Category Archives: Life Science

Sex and the Seahorse

Sex and the seahorse (site broke the link so I removed the link – poor usability):

Unlike the sex roles in the vast majority of animals, the male seahorse looks after the fertilised eggs in a special brood sac on the front of his abdomen, which works much like the womb of a female mammal. The fertilised eggs get embedded into the wall of the pouch and are bathed in a fluid that provides nutrients and oxygen. In effect, the male seahorse becomes pregnant and gives birth to live offspring – the only male in the animal kingdom to do so.

Related: Seahorse podcast (mp3 – NPR Our Ocean World) – Kingdom of the Seahorse (NOVA)

Millennials in our Lifetime?

No I don’t mean the generation Y types born in the 1980s and 1990s I mean 1,000 year old people. I doubt it, but according to Cambridge University geneticist Aubrey de Grey – yes. And his credentials are better than mine, well I guess some of us might see who is right. ‘We will be able to live to 1,000’. Do You Want to Live Forever?:

As he surveyed the literature, de Grey reached the conclusion that there are seven distinct ingredients in the aging process, and that emerging understanding of molecular biology shows promise of one day providing appropriate technologies by which each of them might be manipulated — “perturbed,” in the jargon of biologists. He bases his certainty that there are only seven such factors on the fact that no new factor has been discovered in some twenty years, despite the flourishing state of research in the field known as biogeronÂtology, the science of aging; his certainty that he is the man to lead the crusade for endless life is based on his conception that the qualification needed to accomplish it is the mindset he brings to the problem: the goal-driven orientation of an engineer rather than the curiosity-driven orientation of the basic scientists who have made and will continue to make the laboratory discoveries that he intends to employ.

Aubrey de Grey Responds – Methuselah Mouse Man – Aubrey de Grey on TEDTalks: Aging is “an engineering problem” – The Prophet of Immortality

Cancer Deaths – Declining Trend?

3,000 fewer cancer deaths:

Cancer deaths in the United States dropped for the second year in a row, health officials reported yesterday, confirming that the trend is real and becoming more pronounced, too.

The news was cause for celebration among doctors and politicians. “When we saw the first decline, the number wasn’t that enormous,” Dr. Felice Schnoll-Sussman, a cancer physician at New York-Presbyterian Hospital/Weill Cornell Medical Center said. “But once you start to see a trend like this, it obviously makes you feel like ‘We must be doing something right! ‘”

Is this really a trend? I have not examined the data at all but I seriously doubt it. People (the media even more so) constantly overreact to variation in data. Maybe I am wrong, certainly I should look at the data and see what it says – and I will if I get some time and remember. But I am more confident in my belief this is more overreaction to random variation than in the headlines. Why? Because so often when I do look more closely at the numbers my general observation of overreaction to random variation is confirmed while news reports talk of “trends.” Hopefully I am wrong this time.

Ok, I couldn’t resist and I did a little looking for some data. This is how crazy it is. The press release from the American Cancer Society states:
Continue reading →

Cheap, Safe Cancer Drug?

Cheap, safe drug kills most cancers:

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Well I have been told I am too skeptical, but it does sound too good to be true. How many stories of cancer cures do we hear every year? Even if the drug companies leave it alone (I would imagine they could easily find ways to have drugs that partially rely on this and partially on things they can patent, but anyway…) foundations and universities will invest in it if it is truly deserving. Now maybe I am being too optimistic?

Edinburgh University $115 Million Stem Cell Center

Stem cell centre plan confirmed

Additional Scottish Executive funding of Â£24m will allow Edinburgh University to develop the Â£59m centre in collaboration with Scottish Enterprise. The Scottish Centre for Regenerative Medicine (SCRM) is thought to be equalled only one in Kobe, Japan. Prof Ian Wilmut, formerly of the Roslin Institute, will be the director.

The state-of -the-art facilities are expected to house 220 academic researchers and will include a centre for “scale-up” development and manufacture of cells. Space will also be made available for commercial regenerative medicine. It is hoped that the SCRM, which will be part of the new Centre for Biomedical Research at Edinburgh’s Little France, will create about 560 jobs and generate Â£18.2m per year for the Scottish economy.

via: Univ. of Edinburgh Launches $115 Million Dollar Stem Cell Research Center

Harvard Plans Life Sciences Campus

Harvard Unveils Plans for 250 Acre Stem Cell and Life Sciences Campus:

During the first 20 years of the expansion, Harvard would build 4 million to 5 million square feet of buildings and create at least 5,000 jobs, university officials said. Construction in Allston could begin this summer when Harvard hopes to break ground on a 500,000-square-foot (46,450-square-metre) science complex that will house the school’s stem-cell researchers and other institutes. The science complex, university officials said, would be the nucleus for new interdisciplinary research and is expected to go a long way toward boosting Boston’s economy by encouraging partnerships with biotechnology firms that may displace the region’s long-fading manufacturing base.

5,000 jobs is a huge number (even looking out 20 years). Manufacturing is still a huge economic factor (for the USA and the world) but investing in creating science and engineering centers of excellence is critical in determining where strong economies and good jobs will be 30+ years from now. They don’t explain what those 5,000 jobs are, but it seems that thousands could be for science and engineering graduates. The value of that to Boston’s economy is huge.

Evolved for Cancer?

Evolved for Cancer? by Carl Zimmer:

In cancer, cells play the role of organisms. Cancer- causing changes to DNA cause some cells to reproduce more effectively than ordinary ones. And even within a single tumor, more adapted cells may outcompete less successful ones.
…
Tumor suppressor proteins are among the most effective defenses against cancer. Studies suggest that some of these proteins prevent cancer by monitoring how a cell reproduces. If the cell multiplies in an abnormal way, the proteins induce it to die or to slip into senescence, a kind of early retirement. The cell survives, but it can no longer divide. Tumor suppressor proteins play a vital role in our survival, but scientists have recently discovered something strange about them: in some respects, we would be better off without them.

Scientists discover new class of RNA

These new RNAs are named after their distinctive features: Each molecule contains 21 chemical building blocks (or nucleotides), and each begins with the chemical uridine, represented by the letter U (the only RNA nucleotide not also found on DNA). In addition, each of the 5,000 different 21U-RNA molecules comes from one of two chromosomal regions.

Further, “we can predict where additional 21U-RNA genes might reside,” says Bartel, who is also a member of the Whitehead Institute for Biomedical Research and a Howard Hughes Medical Institute investigator. “Combining these predictions with the 5,000 (21U-RNAs) that we experimentally identified, we suspect that there are more than 12,000 different 21U-RNA genes in the genome.” Because each gene typically produces a unique 21U-RNA, a very large diversity of molecules is made.

RNA description from the Nobel Prize site:

When an organism needs to use the data stored in the genome, e.g. to build components of a new cell, a copy of the required DNA part is made. This copy is called RNA and is almost identical to DNA. Just like DNA, RNA is an abbreviated form of a chemical name which in the case of RNA is ribonucleic acid. Unlike the double stranded DNA, RNA is only made up of a single strand. Furthermore, the base T, thymine, is replaced by U, uracil in RNA. This RNA string is used by the organism as a template when it builds protein molecules, sometimes called the building blocks of the body. For example, your muscles and hair are mostly made up of proteins.

Related: DNA-RNA-Protein Introduction

Can Brain Exercises Prevent Mental Decline?

Last month we posted about: Short Mental Workouts May Slow Decline of Aging Minds. Now here is another article on the same topic: Little proof that brain exercises can prevent mental decline by Alice Dembner

Richard Suzman, who oversees behavioral and social research at the National Institute on Aging, said the downside of using the programs include “harm to the wallet or false hope,” or health setbacks if people spend time brain-training instead of getting physical exercise. But others say, despite the lack of evidence, that the programs may be worth trying, particularly in conjunction with other activities that may help with brain health such as a healthy diet, exercise, managing stress, and keeping up social contacts.
…
And only last month did the first rigorous study suggest that brain training could positively affect daily-life activities and might delay age-related declines in everyday functioning. Even in that large, government-funded study, the evidence was far from conclusive.

In the original post we mentioned: “Another Paper Questions Scientific Paper Accuracy (just a reminder that the conclusions of many studies are not confirmed in future studies).” That is always important to keep in mind, even though we don’t post that reminder every time.

Human Embryo Hybrids

Embryo hybrids are used to grow human stem cells (for a few days) in eggs from animals. Public debate on embryo hybrids

Allowing DNA from humans and animals to be mixed should be put to a public debate, a regulatory body has said.

The Human Fertilisation and Embryology Authority (HFEA), which oversees embryo research and fertility treatment, said the research could fall under its remit and would not be prohibited by law after a meeting of experts on Wednesday.

Door left open for creation of hybrid embryos:

Two teams of British scientists have applied for licences to create “hybrid” embryos that would be about 99.9 per cent human and 0.1 per cent animal to produce embryonic stem cells — the body’s building blocks that can grow into all other types of cells.
advertisement

They want to use stem cells to understand and develop therapies for diseases such as Alzheimer’s, Parkinson’s, cystic fibrosis, motor neurone disease and Huntington’s. The hybrid embryos would be destroyed within 14 days when they were no bigger than a pinhead.