Parasites in the Gut Help Develop a Healthy Immune System

It has long been known that microbes in the gut help to develop a healthy immune system, hence the rise in popularity of probiotic yoghurts that encourage ‘friendly’ bacteria. But new research by Professors Richard Grencis and Ian Roberts shows that larger organisms such as parasitic worms are also essential in maintaining our bodily ‘ecosystem’. “The worms have been with us throughout our evolution and their presence, along with bacteria, in the ecosystem of the gut is important in the development of a functional immune system.”

Parasite Rex is a great book, I have written about previously looking at parasites and their affect on human health.

Professor Grencis adds: “If you look at the incidence of parasitic worm infection and compare it to the incidence of auto-immune disease and allergy, where the body’s immune system over-reacts and causes damage, they have little overlap. Clean places in the West, where parasites are eradicated, see problems caused by overactive immune systems. In the developing world, there is more parasitic worm infection but less auto-immune and allergic problems.

“We are not suggesting that people deliberately infect themselves with parasitic worms but we are saying that these larger pathogens make things that help our immune system. We have evolved with both the bugs and the worms and there are consequences of that interaction, so they are important to the development of our immune system.”

Whipworm, also known as Trichuris, is a very common type of parasitic worm and infects many species of animals including millions of humans. It has also been with us and animals throughout evolution. The parasites live in the large intestine, the very site containing the bulk of the intestinal bacteria.

Heavy infections of whipworm can cause bloody diarrhoea, with long-standing blood loss leading to iron-deficiency anaemia, and even rectal prolapse. But light infections have relatively few symptoms.
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Students Will Spend Year Doing Career-Changing Research Thanks to HHMI

This year, 116 medical, dental, and veterinary students from 47 schools across the country will take a break from memorizing molecular metabolism and studying drug interactions to spend a year in a lab doing hands-on research. The break from regular coursework, funded through a $4 million Howard Hughes Medical Institute (HHMI) initiative, is intended to give students an opportunity to immerse themselves in science and consider whether they want to pursue a career as a physician-scientist.

Nearly 500 medical students applied for the research year through the HHMI-National Institutes of Health (NIH) Medical Research Scholars and HHMI Medical Research Fellows programs. Both efforts seek to strengthen and expand the pool of medically-trained researchers. The funding HHMI provides is a great resource.

“We want medical, dental, and veterinary students to become immersed in the life of academic science for at least a year. And we hope they get so engaged in the process and life of scientific research that they will decide to continue it for the rest of their lives,” says Peter Bruns, HHMI’s vice president for grants and special programs. “We need more doctors who do basic research to improve human health.”

As part of its commitment to fostering the translation of basic research discoveries into improved diagnoses and treatments, HHMI has developed a range of programs to nurture the careers of researchers who bridge the gap between clinical medicine and basic science. In addition to the programs for medical students, the Institute supports medical training for Ph.D. students in the basic sciences and has made specific efforts to fund top physician-scientists as HHMI investigators.

The medical research scholars and fellows programs are open to medical, dental, and veterinary students enrolled in U.S. schools. Most have completed the second or third year of their professional program when they spend a year working in a lab either at the NIH or at an academic medical center or research university they select. During the last 25 years, more than 2,100 students have participated.

The HHMI Medical Research Fellowships program allows medical, dental, and veterinary students to pursue biomedical research at a laboratory anywhere in the United States except the NIH campus in Bethesda. Each student submits a research plan to work in a specific lab with a mentor they have identified. Since 1989, about 1,200 students have participated.

This year, 74 students from 26 medical schools and two veterinary schools were chosen as fellows from a pool of 274. While most students elect to stay at their home institution to do their research, this year 17 fellows will work in labs at a different school. Their research topics include schizophrenia, wound healing, organ development, and many other important biological questions.

The HHMI-NIH Research Scholars program was established in 1985 to encourage medical students to pursue research by allowing them to take a year off from their medical studies. The program has since been expanded to include dental and veterinary students. It has enabled about 1,000 students to work in NIH labs.

Students selected as research scholars often enter the program with only a general idea of what type of research they would like to do. As soon as they are accepted, they begin researching the more than 1,100 laboratories at NIH. They meet with a number potential mentors before finalizing which project to pursue under the guidance of their NIH advisor and HHMI’s staff. The students are sometimes called “cloister scholars” because they live in apartments or dorm-style rooms in a refurbished cloister on the NIH campus in Bethesda.

This year, 42 students from 28 medical schools and one veterinary school were chosen as research scholars. More than 200 students from 93 schools applied.

All present-day Life on Earth Has A Single Ancestor

All present-day life arose from a single ancestor

All life on Earth shares a single common ancestor, a new statistical analysis confirms.
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Because microorganisms of different species often swap genes, some scientists have proposed that multiple primordial life forms could have tossed their genetic material into life’s mix, creating a web, rather than a tree of life.
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A universal common ancestor is at least 10^2,860 times more probable than having multiple ancestors, Theobald calculates.
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For his analysis, Theobald selected 23 proteins that are found across the taxonomic spectrum but have structures that differ from one species to another. He looked at those proteins in 12 species – four each from the bacterial, archaeal and eukaryotic domains of life.

Then he performed computer simulations to evaluate how likely various evolutionary scenarios were to produce the observed array of proteins. Theobald found that scenarios featuring a universal common ancestor won hands down against even the best-performing multi-ancestor models.

Very interesting. Surprising too. As the article points out this doesn’t mean all life ever on Earth evolved from the single ancestor – life that has gone extinct could be from outside this single “tree.”

Droid Incredible

The Droid Incredible really is a great gadget. I am too cheap to get it but if I were to use a cell phone much I think this is the one I would get. I personally prefer more open software like Android (which the Droid Incredible uses) to Apple (though Apple’s user experience is great, I admit).

The Droid Incredible by HTC features a body design that measures 4.63 x 2.3 x 0.47 inches (HxWxD), making it easy to slip into your pocket. A large, 3.7-inch HD screen with 480×800 resolution graces the front of the device. The responsive OLED touch screen features rich colors and is easy to use.

With a 1 GHz Snapdragon processor, 512 MB of RAM, and 8 GB of internal flash memory, the Droid Incredible delivers incredible performance, letting you run multiple applications. It includes an 8-megapixel camera with auto focus and 2x power LED flash, and also Google Maps Navigation, which provides GPS-based turn-by-turn voice guidance to get you where you need to go.

New Server Uses 75% Less Power and Space

SeaMicro drops an atom bomb on the server industry

[SeaMicro] has created a server with 512 Intel Atom chips that gets supercomputer performance but uses 75 percent less power and space than current servers.
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Today’s servers are so inefficient when it comes to being properly utilized,” Feldman said. “This misalignment between the server and the work load is the root of the power consumption problem.”

So SeaMicro guessed that servers could benefit instead by using lots of smaller processors, and it got lucky when Intel started promoting its low-power, low-cost Atom chip for netbooks. That lowered power consumption, since Atom processors deliver three times the performance per watt versus Intel’s server chips.
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But SeaMicro also attacked the power consumption in the rest of the system, which accounts for about two thirds of the power consumed by a server.
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it applied the concept of virtualization to the inside of a server. Feldman designed custom chips that could take the tasks that were handled by everything beyond the Intel microprocessor and its chip set. The custom chips virtualize all of those other components so that it finds the resource when it’s needed. It essentially tricks the microprocessor into thinking that the rest of the system is there when it needs it.

SeaMicro virtualized a lot of functions that took up a lot of space inside each server in a rack. It also did the same with functions such as storage, networking, server management and load balancing. Full told, SeaMicro eliminates 90 percent of the components from a system board. SeaMicro calls this CPU/IO virtualization. With it, SeaMicro shrinks the size of the system board from a pizza box to the size of a credit card.
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This advance is coming just in time. Google said recently that if current power trends continue, the cost of energy consumed by a server during its three-year life span could surpass the initial purchase cost for the hardware. The Environmental Protection Agency reports that volume servers consume more than 1 percent of the total electricity in the US—representing billions of dollars in wasted operating expense each year.

Variation in Human DNA

Variation on the order of thousands to hundreds of thousands of DNA’s smallest pieces – large swaths varying in length or location or even showing up in reverse order – appeared 4,205 times in a comparison of DNA from just four people.

Those structural differences popped into clear view through computer analysis of more than 500 linear feet of DNA molecules analyzed by the powerful genome mapping system developed over nearly two decades by David C. Schwartz, professor of chemistry and genetics at UW-Madison.

“We probably have the most comprehensive view of the human genome ever,” Schwartz says. “And the variation we’re seeing in the human genome is something we’ve known was there and important for many years, but we haven’t been able to fully study it.”

To get a better picture of those structural variations, Schwartz and his team developed the Optical Mapping System, a wholly new type of genome analysis that directly examines millions of individual DNA molecules.

“Our newer genome analysis systems, if commercialized, promise genome analysis in one hour, at under $1,000,” Schwartz says. “And we require that high speed and low cost to power the new field of personal genomics.”

Read full press release

NASA to Launch GM Co-Developed Robot to International Space Station

NASA will launch the first human-like robot to space later this year to become a permanent resident of the International Space Station. Robonaut 2, or R2, was developed jointly by NASA and General Motors under a cooperative agreement to develop a robotic assistant that can work alongside humans, whether they be astronauts in space or workers at GM manufacturing plants on Earth.

The 300-pound R2 consists of a head and a torso with two arms and two hands and will launch on space shuttle Discovery as part of the STS-133 mission planned for September. Once aboard the station, engineers will monitor how the robot operates in weightlessness. R2 joins another station robot, known as Dextre. That robot, built by the Canadian Space Agency, consists of two, long arms to perform tasks that normally require spacewalking astronauts to complete.

While Dextre is located on the station’s exterior, R2 will be confined to operations in the station’s Destiny laboratory. However, future enhancements could allow it to move more freely around the station’s interior, and it could one day be modified to operate outside the complex.

“The use of R2 on the space station is just the beginning of a quickening pace between human and robotic exploration of space,” said John Olson, director of NASA’s Exploration Systems Integration Office. “The partnership of humans and robots will be critical to opening up the solar system and will allow us to go farther and achieve more than we can probably even imagine today.”

The dexterous humanoid robot not only looks like a human, it is designed to work like one. With human-like hands and arms, R2 is able to use the same tools that station crew members use. In the future, the greatest benefit of humanoid robots in space may be as an assistant or stand-in for astronauts during spacewalks or for tasks too difficult or dangerous for humans. For now, R2 is still a prototype and lacks adequate protection needed to exist outside the space station in the extreme temperatures of space.

Whales Evolved in the Blink of an Eye, Only 5 Million Years

Whales Evolved in the Blink of an Eye

Whales’ sizes stretch the imagination from the 100-foot (30-meter) long blue whale – the largest animal to have ever existed – to a small species about the size of a dog.
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Around 35 million years ago, when modern whales began to appear in the ocean, whale evolution ignited. Whales began as basically similar body types and evolved into everything from porpoises to blue whales over the next 5 million years, said study lead author Graham Slater of UCLA. “Five million years is like the blink of an eye,” Slater told LiveScience.

The finding supports what’s known as the explosive radiation hypothesis. The idea is that a few key traits allowed the earliest ancestors of modern cetaceans – marine mammals, including whales, dolphins and porpoises – to explore new ways of living. Once these ancestors branched out into a new body form, they stayed the course.

The key traits credited with the explosive evolution include sonar, large brains, baleen (the stringy looking stuff across some whales’ mouths that filters small animals from sea water), and complex sociality.

Updated Black and Decker Codeless Lawn Mower Review

Update: Less than 2 years old the battery can’t even mow 1/2 of what the old lawn mower battery could mow after it was much older. Unfortunately it seem that even my pessimistic expectations were too high. They managed to provide worse battery product after years of breakthroughs in improving batteries. I would recommend avoiding Black and Decker.

Better options: Toro 20360 e-Cycler 20-Inch 36-Volt Cordless Electric Lawn Mower – Earthwise 60120 20-Inch 24-Volt Cordless Electric Lawn Mower

The bag is indeed much better than the old version but it is the only improvement. The other problems I mentioned do indeed continue to annoy as it is used.

My old version of this mower just stopped working and the repair guy said it would cost $250 for a new starter, new battery… So I bought a new one: Black & Decker 19-Inch 24-Volt Cordless Electric Mulching Lawn Mower #CMM1200. He said that the new ones were not as well manufactured. I couldn’t imagine how you could make things worse (it is a simple product and just adopting improvement over the years should be really easy).

But, the starter on this model is horrible. You have to tun this incredibly cheap key in a very poorly designed socket. Fails over 80% of the time. The old model started easily essentially every time. The design was just as you would expect, foolproof. Whatever pointy haired boss approved this design needs to go into another line of work.

The ability of the mower to cope with high grass is very poor – much worse than the previous model. I had a good test at first given the time between my mower breaking and getting the new one. Not often an issue, but still not a good thing.

They had a poor indication of the charge left in the battery previously. They now provide no indication of the charge left. It makes you realize that a poor indication was much better than none.

Battery technology has improved a great deal, and that was one of biggest the weaknesses of the last one. Well they seem to have managed to provide worse battery performance after 5 years of improvement in that technology. Pretty sad.
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All About Circuits

All About Circuits is an online textbook covering electricity and electronics. Topics covered include: Basic Concepts of Electricity’ OHM’s Law; Electrical Safety; Series and Parallel Circuits; Physics of Conductors and Insulators; Solid-State Device Theory; Binary Arithmetic; Logic Gates; Switches; Digital Storage? It is a great resource. Enjoy.