Category Archives: Research

Evolution of Antibiotic Resistance

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance from the Public Library of Science Biology Journal:

The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders pathogenic Escherichia coli unable to evolve resistance in vivo to ciprofloxacin or rifampicin, important quinolone and rifamycin antibiotics. We show in vitro that LexA cleavage is induced during RecBC-mediated repair of ciprofloxacin-mediated DNA damage and that this results in the derepression of the SOS-regulated polymerases Pol II, Pol IV and Pol V, which collaborate to induce resistance-conferring mutations. Our findings indicate that the inhibition of mutation could serve as a novel therapeutic strategy to combat the evolution of antibiotic resistance.

Neutrino Detector Searching for String Theory Evidence

Excellent 10 minute podcast presents details on search for evidence of string theory via Project IceCube.

Main IceCube web site – “IceCube is a one-cubic-kilometer international high-energy neutrino observatory being built and installed in the clear deep ice below the South Pole Station.”

South Pole Neutrino Detector Could Yield Evidences of String Theory:

Researchers at Northeastern University and the University of California, Irvine say that scientists might soon have evidence for extra dimensions and other exotic predictions of string theory. Early results from a neutrino detector at the South Pole, called AMANDA, show that ghostlike particles from space could serve as probes to a world beyond our familiar three dimensions, the research team says.

Magnetic Misfit Bacteria

Magnetic Misfits: South Seeking Bacteria in the Northern Hemisphere

Magnetotactic bacteria contain chains of magnetic iron minerals that allow them to orient in the earth’s magnetic field much like living compass needles. These bacteria have long been observed to respond to high oxygen levels in the lab by swimming towards geomagnetic north in the Northern Hemisphere and geomagnetic south in the Southern Hemisphere. In either hemisphere, this behavior would also lead them downward in the water column into areas with their preferred oxygen level. But an unusual bacterium in New England has been found doing just the opposite, a magnetic misfit of sorts.
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Simmons, a graduate student in the MIT/WHOI Joint Program in Oceanography and Applied Ocean Science and Engineering, received some additional support for her study from a National Defense Science and Engineering Graduate Fellowship. Edwards is her advisor.

Africa Scientific

Africa Scientific by Dr. Mohamed H.A. Hassan, Seed:

in Nigeria, the malaria group at the University of Ibadan is conducting research on a local disease problem, as is the Federal University of Technology-Minna, which has developed a typhoid vaccine for their own population. Makerere University’s Medical Biotechnology Laboratories in Kampala, Uganda, has an extensive molecular biology research and training program; among its most noteworthy efforts are studies of alternative treatments of river blindness, a fly-borne parasitic disease that just a decade ago afflicted one out of every three villagers in parts of Burkina Faso, Ghana, Nigeria and other nations.

I lived in Nigeria for a year, when I was a child, while my father taught chemical engineering as a Fulbright scholar. I still remember visiting factories, that I believe he was consulting for, as we traveled around West Africa. I returned to Africa in the 1990s to revisit Kenya and visit Egypt. See my travel photos from Kenya and a travel photo essay from Egypt.

John Hunter

Building Nanotechnological Structures

New Nanotechnological Structures Reported for the First Time by Alex Lyda, Columbia News:

“You can think of nanocrystals as building blocks like the toy Lego, in which a larger structure can be assembled by locking in the pieces according to their shape and the way they prefer to join to each other,” O’Brien says. “Except all of this is on an incredibly small lengthscale — billionths of a meter.”

The Columbia/IBM team has borrowed ideas from the natural world, in which the right conditions can stimulate the slow growth of highly uniform structures out of miniature building blocks. Opals are an example of this phenomenon: opals consist of tiny spherical building blocks of silica packed into an ordered structure. In this new research, the materials used as building blocks are a variety of man-made nanocrystals with known useful magnetic or electronic properties.

“This work may lead to the development of an entirely new class of multifunctional materials in which there are cooperative interactions between the nanocrystal components,” says MRSEC director Irving P. Herman, also a professor of applied physics. “Moreover, the properties of these nanocrystals can be tailored during synthesis, and they can be deposited to form the desired ordered array by controlling particle charge and other properties. O’Brien’s study also demonstrates the value of vibrant collaborations between universities and industry.”

Video: Magnetic and Semiconducting Nanocrystals Can Self-Assemble, Says Stephen O’Brien, Columbia University

Symbiotic relationship between ants and bacteria

Study reveals classic symbiotic relationship between ants, bacteria

Ants that tend and harvest gardens of fungus have a secret weapon against the parasites that invade their crops: antibiotic-producing bacteria that the insects harbor on their bodies.

“Every ant species [that we have examined] has different, highly modified structures to support different types of bacteria,” says Currie. “This indicates the ants have rapidly adapted to maintain the bacteria. It also indicates that the co-evolution between the bacteria and the ants, as well as the fungus and parasites, has been occurring since very early on, apparently for tens of millions of years.”

Furthermore, Currie says, the fact that the species have coexisted for so long means there might be a mechanism in place to decrease the rate of antibiotic resistance – which could help address a significant problem facing modern medicine. “We can learn a lot about our own use of antibiotics from this system,” he says.

Read more about the overuse of antibiotics

DNA Offers New Insight Concerning Cat Evolution

DNA Offers New Insight Concerning Cat Evolution, Nicholas Wade, New York Times:

Before DNA, taxonomists had considerable difficulty in classifying the cat family. The fossil record was sparse and many of the skulls lacked distinctiveness. One scheme divided the family into Big Cats and Little Cats. Then, in 1997, Dr. Johnson and Dr. O’Brien said they thought most living cats fell into one of eight lineages, based on the genetic element known as mitochondrial DNA.

Having made further DNA analyses, the researchers have drawn a full family tree that assigns every cat species to one of the lineages. They have also integrated their tree, which is based solely on changes in DNA, with the fossil record. The fossils, which are securely dated, allow dates to be assigned to each fork in the genetic family tree.
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The leopard lineage appeared around 6.5 million years ago in Asia. The youngest of the eight lineages, which led eventually to the domestic cat, emerged some 6.2 million years ago in Asia and Africa, either from ancestors that had never left Asia or more probably from North American cats that had trekked back across the Bering land bridge.

Photos from Curious Cat Travel Photos – Kenya

Florida State lures Applied Superconductivity Center from Wisconsin

Ching-Jen “Marty” Chen, dean of the College of Engineering, and Chiang Shih, chairman of the college’s department of mechanical engineering, also were heavily involved in negotiations to bring ASC to FSU.

“The College of Engineering joins the National High Magnetic Field Laboratory in welcoming the move of the Applied Superconductivity Center to Tallahassee,” Chen said.

“This is an excellent example of multidisciplinary collaboration between the sciences and engineering. The affiliation of ASC with the College of Engineering amplifies many ongoing efforts in material engineering research in the college and the magnet lab.”

Four top ASC researchers, including Director David C. Larbalestier, will begin relocating by January 2006. They will be followed over the next six months by eight post-doctoral researchers, several highly skilled machinists and a few graduate students. In all, ASC may bring as many as 30 researchers to Tallahassee, along with some $2 million in research grants and another $2.5 million worth of precision laboratory equipment.

Larbalestier is viewed by many of his peers as the leading researcher in the United States, and possibly the world, in the basic research of practical superconducting materials for magnets and power applications. Over a 35-year career, he has profoundly influenced the development of high-field magnets for high-energy physics and other applications, such as magnetic resonance imaging (MRI), that have evolved from them. Among the highlights of his career is his election in 2003 to the prestigious National Academy of Engineering.

“The Economic Development Council of Tallahassee/Leon County (EDC) is excited with this impressive level of investment and ongoing million-dollar payroll that will leave a lasting and positive influence on our regional economy,” said Brad Day, executive director of the ECD. “With the recruitment of research and development activities like this, our community continues to earn its reputation as a technology-rich economy.”

On the ASC site, hosted at Madison, they don’t spin the story quite the same way – Breaking News: ASC will be teaming up with NHMFL in Tallahassee, FL in 2006. Still that headline links directly to the FSU news release.

2006 Draper Prize for Engineering

Draper Prize for Engineering Medal

2006 Charles Stark Draper Prize Won by Inventors of Charge-coupled Devices

The 2006 Charles Stark Draper Prize will be presented by the National Academy of Engineering to the inventors of charge-coupled devices (CCDs), Willard S. Boyle and George E. Smith, on Feb. 21 in Washington , D.C. Boyle and Smith will share the $500,000 prize for inventing CCDs, which are imaging sensors or optical elements that convert light to digital data. CCDs are widely used in consumer products, such as camcorders and cell phone cameras, as well as in advanced electronic imaging tools, such as telescopes and imaging satellites.

CCDs are the first practical solid-state imaging devices. They were invented in 1969 by Boyle and Smith while working at Bell Laboratories. Because CCDs are silicon-based devices, they are fairly inexpensive to produce, compact, and fairly rugged, making them suitable for commercial product use. Their high sensitivity, excellent stability, and lack of distortion make CCDs attractive for use in scientific research imaging systems. CCDs are capable of imaging a variety of sources, including optical, x-ray, ultraviolet, and infrared emissions.

Administered by the National Academy of Engineering, the Draper Prize is endowed by The Charles Stark Draper Laboratory, Inc., and was established in 1988. The Prize is awarded for outstanding achievement, particularly innovation and reduction to practice, in engineering and technology contributing to the advancement of the welfare and freedom of humanity. The Prize honors the memory of Draper Laboratory’s founder, Dr. Charles Stark Draper, who pioneered inertial navigation. It is intended to increase public understanding of the contributions of engineering and technology. Originally biennial, the Prize is now awarded annually.

Previous years awards include:
2002: Dr. Robert S. Langer for extraordinary contributions to the bioengineering of revolutionary medical drug delivery systems
2001: Drs. Vinton Cerf, Robert Kahn, Leonard Kleinrock, and Lawrence Roberts for the invention of the Internet

China’s Economic Science Experiment

The Great Chinese Experiment, Horace Freeland Judson, MIT Technology Review. China is betting its economic health on becoming a world leader in the sciences. But will it succeed? This long detailed article provides insight into the challenges, practices and potential for China’s economy and scientific innovation going forward.

“The major scientific program running right now in China is this one, called 97-3 Program,” Professor Cao said. “A major huge program to catch up with the scientific development of the whole world. Started in 1997, March. This program is for basic research. According to the needs of the nation.” Technological applications? Or basic science? “Both,” she said with a sharp nod. The goal is split in two? “Yes,” she said. “I think that the major scientific program is the whole-world program. Not just for China. The second is the urgent requirement for our country’s social and economic development.”

The 97-3 Program concentrates research in six areas, agricultural biotechnology, energy, informatics, natural resources and the environment, population and health, and materials science. Cao’s own concern is with population and health. In this area the research is divided into 20 fields. She took me through them with the aid of a 33-page position paper she had put together in anticipation of my visit. The list is diverse, the projects ambitious. Yet even the most basic research — in stem cells, for example — has been defined in terms of immediate applications.

Information on the China 973 basic research program from the Chinese government’s web site:

Stipulation and implementation of the 973 Program is an important decision of our country to carry out the two development strategies of ” Rejuvenating the country through science and technology ” and ” sustainable development”, as well as to further reinforce basic research and science and technology work. It is an important measure of our country to achieve the great objectives of China’s economic, scientific & technology, and social development by 2010-2050 , to upgrade the sustainable S & T innovative capabilities and to meet the challenges of the new century.

While the engineering credentials of China’s leadership is noted often, it is still interesting to note that China’s 9 senior government officials are all engineers. A Technocrat Riding a Wild Tiger:

When China’s leaders meet with Hu each week in Beijing’s government district, Zhongnanhai, they could spend hours discussing cables, switches, tool-making machines and control devices. That’s because every one of them has a degree in engineering. The president himself, the son of a tea merchant from Jiangsu Province, trained to build hydroelectric power stations, while the others hold degrees in electrical engineering, metallurgy and geology.