Category Archives: Research

Why Most Published Research Findings Are False

Why Most Published Research Findings Are False by John P. A. Ioannidis

A finding from a well-conducted, adequately powered randomized controlled trial starting with a 50% pre-study chance that the intervention is effective is eventually true about 85% of the time. A fairly similar performance is expected of a confirmatory meta-analysis of good-quality randomized trials: potential bias probably increases, but power and pre-test chances are higher compared to a single randomized trial.

Another Paper Questions Scientific Paper Accuracy

Most Scientific Papers are Probably Wrong, New Scientist.

Assuming that the new paper is itself correct, problems with experimental and statistical methods mean that there is less than a 50% chance that the results of any randomly chosen scientific paper are true.

Funding Basic Research

The West has lost the will to fund basic research by William Brody.

In the US, university basic research has withered in many important fields, especially in the physical and information sciences and engineering.
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Industrial basic research has failed to demonstrate a return on investment that satisfies the ravenous appetite of financial markets for short-term earnings growth. As a result, companies have been directing capital to applied research and development, rather than basic invention and innovation.

The writer is president of the Johns Hopkhins University, the co-founder of three medical device companies and co-chairman of the US Council on Competitiveness’s National Innovation Initiative.

World’s Lightest Flying Robot

Epson Announces Advanced Model of the World’s Lightest Micro-Flying Robot:

The key concept behind Epson’s R&D efforts in micro-flying robots has been to expand the horizons of microrobot activities from two-dimensional space to three-dimensional space. Now, with the successful implementation of Bluetooth communications and independent flight in the FR-II, Epson has literally added a new dimension to microrobotics while greatly expanding the potential range of microrobot applications by incorporating image capture and transmission functions.

The site includes a video.

NSF TeraGrid

$150 Million TeraGrid Award Heralds New Era for Scientific Computing:

“We fully expect TeraGrid to catalyze the next generation of scientific discoveries,” said Deborah Crawford, acting director of NSF’s Office of Cyberinfrastructure. “Simply put, breakthrough science and engineering depends on a first-class cyberinfrastructure.”

Vast Community of Bacteria and Clams Under Antarctic Ice

Beneath Ice Shelf’s Remains, Life Blossoms from Washingtonpost.com

The area had been isolated under the ice for at least 10,000 years, and the discovery means that “the chance of life happening in other places that are even more restricted is increased,”
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The bacteria under the Larsen B ice shelf evolved in far colder conditions than other known cold-seep communities, thriving in near- or below-freezing temperatures, and may have unique properties.

Planting Trees May Create Deserts

Planting Trees May Create Deserts, New Scientist:

Forests planted with the intention of trapping moisture are instead depleting reservoirs and drying out soils.

Studying the actual results let us learn what actually happens. Making decisions using the best available information at the time is what we must do. But then we need to study what happens. See, previous post on: Medical Study Results Questioned.

Medical Study Results Questioned

Third of study results don’t hold up (cnn broke the link so I removed it);

in a review of major studies published in three influential medical journals between 1990 and 2003, including 45 highly publicized studies that initially claimed a drug or other treatment worked.

Subsequent research contradicted results of seven studies — 16 percent — and reported weaker results for seven others, an additional 16 percent.

The scientific community will gain once the barriers to the flow of knowledge created by subscription sites. We would link to the actual study but it is not available – it is behind a subscription wall. Support the adoption of the Public Library of Science and the Public Library of Medicine.

The Mysteries of Mass

The Mysteries of Mass (bozos at Scientific American broke the page so I removed the link – poor usability):

Physicists are hunting for an elusive particle that would reveal the presence of a new kind of field that permeates all of reality. Finding that Higgs field will give us a more complete understanding about how the universe works.

Autonomous Vehicle Technology Competition

DARPA Grand Challenge:

The Defense Advanced Research Projects Agency (DARPA) today announced the 40 teams selected to advance to the semifinals of the DARPA Grand Challenge 2005 autonomous ground vehicle competition. The teams come from 14 states and Canada and represent varied backgrounds including universities, individuals, corporations, and a high school.
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The team that develops an autonomous ground vehicle that finishes the designated route most quickly within 10 hours will receive $2 million.

Only if a team succeeds will the the money be paid. Last year no team succeeded.