Resurrection of the Human IRGM Gene

Interesting open access paper on Death and Resurrection of the Human IRGM Gene. Author summary:

The IRG gene family plays an important role in defense against intracellular bacteria, and genome-wide association studies have implicated structural variants of the single-copy human IRGM locus as a risk factor for Crohn’s disease. We reconstruct the evolutionary history of this region among primates and show that the ancestral tandem gene family contracted to a single pseudogene within the ancestral lineage of apes and monkeys.

Phylogenetic analyses support a model where the gene has been “dead” for at least 25 million years of human primate evolution but whose ORF became restored in all human and great ape lineages. We suggest that the rebirth or restoration of the gene coincided with the insertion of an endogenous retrovirus, which now serves as the functional promoter driving human gene expression. We suggest that either the gene is not functional in humans or this represents one of the first documented examples of gene death and rebirth.

Electrolyzed Water Replacing Toxic Cleaning Substances

Simple elixir called a ‘miracle liquid’

The stuff is a simple mixture of table salt and tap water whose ions have been scrambled with an electric current. Researchers have dubbed it electrolyzed water
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Used as a sanitizer for decades in Russia and Japan, it’s slowly winning acceptance in the United States. A New York poultry processor uses it to kill salmonella on chicken carcasses. Minnesota grocery clerks spray sticky conveyors in the checkout lanes. Michigan jailers mop with electrolyzed water to keep potentially lethal cleaners out of the hands of inmates.

In Santa Monica, the once-skeptical Sheraton housekeeping staff has ditched skin-chapping bleach and pungent ammonia for spray bottles filled with electrolyzed water to clean toilets and sinks. “I didn’t believe in it at first because it didn’t have foam or any scent,” said housekeeper Flor Corona. “But I can tell you it works. My rooms are clean.”
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It turns out that zapping salt water with low-voltage electricity creates a couple of powerful yet nontoxic cleaning agents. Sodium ions are converted into sodium hydroxide, an alkaline liquid that cleans and degreases like detergent, but without the scrubbing bubbles. Chloride ions become hypochlorous acid, a potent disinfectant known as acid water.

“It’s 10 times more effective than bleach in killing bacteria,” said Yen-Con Hung, a professor of food science at the University of Georgia-Griffin, who has been researching electrolyzed water for more than a decade. “And it’s safe.”

There are drawbacks. Electrolyzed water loses its potency fairly quickly, so it can’t be stored long. Machines are pricey and geared mainly for industrial use. The process also needs to be monitored frequently for the right strength.

Very cool use of science: providing a green cleaning agent that is effective.

Darwin’s Jellyfishes

Palau’s marine-lake jellyfish actually diverged very quickly from their common ancestor, the spotted jellyfish. Like other jellyfish, the spotted jellies are cnidarians, a scientific grouping that includes reef-building corals. The spotted jellyfish drift in Palau’s lagoon, zapping the occasional zooplankton with their stinging nettles and absorbing the sugary by-products of photosynthesizing algae living in their tissues.

Like many jelly species, the spotted jellyfish has a multi-stage life cycle. Adult males and females with the familiar bell-shaped bodies are called medusae, but you would not recognize very young jellyfish as jellyfish at all. After medusae release eggs and sperm into the water, fertilized eggs hatch as larvae that drift for a few days before attaching to solid objects, such as rocks. The larvae morph into polyps resembling tiny anemones. Polyps can bud off into more polyps or, when conditions are right, into new young medusae.
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the jellyfish do not “eat” algae. Like their lagoon ancestors, the jellyfish simply absorb their algae’s photosynthetic leftovers. The jellies get about three-fourths of their energy from algal excretions and the remainder from prey. In essence, the jellyfish are landlords that hunt a bit on the side.

The jellyfish-algae partnership did not originate in the lakes, either. Ancestral spotted jellyfish brought the arrangement with them. “Spotted jellyfish in the lagoon have basic behaviors that help ‘sun’ their algae,” Martin explains. “They move eastward in the morning. The lake jellies have adapted this migration to each individual lake. The most spectacular migration is in Jellyfish Lake.”

The jellies’ migration delicately balances time in the sun (to benefit their algae) and predator avoidance. The gelatinous masses of peanut-shaped Jellyfish Lake begin their day in the western basin. As the sun rises they pulsate eastward toward the rising sun—but not too far east, because the lakeshore is covered with jellyfish-eating anemones. The jellies stop swimming east when they hit the shade cast by mangrove trees lining the shore.
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At nightfall the jellies switch to a vertical migration. Jellyfish Lake reaches depths of 100 feet, but only the top 45 feet contain oxygen. The bottom is a toxic vat of hydrogen sulfide. Bacteria do a brisk business at the interface, metabolizing both the oxygen above and hydrogen sulfide below. Every night the jellies bob up and down from the surface to the bacterial layer. Besides helping the jellyfish stay in place, dipping down treats the jellies’ algae to a midnight snack of nutrients excreted by the microbial masses.

Very Cool.

Rare Saharan Cheetahs Photographed

Â© Farid Belbachir/ZSL/OPNA

The first systematic camera trap survey across the central Sahara, identified four different Saharan cheetahs using spot patterns unique to each individual. ‘The Saharan cheetah is critically endangered, yet virtually nothing is known about the population, so this new evidence, and the ongoing research work, is hugely significant,’ said Dr Sarah Durant, Zoological Society of London Senior Research Fellow.

Farid Belbachir, who is implementing the field survey, adds: ‘This is an incredibly rare and elusive subspecies of cheetah and current population estimates, which stand at less than 250 mature individuals, are based on guesswork. This study is helping us to turn a corner in our understanding, providing us with information about population numbers, movement and ecology.’

The Northwest African cheetah is found over the Sahara desert and savannas of North and West Africa, respectively, including Algeria, Niger, Mali, Benin, Burkina-Faso and Togo. The populations are very fragmented and small, with the biggest thought to be found in Algeria.

Read the full press release

Update Dec 2010: Nighttime photos of Saharan cheetah and other Saharan cat photos.

Open Science: Explaining Spontaneous Knotting

Shedding light on why long strands tend to become knotted

Anyone who has ever put up Christmas lights knows the problem: Holiday strands so carefully packed away last year are now more knotty than nice. In fact, they have become an inextricable, inexplicable, seemingly inevitable mess. It happens every year, like some sort of universal law of physics.

Which, it turns out, it basically is. In October, two UCSD researchers published the first physical explanation of why knots seem to form magically, not just in strands of Christmas lights, but in pretty much anything stringy, from garden hoses to iPod earbud cords to DNA.
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“We’re not mathematicians,” Smith said. “We’re physicists. Physicists do experiments.”

UCSD researchers constructed a knot probability machine that involved placing a single length of string in a plastic box, sealing it, then rotating the box at a set speed for a brief period of time.
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The experiment involved placing a single length of floppy string into a plastic box, sealing it, then rotating the box at a set speed for a brief time. The researchers did this 3,415 times, sometimes changing variables such as box size and string length.

Open access research paper: Spontaneous knotting of an agitated string by Dorian M. Raymer and Douglas E. Smith.

Above a critical string length, the probability P of knotting at first increased sharply with length but then saturated below 100%. This behavior differs from that of mathematical self-avoiding random walks, where P has been proven to approach 100%. Finite agitation time and jamming of the string due to its stiffness result in lower probability, but P approaches 100% with long, flexible strings.
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As L [length] was increased from 0.46 to 1.5 m, P increased sharply. However, as L was increased from 1.5 to 6 m, P saturated at 50%.
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Tripling the agitation time caused a substantial increase in P, indicating that the knotting is kinetically limited. Decreasing the rotation rate by 3-fold while keeping the same number of rotations caused little change in P.
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We also did measurements with a stiffer string and observed a probability of finding a knot would approach 100% with an substantial drop in P.

Yet another interesting case of scientists explaining the world around us (and the value of open science).

John Conyers Against Open Science

Lawrence Lessig once again has written a good blog post: John Conyers and Open Access

Open access journals, such as, for example, those created by the Public Library of Science, have adopted a different publishing model, to guarantee that all all research is freely accessible online (under the freest Creative Commons license) immediately, to anyone around the world. This guarantee of access, however, is not purchased by any compromise in academic standards. There is still a peer-review process. There is still even a paper-based publication.

Pushed by scientists everywhere, the NIH and other government agencies were increasingly exploring this obviously better model for spreading knowledge. Proprietary publishers, however, didn’t like it. And so rather than competing in the traditional way, they’ve adopted the increasingly Washington way of competition — they’ve gone to Congress to get a law to ban the business model they don’t like. If H.R. 801 is passed, the government can’t even experiment with supporting publishing models that assure that the people who have paid for the research can actually access it. Instead, if Conyers has his way, we’ll pay for the research twice.
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The insanity in this proposal is brilliantly described by Jamie Boyle in this piece in the FT. But after you read his peace, you’ll be even more puzzled by this. For what possible reason could Conyers have for supporting a bill that 33 Nobel Prize Winners, and the current and former heads of the NIH say will actually hurt scientific research in America? More pointedly, what possible reason would a man from a district that insists on the government “Buying American” have for supporting a bill that basically subsidizes foreign publishers (for the biggest players in this publishing market are non-American firms, making HR 801 a kind of “Foreign Publishers Protection Act”)?
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the co-sponsors of this bill who sit on the Judiciary Committee received on average two-times the amount of money from publishing interests as those who haven’t co-sponsored the bill.

The damage done to science by dinosaurs fighting progress and corrupt or inept politicians is very disheartening. Thankfully we have been able to achieve great things in spite of politicians trying to favor their donors and harm the scientific community.

Jon Stewart Explains Twitter and John Hunter on Twitter

The Daily Show With Jon StewartM – Th 11p / 10c

Twitter Frenzy

Daily Show Full Episodes
Important Things With Demetri Martin

Political Humor
Joke of the Day

Jon Stewart does a great job of explaining Twitter. Still, for some reason I am going to try Tweeting. Follow curiouscat_com if you are interested.

Macropinna Microstoma: Fish with a Transparent Head

That is a pretty awesome fish. The eyes were believed to be fixed in place and seemed to provide only a “tunnel-vision” view of whatever was directly above the fish’s head. A new paper by Bruce Robison and Kim Reisenbichler shows that these unusual eyes can rotate within a transparent shield that covers the fish’s head. This allows the barreleye to peer up at potential prey or focus forward to see what it is eating.

Deep-sea fish have adapted to their pitch-black environment in a variety of amazing ways. Several species of deep-water fishes in the family Opisthoproctidae are called “barreleyes” because their eyes are tubular in shape. Barreleyes typically live near the depth where sunlight from the surface fades to complete blackness. They use their ultra-sensitive tubular eyes to search for the faint silhouettes of prey overhead.

Full press release

Study Shows Weight Loss From Calorie Reduction Not Low Fat or Low Carb

A Randomized Trial Comparing Low-Fat and Low-Carbohydrate Diets Matched for Energy and Protein

The preliminary results presented in this paper are for the first four of six postmenopausal overweight or obese participants who followed, in random order, both a VLC [very-low-carbohydrate] and an LF [low-fat] diet for 6 weeks. Other outcome measures were serum lipids, glucose, and insulin, as well as dietary compliance and side effects. Our results showed no significant weight loss, lipid, serum insulin, or glucose differences between the two diets. Lipids were dramatically reduced on both diets, with a trend for greater triglyceride reduction on the VLC diet. Glucose levels were also reduced on both diets, with a trend for insulin reduction on the VLC diet. Compliance was excellent with both diets, and side effects were mild

Essentially the study showed that the calories had an impact on weight loss but the makeup of those calories did not. Don’t forget this is just one study. Listen to interview with the Author, Frank Sacks, on Science Friday on NPR.

Carnegie Foundation Calls for Overhaul of Engineering Education

Yet another call for the overhaul of engineering eduction. This time in a Carnegie Foundation Report

The nation’s engineering schools are using outdated educational practices that focus too heavily on imparting technical knowledge and do not do enough to prepare undergraduate students for the profession
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in the midst of worldwide transformation of the engineering profession, undergraduate engineering programs in the United States continue to approach problem-solving and knowledge acquisition in an outdated manner. Moreover, engineering programs’ solution to improving the education they offer has been simply to add more courses, rather than reconsidering the design of their programs.

Instead of having a “jam-packed curriculum focused on technical knowledge,” engineering programs should be doing more to help students develop analytical reasoning, practical skills, and professional judgment, the report says.

“We are calling for a new model that will involve fundamentally rethinking the role and even the makeup of the faculty,”

A summary is available online and worth reading for those interested in undergraduate engineering education. I question the wisdom of a foundation urging innovation and then telling people to buy order their book to lean more. If a foundation wants to drive change today, I would think you do so by making material available online easily. Obviously they disagree.