Category Archives: Science

More on the Problems with Bisphenol-A

Milwaukee Journal-Sentinel: Bisphenol-A, that plasticizer, gets a media reaming

But few reports that The Tracker has seen match, in fury and conviction, the lambasting that a team of Milwaukee Journal Sentinel reporters, Susanne Rust, Meg Kissinger, and Cary Spivak, have given to these things, especially bisphenol-A, in the last two weeks. They say they reviewed 250 papers, interviewed more than 100 scientists, industry reps, and government regulators, read thousands of pages of additional documents. They give it a one-two punch, with that second one the roundhouse. They are going for a knockout.

The stories make The Tracker, a person with a tendency to say “on the other hand…”, a little nervous. There aren’t many maybes in here, not much calibration. The reporters appear fully convinced bisphenol-A is a menace. I’ve heard reports on the stuff too, and it does give one the jim jams. But one seldom sees, as here and without equivocation, declarations that a recent government review was flatly biased in its selection of which studies to give most weight, the gov’t used outdated methods, it looked mainly at chemical industry-funded studies, it ignored academic and presumably unbiased work.

The original articles: Are your products safe? You can’t tell. Labels often fail to list compounds that can disrupt biological development – WARNING: The chemical bisphenol A has been known to pose severe health risks to laboratory animals. AND THE CHEMICAL IS IN YOU.

In the first analysis of its kind by a newspaper, the Journal Sentinel reviewed 258 scientific studies of the chemical bisphenol A, a compound detected in the urine of 93% of Americans recently tested. An overwhelming majority of these studies show that the chemical is harmful – causing breast cancer, testicular cancer, diabetes, hyperactivity, obesity, low sperm counts, miscarriage and a host of other reproductive failures in laboratory animals.

Studies paid for by the chemical industry are much less likely to find damaging effects or disease. U.S. regulators so far have sided with industry by minimizing concern about the compound’s safety.

I believe in there are real risks that should be addressed. And I am not convinced the regulators are doing a good job, see my previous post in April, 2007 on Bisphenol A.

Related: Flushed Drugs Pollute Water – FDA May Make Decision That Will Speed Antibiotic Drug Resistance – The A to Z Guide to Political Interference in Science – Researcher Provides Undisclosed Data to FDA – Scientists Denounce Global Warming Report ‘Edits’

Girls Sweep Top Honors at Siemens Competition in Math, Science and Technology

Girls Make History by Sweeping Top Honors at a Science Contest

Janelle Schlossberger and Amanda Marinoff, both 17 and seniors at Plainview-Old Bethpage John F. Kennedy High School on Long Island, split the first prize – a $100,000 scholarship – in the team category for creating a molecule that helps block the reproduction of drug-resistant tuberculosis bacteria.

Isha Himani Jain, 16, a senior at Freedom High School in Bethlehem, Pa., placed first in the individual category for her studies of bone growth in zebra fish, whose tail fins grow in spurts, similar to the way children’s bones do. She will get a $100,000 scholarship.
…
Three-quarters of the finalists have a parent who is a scientist. The parents of Alicia Darnell, who won second place, are medical researchers at Rockefeller University, and her maternal grandparents were scientists, too. Isha Himani Jain, who took home the top individual prize, published her first research paper with her father, a professor at Lehigh University, when she was 10 or 11; her mother is a doctor.

Read about projects by the finalists.

Related: Siemens Competition in Math, Science and Technology – Student Algae Bio-fuel Project – Siemens Westinghouse Competition Winners 2005 – Intel International Science and Engineering Fair 2007 – Intel International Science and Engineering Fair Awards (2006)

Dinosaur Remains Found with Intact Skin and Tissue

Hadrosaur Dinasaur

“Dinosaur Mummy” Found; Has Intact Skin, Tissue by John Roach, National Geographic News:

Scientists today announced the discovery of an extraordinarily preserved “dinosaur mummy” with much of its tissues and bones still encased in an uncollapsed envelope of skin. Preliminary studies of the 67-million-year-old hadrosaur, named Dakota, are already altering theories of what the ancient creatures’ skin looked like and how quickly they moved, project researchers say
…
The hadrosaur, or duck-billed dinosaur, was discovered in 1999 by then-teenage paleontologist Tyler Lyson on his family’s North Dakota property.
…
Plant-eating hadrosaurs are often called the “cows of the Cretaceous”—the geologic period that spanned 145 million to 65 million years ago—Manning said. They had horny, toothless beaks but hundreds of teeth in their cheeks and a long, stiff tail that was likely used for balance. Preliminary studies are revealing a surprising side to these reptiles, suggesting that Dakota—even though roughly 35 feet (12 meters) long and weighing some 35 tons—was no slowpoke.
…
The preliminary calculations suggest Dakota could run 28 miles (45 kilometers) an hour. Tyrannosaurus rex tops out at about 20 miles (32 kilometers) an hour, according to the model

The dig and subsequent scanning are the subjects of Dino Autopsy, a National Geographic Channel special airing on December 9th.

Amazing find of dinosaur ‘mummy’, BBC:

this hadrosaur came complete with fossilised skin, ligaments, tendons and possibly some internal organs, according to researchers. “It’s unbelievable when you look at it for the first time,” said palaeontologist Phillip Manning from the University of Manchester, UK. “There is depth and structure to the skin. The level of detail expressed in the skin is just breathtaking.”

Related: Nigersaurus – T-rex Treasure – Most Dinosaurs Remain Undiscovered

Science and Engineering in Politics

Politics of engineering by Patrick Mannion, EE Times:

Engineering interests historically haven’t been at the forefront of the political debate, at least not compared with those of, say, farming, law or health care. But given the importance of the technological advances that engineers help effect and the need to maintain our competitive edge in a rapidly changing global environment, that situation needs to change, and fast.
…
Then came word of the $25 billion being handed to farmers in yet another subsidy, loudly denounced by some as welfare for the wealthy. I’m not going to get into the right or wrong of the subsidies–but I am amazed at the ability of agribusiness to get them at all. It shows the power of the farm lobby. Ditto for pharmaceuticals, HMOs, lawyers, “big oil” and so on. It underscores the relative political weakness of the engineering community.

If the science and engineering community are not well represented to our representatives the interests of the science and engineering community will get short changed. Especially since so few politicians in the USA have even a basic understanding of science and the scientific method. And a very small percentage have any advanced degrees in science and engineering fields or work experience in them. That being said the political arena is much like a tar pit: that is it is difficult to interact with without becoming entangled in a big mess. And it is not as though the scientific and engineering community are even close to unified but still the impact of political decisions is very significant and science and engineering leaders need to be heard.

China’s Economic Science Experiment – China’s 9 most senior government official are all engineers (in 2006 – I am not sure now):

When China’s leaders meet with Hu each week in Beijing’s government district, Zhongnanhai, they could spend hours discussing cables, switches, tool-making machines and control devices. That’s because every one of them has a degree in engineering. The president himself, the son of a tea merchant from Jiangsu Province, trained to build hydroelectric power stations, while the others hold degrees in electrical engineering, metallurgy and geology.

Related: Larry Page on Marketing Science – The A to Z Guide to Political Interference in Science – Diplomacy and Science Research – Open Access Legislation – Proposal to Triple NSF Graduate Research Fellowship Awards – Science Interview with John Edwards – Proposed Legislation on Science and Education – House Testimony on Engineering Education – Germany’s Science Chancellor – Nanotechnology Investment as Strategic National Economic Policy – Singapore Supporting Science Researchers – Farming Without Subsidies in New Zealand

People Have More Bacterial Cells than Human Cells

Humans Carry More Bacterial Cells than Human Ones

All the bacteria living inside you would fill a half-gallon jug; there are 10 times more bacterial cells in your body than human cells
…
The infestation begins at birth: Babies ingest mouthfuls of bacteria during birthing and pick up plenty more from their mother’s skin and milk—during breast-feeding, the mammary glands become colonized with bacteria. “Our interaction with our mother is the biggest burst of microbes that we get,”
…
there are estimated to be more than 500 species living at any one time in an adult intestine, the majority belong to two phyla, the Firmicutes (which include Streptococcus, Clostridium and Staphylococcus), and the Bacteroidetes (which include Flavobacterium).
…
probiotics – dietary supplements containing potentially beneficial microbes – have been shown to boost immunity. Not only do gut bacteria “help protect against other disease-causing bacteria that might come from your food and water,” Huffnagle says, “they truly represent another arm of the immune system.”
…
But the bacterial body has made another contribution to our humanity – genes. Soon after the Human Genome Project published its preliminary results in 2001, a group of scientists announced that a handful of human genes – the consensus today is around 40 – appear to be bacterial in origin.

How cool is science? Very, I think 🙂

Related: Tracking the Ecosystem Within Us – Beneficial Bacteria – Energy Efficiency of Digestion – Large Number of Bacteria on our Skin – Where Bacteria Get Their Genes – Amazing Science: Retroviruses

Fighting Tuberculosis

Signaling an End to TB by Kathleen M. Wong

Once routinely treated with cheap antibiotics, TB is poised to make a terrifying comeback. More and more, doctors in developing nations are finding patients infected with strains of TB invulnerable to all but a handful of extremely expensive, exotic drugs. Worldwide, TB already infects one in every three people and sickens one in ten. Without new methods to stop the spread of drug-resistant strains, the cost of treating this ancient human pathogen could bankrupt even the most prosperous economies.
…
TB could, in theory, develop resistance to this new class of drugs, too. But Alber thinks he can skew the odds to favor humans. Identifying a drug capable of knocking out several TB enzymes at once could make it next to impossible for the bacterium to evolve resistance on multiple fronts.

Though TB is a daunting foe, Alber remains confident about the prospects of beating the disease. “As a bacterium, it should be easier to treat than HIV or malaria. Those kinds of diseases-caused by viruses and protozoans-we generally don’t know how to cure,” Alber says. “From a scientific perspective, TB is a simpler problem.”

Good luck, it may be easier but it still isn’t easy. Related: Tuberculosis Risk – ‘Virtually untreatable’ TB – Extensively Drug-resistant Tuberculosis (XDR TB) – TB Pandemic Threat

Open Source: The Scientific Model Applied to Programming

xo-laptop: On the Open-Sourcing of Business – interesting post worth reading, though I disagree with some points:

There is no obligation to “give back” anything, though it often makes sense to participate in the community based on a particular open-source project. However, that is a strategic decision for you to make. Your sole obligation is to respect the license terms.

There is a difference between your sole legal obligation and your sole obligation. I agree legally all you are obliged to do is comply with the legal requirements. That does not mean that is your sole obligation. I don’t see any problem making money in efforts involving open source efforts but I do believe that as that happens an obligation (perhaps not legal but real none-the-less) grows to give back to the community (Google’s summer of code is a great example of giving back). Most open source efforts require that any additions you make to the software be given back to the community (those involved in open souce know this, I add this just for the information of those not familiar with open source practices). Legal obligations are the minimum you can be forced to do, not the only obligations one has. Great quote (emphasis mine):

I think the best is one I have often seen expressed by Linus Torvalds, and it was one of the explanations I gave in a talk to the New York City Linux User Group in a talk in December, 1999.

Simply put, free and open-source software is just the scientific model applied to programming: free sharing of work open collaboration; open publication; peer review; recognition of the best work, with priority given to the first to do a meaningful new piece of work; and so forth. As a programmer, it is the best arena in which to work. There are no secrets; the work must stand on its own.

Another great post on this topic: What Business Can Learn from Open Source.

Related: Open Source for LEGO Mindstorms – Young Scientists Design Open-Source Program at NASA – Open-Source Biotech – Publishers Continue to Fight Open Access to Science

Science Books 2007

Some science books published this year.

Related: Coming to Life: How Genes Drive Development by Christiane Nusslein-Volhard (2006) – Science books – Gadgets and Gifts

Amazing Science: Retroviruses

One of the great things about writing this blog is I find myself more focused on reading about interesting science. Retroviruses are very interesting and frankly amazing. Darwin’s Surprise by Michael Specter, The New Yorker:

A retrovirus stores its genetic information in a single-stranded molecule of RNA, instead of the more common double-stranded DNA. When it infects a cell, the virus deploys a special enzyme, called reverse transcriptase, that enables it to copy itself and then paste its own genes into the new cell’s DNA. It then becomes part of that cell forever; when the cell divides, the virus goes with it. Scientists have long suspected that if a retrovirus happens to infect a human sperm cell or egg, which is rare, and if that embryo survives – which is rarer still – the retrovirus could take its place in the blueprint of our species, passed from mother to child, and from one generation to the next, much like a gene for eye color or asthma.

When the sequence of the human genome was fully mapped, in 2003, researchers also discovered something they had not anticipated: our bodies are littered with the shards of such retroviruses, fragments of the chemical code from which all genetic material is made. It takes less than two per cent of our genome to create all the proteins necessary for us to live. Eight per cent, however, is composed of broken and disabled retroviruses, which, millions of years ago, managed to embed themselves in the DNA of our ancestors. They are called endogenous retroviruses, because once they infect the DNA of a species they become part of that species. One by one, though, after molecular battles that raged for thousands of generations, they have been defeated by evolution. Like dinosaur bones, these viral fragments are fossils. Instead of having been buried in sand, they reside within each of us, carrying a record that goes back millions of years. Because they no longer seem to serve a purpose or cause harm, these remnants have often been referred to as “junk DNA.” Many still manage to generate proteins, but scientists have never found one that functions properly in humans or that could make us sick.

How amazing is that? I mean really think about it: it is incredible. The whole article is great. Related: Old Viruses Resurrected Through DNA – DNA for once species found in another species’ Genes – New Understanding of Human DNA – Retrovirus overview (Tulane) – Cancer-Killing Virus
Continue reading →

Google Investing Huge Sums in Renewable Energy and is Hiring

Towards more renewable energy posted to Google’s blog by Larry Page, Co-Founder and President of Products:

Promising technologies already exist that could be developed to deliver renewable energy cheaper than coal. We think the time is ripe to build rapidly on the tremendous work on renewable energy. For example, I believe that solar thermal technology provides a very plausible path to generating cheaper electricity. By combining talented technologists, great partners and large investments, we have an opportunity to quickly push this technology forward. Our goal is to build 1 gigawatt of renewable energy capacity that is cheaper than coal. We are optimistic that this can be done within years, not decades. If we succeed, it would likely provide a path to replacing a substantial portion of the world’s electricity needs with renewable energy sources.

To lead this effort, we’re looking for a world-class team. We need creative and motivated entrepreneurs and technologists with expertise in a broad range of areas, including materials science, physics, chemistry, mechanical engineering, electrical engineering, land acquisition and management, power transmission and substations, construction, and regulatory issues. Join us. And if you’re interested, read about our previous work toward a clean energy future

Very cool. And I think something Google might be able to pull off well. It is also true this may be a distraction and not work well. For many companies that would be my guess for how it would play out. Google has done an exceptional job of allowing engineers to do what they do best. And I think there is a chance they can translate that into effectively managing such a project as this. Google continues to try what they believe even if that is not the conventional path. Good for them.

Related: posts on energy – posts on Google management – Google’s cheaper-than-coal target – Wind Power – Large-Scale, Cheap Solar Electricity – 12 Stocks for 10 Years Update – Larry Page and Sergey Brin Interview Webcast – Google’s Renewable Energy Cheaper than Coal (press release)

Continue reading →