Category Archives: Science

Eat food. Not too much. Mostly plants.

Excellent articles on eating healthy but also provides a nice insight in the practice scientific inquiry: Unhappy Meals by Michael Pollan:

Eat food. Not too much. Mostly plants. That, more or less, is the short answer to the supposedly incredibly complicated and confusing question of what we humans should eat in order to be maximally healthy.

That is the advice on how to eat more healthfully by Michael Pollan the author of The Omnivore’s Dilemma

If nutritional scientists know this, why do they do it anyway? Because a nutrient bias is built into the way science is done: scientists need individual variables they can isolate. Yet even the simplest food is a hopelessly complex thing to study, a virtual wilderness of chemical compounds, many of which exist in complex and dynamic relation to one another, and all of which together are in the process of changing from one state to another. So if you’re a nutritional scientist, you do the only thing you can do, given the tools at your disposal: break the thing down into its component parts and study those one by one, even if that means ignoring complex interactions and contexts, as well as the fact that the whole may be more than, or just different from, the sum of its parts. This is what we mean by reductionist science.

Interactions are critical in many experiments. That is why multi-factor experimentation is so important (One-Factor-at-a-Time Versus Designed Experiments) though even using these techniques the complexity of interactions provides an incredibly challenging environment.

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The Future of the Scholarly Journal

Publishing Group Hires ‘Pit Bull of PR’:

Those groups, along with many members of Congress, want to make the published results of federally financed medical research freely available to the public whose taxes funded the work — results that today are typically available only to journal subscribers or to people willing to pay expensive per-page fees.

The publishing association, which includes among its members some of the world’s biggest and most profitable scientific journals, has argued that free Internet access to the publicly funded portion of their contents would undermine their subscription bases. Lacking that income, they claim, they would not be able to do the invisible, unsung but important, work of screening out bad science and publishing and archiving the very best.

As I have said before, this information should be publicly available. The funding mechanism for peer review needs to change. If the Journals want to stay in business they need to find a way to add value that doesn’t keep public funded information from the public.

Feedback Within the Context of Systems Theory

Good read – Lengthening the Feedback Loop: A History of Feedback Within the Context of Systems Theory by Julia Evans:

Once you start looking for feedback loops, you see them everywhere. As I write this, my refrigerator clicks on, reminding me that negative feedback from its thermostat is responsible for keeping my food from spoiling.
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The purpose of this paper is to show how feedback developed from an engineering principle to part of a unifying theory that helps to shape the way we look at the world. I will trace the concept of feedback through history within the broader framework of systems theory, and demonstrate how it is being applied to business, economics, and society at large.

via: Agile Management

Webcasts by Chemistry and Physics Nobel Laureates

Designed to inspire the next generation of engineers and scientists, The Honeywell – Nobel Initiative establishes a forum for students worldwide to learn directly from Nobel Laureates in Chemistry and Physics.

The Honeywell – Nobel Initiative includes a large number of short podcasts by Nobel prize winners, such as:

Leon Lederman explains that there is a flaw in current quantum theory. He describes how the Higgs particle would provide information to refine the theory…

Steven Chu describes how he and other scientists use lasers to manipulate atoms in order to answer fundamental questions in quantum physics…

The temperature of the earth is increasing. Mario Molina discusses the consequences of this phenomenon caused by human activity…

Students must be taught the value of science at an early age. Richard Schrock considers helping students to appreciate the contributions of science and to inspire…

The site is pretty and the videos are excellent but once again they offer an example of a site that fails to follow basic web usability practices. You can’t link to the location of these collections of webcasts easily. If you have trouble finding them, which I image some will – click on the links to “video lab.”

Millennials in our Lifetime?

No I don’t mean the generation Y types born in the 1980s and 1990s I mean 1,000 year old people. I doubt it, but according to Cambridge University geneticist Aubrey de Grey – yes. And his credentials are better than mine, well I guess some of us might see who is right. ‘We will be able to live to 1,000’. Do You Want to Live Forever?:

As he surveyed the literature, de Grey reached the conclusion that there are seven distinct ingredients in the aging process, and that emerging understanding of molecular biology shows promise of one day providing appropriate technologies by which each of them might be manipulated — “perturbed,” in the jargon of biologists. He bases his certainty that there are only seven such factors on the fact that no new factor has been discovered in some twenty years, despite the flourishing state of research in the field known as biogeronÂtology, the science of aging; his certainty that he is the man to lead the crusade for endless life is based on his conception that the qualification needed to accomplish it is the mindset he brings to the problem: the goal-driven orientation of an engineer rather than the curiosity-driven orientation of the basic scientists who have made and will continue to make the laboratory discoveries that he intends to employ.

Aubrey de Grey Responds – Methuselah Mouse Man – Aubrey de Grey on TEDTalks: Aging is “an engineering problem” – The Prophet of Immortality

Asia: Rising Stars of Science and Engineering

Great report – The Atlas of Ideas: How Asian innovation can benefit us all by Charles Leadbeater and James Wilsdon:

Each country will develop differently. In South Korea strong government support has created a world-class information infrastructure.
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China is mobilising massive resources for innovation through ambitious long-term plans, funded by rapid economic growth. Beijing’s university district produces as many engineers as all of western Europe. China is developing world-class universities and attracting multinational innovation centres.
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India’s elite, trained at the Indian Institutes of Technology, are second to none. New institutions like the National Science and Engineering Foundation could energise a disjointed innovation system. Yet India’s innovation elite may face a rural backlash. Its infrastructure is in poor repair and cities like Bengalooru are congested. Even the much-vaunted IITs do not, unlike their US counterparts, animate innovation clusters.

Percentage of world share of scientific publications

Year	China	France	Germany	Japan	Korea	UK	US	EU-15
1995	2.05	6.09	7.62	8.65	0.79	8.88	33.54	34.36
1998	2.90	6.48	8.82	9.42	1.41	9.08	31.63	36.85
2001	4.30	6.33	8.68	9.52	2.01	8.90	31.01	36.55
2004	6.52	5.84	8.14	8.84	2.70	8.33	30.48	35.18

Excellent reading, the report is full of useful information I have not been able to obsorb yet.
Related: Diplomacy and Science Research – The World’s Best Research Universities – Engineering the Future Economy – Worldwide Science and Engineering Doctoral Degree Data – USA Under-counting Engineering Graduates – Increasing American Fellowship Support for Scientists and Engineers
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Get Your Own Science Art

hemoglobin represented in crystal

Cool science art from Bathsheba Sculpture.

The Molecule that Makes Breathing Worthwhile – Hemoglobin is the iron-bearing protein that most animals use to carry oxygen from their lungs to their muscles, or wherever it’s needed for metabolism, i.e. life. It’s the most important part of red blood cells, and its iron is what makes them red.

This sculpture, etched in a heavy 3 1/4″ glass cube, shows hemoglobin’s beautiful structure: the four heme groups each with its iron atom, the two alpha and two beta subunits, and the translucent molecular surface over all.

As well as being handsome and useful, hemoglobin is a star of scientific history. With its close relative myoglobin, it was the first protein to have its 3D structure determined by X-ray crystallography. Max Perutz and John Kendrew at Cambridge University received the Nobel Prize in 1962 for doing it.

The site offers various crystals and sculptures created by Bathsheba Grossman. The art itself is very cool and the site includes interesting information on the science represented by the art and the engineering behind creating the art.

The points are tiny (.1mm) fractures created by a focused laser beam. The conical beam, with a focal length of about 3”³, shines into the glass without damaging it except at the focal point. At that one point, concentrated energy heats the glass to the cracking point, causing a microfracture.

To draw more points, the laser is pulsed on and off. To make the beam move between points, it’s reflected from a mirror that is repositioned between pulses. The mirror is moved by computer-controlled motors, so many points can be drawn with great speed and accuracy. A typical design might use several hundred thousand points, or half a million isn’t unusual in a large block, each placed with .001”³ accuracy.

Create Your Own Book

I received a custom made photo book from my brother. It is amazing. It is a hardcover book, full of photos. The quality is amazing. The book is printed by blurb. Looking on their web site the pricing is surprisingly cheap: 150 page full color hardcover book – $39.95 (for 1 copy! – 10% discount at 25 copies…), as little as $18.95 for a full color softcover book up to 40 pages. The site says books are normally printed in under a week.

I have not tried it but it appears printing your own great looking book is about as easy as creating a blog. I knew it was getting easier to print books, but still I find this very cool. Blurb can import photos from Flickr and Picasa.

This technology enabled self publishing also brings us: The Best Writing on Science Blogs 2006, using lulu: “Lulu is fast, easy and free, No set-up fees. No minimum order. Keep control of the rights. Set your own price. Each product is printed as it is ordered. No excess inventory.”

Helium-3 Fusion Reactor

Future In Fusion? by John Lasker:

Nevertheless, UW fusion researchers believe their plan could get civilization off fossil fuels. That’s if crews could return to the moon to mine for helium-3, super-heat it out of the lunar soil to process the gas, and return it to the Earth.
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But scientists and investors have taken notice. Nearly all of UW fusion research is privately funded. And meanwhile, with China, India, the European Space Agency and at least one Russian corporation all pursuing plans for a manned lunar base in the coming decades, there is increasing talk of a race to control this fuel, one shuttle load of which could theoretically power the United States for a year.
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Aftergood doesn’t believe a race with China for lunar helium-3 has begun. Yet a race to the moon against China — whether real or superficial — may be in NASA’s best interest, he said. “There are some who wish this would be the case — this race with China. They believe it would recapture the dynamic of the United States’ and Russia’s race to the moon,” he said.

This sounds pretty incredible to me and I find the claims of using fuel from the Moon economically to power our needs on Earth. Still it is interesting and just because it sounds fantastic does not mean it can’t be true. But I am skeptical.

Scientists discover new class of RNA

These new RNAs are named after their distinctive features: Each molecule contains 21 chemical building blocks (or nucleotides), and each begins with the chemical uridine, represented by the letter U (the only RNA nucleotide not also found on DNA). In addition, each of the 5,000 different 21U-RNA molecules comes from one of two chromosomal regions.

Further, “we can predict where additional 21U-RNA genes might reside,” says Bartel, who is also a member of the Whitehead Institute for Biomedical Research and a Howard Hughes Medical Institute investigator. “Combining these predictions with the 5,000 (21U-RNAs) that we experimentally identified, we suspect that there are more than 12,000 different 21U-RNA genes in the genome.” Because each gene typically produces a unique 21U-RNA, a very large diversity of molecules is made.

RNA description from the Nobel Prize site:

When an organism needs to use the data stored in the genome, e.g. to build components of a new cell, a copy of the required DNA part is made. This copy is called RNA and is almost identical to DNA. Just like DNA, RNA is an abbreviated form of a chemical name which in the case of RNA is ribonucleic acid. Unlike the double stranded DNA, RNA is only made up of a single strand. Furthermore, the base T, thymine, is replaced by U, uracil in RNA. This RNA string is used by the organism as a template when it builds protein molecules, sometimes called the building blocks of the body. For example, your muscles and hair are mostly made up of proteins.

Related: DNA-RNA-Protein Introduction