Category Archives: Science

Refrigeration Without Electricity

Lack of electricity is a serious problem for vaccines and medicines that need to be cooled. It is hard to imagine that this is a problem, living in the USA, but this is still a problem today. As readers of this blog notice I really like appropriate technology solutions that provide real quality of life enhancements for hundreds of millions of people (which undoubtedly is influence by my father).

Fold.it – the Protein Folding Game

Foldit is a revolutionary new computer game enabling you to contribute to important scientific research. This is another awesome combination of technology, distributed problem solving, science education…

Essentially the game works by allowing the person to make some decisions then the computer runs through some processes to determine the result of those decisions. It seems the human insight of what might work provides an advantage to computers trying to calculate solutions on their own. Then the results are compared to the other individuals working on the same protein folding problem and the efforts are ranked.

This level of interaction is very cool. SETI@home, Rosetta@home and the like are useful tools to tap the computing resources of millions on the internet. But the use of human expertise really makes fold.it special. And you can’t help but learn by playing. In addition, if you are successful you can gain some scientific credit for your participation in new discoveries.

The site includes some excellent educational material on proteins and related material. What is a protein:

Proteins are the workhorses in every cell of every living thing. Your body is made up of trillions of cells, of all different kinds: muscle cells, brain cells, blood cells, and more. Inside those cells, proteins are allowing your body to do what it does: break down food to power your muscles, send signals through your brain that control the body, and transport nutrients through your blood. Proteins come in thousands of different varieties, but they all have a lot in common. For instance, they’re made of the same stuff: every protein consists of a long chain of joined-together amino acids.
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structure specifies the function of the protein. For example, a protein that breaks down glucose so the cell can use the energy stored in the sugar will have a shape that recognizes the glucose and binds to it (like a lock and key) and chemically reactive amino acids that will react with the glucose and break it down to release the energy.
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Proteins are involved in almost all of the processes going on inside your body: they break down food to power your muscles, send signals through your brain that control the body, and transport nutrients through your blood. Many proteins act as enzymes, meaning they catalyze (speed up) chemical reactions that wouldn’t take place otherwise. But other proteins power muscle contractions, or act as chemical messages inside the body, or hundreds of other things.

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Physicist Swimming Revolution

A Revolution That Began With a Kick by Amy Shipley:

The answer, they say, cannot lie solely in the latest high-tech swimsuits introduced amid a swirl of controversy this winter, because the world-record smashing began at last year’s world championships — long before the newest of the newfangled apparel came out.

Swimmers, coaches and scientists say it is impossible to pinpoint one explanation. They cite many contributing factors, ranging from professional training groups that have sprouted across the United States to greater access to underwater cameras and other advanced technology.

But some say the most significant breakthrough has been a revival of a swimming maneuver developed more than 70 years ago by one of the physicists who worked on the atomic bomb.

Though utilized for decades, the underwater dolphin kick had not been fully exploited by the swimming mainstream until Olympic megastar Michael Phelps and a few other stars began polishing it — and crushing other swimmers with it — in recent years.

Very interesting and another example of how good ideas are often ignored for a long time.

The underwater dolphin kick attracted the interest of swimming innovators as early as the 1930s. The late Volney C. Wilson explored its possibilities before diving into later work on nuclear fission and the atomic bomb, according to David Schrader, a research professor at Marquette University who is Wilson’s biographer.

Schrader said Wilson, an alternate on the 1932 Olympic water polo team who studied fish propulsion at a Chicago aquarium, claimed to have shown the kick to Johnny Weissmuller, a training mate at the Illinois Athletic Club. “Weissmuller reproduced it perfectly, but was not impressed by it,” said Schrader in a phone interview, recalling a conversation with Wilson.
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One of the first swimmers to turn heads with the underwater dolphin kick was David Berkoff, a Harvard graduate who became known for the “Berkoff Blastoff.” In 1988, Berkoff set several world records in the 100 backstroke by dolphin-kicking for 35 meters underwater at the start of the race.

Which goes to show you that you can gain advantages just by using the information that is available – your own innovation is not the only way to get ahead. Just doing a better job of adapting what others learn to your challenges can be very rewarding.

The Science Behind Spore

Spore is the hugely anticipated game from Wil Wright (the creator of Sims). In this webcast he discusses the science behind Spore. The creature creator was released this week and the full game will be released soon. Spore has been doing a great job marketing the product and they continue to do so with lots of material on You Tube including the Spore Ultimate Dance Contest.

The idea of the game is to design creatures that then go out into the world and interact and evolution takes it course. It looks very cool.

Lancelet Genome Provides Answers on Evolution

Lancelet genome shows how genes quadrupled during vertebrate evolution by Robert Sanders

“If you compare the 23 chromosomes of humans with the 19 chromosomes of amphioxus, you find that both genomes can be expressed in terms of 17 ancestral pieces. So, we can say with some confidence that 550 million years ago, the common ancestor of amphioxus and humans had 17 chromosomal elements.”
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Each of those 17 ancestral segments was duplicated twice in the evolution of vertebrates, after which most of the routine “housekeeping” genes lost the extra copies. Those left, totaling a couple thousand genes, found new functions that, Putnam said, make us different from all other creatures.

“These few thousand genes have been retooled to make humans more elaborate than their simpler ancestors. They are involved in setting up the body plan of an animal and differentiating different parts of the animal,” he said. “The hypothesis, pretty strongly supported by this data, is that the multiplication of this particular kind of gene and differentiation into different functions was important in the formation of vertebrates as we know them.”

“The most exciting thing that the amphioxus genome does is provide excellent evidence for the idea that Ono proposed in 1970, that the human genome had undergone two rounds of whole-genome duplication with subsequent losses,”

A great example of the scientific method in action. It often isn’t a matter of developing a theory one day, testing it the next and learning the outcome the next. The process can take decades for complex matters.

How Humans Evolved Allergies

Ancient antibody molecule offers clues to how humans evolved allergies

The chicken molecule, an antibody called IgY, looks remarkably similar to the human antibody IgE. IgE is known to be involved in allergic reactions and humans also have a counterpart antibody called IgG that helps to destroy invading viruses and bacteria. Scientists know that both IgE and IgG were present in mammals around 160 million years ago because the corresponding genes are found in the recently published platypus genome. However, in chickens there is no equivalent to IgG and so IgY performs both functions.

Lead researcher, Dr. Rosy Calvert said: “Although these antibodies all started from a common ancestor, for some reason humans have ended up with two rather specialised antibodies, whereas chickens only have one that has a much more general function.
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Professor Brian Sutton, head of the laboratory where the work was done said: “It might be that there was a nasty bug or parasite around at the time that meant that humans needed a really dramatic immune response and so there was pressure to evolve a tight binding antibody like IgE. The problem is that now we’ve ended up with an antibody that can tend to be a little over enthusiastic and causes us problems with apparently innocuous substances like pollen and peanuts, which can cause life-threatening allergic conditions.”

Mathematicians Critique Journal Rankings

Three international math groups joined forces to issue a report last week decrying the use of citation statistics to evaluate scientific journals, research institutions and individual scientists. These statistics, sometimes called “bibliometrics,” measure how frequently a given journal’s articles are cited by other journals.

Read the report on Citation Statistics. This concern is justified. I do have some interest in some of these (and related) statistics but one must always remember their limitations.

TX Active Cement

TX active cement graphic

Industry scrambles to find a ‘greener’ concrete

While Italcemente’s smog-eating cement has been used in Europe for several years, it was released in the United States only in 2007 under the name TX Active. It contains titanium dioxide, which, in the presence of sunlight, acts as a photocatalyer, hastening the decomposition of such pollutants as nitrogen oxides, sulfur oxides, and ozone. TX Active also keeps a building shiny white – a quality admired by architects – by preventing the buildup of pollutants on the surface.

Research suggests that if 15 percent of the surface area of Milan, Italy, were covered in TX Active, air pollutants there could be reduced by 50 percent.

When weighing the environmental effects of concrete, some other benefits need to be included, says Rick Bohan of the Portland Cement Association (PCA), a nonprofit trade group based in Skokie, Ill. For example, the insulation provided by concrete walls combats greenhouse-gas emissions by reducing the energy needed for heating and cooling a building by up to 40 percent compared with wood- and steel-frame structures, according to PCA research.

TXActive Cement graphic from HeidelbergCement

Cloak of Silence

Experts unveil ‘cloak of silence’

“The mathematics behind cloaking has been known for several years,” said Professor John Pendry of Imperial College London, UK, an expert in cloaking. “What hasn’t been available for sound is the sort of materials you need to build a cloak out of.”
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The Spanish team who conducted the new work believe the key to a practical device are so-called “sonic crystals”. These artificial composites – also known as “meta-materials” – can be engineered to produce specific acoustical effects.
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The research builds on work by scientists from Duke University in North Carolina, US, and the Hong Kong University of Science and Technology. Earlier this year, independent teams from the two institutions demonstrated the mathematics necessary to create an acoustic cloak. Other scientists have shown that objects can be cloaked from electromagnetic radiation, such as microwaves.

Shaw Laureates 2008

Image of the Shaw Prize Medal

The Shaw Prize awards $1 million in each of 3 areas: Astronomy; Life Science and Medicine; and Mathematical Sciences. The award was established in 2002 by Run Run Shaw who was born in China and made his money in the movie industry. The prize is administered in Hong Kong and awards those “who have achieved significant breakthrough in academic and scientific research or application and whose work has resulted in a positive and profound impact on mankind.” The 2008 Shaw Laureates have been selected.

Astronomy
Professor Reinhard Genzel, Managing Director of the Max Planck Institute for Extraterrestrial Physics, in recognition of his outstanding contribution in demonstrating that the Milky Way contains a supermassive black hole at its centre.

In 1969, Donald Lynden-Bell and Martin Rees suggested that the Milky Way might contain a supermassive black hole. But evidence for such an object was lacking at the time because the centre of the Milky Way is obscured by interstellar dust, and was detected only as a relatively faint radio source. Reinhard Genzel obtained compelling evidence for this conjecture by developing state-of-the-art astronomical instruments and carrying out a persistent programme of observing our Galactic Centre for many years, which ultimately led to the discovery of a black hole with a mass a few million times that of the Sun, in the centre of the Milky Way.

Supermassive black holes are now recognized to account for the luminous sources seen at the nuclei of galaxies and to play a fundamental role in the formation of galaxies.

Mathematical Sciences
Vladimir Arnold, together with Andrei Kolmogorov and Jurgen Moser, made fundamental contributions to the study of stability in dynamical systems, exemplified by the motion of the planets round the sun. This work laid the foundation for all subsequent developments right up to the present time.

Arnold also produced extremely fruitful ideas, relating classical mechanics to questions of topology. This includes the famous Arnold Conjecture which was only recently solved.

In classical hydrodynamics the basic equations of an ideal fluid were derived by Euler in 1757 and major steps towards understanding them were taken by Helmholtz in 1858, and Kelvin in 1869. The next significant breakthrough was made by Arnold a century later and this has provided the basis for more recent work.

Ludwig Faddeev has made many important contributions to quantum physics. Together with Boris Popov he showed the right way to quantize the famous non-Abelian theory which underlies all contemporary work on sub-atomic physics. This led in particular to the work of ”²t Hooft and Veltman which was recognized by the Nobel Prize for Physics of 1999.
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