Category Archives: Research

Lethal Secrets of 1918 Flu Virus

Lethal secrets of 1918 flu virus

Analysis at the University of Wisconsin at Madison (UW) revealed that a key component of the immune system, a gene called RIG-1 appeared to be involved. Levels of the protein produced by the gene were lower in tissue infected with the 1918 virus, suggesting it had a method of switching it off, causing immune defences to run wild.

This ability to alter the body’s immune response is shared with the most recent candidate for mutation into a pandemic strain, the H5N1 avian flu. Experts are worried that if the virus changes so that it can infect humans easily, it could again be far more lethal than normal seasonal flu. “What we see with the 1918 virus in infected monkeys is also what we see with H5N1 viruses,” said Yoshihiro Kawaoka, who led the analysis at UW.

Cheap, Safe Cancer Drug?

Cheap, safe drug kills most cancers:

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Well I have been told I am too skeptical, but it does sound too good to be true. How many stories of cancer cures do we hear every year? Even if the drug companies leave it alone (I would imagine they could easily find ways to have drugs that partially rely on this and partially on things they can patent, but anyway…) foundations and universities will invest in it if it is truly deserving. Now maybe I am being too optimistic?

3 “Moore Generations” of Chips at Once

HP nanotech design could be leap forward for chips by Therese Poletti

The scientists said their advance would equal a leap of three generations of Moore’s Law, a prediction formulated in 1964 by Intel co-founder Gordon Moore that forecast chip makers could double the number of transistors on a chip every couple of years. “This is three generations of Moore’s Law, without having to do all the research and development to shrink the transistors,” said Stan Williams, a senior fellow at HP in Palo Alto. “If in some sense we can leapfrog three generations, that is something like five years of R&D. That is the potential of this breakthrough.”
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HP researchers plan to start manufacturing prototypes of their chip design later this year. They also said they expect to see a high rate of defects in the finished products, but that the greater amount of defects will be compensated for by the ability of the circuitry to quickly route around the failed circuits. The model for their chip design is based on a 45-nanometer chip, but with much smaller wiring in the chicken-wire crossbars of 4.5 nanometers.

“Hopefully, by the middle of this year, we will have a real working chip that we have run through an HP fab,” Williams said. “Our goal is that by 2010, we will have something that we can give our customers to play with.”

Helium-3 Fusion Reactor

Future In Fusion? by John Lasker:

Nevertheless, UW fusion researchers believe their plan could get civilization off fossil fuels. That’s if crews could return to the moon to mine for helium-3, super-heat it out of the lunar soil to process the gas, and return it to the Earth.
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But scientists and investors have taken notice. Nearly all of UW fusion research is privately funded. And meanwhile, with China, India, the European Space Agency and at least one Russian corporation all pursuing plans for a manned lunar base in the coming decades, there is increasing talk of a race to control this fuel, one shuttle load of which could theoretically power the United States for a year.
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Aftergood doesn’t believe a race with China for lunar helium-3 has begun. Yet a race to the moon against China — whether real or superficial — may be in NASA’s best interest, he said. “There are some who wish this would be the case — this race with China. They believe it would recapture the dynamic of the United States’ and Russia’s race to the moon,” he said.

This sounds pretty incredible to me and I find the claims of using fuel from the Moon economically to power our needs on Earth. Still it is interesting and just because it sounds fantastic does not mean it can’t be true. But I am skeptical.

Edinburgh University $115 Million Stem Cell Center

Stem cell centre plan confirmed

Additional Scottish Executive funding of Â£24m will allow Edinburgh University to develop the Â£59m centre in collaboration with Scottish Enterprise. The Scottish Centre for Regenerative Medicine (SCRM) is thought to be equalled only one in Kobe, Japan. Prof Ian Wilmut, formerly of the Roslin Institute, will be the director.

The state-of -the-art facilities are expected to house 220 academic researchers and will include a centre for “scale-up” development and manufacture of cells. Space will also be made available for commercial regenerative medicine. It is hoped that the SCRM, which will be part of the new Centre for Biomedical Research at Edinburgh’s Little France, will create about 560 jobs and generate Â£18.2m per year for the Scottish economy.

via: Univ. of Edinburgh Launches $115 Million Dollar Stem Cell Research Center

Harvard Plans Life Sciences Campus

Harvard Unveils Plans for 250 Acre Stem Cell and Life Sciences Campus:

During the first 20 years of the expansion, Harvard would build 4 million to 5 million square feet of buildings and create at least 5,000 jobs, university officials said. Construction in Allston could begin this summer when Harvard hopes to break ground on a 500,000-square-foot (46,450-square-metre) science complex that will house the school’s stem-cell researchers and other institutes. The science complex, university officials said, would be the nucleus for new interdisciplinary research and is expected to go a long way toward boosting Boston’s economy by encouraging partnerships with biotechnology firms that may displace the region’s long-fading manufacturing base.

5,000 jobs is a huge number (even looking out 20 years). Manufacturing is still a huge economic factor (for the USA and the world) but investing in creating science and engineering centers of excellence is critical in determining where strong economies and good jobs will be 30+ years from now. They don’t explain what those 5,000 jobs are, but it seems that thousands could be for science and engineering graduates. The value of that to Boston’s economy is huge.

Scientists discover new class of RNA

These new RNAs are named after their distinctive features: Each molecule contains 21 chemical building blocks (or nucleotides), and each begins with the chemical uridine, represented by the letter U (the only RNA nucleotide not also found on DNA). In addition, each of the 5,000 different 21U-RNA molecules comes from one of two chromosomal regions.

Further, “we can predict where additional 21U-RNA genes might reside,” says Bartel, who is also a member of the Whitehead Institute for Biomedical Research and a Howard Hughes Medical Institute investigator. “Combining these predictions with the 5,000 (21U-RNAs) that we experimentally identified, we suspect that there are more than 12,000 different 21U-RNA genes in the genome.” Because each gene typically produces a unique 21U-RNA, a very large diversity of molecules is made.

RNA description from the Nobel Prize site:

When an organism needs to use the data stored in the genome, e.g. to build components of a new cell, a copy of the required DNA part is made. This copy is called RNA and is almost identical to DNA. Just like DNA, RNA is an abbreviated form of a chemical name which in the case of RNA is ribonucleic acid. Unlike the double stranded DNA, RNA is only made up of a single strand. Furthermore, the base T, thymine, is replaced by U, uracil in RNA. This RNA string is used by the organism as a template when it builds protein molecules, sometimes called the building blocks of the body. For example, your muscles and hair are mostly made up of proteins.

Related: DNA-RNA-Protein Introduction

Can Brain Exercises Prevent Mental Decline?

Last month we posted about: Short Mental Workouts May Slow Decline of Aging Minds. Now here is another article on the same topic: Little proof that brain exercises can prevent mental decline by Alice Dembner

Richard Suzman, who oversees behavioral and social research at the National Institute on Aging, said the downside of using the programs include “harm to the wallet or false hope,” or health setbacks if people spend time brain-training instead of getting physical exercise. But others say, despite the lack of evidence, that the programs may be worth trying, particularly in conjunction with other activities that may help with brain health such as a healthy diet, exercise, managing stress, and keeping up social contacts.
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And only last month did the first rigorous study suggest that brain training could positively affect daily-life activities and might delay age-related declines in everyday functioning. Even in that large, government-funded study, the evidence was far from conclusive.

In the original post we mentioned: “Another Paper Questions Scientific Paper Accuracy (just a reminder that the conclusions of many studies are not confirmed in future studies).” That is always important to keep in mind, even though we don’t post that reminder every time.

Human Embryo Hybrids

Embryo hybrids are used to grow human stem cells (for a few days) in eggs from animals. Public debate on embryo hybrids

Allowing DNA from humans and animals to be mixed should be put to a public debate, a regulatory body has said.

The Human Fertilisation and Embryology Authority (HFEA), which oversees embryo research and fertility treatment, said the research could fall under its remit and would not be prohibited by law after a meeting of experts on Wednesday.

Door left open for creation of hybrid embryos:

Two teams of British scientists have applied for licences to create “hybrid” embryos that would be about 99.9 per cent human and 0.1 per cent animal to produce embryonic stem cells — the body’s building blocks that can grow into all other types of cells.
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They want to use stem cells to understand and develop therapies for diseases such as Alzheimer’s, Parkinson’s, cystic fibrosis, motor neurone disease and Huntington’s. The hybrid embryos would be destroyed within 14 days when they were no bigger than a pinhead.

NSF Strategic Plan

National Science Foundation Investing in America’s Future Strategic Plan FY 2006-2011

We will support transformational research and promote excellence in science and engineering education in ways that will fuel innovation, stimulate the economy, and improve quality of life. We will also nurture the vibrant and innovative science and engineering enterprise necessary to achieve these goals and stimulate broader participation in this enterprise throughout the nation.

That is pretty broad strokes but they have details and recognizable changes in attitude also.

abroad. Increasing international competition and workforce mobility, combined with a surge in international collaboration in science and engineering research, continue to alter the science and engineering landscape worldwide. To lead within this broader global context, the U.S. science and engineering workforce must build greater capacity for productive international collaboration.

More priorities: “Promote transformational, multidisciplinary research.” “Prepare a diverse, globally engaged STEM workforce.” “Engage and inform the public in science and engineering through informal education.” “Identify and support the next generation of large research facilities.” “Expand efforts to broaden participation from underrepresented groups and diverse institutions in all NSF activities.”