Backyard Wildlife: Mountain Lion

Sadly this isn’t my backyard. I would love to see a mountain lion like this. So close. A real wild mountain lion. And I am safe.

Citizen Science

Citizen science enters a new era

Another online program, Phylo, is advancing scientists’ knowledge of genetics by making a game out of DNA matching. If areas of genetic sequence are roughly similar between species, it suggests strongly that they could have an important function. Finding them has been beyond the scope of computer algorithms. But earlier this month, researchers published a study where gamers outsmarted the best computers – they made the best possible DNA sequence match between up to eight species at a time.

The potential for regular people contributing to science is great. This has a long history. For most of human history science was done by non-scientists since there were no scientists. Calling is science might be a stretch but to me it was (passing on what health cures worked for various sicknesses, how to use various tools, how to grow crops…). As scientists came into being they were primarily unprofessional – that is they practiced science but were doing so as a hobby, they were not paid and had no requirements to get a PhD or anything.

Today regular people help by collecting data (counting birds, documenting plant growth [time of year], migration data, weather data…) sharing knowledge with scientists who ask, sharing their computer to be used to analyze data, analyzing data (for example, in astronomy hobbyists often make new discoveries) and the latest way people help is through games (that essentially tap human brainpower to analyze data – such as Foldit, which I have posted about previously).

I like the contributions people can make to science but I think the biggest value is the scientific understanding people gain while participating. As Neil Degrasse Tyson says the scientifically literate see a different world.

Cornell University provides an online tool to find opporunities participate in scientific research.

And we shouldn’t forget the amazing science done by students like those honored with Intel Talent Search, though the work those winning the awards do I would lump with science by “real scientists” (I believe now most of those who win are working on projects with university scientists).

Friday Fun: Elephant Playing with a Smart Phone

An elephant plays with a smart phone (Samsung Galaxy Note).

Dangerous Drug-Resistant Strains of TB are a Growing Threat

Drug-resistant strains of TB are out of control

The fight against new, antibiotic-resistant strains of tuberculosis has already been lost in some parts of the world, according to a senior World Health Organisation expert.
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Dr Paul Nunn, head of the WHO’s global TB response team, is leading the efforts against multi-drug resistant TB (MDR-TB). Nunn said that, while TB is preventable and curable, a combination of bad management and misdiagnosis was leaving pharmaceutical companies struggling to keep up. Meanwhile, the disease kills millions every year.

“It occurs basically when the health system screws up,” said Nunn. “Treating TB requires a carefully followed regime of medication over six months. In places where health services are fragmented or underfunded, or patients poor and health professionals ill-trained, that treatment can fall short, which can in turn lead to patients developing drug-resistant strains. It’s been estimated that an undiagnosed TB-infected person can infect 10 others a year.

We tend to do a poor job of dealing with systemic effects of poorly functioning systems. Direct present threats get out attention. And we are decent at directing brain power and resources to find solutions. We are not very good at dealing with failures that put us in much worse shape in the long term. For small threats we can wait until it becomes a present threat and then deal with it. There are costs to doing this (economic and personal) but it can be done.

Some problems though become enormously complicated to deal with once they become obvious. Global climate change, for example. And often, even once they are obvious, we won’t act until the costs (economic and in human lives) are very large. It is possible that once we decide to get serious about dealing with some of these issues that the costs (economic and in human lives) will be catastrophic.

The failure to use anti-biotics medicine properly is a very serious threat to become one of these catastrophic societal failures. While tuberculosis failures may be larger in poorer countries, rich countries are failing probably much more critically in the misuse of anti-biotics (I would guess, without having much evidence at my fingertips to back up my opinion. I believe the evidence exists I am just not an expert). These failures have huge costs for all of humanity but we are risking many premature deaths because we systemically fail to deal with issues until the consequences are immediate.

Google Lets Servers Stay Hot, Saving Air Conditioning Costs

The electricity to run huge server farms is enormous. One of the significant cost is air conditioning to cool down the server rooms.

Too Hot for Humans, But Google Servers Keep Humming

Google’s data center in Belgium, which was the company’s first facility to rely entirely upon fresh air for cooling, instead of energy-hungry chillers.
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For the vast majority of the year, the climate in Belgium is cool enough that this design works with no problems. When it gets hot in Belgium, the temperature inside Google’s data center warms beyond the facility’s desired operating range
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During these periods, the temperature inside the data center can rise above 95 degrees.
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“We’ve had very few excursion hours, and they don’t last long, so we let the site run right through them. We ask our employees to go in and do office work. It’s too warm for people, but the machines do just fine.”

Google’s experience is the latest affirmation that servers are much tougher than we think. Many data centers feel like meat lockers, as servers are maintained in cool environments to offset the heat thrown off by components inside the chassis. Typical temperature ranges in data centers often range from 68 and 72 degrees.

In recent years, rising power bills have prompted data center managers to try and reduce the amount of power used in cooling systems.

The temperatures in Fahrenheit obviously. I was surprised that the servers don’t seem to need to be chilled to perform well.

Is Dirt Healthier Than Broccoli?

That dirt I ate as a kid is maybe why I have been relatively healthy. Ok, probably that hasn’t been the most important factor. But it may be that some dirt and germs (kids licking their dirty hands and the ice cream melts on it, etc.) is actually more important for their long term health than finishing off the broccoli (of course, a healthy diet requires eating a bunch of vegetables, more than most kids eat).

The hygiene hypothesis has become a popular explanation for the boom in asthma, allergies and other health problems. Boiled down to one sentence the hypothesis is that exposure to germs early in life creates a healthy immune system and too little exposure results in a hypersensitive immune system (that is not as effective and leads to things like allergies).

A recent closed science paper, Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function, found mice exposed to more germs early on where healthier:

Exposure to microbes during early childhood is associated with protection from immune-mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show that, in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma compared to specific pathogen-free (SPF) mice. This was associated with increased intestinal and pulmonary expression of the chemokine ligand CXCL16, which was associated with increased mucosal iNKT cells. Colonization of neonatal—but not adult—GF mice with a conventional microbiota protected the animals from mucosal iNKT accumulation and related pathology. These results indicate that age-sensitive contact with commensal microbes is critical for establishing mucosal iNKT cell tolerance to later environmental exposures.

The microscopic battles waged in our bodies every day and over our lifetimes are amazing.

Lean Science: Using Cheap Robots to Aid Research

Fun video showing how scientists use Lego Mindstorm robots to aid research into creating artificial bones. Lego Mindstorm robots are useful at a very reasonable price.

The webcast also includes this practical quote from Michelle Oyen, lecturer in the Department of Engineering at Cambridge University: “without your bones you would be a pile of goo lying on the floor.”

The thinking discussed in the webcast echos the lean manufacturing principles discussed in the Curious Cat Management Improvement Blog: finding good solutions to aid people in doing their jobs. The type of custom solutions they discuss here are great.

This type of use of technology is great. One of the problems we often see with technology solutions though is when they are imposed on the workplace in a way that doesn’t aid people. There is a big difference between what Toyota does (using robots to make people’s jobs easier) and what others do in trying to copy Toyota (using robots to eliminate jobs). Lean manufacturing stressed the importance of using brainpower people bring to work every day. You want to use technology to enable people. These scientists understand that. Unfortunately many managers don’t.

Photosynthesis: Science Explained

Another very good webcast on a science topic from Crash Course. It is packed with info, thankfully you can pause and rewind as much as you need. Well normally you can, YouTube decided to not let me do that just now 🙁

Friday Fun: Monkey and Kitten Playing

If somehow you need more to entice you to watch the webcast, there are even cameos by a dog and people. But if you need to know more than kitten and monkey maybe you need to connect to your inner 5 year old self.

Â£50m Package to Attract Scientists and Boost Welsh Economy

‘Star scientists’ Â£50m package to boost Welsh economy

First Minister Carwyn Jones said the fund would be used to encourage leading professors to move to Wales to work and boost research and the economy. It will pay for specialist equipment, top-up salaries to the level outstanding academics would expect and will fund members of their teams.
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our network plans will enable us to attract more talent to Wales to help drive this figure up and in due course create more high quality business and research jobs in Wales.” The strategy sets out three key areas to boost research and businesses – the life sciences and health; low carbon, energy and environment; and advanced engineering and materials.

The Welsh government said it wanted to see more industry-academic partnerships like SPECIFIC led by Swansea University with Tata Steel UK. The Â£20m project aims to turn homes and businesses into self-generating “power stations” by developing a special coating for ordinary building materials, such as steel and glass, that traps and stores solar energy.

The USA dominated the practice of attracting leading scientists a few decades ago. In the last decade or two Europe stepped up and was able to attract global talent. Lately Asia (Singapore, Korea, China…) has been spending to attract leading scientists. I believe Asia will continue to do so and the benefits of doing so will pay off handsomely for Asia (at the expense of Europe and the USA).