Category Archives: Science

Medical Study Integrity (or Lack Thereof)

The drug maker Merck drafted dozens of research studies for a best-selling drug, then lined up prestigious doctors to put their names on the reports before publication, according to an article to be published Wednesday in a leading medical journal.

The article, based on documents unearthed in lawsuits over the pain drug Vioxx, provides a rare, detailed look in the industry practice of ghostwriting medical research studies that are then published in academic journals.
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“It almost calls into question all legitimate research that’s been conducted by the pharmaceutical industry with the academic physician,” said Ross, whose article, written with colleagues, was published Wednesday in JAMA, The Journal of the American Medical Association, and posted Tuesday on the journal’s Web site.

Merck acknowledged Tuesday that it sometimes hired outside medical writers to draft research reports before handing them over to the doctors whose names eventually appear on the publication. But the company disputed the article’s conclusion that the authors do little of the actual research or analysis.

It is sad that the integrity of journals and scientists is so weak that they leave them open to such charges. The significant presence of the corrupting influence of too much money leaves doubt in my mind that the best science is the goal. Which is very sad. In, Funding Medical Research, I discussed my concern that universities are acting more like profit motivated organizations than science motivated organizations. I am in favor of profit motivated organization (those getting the micro-financing in this link, for example) but those organization should not be trusted to provide honest and balanced opinions they should be expected to provide biased opinions.

If universities (and scientists branding themselves as … at X university) want to be seen as honest brokers of science they can’t behave as though raising money, getting patents… are their main objectives. Many want to be able to get the money and retain the sense of an organization focused on the pursuit of science above all else. Sorry, you can’t have it both ways. You can, and probably should, try stake out some ground in the middle. And for me right now, partially because they fail to acknowledge the extent to which money seems to drive decisions I don’t believe they are trying to be open and honest, instead I get the impression they are leaning more toward trying to market and sell.
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The Last Lecture Book

We wrote about this last August: CMU Professor Gives His Last Lesson on Life. If you haven’t seen the lecture I encourage you to do so now. Now there is a book by Dr. Randy Pausch called The Last Lecture where he expands on his lecture with “many more stories from my life and the attendant lessons I hope my kids can take from them.”

Like any teacher, my students are my biggest professional legacy. I’d like to think that the people I’ve crossed paths with have learned something from me, and I know I learned a great deal from them, for which I am very grateful. Certainly, I’ve dedicated a lot of my teaching to helping young folks realize how they need to be able to work with other people–especially other people who are very different from themselves.

Is Computer Science a Science?

Is computer science a science?

Most people seem to apply a certain litmus test of sorts to determine if something is a science. Something is a science if

(1) it uses the scientific method (i.e., empirical research and observation)
(2) it involves studying “fundamental principles” of the natural or physical world

(1) is, I think, a bit easier to address. I use the scientific method all the time in my work: I form hypotheses about how a particular system or algorithm should behave, develop experiments to test the hypothesis, gather data, analyze, etc. Several commenters to the first post in the series discuss the same thing. Joe, for instance, says this about his work: “One of the things I’ve noticed as a developer/engineer for the last 20 years is that I use the techniques of science all the time, only I’m not studying “nature” (be it the physics world, chemicals, biology, or people). I’m applying the disciplines and the scientific process to stuff that other people have done.” (I’ll get back to this point in a minute.)

Bikini Atoll 50 Years Later

Nuked coral reef bounces back

Three islands of Bikini Atoll were vapourised by the Bravo hydrogen bomb in 1954, which shook islands 200 kilometres away. Instead of finding a bare underwater moonscape, ecologists who have dived it have given the 2-kilometre-wide crater a clean bill of health.

“It was fascinating – I’ve never seen corals growing like trees outside of the Marshall Islands,” says Zoe Richards of the ARC Centre of Excellence for Coral Reef Studies in Australia. Richards and colleagues report a thriving ecosystem of 183 species of coral, some of which were 8 metres high. They estimate that the diversity of species represents about 65% of what was present before the atomic tests. The ecologists think the nearby Rongelap Atoll is seeding the Bikini Atoll, and the lack of human disturbance is helping its recovery.
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“When I put the Geiger counter near a coconut, which accumulates radioactive material from the soil, it went berserk,” says Beger.

Scientists Witness the Birth of a Brain Cell

The Birth of a Brain Cell: Scientists Witness Neurogenesis

For the first time, researchers have developed a way to view stem cells in the brains of living animals, including humans—a finding that allows scientists to follow the process neurogenesis (the birth of neurons). The discovery comes just months after scientists confirmed that such cells are generated in adult as well as developing brains.
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The key ingredient in this process is a substance unique to immature cells that is neither found in mature neurons nor in glia, the brain’s nonneuronal support cells. Maletic-Savatic and her colleagues collected samples of each of the three cell types from rat brains (stem cells from embryonic animals, the others from adults) and cultured the varieties separately in the lab. They were able to determine the chemical makeup of each variety – and isolate the compound unique to stem cells – with nuclear magnetic resonance (NMR) spectroscopy. (NMR helps to determine a molecule’s structure by measuring the magnetic properties of its subatomic particles.) Although the NMR could identify the biomarker, but not its makeup, Maletic-Savatic speculates it is a blend of fatty acids in a lipid (fat) or lipid protein.

Vega Science Lectures: Feynman and More

Vega Science Lectures

Vega is building a collection of classic lectures by eminent scientists, both from its own source material and donations from universities and other independent groups such as the Feynman family.
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A set of four priceless archival recordings from the University of Auckland (New Zealand) of the outstanding Nobel prize-winning physicist Richard Feynman – arguably the greatest science lecturer ever. Although the recording is of modest technical quality the exceptional personal style and unique delivery shine through.

Great content. Enjoy.

‘Refrigerator’ Without Electricity

photo of pot in pot

2000 Rolex award to Mohammed Bah Abba of Nigeria for the Pot in Pot Cooling System:

Ingenious technique that requires no external energy supply to preserve fruit, vegetables and other perishables in hot, arid climates. The pot-in-pot cooling system, a kind of “desert refrigerator”, helps subsistence farmers by reducing food spoilage and waste and thus increasing their income and limiting the health hazards of decaying foods. Abba says he developed the pot-in-pot “to help the rural poor in a cost-effective, participatory and sustainable way”.

The pot-in-pot consists of two earthenware pots of different diameters, one placed inside the other. The space between the two pots is filled with wet sand that is kept constantly moist, thereby keeping both pots damp. Fruit, vegetables and other items such as soft drinks are put in the smaller inner pot, which is covered with a damp cloth. The phenomenon that occurs is based on a simple principle of physics: the water contained in the sand between the two pots evaporates towards the outer surface of the larger pot where the drier outside air is circulating. By virtue of the laws of thermodynamics, the evaporation process automatically causes a drop in temperature of several degrees, cooling the inner container, destroying harmful micro-organisms and preserving the perishable foods inside.

He also received the 2001 Shell Award for Sustainable Development. Great stuff:

Born in 1964 into a family of pot makers and raised in the rural north, Mohammed Bah Abba was familiar from an early age with the various practical and symbolic uses of traditional clay pots, and learned as a child the rudiments of pottery. Subsequently studying biology, chemistry and geology at school, he unravelled the technical puzzle that led him years later to develop the “pot-in-pot preservation/cooling system”.

Orzel: What Everyone Should Know About Science

What Everyone Should Know About Science by Chad Orzel:

1) Science is a Process, Not a Collection of Facts The essence of science, broadly defined, is that it is a systematic approach to figuring out how the world works:

1. look at the world around you
2. come up with an idea for why it might work that way.
3. test your idea against reality.
4. tell everybody you know the results of the test.

Put those steps together, over and over, and you have the best method ever devised for increasing our store of reliable knowledge. The precise facts found by this method are not as important as the process for finding them– given the process, and enough time, you can reconstruct whatever facts you need. The facts without the process are worse than useless, they’re dangerous.

Androgenesis

All Dad by Carl Zimmer

This week’s revelation is androgenesis. Androgenesis is what happens when kids get all their genes from their father.
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Androgenesis, it turns out, transforms fatherhood into a parasitic invasion. It begins like normal fertilization, with a sperm fusing to an egg. But then the egg’s DNA gets hurled out of its nucleus, so that the sperm’s genes are the only ones left in the egg. The egg begins to develop into an embryo, but only after it has lost the mother’s DNA.

Squid Materials Engineering

Scientists find that squid beak is both hard and soft

The sharp beak of the Humboldt squid is one of the hardest and stiffest organic materials known. Engineers, biologists, and marine scientists at the University of California, Santa Barbara, have joined forces to discover how the soft, gelatinous squid can operate its knife-like beak without tearing itself to pieces.
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The key to the squid beak lies in the gradations of stiffness. The tip is extremely stiff, yet the base is 100 times more compliant, allowing it to blend with surrounding tissue. However, this only works when the base of the beak is wet. After it dries out, the base becomes similarly stiff as the already desiccated beak tip.
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“You can imagine the problems you’d encounter if you attached a knife blade to a block of Jell-o and tried to use that blade for cutting. The blade would cut through the Jell-o at least as much as the targeted object. In the case of the squid beak, nature takes care of the problem by changing the beak composition progressively, rather than abruptly, so that its tip can pierce prey without harming the squid in the process. It’s a truly fascinating design!”
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“If we could reproduce the property gradients that we find in squid beak, it would open new possibilities for joining materials,” explained Zok. “For example, if you graded an adhesive to make its properties match one material on one side and the other material on the other side, you could potentially form a much more robust bond,” he said. “This could really revolutionize the way engineers think about attaching materials together.”