Were Remains of a Baby Woolly Mammoth Discovered this Week?

Our blog received a spike in traffic to one of our previous posts (Well Preserved Baby Mammoth Discovered in Permafrost), taking a look at what the cause was I found out is was due to a new baby woolly mammoth possible discovery.

Woolly mammoth calf fossil? No, just a wayward walrus

Authorities in the Yamalo-Nenets region said yesterday morning they were scrambling a helicopter to the location. “If what is said about how it is preserved turns out to be true, this will be another sensation of global significance,” said the leader of the expedition, Natalia Fyodorova.

Disappointment was in store, however. “It turned out to be a walrus skull; apparently a fossilised one,” said Ms Fyordorova, who is the director of the local museum.

All the sites I look at that published the discovery news give no indication that they have learned new info, so I don’t really know what the status of the “discovery” is.

MIT Scientists Find New Drug That Could Cure Nearly Any Viral Infection

New drug could cure nearly any viral infection

The drug works by targeting a type of RNA produced only in cells that have been infected by viruses. “In theory, it should work against all viruses,” says Todd Rider, a senior staff scientist in Lincoln Laboratory‘s Chemical, Biological, and Nanoscale Technologies Group who invented the new technology.
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There are a handful of drugs that combat specific viruses, such as the protease inhibitors used to control HIV infection, but these are relatively few in number and susceptible to viral resistance.

Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-stranded RNA Activated Caspase Oligomerizers), from living cells’ own defense systems. When viruses infect a cell, they take over its cellular machinery for their own purpose — that is, creating more copies of the virus. During this process, the viruses create long strings of double-stranded RNA (dsRNA), which is not found in human or other animal cells.

As part of their natural defenses against viral infection, human cells have proteins that latch onto dsRNA, setting off a cascade of reactions that prevents the virus from replicating itself. However, many viruses can outsmart that system by blocking one of the steps further down the cascade.

Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) — launched, for example, when a cell determines it is en route to becoming cancerous. Therefore, when one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to initiate cell suicide.

Combining those two elements is a “great idea” and a very novel approach, says Karla Kirkegaard, professor of microbiology and immunology at Stanford University. “Viruses are pretty good at developing resistance to things we try against them, but in this case, it’s hard to think of a simple path pathway to drug resistance,” she says.

Each DRACO also includes a “delivery tag,” taken from naturally occurring proteins, that allows it to cross cell membranes and enter any human or animal cell. However, if no dsRNA is present, DRACO leaves the cell unharmed.

Very cool stuff and potentially hugely beneficial. Just a reminder: this works against viruses – not bacteria (just as antibiotics do not work against viruses).

Swarmanoid: Cooperative Robot Networks

Very cool cooperation between robots. It seems more and more research is going on in cooperative robotics. It would seem this would let us have specialized robots for various tasks instead of having to have robots that can do everything (which is very complex and difficult). Plus cooperating robots are just cool. See the Swarmanoid project web site and the overarching Swarmbot site. I look forward to what these scientists and engineers can create for us.

Quantum Information Theory Postulated As Source of Emergent Theory of Gravity

I love the advances we have made using our understanding of science and engineering, like the internet, air conditioning and antibiotics. I also love the discussion of research where we really have only educated guesses about what the scientific inquiry process is telling us about the way things are. This research from the University of York is very interesting.

Escaping gravity’s clutches: the black hole breakout

Professor Braunstein says: “Our results didn’t need the details of a black hole’s curved space geometry. That lends support to recent proposals that space, time and even gravity itself may be emergent properties within a deeper theory. Our work subtly changes those proposals, by identifying quantum information theory as the likely candidate for the source of an emergent theory of gravity.”
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Dr Patra adds: “We cannot claim to have proven that escape from a black hole is truly possible, but that is the most straight-forward interpretation of our results. Indeed, our results suggest that quantum information theory will play a key role in a future theory combining quantum mechanics and gravity.”

It is too bad the University of York supports closed science and allows work to be withheld from the public to support outdated publishers business models. Luckily scientists often support open science and publish material openly – I have provided a link for those interested in science instead of the link the University of York gives to a publishers closed system.

Black Hole Evaporation Rates without Spacetime

Verlinde recently suggested that gravity, inertia, and even spacetime may be emergent properties of an underlying thermodynamic theory. This vision was motivated in part by Jacobson’s 1995 surprise result that the Einstein equations of gravity follow from the thermodynamic properties of event horizons. Taking a first tentative step in such a program, we derive the evaporation rate (or radiation spectrum) from black hole event horizons in a spacetime-free manner. Our result relies on a Hilbert space description of black hole evaporation, symmetries therein which follow from the inherent high dimensionality of black holes, global conservation of the no-hair quantities, and the existence of Penrose processes. Our analysis is not wedded to standard general relativity and so should apply to extended gravity theories where we find that the black hole area must be replaced by some other property in any generalized area theorem.

Career Prospect for Engineers Continues to Look Positive

As I have written previously the career prospects for engineers are bright around the globe. Many countries realize the importance of engineering and have taken steps to compete as a center of excellence for engineering. It is a smart economic policy. Ironically, the USA, that did such a great job at this in the 1960’s and 1970’s, has been falling down in this regard. A significant reason for this is the USA can only fund so many things and a broken health care system, military complex, bailouts to bankers (trust fund babies and others) cost a lot of money. You chose what to fund, and those are taking much of the available USA funds. There are also non-economic reasons, such as the turn in the last decade in the USA to make the barriers for foreigner engineers (and others) to go through to go to school, visit and stay in the USA have all increased dramatically.

Back to the prospects for engineers: their are shortages of good engineers all over (and the future projections don’t show any reason to believe this will change). Germany Faces a Shortage of Engineers:

In June, the Association of German Engineers (VDI) reported that there were 76 400 vacant engineering jobs—an all-time high.
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Policymakers in Berlin have responded to the shortage of skilled workers with a number of measures, including changes in immigration rules that allow German companies to hire engineers from other countries, including those outside of the European Union. Among them: The annual salary that companies must pay foreigners has been lowered from 60,000 Euro (US $95,000) to 40,000 Euro, which is roughly the starting salary of an engineering graduate in Germany…

To make it easy for engineers to move around Europe, engineering associations and other groups across Europe are working with the European Commission (the executive arm of the European Union) to launch the new Engineering Card. The card, which German engineers can apply for now and other countries are planning to launch, provides standardized information about the engineer’s qualifications and skills for greater transparency.
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“We don’t expect many engineers will come, because among other reasons, there is a shortage of engineers across Europe,”

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What Happens If the Overuse of Antibiotics Leads to Them No Longer Working?

Antibiotics have been a miraculous tool to keep up healthy. Like vaccines this full value of this tool is wasted if it is used improperly. Vaccines value is wasted when they are not used enough. Antibiotics lose potency when they are overused. The overuse of anti-biotics on humans is bad (especially the huge amount of just lazy, not scientific use). But the massive overuse in livestock is much worse, it seems to me.

The health system in the USA is broken in a huge way in which it is broken is the failure to address creating systemic behavior that promotes human health and instead just treating illness. It is much better to avoid a situation where we breed super bugs and then try to treat those super bugs that have evolved to be immune to the antibiotics we have to use.

When antibiotics no longer work

While the source of the current salmonella outbreak remains murky, we can reasonably speculate about the genesis of the bug’s drug-resistance: the reportedly endemic overuse of antibiotics by the agricultural industry.

Drugs are given to livestock for multiple reasons. An obvious one is for the treatment of diseases. When livestock are sick, veterinarians administer a significant dosage in hopes of eliminating the animal’s affliction. Another reason is preventative. Animals in close quarters are more susceptible to infection, so farmers will often administer medicine to healthy animals in order to nip anything nasty in the bud. Most controversially, though, members of the agricultural industry use antibiotics for the express purpose of promoting livestock growth.

It’s a well-known, if not entirely intuitive, fact that healthy animals who are fed small, or “sub-therapeutic,” doses of antibiotics will wind up larger than their unmedicated counterparts. In many such cases, these drugs are given to livestock through their feed or water, and without the prescription or oversight of a veterinarian, according to Dr. Gail Hansen, a senior officer at the Pew Campaign on Human Health and Industrial Farming.

An estimated 80 percent of all antibiotics in the U.S. are given to food-producing livestock, according to the FDA. And approximately 83 percent of that medicine is “administered flock- or herd-wide at low levels for non-therapeutic purposes, such as growth promotion and routine disease prevention,” according to a lawsuit filed against the FDA in May. These figures could have very real consequences for public health, because the Catch-22 of this antibiotic abandon is the widespread development of drug-resistant bacteria, colloquially referred to as “super-bugs.”
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In 2006, the European Union banned all use of antibiotics on livestock for growth promotion. And the U.S. Senate will consider similar legislation this year. Sen. Dianne Feinstein, D-Calif., reintroduced the “Preservation of Antibiotics for Medical Treatment Act” last month, which would significantly rein in agricultural drug use, and strictly prohibit the application of sub-therapeutic doses of drugs that have benefits for humans.

Still, the agricultural industry disputes data about its use of antibiotics and the rise of super-bugs, and it has aggressively fought efforts to legislate the matter. As a result, it’s hard to tell how far the legislation might proceed.

The end of the era of antibiotics

How did this happen? The driving forces are Darwin and human carelessness. Bacteria are constantly evolving, adapting to the changing conditions they face. Antibiotics usually kill bacteria. But sometimes a bacteria will develop a biological defense – particularly if too small a dose is used.
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Antibiotics require a prescription in America, but our nation is still very much a part of the problem. Patients routinely demand these drugs, and doctors acquiesce, for respiratory infections and other ailments that will not respond to antibiotics because they are caused by a virus. We use soap with antimicrobial agents when regular soap does equally well. And we allow farmers to feed antibiotics to livestock in horrifying amounts, not to treat illnesses but to make farming more efficient.

The Potential Role of Concentrated Animal Feeding Operations in Infectious Disease Epidemics and Antibiotic Resistance

This working group, which was part of the Conference on Environmental Health Impacts of Concentrated Animal Feeding Operations: Anticipating Hazards—Searching for Solutions, considered the state of the science around these issues and concurred with the World Health Organization call for a phasing-out of the use of antimicrobial growth promotants for livestock and fish production. We also agree that all therapeutic antimicrobial agents should be available only by prescription for human and veterinary use.

Antibiotic Resistance in Livestock: More at Risk Than Steak
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MIT Engineering Design Workshop for Boston High School Students

This summer, a few dozen Boston-area high school students chose to spend their mornings toiling away with a variety of materials to create working marvels of engineering in the Engineering Design Workshop, a month-long program that gives teenagers a hands-on experience with the joys and challenges of engineering.

None of the activities are prescribed; instead, students take part in brainstorming sessions on the first day, and things develop from there. Typically, the “counselors” — a mix of undergraduate and graduate students from MIT and other local universities — present a few ideas, and the high school students decide which projects they’d most like to work on. I really like the idea of involving the college students.

This year, the 22 students divided themselves into five projects: a modified Razor scooter, equipped with a motor and brakes; a sound system of giant tower speakers; remote-controlled “anything” (which ended up including cars, fish, birds and even a flying turtle); a mosaic tiger meticulously assembled from pieces of stained glass; and an electric cello.

Each student is allotted $100 to spend on materials for his or her group’s project; this way, projects that attract more students have a larger budget to work with. Counselors help them purchase supplies online and work with them on the construction from the ground up.

There are probably thousands of similar type activities throughout the year to help engage students in engineering. I think it is great, but we need to do more. We need to let young students know what they are missing. If people know the wonders of engineering and choose something else for their career path, that is fine. It is a shame when people don’t get to decide, because they never experience what engineering has to offer.

Read the full press release.

Science is at its best when curious people are just trying to find things out

Brian Cox has a new television show, Wonders Of The Universe (a co-production of the BBC, the Discovery Channel, and the Science Channel), that looks like it will be wonderful. I would love more great shows on science. BBC has done some great stuff, so has PBS and the Discovery channel. I’ll be exploring what kind of access those channels have provided over the internet in the next year. I hope it is good. I was going to link to the web site for the show but the first 2 videos I tried to click on to view they wouldn’t show, so I don’t see the point in linking – hopefully eventually people that care about promoting science will make decisions to use the internet sensibly).

Interview of Professor Brian Cox

That’s a very important point about scientific discovery in general. Most scientists are interested in just looking at the universe, looking at nature. I don’t think there are many great discoveries that you can point to that were the result of someone wanting to find the answer to a particular question. If you look back at Einstein or Newton, you find that people are fascinated often by the smallest things, actually. In terms of Einstein, cosmology—which is a real part of the way the universe evolved, the way the universe began, the Big Bang—all that stuff came from Einstein really just being interested in the speed of light. He was just interested. It was a question he’d always asked. He’d always wondered about how light travels. It’s a useful lesson, in general, not only to the theories, but that science is at its best when curious people are just trying to find things out.
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There’s a very famous quote from [Alexander] Fleming, when he discovered penicillin, he said something like, “On September something 1928, I didn’t expect to wake up and revolutionize medicine.” He woke up playing around with little bits of mold in his kitchen, basically. He was just interested in moldy things. [Laughs.] And he revolutionized everybody’s life. Everybody. Virtually everybody who is over the age of about 40 or 50 is alive today because of antibiotics. Virtually everybody would have died if it hadn’t been for that. And it wasn’t someone trying to discover antibiotics that did it. It was someone exploring nature. So, the argument, “Couldn’t we just spend our money making everybody’s lives better?” We are doing that. That’s what exploration actually does.

The Sun is a Miasma of Incandescent Plasma

They Might be Giants once again provide an enjoyable view into the wonders of science. Previously they published the video, The Sun is a Mass of Incandescent Gas. They published an updated video, a couple years ago, which captures the best current understanding based on the scientific inquiry process: Why Does the Sun Really Shine? (The Sun is a Miasma of Incandescent Plasma).

I really do love, They Might be Giants. Even before their focus on science I enjoyed their music. But they have done wonders with all their recent work. Go Giants. Get their DVD: Here Comes Science.

Their previous video, The Sun is a Mass of Incandescent Gas, Continue reading →

Wesley the Owl: Love Story of an Owl and His Girl

This story begins on Valentine’s Day in 1985 when biologist Stacey O’Brien meets a four-day-old baby barn owl in a fateful encounter that would turn into an astonishing 19-year saga. With nerve damage in one wing, the owlet’s ability to fly was forever compromised and he had no hope of surviving on his own in the wild. A young assistant in the owl laboratory at Caltech, O’Brien promised to care for the helpless owlet and give him a permanent home. O’Brien’s heartfelt memoir of life with this wild bird, Wesley the Owl: The Remarkable Love Story of an Owl and His Girl recounts their dramatic, and often humorous, life together.

For almost two decades, O’Brien studied Wesley and his strange habits intensively and providing a mice-only diet. With a heart-shaped face and outsized personality that belied his 18-inch stature, the gorgeous white-and-gold Wesley fascinated everyone he met, and touched many lives. Stacey and Wesley’s bond was especially deep; O’Brien discovered that owls are highly sentient beings with individual personalities, subtle emotions, and a playful nature that can also turn fiercely loyal and protective.

Cool fact: “While we hear in two dimensions, owls hear in three.” Owls can detect a mouse heartbeat under three feet of snow.
Related: Friday Fun: Cat and Owl Playing – Bird Brain (smart crows) – Using Barn Owls for Bilogical Pest Control in Israel
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