have a viable product.
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The complexities of the chemistry resembled a pharmaceutical more than a toy. So I enlisted the help of Gary Willingham, and the Belgium development team, at Fisher Scientific. Fisher is a pharmaceutical chemical manufacturer with the equipment and expertise needed to manufacture tons of our dyes.
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Due to the complexities of the chemistry, Jamm decided to stay close to the production process and manufacture Zubbles in the US. The first bottles rolled off the line this week. Jamm presented me with the very first case of Zubbles. And it was a very strange feeling to finally hold the product in my hand—15 years after I mixed my first batch of dishwashing detergent and food coloring.

Being an entrepreneur is a challenge any time. When your product requires complex science and engineering that adds additional challenges. It is great to see this product is now available.

Jetman Jumps from Plane Then Into the Ocean

Yves Rossy’s attempt to fly 28 km across the the Strait of Gibraltar from Tangier in Morocco to Atlanterra in southern Spain fell short. He did make it about 15 km flying his jetwing before he ditched into the Atlantic. I posted about him before: Jetson Jetplane Over English Channel and Jetson Jetplane.

President Obama Speaks on Getting Students Excited About Science and Engineering

The President announces the “Educate to Innovate” initiative, a campaign to get students excited about pursuing careers in science, technology, engineering and mathematics. Quotes from President Obama from his speech – (see webcast above):

“As President, I believe that robotics can inspire young people to pursue science and engineering.”

“Now the hard truth is that for decades we’ve been losing ground. One assessment shows American 15-year-olds now rank 21st in science and 25th in math when compared to their peers around the world.”

“And today, I’m announcing that we’re going to have an annual science fair at the White House with the winners of national competitions in science and technology. If you win the NCAA championship, you come to the White House. Well, if you’re a young person and you’ve produced the best experiment or design, the best hardware or software, you ought to be recognized for that achievement, too. Scientists and engineers ought to stand side by side with athletes and entertainers as role models, and here at the White House we’re going to lead by example. We’re going to show young people how cool science can be.”

“improving education in math and science is about producing engineers and researchers and scientists and innovators who are going to help transform our economy and our lives for the better.”

Kids Not Clamoring for Engineering Careers

Engineering careers with experiences

Engineers are terribly misunderstood. Which might be one reason 85 percent of kids say “no way” to an engineering career. “The stereotype of the engineer is just wrong,” says Warren Miller, a retired Florida engineer who e-mailed me after I wrote about the short supply of workers in science and technology.

They think it’s “someone who is half-robot super genius” and “way more interested in machinery or circuitry than people.”
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Part of the misunderstanding starts with adults who influence future workers. The survey found that only 20 percent of parents have encouraged or will encourage their children to consider an engineering career. More girls say their parents are likely to encourage them to become an actress than an engineer.
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The National Science Foundation estimates a shortage of 70,000 engineers by 2010. To reverse the trend, we need to apply the engineer’s biggest tool: logic.

Based on the title of this blog you can guess I am in favor of engineers. Engineers can find great rewards in their careers from interesting work to high pay and leadership positions. In the modern world you need an understanding of science and engineering just to be a literate member of society.