Category Archives: Life Science

Ancient Sea Monster

A fossilised “sea monster” unearthed on an Arctic island is the largest marine reptile known to science, Norwegian scientists have announced. The 150 million-year-old specimen was found on Spitspergen, in the Arctic island chain of Svalbard, in 2006. The Jurassic-era leviathan is one of 40 sea reptiles from a fossil “treasure trove” uncovered on the island. Nicknamed “The Monster”, the immense creature would have measured 15m (50ft) from nose to tail.
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Unfortunately, there was a small river running through where the head lay, so much of the skull had been washed away. A preliminary analysis of the bones suggests this beast belongs to a previously unknown species.

Funding Medical Research

Cheap, ‘safe’ drug kills most cancers

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar.

Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis’s experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died

The University of Alberta is raising funds to further the research. Some look at this and indite a funding system that does not support research for human health unless there is profit to be made. Much of the blame seems to go to profit focused drug companies. I can see room for some criticism. But really I think the criticism is misplaced.

The organizations for which curing cancer is the partial aim (rather than making money) say government (partial aim or public health…), public universities (partial aim of science research or medical research…), foundations, cancer societies, private universities… should fund such efforts, if they have merit. Universities have huge research budgets. Unfortunately many see profit as their objective and research as the means to the objective (based on their actions not their claims). These entities with supposedly noble purposes are the entities I blame most, not profit focused companies (though yes, if they claim an aim of health care they I would blame them too).

Now I don’t know what category this particular research falls into. Extremely promising or a decent risk that might work just like hundreds or thousands of other possibilities. But lets look at several possibilities. Some others thoughts on where it falls: Dichloroacetate to enter clinical trials in cancer patients, from a previous post here – Not a Cancer Cure Yet, The dichloroacetate (DCA) cancer kerfuffle, CBC’s ‘The Current’ on dichloroacetate (DCA), Dichloroacetate (DCA) Phase II Trial To Begin (“Like hundreds (if not, thousands) of compounds being tested to treat cancer, DCA was shown by Michelakis’ group earlier this year to slow the growth of human lung tumors in a preclinical rodent model.”).
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Your Inner Fish

photo of Neil Shubin

Your Inner Fish: A Journey into the 3.5-Billion-Year History of the Human Body by Neil Shubin. A great piece from the University of Chicago, Fish out of Water, provides a good preview to the book:

What are the leading causes of death in humans? Four of the top ten causes—heart disease, diabetes, obesity, and stroke – have some sort of genetic basis and, likely, a historical one. Much of the difficulty is almost certainly due to our having a body built for an active animal but the lifestyle of a spud.
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The problem is that the brain stem originally controlled breathing in fish; it has been jerry-rigged to work in mammals… This works well in fish, but it is a lousy arrangement for mammals.
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The example from microbes is not unique. Judging by the Nobel Prizes awarded in medicine and physiology in the past 13 years, I should have called this book Your Inner Fly, Your Inner Worm, or Your Inner Yeast. Pioneering research on flies won the 1995 Nobel Prize in medicine for uncovering a set of genes that builds bodies in humans and other animals. Nobels in medicine in 2002 and 2006 went to people who made significant advances in human genetics and health by studying an insignificant-looking little worm (C. elegans). Similarly, in 2001, elegant analyses of yeast (including baker’s yeast) and sea urchins won the Nobel in medicine for increasing our understanding of some of the basic biology of all cells. These are not esoteric discoveries made on obscure and unimportant creatures. These discoveries on yeast, flies, worms, and, yes, fish tell us about how our own bodies work, the causes of many of the diseases we suffer, and ways we can develop tools to make our lives longer and healthier.

Two of my more controversial posts have been: Evolution is Fundamental to Science and Understanding the Evolution of Human Beings by Country. Evolution is not controversial scientifically. Just as gravity is not. Obviously this understanding is far from universal however.

But it is just a matter of time: similar to Galileo Galilei and heliocentric cosmology. See: Galileo’s Battle for the Heavens – Copernican System – Galileo). We now sit maybe 100 years after Galileo’s death (based on the evidence available in support of each scientific theory). At some point the evidence is accepted and life continues. Though I must admit it, I find it a bit disappointing how long it is taking for some people to accept the evidence of evolution. But I probably need to learn to be more patient – I have been told that more than once. All I can do is try to help present some small amount of the great work so many scientists have done to advance our knowledge. And here I am talking about evolution – for the 28% of those in the USA that couldn’t provide the answer that earth revolves around the sun, in 1998, well, they need much more help than I can provide.

Bacteria Can Transfer Genes to Other Bacteria

From page 115 of Good Gems, Bad Germs:

Microbiologists of the 1950’s did not appreciate the stunning extent to which bacteria swap genes… In 1959 Japanese hospitals experience outbreaks of multidrug-resistant bacterial dysentery. The shigella bacteria, which caused the outbreaks, were shrugging off four different classes of previously effective antibiotics: sulfonamides, streptomycins, chloramphenicols, and tetracyclines… In fact, the Japanese researches found it quite easy to transfer multidrug resistance from E. coli to shingella and back again simply by mixing resistant and susceptible strains together in a test tube.

Virus Engineered To Kill Deadly Brain Tumors

Yale Lab Engineers Virus That Can Kill Deadly Brain Tumors

A laboratory-engineered virus that can find its way through the vascular system and kill deadly brain tumors has been developed by Yale School of Medicine researchers, it was reported this week in the Journal of Neuroscience.

Each year 200,000 people in the United States are diagnosed with a brain tumor, and metastatic tumors and glioblastomas make up a large part of these tumors. There currently is no cure for these types of tumors, and they generally result in death within months.
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“Three days after inoculation, the tumors were completely or almost completely infected with the virus and the tumor cells were dying or dead,” van den Pol said. “We were able to target different types of cancer cells. Within the same time frame, normal mouse brain cells or normal human brain cells transplanted into mice were spared. This underlines the virus’ potential therapeutic value against multiple types of brain cancers.”

Pretty cool. Too bad these press releases never quite live up to the initial promise. Still this one is very cool, if it can succeed in helping even a small percentage of people it will be a great breakthrough. It is also just cool – using a virus to kill tumors – how cool is that?

Bats Are Dying in North-East USA

Vet College scientists aid investigation of why bats in Northeast are mysteriously dying By Krishna Ramanujan

Bat specialists from the New York State Department of Conservation (NYSDEC) have found 15 sites, up from four discovered last year, with sick bats: one in Massachusetts, two in Vermont and 12 in New York between Albany and Watertown. To help diagnose the problem, NYSDEC scientists are sending samples to Beth Buckles, assistant professor of biomedical sciences in Cornell’s College of Veterinary Medicine.

The affected bats are mostly little brown bats (Myotis lucifugus), among the most common North American bats. Other affected bats include the endangered Indiana bat (Myotis Sodalis), the northern long-eared bat (Myotis septentrionalis) and the eastern pipistrelle (Perimyotis subflavus). The bats live year round in the general area of study and usually hibernate each winter in the same caves.

Buckles and colleagues are conducting postmortem exams of organs and tissues and testing for signs of inflammation, bacteria, viruses and toxins. So far, the researchers do not yet know what is causing the massive casualties, Buckles said. “We have some good leads. We are continuing to look for infectious causes and are developing protocols to assess the bats’ metabolic states. They may not have enough fat to make it through the winter,” she said.

Many of the sick bats have a white fungus growing on their faces, are very thin and are congregating near to the cave entrances, a habit of ill bats. But it is “unprecedented” to find so many sick bats grouped near cave entrances, said Buckles. In two caves the researchers studied last year — that together had an estimated 18,000 bats — up to 97 percent died. The caves found this year may hold between 150,000 and 200,000 bats, many of them sick.

Related: Nectar-Feeding Bats – Bye Bye Bees

Leafhopper Feeding a Gecko

Some of this stuff is just fun. The leafhopper feeds on the sap of the tree. And the Gecko will stop by and wait to be fed. The narrator explains that scientists have not determined why this happens, perhaps the Gecko keeps aware predators? That seems somewhat flimsy as a guess to me but what do I know. The narrator does say that the sweet honeydew is what remains from the sap once the leafhopper has extracted the protein.

Some Bacteria Might Fight Cancer

Cancer and the bacterial connection

today, some scientists think Coley had it right: Germs can teach our bodies how to fight back against tumors. Dr. John Timmerman, a cancer immunotherapy expert at UCLA’s Jonsson Cancer Center, says this revolution has produced “the most exciting sets of compounds in cancer immunolog
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The studies also imply that our cleaner, infection-free lifestyles may be contributing to the rise in certain cancers over the last 50 years, scientists say, because they make the immune system weaker or less mature. Germs cause disease but may also fortify the body, a notion summed up in a 2006 report by a team of Canadian researchers as “whatever does not kill me makes me stronger.”
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Other groups have been experimenting with injections of other types of heat-killed bacteria, including Myobacterium vaccae, a tuberculosis relative. In two studies in January’s European Journal of Cancer, researchers report that these bacteria may help fight certain lung and renal cancers.

The rich interplay of complex systems are often very difficult to grasp simply. I discusses this concept in the post on the excellent book, Parasite Rex.

One Reason Bacteria Gain Tolerance So Quickly

I recently read Good Gems, Bad Germs as part of my effort to learn more about bacteria, viruses, how are bodies work, cells, microbiology etc.. It is a great book, I highly recommend it. Page 111:

In 1951 the husband-wife team of Joshua and Esther Lederberg, microbiologists at the University of Wisconsin, demonstrated that their elegantly simple proof that preexisting mutations, not gradual tolerance, accounted for the many instances of new drug resistance… This meant that every new antibiotic became a powerful new force for bacterial evolution, winnowing away every bacterium but the otherwise unremarkable one that could survive its effects. With its competition gone, that lucky mutant could populate, giving rise to a newly resistant colony overnight.

Since bacteria can grow remarkably quickly, eliminating all but a small number just means that the new population boom will come from those few, resistant, ancestors. But that is not the only reason bacteria are so challenging to fight. They have been around billions or years and have survived because they can adapt well. Bacteria, in fact, can get their genes from distantly related bacteria. So if one bacteria gains immunity another bacteria can get that immunity by getting genes from that other bacteria (seems like science fiction but it is actually science fact).

Really Old Coral – Over 2,000 Years Old

photo of sea coral (leiopathes_glaberrima)

Worlds oldest animal aged to 4000 years

deep-sea gold corals (Geradia sp.) and black corals (Leiopathes glaberrima, pictured left) indicate these animals live between two and four millennia
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The new findings break all records previously claimed for marine invertebrates like the cold seep tubeworms (estimated 200 years old), quahog clams (estimated 400 years old), as well as the deep-sea wannabees Primnoa spp. and bamboo corals (45 – 300 years old). Given the new results, deep-sea animals can finally measure up to the longevity of the “Methuselah tree”, the Bristlecone Pine, estimated to be near 5000 years old.
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perhaps the most important thing to mention is that gold and black corals are colonial zoantharians. No single polyp is thought to be this old, just the skeletal axis.

How is Coral an animal?

Coral is an animal that belongs to the phylum cnidaria…
During the mating season coral polyp release eggs and sperm into the water (picture below) and when an egg and a sperm meet they form a larva known as a planula…
The baby coral looks like a little tiny jellyfish and it floats around in the water until it finds a hard place to attach to, usually a coral reef. Then it lands and starts to build itself a shell. It builds it by combining carbon dioxide (CO2) and calcium (Ca) in the water to make calcium carbonate (CaCO3) also known as limestone. This shell is shaped like a round vase and the coral polyp lives inside…