Category Archives: quote

Bacteria and Efficient Food Digestion

Gut Bacteria May Cause And Fight Disease, Obesity

“We’re all sterile until we’re born,” says Glenn Gibson, a microbiologist at the University of Reading in Britain. “We haven’t got anything in us right up until the time we come into this big, bad, dirty world.”

But as soon as we pass out of the birth canal, when we are fetched by a doctor’s hands, placed in a hospital crib, put on our mother’s breast, when we drag a thumb across a blanket and stick that thumb in our mouths, when we swallow our first soft food, we are invaded by all sorts of bacteria. Once inside, they multiply – until the bacteria inside us outnumber our human cells.
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University of Chicago immunologist Alexander Chervonsky, with collaborators from Yale University, recently reported that doses of the right stomach bacteria can stop the development of type 1 diabetes in lab mice. “By changing who is living in our guts, we can prevent type 1 diabetes,” he told The Wall Street Journal.

The bottom line: We now have two sets of genes to think about – the ones we got from our parents and the ones of organisms living inside us. Our parents’ genes we can’t change, but the other set? Now that is one of the newest and most exciting fields in cell biology.

Follow link with related podcast: Gut bacteria may cause and fight, disease, obesity. This whole area of the ecosystem within us and our health I find fascinating. And I fall for confirmation bias on things like becoming inefficient at converting food to energy as a way reduce obesity.

You could have two people sitting down to a bowl of cheerios, they could each eat the same number of cheerios but because of a difference in their gut bacteria one will get more calories than the other.

They then gave an example of the difference being 95 calories versus 99 calories. Hardly seems huge but it would add up. Still that is a less amazing difference than I was expecting.

Monitor-Merrimac Memorial Bridge-Tunnel

photo of Hampton Roads Virginia Bridge-Tunnel

Now that is some cool engineering: a bridge that becomes a tunnel. The Monitor-Merrimac Memorial Bridge-Tunnel is a 4.6 miles (7.4 km) crossing for Interstate 664 in Hampton Roads, Virginia, USA. It is a four-lane bridge-tunnel composed of bridges, trestles, man-made islands, and tunnels under a portion of the Hampton Roads harbor where the James, Nansemond, and Elizabeth Rivers come together in the southeastern portion of Virginia.

If you like this post, please look at our other popular posts, and consider adding our blog feed to your blog reader. Posts such as: Bacteriophages: The Most Common Life-Like Form on Earth, Robot Finds Lost Shoppers and Provides Directions and The Engineer That Made Your Cat a Photographer

It was completed in 1992, after 7 years of construction, at a cost $400 million, and it includes a four-lane tunnel that is 4,800 feet (1,463 m) long, two man-made portal islands, and 3.2 miles (5.1 km) of twin trestle.

Photos by Virginia Department of Transportation. Details from wikipedia. Google satellite view of the bridge-tunnel.

Foreign Cells Outnumber Human Cells in Our Bodies

This is one of those area I find very interesting: People Have More Bacterial Cells than Human Cells. Colin Nickerson has written an interesting article on the topic: Of microbes and men

Scientists estimate that 90 percent of the cells contained in the human body belong to nonhuman organisms – mostly bacteria, but also a smattering of fungi and other eensy entities. Some 100 trillion microbes nestle in niches from our teeth to our toes.

But what’s setting science on its heels these days is not the boggling numbers of bugs so much as the budding recognition that they are much more than casual hitchhikers capable of causing disease. They may be so essential to well-being that humans couldn’t live without them.

In this emerging view, humans and their microbes – or, as some biologists playfully put it, microbes and their attached humans – have evolved together to form an extraordinarily complex ecosystem.

The understanding of the complex interaction is something I came to through reading on the overuse of antibiotics. And the more I read the more interesting it gets.

“We can’t take nutrition properly without bacteria. We can’t fight bad germs without good germs,” he said. “It may turn out that secretions from bacteria affect not only long-term health, but hour-by-hour moods – could a person’s happiness depend on his or her bugs? It’s possible. Our existences are so incredibly intertwined.”

However, in the opinion of some researchers, this strange union may be headed for trouble because of profligate use of antibiotics and antiseptic lifestyles that deter the transfer of vital strains of bacteria that have swarmed in our systems at least since early humans ventured out of Africa.

Illinois and Olin Aim to Transform Engineering Education

It appears Illinois is preparing to attempt to apply some of the idea piloted at Olin on a larger scale. It will be very interesting to see what happens. Illinois Partners with Olin College to Transform Engineering Education

“Illinois is to be commended for embarking on a serious initiative to demonstrate scalable innovation at a large land-grant school,” Miller stated. “Olin has pioneered many innovations in its multi-disciplinary, project-based engineering curriculum, but we still don’t know how widely applicable these reforms are. Through this partnership, Olin and Illinois will be able to explore how to diffuse innovation more broadly throughout the engineering education community. The partnership is a true collaboration, offering Illinois access to Olin’s unique educational Petri dish, and offering faculty and students at Olin special access to Illinois’ quality researchers and facilities, recognized as among the best in the world.”

As part of this effort Illinois seems to be using a new something (I am not sure what it should be called): iFoundry. Illinois Foundry for Innovation in Engineering Education, is an interdepartmental curriculum incubator in the College of Engineering at the University of Illinois designed to pilot principled change while respecting faculty governance.

Best Research University Rankings – 2008

The annual ranking of research Universities are available from Shanghai’s Jiao Tong University. The methodology values publications and faculty awards which provides a better ranking of research (rather than teaching). Results from the 2008 rankings of Top 500 Universities worldwide, country representation of the top schools:

location	Top 100	% of World Population	% of World GDP	% of top 500
USA	54	4.6%	27.2%	31.6%
United Kingdom	11	0.9	4.9	8.3
Germany	6	1.3	6.0	8.0
Japan	4	2.0	9.0	6.2
Canada	4	0.5	2.6	4.2
Sweden	4	0.1	0.8	2.2
France	3	0.8	4.6	4.6
Switzerland	3	0.1	0.8	1.6
Australia	3	0.3	1.6	3.0
Netherlands	2	0.2	1.4	2.4
Denmark	2	0.1	0.6	0.8
Finland	1	0.1	0.4	1.2
Norway	1	0.1	0.7	0.8
Israel	1	0.1	0.3	1.2
Russia	1	2.2	2.0	0.4
China		20.5	6.6	6.0
India		17.0	1.9	0.4

There is little change in most of the data from last year, which I think is a good sign, it wouldn’t make much sense to have radical shifts over a year in these rankings. Japan lost 2 schools in the top 100, France lost 1. Denmark (Aarhus University) and Australia (University of Sydney) gained 1. Last year there was a tie so there were 101 schools in the top 100.

The most dramatic data I noticed is China’s number of top 500 schools went from 14 to 30, which made me a bit skeptical of what caused that quick change. Looking more closely last year they reported the China top 500 totals as (China 14, China-Taiwan 6 and China-Hong Kong 5). That still gives them an impressive gain of 5 schools.

Singapore has 1 in the 102-151 range. Taiwan has 1 ranked in the 152-200 range, as do Mexico, Korea and Brazil. China has 9 in the 201-302 range (including 3 in Hong Kong). India has 2 in the 303-401 range.

University of Wisconsin – Madison is 17th again 🙂 My father taught there while I grew up.
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Kids on Scientists: Before and After

Fermilab offers some drawing of scientists by seventh graders before and after a visit to Fermilab. Wonderful visuals.

Before	After

I think of a scientist as very dedicated to his work. He is kind of crazy, talking always quickly. He constantly is getting new ideas. He is always asking questions and can be annoying. He listens to others’ ideas and questions them.	I know scientists are just normal people with a not so normal job. . . . Scientists lead a normal life outside of being a scientist. They are interested in dancing, pottery, jogging and even racquetball. Being a scientist is just another job which can be much more exciting.
by Amy

This is one of the more extreme ones but there are lots of other great comparisons. Very reminiscent of: Children’s view of Scientists in England.

S&P 500 CEOs are Engineering Graduates

2007 Data from Spencer Stuart on S&P 500 CEO (they deleted the link so the link was removed – yet another website proves to be unreliable without basic web usability principles being followed) shows once again more have undergraduate degrees in engineering than any other field.

Field	% of CEOs
	2007	2006	2005
Engineering	21	23	20
Economics	15	13	11
Business Administration	13	12	15
Accounting	8	8	7
Liberal Arts	6	8	9
No degree or no data	3	3

The report does not show the fields for the rest of the CEO’s. 40% of S&P CEOs have MBAs. 27% have other advanced degrees. The University of Wisconsin-Madison, Princeton and Harvard tied for the most CEO’s with undergraduate degrees from their universities at 12. University of Texas has 10 and Stanford has 9.

Data for previous years is also from Spencer Stuart: 2006 S&P 500 CEO Education Study – Top degree for S&P 500 CEOs? Engineering (2005 study)

Fold.it – the Protein Folding Game

Foldit is a revolutionary new computer game enabling you to contribute to important scientific research. This is another awesome combination of technology, distributed problem solving, science education…

Essentially the game works by allowing the person to make some decisions then the computer runs through some processes to determine the result of those decisions. It seems the human insight of what might work provides an advantage to computers trying to calculate solutions on their own. Then the results are compared to the other individuals working on the same protein folding problem and the efforts are ranked.

This level of interaction is very cool. SETI@home, Rosetta@home and the like are useful tools to tap the computing resources of millions on the internet. But the use of human expertise really makes fold.it special. And you can’t help but learn by playing. In addition, if you are successful you can gain some scientific credit for your participation in new discoveries.

The site includes some excellent educational material on proteins and related material. What is a protein:

Proteins are the workhorses in every cell of every living thing. Your body is made up of trillions of cells, of all different kinds: muscle cells, brain cells, blood cells, and more. Inside those cells, proteins are allowing your body to do what it does: break down food to power your muscles, send signals through your brain that control the body, and transport nutrients through your blood. Proteins come in thousands of different varieties, but they all have a lot in common. For instance, they’re made of the same stuff: every protein consists of a long chain of joined-together amino acids.
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structure specifies the function of the protein. For example, a protein that breaks down glucose so the cell can use the energy stored in the sugar will have a shape that recognizes the glucose and binds to it (like a lock and key) and chemically reactive amino acids that will react with the glucose and break it down to release the energy.
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Proteins are involved in almost all of the processes going on inside your body: they break down food to power your muscles, send signals through your brain that control the body, and transport nutrients through your blood. Many proteins act as enzymes, meaning they catalyze (speed up) chemical reactions that wouldn’t take place otherwise. But other proteins power muscle contractions, or act as chemical messages inside the body, or hundreds of other things.

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Physicist Swimming Revolution

A Revolution That Began With a Kick by Amy Shipley:

The answer, they say, cannot lie solely in the latest high-tech swimsuits introduced amid a swirl of controversy this winter, because the world-record smashing began at last year’s world championships — long before the newest of the newfangled apparel came out.

Swimmers, coaches and scientists say it is impossible to pinpoint one explanation. They cite many contributing factors, ranging from professional training groups that have sprouted across the United States to greater access to underwater cameras and other advanced technology.

But some say the most significant breakthrough has been a revival of a swimming maneuver developed more than 70 years ago by one of the physicists who worked on the atomic bomb.

Though utilized for decades, the underwater dolphin kick had not been fully exploited by the swimming mainstream until Olympic megastar Michael Phelps and a few other stars began polishing it — and crushing other swimmers with it — in recent years.

Very interesting and another example of how good ideas are often ignored for a long time.

The underwater dolphin kick attracted the interest of swimming innovators as early as the 1930s. The late Volney C. Wilson explored its possibilities before diving into later work on nuclear fission and the atomic bomb, according to David Schrader, a research professor at Marquette University who is Wilson’s biographer.

Schrader said Wilson, an alternate on the 1932 Olympic water polo team who studied fish propulsion at a Chicago aquarium, claimed to have shown the kick to Johnny Weissmuller, a training mate at the Illinois Athletic Club. “Weissmuller reproduced it perfectly, but was not impressed by it,” said Schrader in a phone interview, recalling a conversation with Wilson.
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One of the first swimmers to turn heads with the underwater dolphin kick was David Berkoff, a Harvard graduate who became known for the “Berkoff Blastoff.” In 1988, Berkoff set several world records in the 100 backstroke by dolphin-kicking for 35 meters underwater at the start of the race.

Which goes to show you that you can gain advantages just by using the information that is available – your own innovation is not the only way to get ahead. Just doing a better job of adapting what others learn to your challenges can be very rewarding.

Pax Scientific

Nature Gave Him a Blueprint, but Not Overnight Success

Mr. Harman is a practitioner of biomimicry, a growing movement of the industrial-design field. Eleven years ago, he established Pax Scientific to commercialize his ideas, thinking that it would take only a couple of years to convince companies that they could increase efficiency, lower noise or create entirely new categories of products by following his approach.
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His radical ideas have so far found a cautious reception in the aircraft, air- conditioning, boating, pump and wind turbine industries. Mr. Harman’s experience is not unusual. Rather than beating a path to the door of mousetrap designers, the world seems to actively avoid them.
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Even in fields such as the computer industry, which celebrates innovation, systemic change can be glacial.
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In another hopeful sign, a world that long ignored energy efficiency is suddenly thinking of nothing else. “We tried for years to promote energy conservation, and we couldn’t find one who was interested,” he said. “Now the world has done a U-turn.”

Yet another example that new knowledge is not enough. It takes much longer for good ideas to be put into practice than seems reasonable (until you get your head around the idea it takes a fair amount of time for new ideas to be adopted).

One positive aspect of this reality is that if you can take advantage of new ideas before others you can gain an advantage. It isn’t necessarily true that just because now everyone knows about some new idea that you have no opportunity to use the knowledge before others.