Category Archives: Health Care

Protecting the Food Supply

A few weeks ago we posted about Tracking Down Tomato Troubles as another example of the challenges of scientific inquiry. Too often, in the rare instances that science is even discussed in the news, the presentation provides the illusion of simple obvious answers. Instead it is often a very confusing path until the answers are finally found (posts on scientific investigations in action). At which time it often seems obvious what was going on. But to get to the solutions we need dedicated and talented scientists to search for answers.

Now the CDC is saying tomatoes might not be the source of the salmonella after all: CDC investigates possible non-tomato salmonella sources.

Federal investigators retraced their steps Monday as suspicions mount that fresh unprocessed tomatoes aren’t necessarily causing the salmonella outbreak that has sickened hundreds across the USA.

Three weeks after the Food and Drug Administration warned consumers to avoid certain types of tomatoes linked to the salmonella outbreak, people are still falling ill, says Robert Tauxe with the Centers for Disease Control and Prevention. The latest numbers as of Monday afternoon were 851 cases, some of whom fell ill as recently as June 20, says Tauxe, deputy director of the CDC’s division of foodborne diseases.

The CDC launched a new round of interviews over the weekend. “We’re broadening the investigation to be sure it encompasses food items that are commonly consumed with tomatoes,” Tauxe says. If another food is found to be the culprit after tomatoes were recalled nationwide and the produce industry sustained losses of hundreds of millions of dollars, food safety experts say the public’s trust in the government’s ability to track foodborne illnesses will be shattered.

“It’s going to fundamentally rewrite how we do outbreak investigations in this country,” says Michael Osterholm of the Center for Infectious Disease Research and Policy at the University of Minnesota. “We can’t let this investigation, however it might turn out, end with just the answer of ‘What caused it?’ We need to take a very in-depth look at foodborne disease investigation as we do it today.”

I am inclined to believe the FDA is not enough focused on food safety. Perhaps we are not funding it enough, but we sure are spending tons of money on something so I can’t believe more money needs to be spent. Maybe just fewer bills passed (that the politicians don’t even bother to read) with favors to special interests instead of funding to support science and food safety. Or perhaps we are funding enough (though I am skeptical of this contention) and we just are not allowing food safety to get in the way of what special interests want (so we fund plenty for FDA to have managed this much better, to have systems in place that would provide better evidence but they are either prevented from doing so or failed to do so). I am inclined to believe special interests have more sway in agencies like (NASA, EPA, FDA…) than the public good and scientific openness – which is very sad. And, it seems to me, politicians have overwhelmingly chosen not to support more science in places like FDA, CDC, NIH… while increasing federal spending in other areas dramatically.

Our Genome Changes as We Age

Our Genome Changes Over Our Lifetime

For the new study, researchers first collected DNA samples collected in 1991 and again between 2002 and 2006 from 600 participants already enrolled in the AGES Reykjavik Study. The AGES study is renowned for its value to genetics research because of the historic isolation and reduced number of genetic “variables” among Iceland’s population, making certain patterns of genetic information easier to identify.

Among the 600, the research team measured the total amount of DNA methylation in each of 111 samples and compared total methylation from DNA collected in 2002 to 2005 to that person’s DNA collected in 1991.

They discovered that in almost one-third of the subjects, methylation changed over that 11-year span, with some gaining DNA methylation and others losing it.

“The key thing this part of the study told us is that levels changed over time, proof of principle that an individual’s epigenetic profile does change with age,” said M. Daniele Fallin, Ph.D., an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health.

Still a puzzle, though, was why or how, Fallin said, “so we wondered whether the tendency to those changes was also inherited, right along with our DNA sequences. That would explain why certain families are more susceptible to certain diseases.”

Refrigeration Without Electricity

Lack of electricity is a serious problem for vaccines and medicines that need to be cooled. It is hard to imagine that this is a problem, living in the USA, but this is still a problem today. As readers of this blog notice I really like appropriate technology solutions that provide real quality of life enhancements for hundreds of millions of people (which undoubtedly is influence by my father).

Cloned Immune Cells Clear Patient’s Cancer

Cloned immune cells cleared patient’s cancer

A patient whose skin cancer had spread throughout his body has been given the all-clear after being injected with billions of his own immune cells. Tests revealed that the 52-year-old man’s tumours, which spread from his skin to his lung and groin, vanished within two months of having the treatment, and had not returned two years later.

Doctors attempted the experimental therapy as part of a clinical trial after the man’s cancer failed to respond to conventional treatments.

The man is the first to benefit from the new technique, which uses cloning to produce billions of copies of a patient’s immune cells. When they are injected into the body they attack the cancer and force it into remission.

There are many more wonderful announcements than wonderful solutions that live up to the hope provided by the announcement. Still this is one in the long line of potentially wonderful treatments. If it turns out to be successful the whole world will benefit which is an example of why I am thankful so many countries are investing in science and technology.

Tracking Down Tomato Troubles

Tracking the bug in tomatoes

David Acheson is the nation’s top food detective, but so far he has met his match in the wily tomato.

With the salmonella scare that has plagued tomatoes, Acheson has faced perhaps his biggest test—at least as far as outbreaks of illness go—since he assumed the newly created “food safety czar” post at the U.S. Food and Drug Administration about a year ago.

That position was born amid a growing concern that the FDA couldn’t get a grip on food safety, as tales of food-borne illnesses multiplied. Now comes salmonella-laden tomatoes that have sickened at least 277 people nationwide, hospitalizing 43.
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The FDA concluded that the tainted tomatoes most likely came from Mexico or a certain part of Florida. The agency managed to narrow down the possible origins of the tainted tomatoes largely by a process of elimination. Based on the timing of their growing seasons and tomato harvests, many states or countries could not be the source of the tomatoes that caused illnesses, so they were deemed safe sources.

Restaurants and food retailers say they are now sourcing tomatoes from places deemed safe by the FDA. The outbreak has been a particularly tough one to crack because it has been so widespread. Illness has shown up in people who frequented a variety of restaurants, and who bought tomatoes at myriad grocery stores.

How Humans Evolved Allergies

Ancient antibody molecule offers clues to how humans evolved allergies

The chicken molecule, an antibody called IgY, looks remarkably similar to the human antibody IgE. IgE is known to be involved in allergic reactions and humans also have a counterpart antibody called IgG that helps to destroy invading viruses and bacteria. Scientists know that both IgE and IgG were present in mammals around 160 million years ago because the corresponding genes are found in the recently published platypus genome. However, in chickens there is no equivalent to IgG and so IgY performs both functions.

Lead researcher, Dr. Rosy Calvert said: “Although these antibodies all started from a common ancestor, for some reason humans have ended up with two rather specialised antibodies, whereas chickens only have one that has a much more general function.
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Professor Brian Sutton, head of the laboratory where the work was done said: “It might be that there was a nasty bug or parasite around at the time that meant that humans needed a really dramatic immune response and so there was pressure to evolve a tight binding antibody like IgE. The problem is that now we’ve ended up with an antibody that can tend to be a little over enthusiastic and causes us problems with apparently innocuous substances like pollen and peanuts, which can cause life-threatening allergic conditions.”

Alligator Blood Provides Strong Resistance to Bacteria and Viruses

Gator Blood May Be New Source of Antibiotics

The study authors, from McNeese State University and Louisiana State University, said their research is the first to take an in-depth look at alligator blood’s prospects as an antibiotic source. According to the researchers, alligators can automatically fight germs such as bacteria and viruses without having been exposed to them before launching a defense.

For the study, the researchers extracted proteins known as peptides from white cells in alligator blood. As in humans, white cells are part of the alligator’s immune system. The researchers then exposed various types of bacteria to the protein extracts and watched to see what happened.

In laboratory tests, tiny amounts of these protein extracts killed a so-called “superbug” called methicillin-resistant Staphylococcus aureus, or MRSA. The bacteria has made headlines in recent years because of its killing power in hospitals and its spread among athletes and others outside of hospitals.

The extracts also killed six of eight strains of a fungus known as Candida albicans, which causes a condition known as thrush, and other diseases that can kill people with weakened immune systems.

2,000-year-old Seed to Bear Fruit in Three Years

2,000-year-old seed set to bear fruit in three years

Having been germinated, astoundingly, by an Israeli team more than three years ago, and kept alive since, the “Judean date” sapling appears likely (but not certain) to yield a now-extinct species of date that was renowned in ancient times as a treatment for heart disease, chest problems, the spitting of blood, weakened memory and other medical conditions, possibly even symptoms of cancer and depression.

The seed was discovered during the 1960s archaeological excavations of Masada by Prof. Yigael Yadin, an eminent Israeli archeologist, political leader and the second IDF chief of General Staff.

The Judean Dead Sea region was famous for its extensive and high-quality date culturing in the first century CE. High summer temperatures and low precipitation at Masada contributed to the seed’s exceptional longevity.

Plastic Balls for the Resevoir

photo of Los Angeles resevoir

This photo looks like a April fools joke but I think it is real. Los Angeles Drops 400,000 Balls in Reservoir to Fight Suspected Carcinogen

So why deploy these balls — which are typically used by airports to prevent bird congregation on runways — in particular? Some of the other alternatives, such as a large tarp or metal cover, were considered too costly or impractical. The balls, on the other hand, are (relatively) cheap — costing 40 cents each — and are safe for drinking water; black is also the only color able to deflect UV rays.

The DWP has ordered 6.5 million of these balls, 3 million of which it plans on using to blanket the Ivanhoe and Elysian reservoirs. So, yeah, this probably isn’t the best solution for the city’s water woes but, given the circumstances, maybe the only “realistic” option in the short-term.

Los Angeles Department of Water and Power drops 400,000 balls onto Ivanhoe Reservoir:

The water needs to be shaded because when sunlight mixes with the bromide and chlorine in Ivanhoe’s water, the carcinogen bromate forms, said Pankaj Parekh, DWP’s director for water quality compliance. Bromide is naturally present in groundwater and chlorine is used to kill bacteria, he said, but sunlight is the final ingredient in the potentially harmful mix.

Photo by (Irfan Khan / Los Angeles Times)

Call me a bit skeptical. Adding a huge number of plastic balls to a water supply in order to try and prevent a chemical reaction caused by added chemicals and sunlight seems a bit crazy to me. But who know maybe it is a good idea.

Big Drug Research and Development on Campus

Big Drug R&D on Campus

Merck and Harvard just signed an agreement to develop treatments for the bone disease osteoporosis. On Apr. 25 rival Pfizer (PFE) invested $14 million in an alliance with four universities to study diabetes and obesity.

Drugmakers are counting on these deals to solve a persistent problem: underperforming product pipelines. Merck, Pfizer, and others have been losing sales of one blockbuster drug after another as patents expire and competitors charge in with generics. Big drug companies have fought back by spending more on research, yet the number of new medicines approved each year is falling. In the last week of April alone, the U.S. Food & Drug Administration rejected two of Merck’s experimental drugs, prompting the company to lay off 1,200 salespeople.
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Past deals between industry and academia have been hampered by patent disputes and tussles over publication rights, as companies tried to thwart academics who want to share their discoveries with colleagues around the world. So now the companies have devised policies allowing their Ivory Tower partners to patent and publish their discoveries, even as they draw the professors more deeply into corporate affairs.

Funding university activities this way can lead to conflicts and problems but realistically huge amounts of funding are entangled with possible conflicts of interest. The biggest concern I is that universities will bow to the almighty dollar instead of their missions. And inadequate oversight can damage their credibility (not one failure, most likely, but if a pattern emerges). For example: Researchers Fail to Reveal Full Drug Pay (“The Harvard group’s consulting arrangements with drug makers were already controversial because of the researchers’ advocacy of unapproved uses of psychiatric medicines in children.”). Then find out the companies were paying them well, the professors failed to disclose that and the advocacy is rightfully questioned.