Category Archives: Science

5% of the Universe is Normal Matter, What About the Other 95%?

Great discussion and illustration of the state of our understanding of physics, matter, dark matter and the rest of the stuff our universe has from PhD comics. What is the universe made of? 5% of it is normal matter (the stardust we are made of), 20% dark matter and the other 75% – we have no idea!

Dark Cosmos is a nice book on some of these ideas. It is 5 years old so missing some of the latest discoveries.

The Architecture of Access to Scientific Knowledge

The Architecture of Access to Scientific Knowledge from lessig on Vimeo.

Larry Lessig speaks at CERN about the proper use of copyright and the moral case for open access. As I have written many times, I strongly believe our society is better off when science is open. I believe we now are allowing a few greedy institution (that seek to restrict science for the benefit of their organization) to pay our politicians to damage society for the benefit of a few donors.

Quixperito – New Social Bookmarking Site

I have created a new social bookmarking site. The site is meant to highlight good content online and is moderated to remove low value and spam content. By developing a community of users that share interests in worthwhile content on a variety of topics I hope to create a useful resource for people.

The topics included now are limited to help focus on high value content and develop a community of users around various topics. Please join and participate. Without a community the value of the site is low. Currently there is a technology section that will be of interest to readers of this Curious Cat Science and Engineering Blog.

Other sections include: science, investing and business.

If you are interested in helping build the community please join and participate. You can post your related articles and posts and find new readers for your content. And by voting on others posts you can help highlight posts that the community finds worth reading.

Image of Map Showing Concentration of Life in Oceans

This image shows the abundance of life in the sea, measured by the SeaWiFS instrument aboard the Seastar satellite. Dark blue represents warmer areas where there is little life due to lack of nutrients, and greens and reds represent cooler nutrient-rich areas.

The nutrient-rich areas include coastal regions where cold water rises from the sea floor bringing nutrients along and areas at the mouths of rivers where the rivers have brought nutrients into the ocean from the land. NASA has posted a large gallery of great images for Earth Day.

Cancer Vaccines

A reader commented on a previous post (MIT Engineers Design New Type of Nanoparticle for Vacines) asking about how vaccines can fight cancer. Preventative vaccines can build up immune response to viruses which cause cancer. So the vaccine actually works against the virus which prevents the virus from causing cancer.

The U.S. Food and Drug Administration (FDA) has approved two vaccines, GardasilÂ® and CervarixÂ®, that protect against infection by the two types of human papillomavirus (HPV) – types 16 and 18 – that cause approximately 70% of all cases of cervical cancer worldwide. At least 17 other types of HPV are responsible for the remaining 30% of cervical cancer cases. HPV types 16 and/or 18 also cause some vaginal, vulvar, anal, penile, and oropharyngeal cancers.

Many scientists believe that microbes cause or contribute to between 15% and 25% of all cancers diagnosed worldwide each year, with the percentages being lower in developed than developing countries.

Vaccines can also help stimulate the immune system to fight cancers.

B cells make antibodies, which are large secreted proteins that bind to, inactivate, and help destroy foreign invaders or abnormal cells. Most preventive vaccines, including those aimed at hepatitis B virus (HBV) and human papillomavirus (HPV), stimulate the production of antibodies that bind to specific, targeted microbes and block their ability to cause infection. Cytotoxic T cells, which are also known as killer T cells, kill infected or abnormal cells by releasing toxic chemicals or by prompting the cells to self-destruct (a process known as apoptosis).

Other types of lymphocytes and leukocytes play supporting roles to ensure that B cells and killer T cells do their jobs effectively. These supporting cells include helper T cells and dendritic cells, which help activate killer T cells and enable them to recognize specific threats.

Cancer treatment vaccines are designed to work by activating B cells and killer T cells and directing them to recognize and act against specific types of cancer. They do this by introducing one or more molecules known as antigens into the body, usually by injection. An antigen is a substance that stimulates a specific immune response. An antigen can be a protein or another type of molecule found on the surface of or inside a cell.

Gravity and the Scientific Method

One of the topics I return to repeatedly is the scientific method – theories must to tested. As evidence mounts that new ideas do a good job of explaining theories they become more accepted. But they continue to be tested in new ways as the ideas are extended and ramification are explored. And science progress means that old conventions can be overturned as new evidence is gathered.

Science is not about current beliefs. Science is about seeking knowledge. If the search for knowledge leads to evidence that old ideas were wrong those ideas are overturned. Since people are involved that process isn’t as clean as it sounds above. People get comfortable with beliefs. They build careers on expanding those beliefs. Most are uncomfortable when they are challenged and don’t accept new ideas even when the evidence mounts. But some do accept the new ideas. Some challenge the new ideas by running experiments. And some of those prove the new ideas faulty. Some become convinced of the new ideas as the results of their experiments make the new ideas seem more sensible (instead of getting the results they expected).

Building the body of scientific knowledge is not nearly as clean and simple as most people think. It isn’t a simple process, what is the underlying truth can be debatable. But the beauty of the scientific process is how it helps us overcome our biases and provide evidence to support the theories we support. The scientific method (combined with our human involvement) doesn’t mean new ideas are accepted easily but it does mean new ideas compete on the basis of evidence not just the power of those that hold the beliefs.

Is gravity not actually a force? Forcing theory to meet experiments
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How To Make Your Own Pesticide with Ingredients from Your Kitchen

Video by the Singapore National Park Board, on creating your own pesticide with just water, dish-washing liquid, chili, garlic and cooking oil.

$60 Million in Grants for Undergraduate Science Education

The Howard Hughes Medical Institute (HHMI) is challenging colleges and universities to think creatively about how they educate future scientists, science teachers, and a scientifically-literate public. The Institute has invited 215 undergraduate-focused colleges and universities from across the country to apply for a total of $60 million in science education grants. I am very happy that HHMI continues to help provide support for science education.

Sadly USA government leaders (local and national) have chosen to cut the importance they place on science education over the last few decades we have coasted on the gains we made in the 1960s and 1970s. That is no way to succeed. Thankfully a few foundations, with HHMI probably leading the way, and some great schools have kept the USA in a leadership position, but that leadership shrinks each year. And at the primary and secondary school level the USA dropped far back in the pack decades ago for science eduction The top countries in primary and secondary science education are now Finland, Hong Kong and Korea.

Since 1988, the Howard Hughes Medical Institute has awarded $820 million to 264 colleges and universities to support science education. Those grants have generally been awarded through two separate but complementary efforts, one aimed at undergraduate-focused institutions and the other at research universities. HHMI support has enabled more than 80,000 students nationwide to work in research labs and developed programs that have helped 95,000 K-12 teachers learn how to teach science more effectively.

The new grants will range from $800,000 to $1.6 million over four years for individual institutions and up to $4.8 million over four years for those applying jointly.

The biggest change in the new 2012 competition is the requirement that applicants focus on a single educational goal that unites their proposed science education program. In the past, HHMI’s grants have allowed applicants to submit projects in four categories: student research, faculty development, curriculum and laboratory development, and outreach. Although schools were not expected to put forward a program in every category, Asai notes the modular design of the grant competition often led schools to “check the boxes” rather than encouraging them to think strategically about how these activities can help them reach an overarching science education objective.
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Cat Allergy Vaccine Created

McMaster University researchers have developed aÂ vaccine which successfully treats people with anÂ allergy to cats. Traditionally, frequent allergy shots have been considered the most effective way to bring relief — other than getting rid of the family pet — for the 8 to 10% of the population allergic to cats.

Both options, may now be avoided thanks to the work of immunologistÂ Mark LarchÃ©, professor at theÂ Michael G. DeGroote School of Medicine andÂ Canada Research Chair in Allergy & Immune Tolerance.

Building on research he’s conducted for the past 10 years in Canada and Britain, LarchÃ© and his research team have developed a vaccine which is effective and safe with almost no side effects. The research is published in a the January 2011 issue of theÂ Journal of Allergy & Clinical Immunology, a leading journal in the allergy field.

The researchers took one protein (molecule) that cats secrete on their fur which causes the majority of allergic problems. Using blood samples from 100 patient volunteers allergic to cats, they deconstructed the molecule and identified short regions within the protein which activate T-cells (helper cells that fight infection) in the immune system.

Using the amino acid code for the whole protein, researchers made synthetic versions of these regions. For the cat allergy vaccine, they found seven peptides (strings of amino acids). “And those synthetic peptides are what we mix together to make the vaccine,” said LarchÃ©. “We picked the peptides that would work in as much of the population as possible.”

Known as “peptide immunotherapy,” a low dose of the vaccine is given into the skin. Initially, four to eight doses a year may be required, but the side effects of the traditional allergy shots do not arise, LarchÃ© said. The optimal dose will be determined in phase three clinical trials which are getting underway with a much larger group of cat allergy sufferers.

The development of a vaccine to treat people allergic to cats is the first in a line of vaccines developed withÂ Adiga Life Sciences, a company established at McMaster in 2008. It is a joint venture between McMaster University Circassia Ltd., a UK-based biotech company.

Adiga and McMaster are now collaborating on research into the use of peptide immunotherapy for house dust mite, ragweed, grass, birch tree and moulds

New Analysis of Primordial Soup Experiment Half a Century Later

Open access paper: Primordial synthesis of amines and amino acids in a 1958 Miller H₂S-rich spark discharge experiment

Archived samples from a previously unreported 1958 Stanley Miller electric discharge experiment containing hydrogen sulfide (H₂S) were recently discovered and analyzed using high-performance liquid chromatography and time-of-flight mass spectrometry. We report here the detection and quantification of primary amine-containing compounds in the original sample residues, which were produced via spark discharge using a gaseous mixture of H₂S, CH₄, NH₃, and CO₂. A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples.

The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordial environments. The relative yield of some amino acids, in particular the isomers of aminobutyric acid, are the highest ever found in a spark discharge experiment.

The simulated primordial conditions used by Miller may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H₂S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H₂S may have played an important role in prebiotic reactions in early solar system environments.