Changing Life as We Know It

Update: Independent researchers find no evidence for arsenic life in Mono Lake

NASA has made a discovery that changes our understanding of the very makeup of life itself on earth. I think my favorite scientific discipline name is astrobiology. NASA pursues a great deal of this research not just out in space but also looking at earth based life. Their astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth.

Felisa Wolfe-Simon processing mud from Mono Lake to inoculate media to grow microbes on arsenic.

Carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur are the six basic building blocks of all known forms of life on Earth. Phosphorus is part of the chemical backbone of DNA and RNA, the structures that carry genetic instructions for life, and is considered an essential element for all living cells.

Phosphorus is a central component of the energy-carrying molecule in all cells (adenosine triphosphate) and also the phospholipids that form all cell membranes. Arsenic, which is chemically similar to phosphorus, is poisonous for most life on Earth. Arsenic disrupts metabolic pathways because chemically it behaves similarly to phosphate.

Researchers conducting tests in the harsh, but beautiful (see photo), environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. The microorganism substitutes arsenic for phosphorus in its cell components.

“The definition of life has just expanded,” said Ed Weiler, NASA’s associate administrator for the Science Mission Directorate. “As we pursue our efforts to seek signs of life in the solar system, we have to think more broadly, more diversely and consider life as we do not know it.” This finding of an alternative biochemistry makeup will alter biology textbooks and expand the scope of the search for life beyond Earth.

In science such huge breakthroughs are not just excepted without debate, however, which is wise.

Thriving on Arsenic:

In other words, every experiment Wolfe-Simon performed pointed to the same conclusion: GFAJ-1 can substitute arsenic for phosphorus in its DNA. “I really have no idea what another explanation would be,” Wolfe-Simon says.

But Steven Benner, a distinguished fellow at the Foundation for Applied Molecular Evolution in Gainesville, FL, remains skeptical. If you “replace all the phosphates by arsenates,” in the backbone of DNA, he says, “every bond in that chain is going to hydrolyze [react with water and fall apart] with a half-life on the order of minutes, say 10 minutes.” So “if there is an arsenate equivalent of DNA in that bug, it has to be seriously stabilized” by some as-yet-unknown mechanism.

It is sure a great story if it is true though. Other scientists will examine more data and confirm or disprove the claims.

“We know that some microbes can breathe arsenic, but what we’ve found is a microbe doing something new — building parts of itself out of arsenic,” said Felisa Wolfe-Simon, a NASA Astrobiology Research Fellow in residence at the U.S. Geological Survey in Menlo Park, Calif., and the research team’s lead scientist. “If something here on Earth can do something so unexpected, what else can life do that we haven’t seen yet?”
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Aerobic Exercise Plus Resistance Training Helps Control Type 2 Diabetes

Exercise Combo Best for Controlling Diabetes

A combination of aerobic exercise and resistance training may offer the biggest benefits for people with type 2 diabetes in helping them control their disease.
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HbA1c is a test that measures blood sugar control for the previous few months. Normal HbA1c is 6% or less. People with diabetes are urged to keep their HbA1c below 7%.

In the study, researchers compared the effects of a nine-month aerobic exercise program, a resistance training program, and combination exercise program vs. not exercising in 262 previously sedentary men and women with type 2 diabetes. The results showed that improvements in HbA1c levels were greatest among those who were in the combination group.
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Thirty-nine percent of non-exercisers had to increase these medications compared with 32% in the resistance training group, 22% in the aerobic exercise group, and 18% in the combination group.

Diabetes is a huge and growing problem. Exercise is a good strategy to remain healthy. It is best to exercise and avoid becoming sick. But if you do get diabetes then it is even more important to take care to exercise properly.

Backyard Wildlife: Robins Attack Holly Tree

Robins like to attack my holly tree and feed on the berries. Getting photos of them is hard but there are lots of them flying around all excited (I did manage to catch one of them in the photo on the left). This tree was actually here when I moved in but I also do try to nurture and add plants that feed wildlife. I like just planting things that will feed and shelter birds (and others) rather than filling bird feeders myself. There is information on how to use your backyard to promote wildlife.

Great Furniture for Small Spaces

Wonderful design from Italy with great space saving furniture. Great design with wonderful engineering provides solutions that are a joy to see and live with. These are not cheap though. New York City distributors of the furniture.

Backyard Wildlife: Walking Leaf

photo of insect that looks like a leaf

See some more great photos of the hike on Penang Island in Malaysia, from the Capturing Penang blog.

Fix it Goo

5 years of discovery and experimentation culminated in Sugru. It cures at room tempature, is self-adhesive, is flexible, waterproof and dish-washer-proof. Another post on home fixing.

Fiskars Cuts+More 5-in-1 Multi-Purpose Scissors

These are some well engineering scissors with all sorts of handy features. Fiskars makes some great products. High-quality blades provide excellent cutting performance on a wide variety of materials. Large, ergonomically sculpted finger and thumb loops provide excellent comfort and control when cutting.

Additional features include a power notch for cutting light rope, wire cutter, twine cutter, pointed awl tip and bottle opener. You can even take the scissors apart and use the titanium-coated blade as a knife. It’s dishwasher safe and includes an innovative sheath with a built-in tape cutter and a ceramic scissors sharpener to keep the blades performing at their best. Ergonomically sculpted handles provide comfortable use and cutting control. Power notch cuts light rope. Wire cutter makes cutting wire without damaging the blades quick and easy.

A pointed awl tip is perfect for piercing small holes in cardboard, leather and more. Bottle opener makes it easy to open bottles. Take-apart design offers a titanium-coated knife that is three times harder than steel for general cutting needs. Dishwasher safe for easy cleaning. The sheath protects blades, sharpens scissors and includes a tape cutter for opening boxes.

Bronx High School of Nobel Prize for Physics Laureates

Bronx physics

Bronx Science owes its historic status to the fact that seven future Nobel-prize-winning physicists went through its doors – more than any other high school in the world and more than most countries have ever achieved. The school, which opened in 1938, was founded by the educator Morris Meister, who believed that if a school put bright students together, it would kindle ill-defined but valuable learning processes. The school seems to have proved him right: according to the Bronx laureates, their physics learning took place mainly outside the classroom.
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Leon Cooper, who shared the 1972 prize for work on superconductivity, recalls physics lessons as boring, and was far more enchanted by his biology classes, which lured him to stay late after school designing and running experiments “until they threw me out”. Indeed, the school’s basic-physics textbook was written by a certain Charles E Dull, whose work, though widely used in US high schools, lived up to his name. The future particle physicist Melvin Schwartz, who shared the 1988 Nobel gong, once told me his classmates’ excited discussions – not his teacher – were what first awakened his interest in physics.
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[today] the school’s most fearsome physics module – Advanced Placement Physics C – is tougher than most college-physics courses. Its dynamic instructor is Ghada Nehmeh, who was born in Lebanon and studied nuclear physics. Diminutive – smaller than most of her students – and scarf-clad, she jumps rapidly from lab table to lab table, helping piece together equipment and analyse results. Famous for being ruthlessly demanding, she tests the students on their first day by assigning them 40 calculus problems, due back the next day. “I’d never seen derivatives before,” says Kezi Cheng, a senior interested in theoretical physics. So Cheng did what most Bronx Science students do – she asked her classmates to give her a crash course on the subject. “They’re always willing to help.”

Sounds like a great place to go to school. The article also has some good anecdotes about how these students learned by seeking knowledge themselves not passively sitting and being lectured to.

Fixers Collective

Very cool. I like everything about this idea. I like the reuse (very environmentally friendly). I like the humanity and psychology of connecting with others. I like the tinkering/learning/fixing attitude and behavior. I like the very well done use of the internet to help fund such efforts. I like the exploration of the products and object we use. I like the rejection of a disposable attitude (just throw it away). I like the appropriate technology attitude. I made a donation, you can too (see what projects I am funding).

Shrink Serving Sizes

Helping Wally Eat Less

When I was a boy, we were admonished to “clean your plate” because “children are starving.” Many of my friends’ mothers were concerned about the children in China. Since my father had organized food relief to German families after WW II, we cleaned our plates for the children “in Europe.” My friend Larry’s family ate their bit for African children.

Now that I am a full-grown man, this conditioning should be easy to overcome, but it isn’t. Normally I have great willpower and discipline. Alas, that’s not true when it comes to eating my wife’s cooking. Put that great food on my plate and will be gone soon.

I’ve tried “eat less” goals. They don’t work. Delicious food appears on my plate, served by my wife’s loving hands. Somewhere in my subconscious my mother is whispering, “Children are starving in Europe.” My willpower is no match.

What to do? Clearly, admonishing myself to “eat less” does not work. In fact, it’s a recipe (pardon the pun) for frustration. You may have situations like that. You or one of your team members or someone you love has a problem. It seems like willpower or goal setting will solve it. But somehow it never does.
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The other part of the systems solution is simplicity itself. Serve Wally using smaller bowls and plates. The plate is full, but there’s less food on it. I can eat everything on my plate to the betterment of those European children and my waistline.

Smaller serving sizes is a good idea. Increasing serving sizes over the last few decades is one of the big problems in the USA’s obesity epidemic. From a problem solving approach another good idea is to look beyond the problem at the larger system (the smaller serving size is a great system solution that is inside the eating problem). In this case for some people a way to deal with an eating problem is to exercise more. By changing the overall system a problem of eating too much can sometimes be changed into not a problem (due to a change outside the system).