Tag Archives: Awards

2011 Nobel Prize in Physiology or Medicine

The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity.

This year’s Nobel Laureates have revolutionized our understanding of the immune system by discovering key principles for its activation.

Scientists have long been searching for the gatekeepers of the immune response by which man and other animals defend themselves against attack by bacteria and other microorganisms. Bruce Beutler and Jules Hoffmann discovered receptor proteins that can recognize such microorganisms and activate innate immunity, the first step in the body’s immune response. Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which microorganisms are cleared from the body.

The discoveries of the three Nobel Laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases.

We live in a dangerous world. Pathogenic microorganisms (bacteria, virus, fungi, and parasites) threaten us continuously but we are equipped with powerful defense mechanisms (please see image below). The first line of defense, innate immunity, can destroy invading microorganisms and trigger inflammation that contributes to blocking their assault. If microorganisms break through this defense line, adaptive immunity is called into action. With its T and B cells, it produces antibodies and killer cells that destroy infected cells. After successfully combating the infectious assault, our adaptive immune system maintains an immunologic memory that allows a more rapid and powerful mobilization of defense forces next time the same microorganism attacks. These two defense lines of the immune system provide good protection against infections but they also pose a risk. If the activation threshold is too low, or if endogenous molecules can activate the system, inflammatory disease may follow.

The components of the immune system have been identified step by step during the 20th century. Thanks to a series of discoveries awarded the Nobel Prize, we know, for instance, how antibodies are constructed and how T cells recognize foreign substances. However, until the work of Beutler, Hoffmann and Steinman, the mechanisms triggering the activation of innate immunity and mediating the communication between innate and adaptive immunity remained enigmatic.

Ralph Steinman was awarded the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity. He was born in Canada and was a professor at Rockefeller University at the end of his career.

Continue reading →

Great Projects From First Google Science Fair Finalists

15 finalists (from 3 different age groups – 13-14 years old, 15-16 and 17-18) were selected. 11 finalists were from the USA and 1 each from Singapore, Canada, India and South Africa. These examples of what can be done with imagination, effort and a scientific mindset is great.

The grand prize winner, Shree Boseer’s project:

Each year, over 21,000 women are diagnosed with ovariancancer – the 5th leading cause of cancer-related deaths in women in the United States. One of the most common drugs usedin ovarian cancer chemotherapy is cisplatin, a platinum-based chemotherapy treatment. While the drug affects ordinary cells, the significantly higher replication frequency of cancer cells causes cisplatin to have a greater impact in malignant cells. However, cancer cells often develop resistance to cisplatin, rendering the treatment ineffective. To improve the efficiency of cisplatin treatment, this research sought to determine whether AMP kinase, an energy protein of cell, plays a role in the development of cisplatin resistance. Studies with various techniques showed a significant difference on cell death caused by cisplatin insensitive and resistant ovarian cancer cells when AMPK was inhibited,suggesting that AMPK plays a role in the development of resistance. This work,in addition to offering a new treatment regime, also furthers our understanding of ovarian cancer and cancers in general.

This is a great project and the experience for the students is wonderful. Still I do think the prizes should be much larger given all the large corporations involved. Get involved with the next Google Science fair.

Google Science Fair 2011 Projects semi finalists – Intel Science and Engineering Fair 2009 Webcasts – Hats off to the winners of the inaugural Google Science Fair – President Obama Speaks on Getting Students Excited About Science and Engineering
Continue reading →

Google Science Fair 2011 Projects

The Google Science Fair selected 60 semi-finalists in 3 groups (age 13-14, 15-16 and 17-18). The 60 global semi finalists will then be narrowed down by our judging panel to 15 global finalists who will be announced later in May.

The 15 global finalists will be flown to Google HQ in California, USA for our celebratory Science Fair event and finalist judging round will take place on 11 July 2011. These finalists will be expected to present their projects before a panel of acclaimed scientists including Nobel Laureates, tech visionaries and household names.

Sailboats using canting keels are among the world’s fastest ocean-going vessels; however, there are inherent problems. Canting sailboats require the addition of canards or dagger boards to replace the loss of the primary underwater lifting surface, adding significant complexity. The second and more important issue is that the cantilevered weight of the ballast bulb at the end of the keel generates tremendous loads on the vessel. The objective of this research was to test a concept to make sailboats even faster and safer than the current designs. To test the concept, this researcher built a remote control functional model fitted for both canting and hydrodynamic keels. The results showed that the hydrodynamic keel out performs the canting keel both upwind and downwind.

The Grand Prize winner plus one parent or guardian per winner will win an amazing 10 day trip to the Galapagos Islands with National Geographic Expeditions. Traveling aboard the National Geographic Endeavour the winner will visit Darwin’s living laboratory and experience up-close encounters with unique species such as flightless cormorants, marine iguanas, and domed giant tortoises. They also win a $50,000 scholarship, split equally between team members should a team win this prize. This scholarship is intended to be used towards the finalists’ further education.

The 2 age group winners that are not selected as the grand prize winner will win $25,000 scholarships.

You can vote on your favorite projects and help select the people’s choice winner that will receive a $10,000 scholarship.

Google Research Awards

Google Faculty Research Awards, support full-time faculty pursuing research. The most recent quarterly funding totals over $4 million in 75 awards across 18 different areas. The areas that received the highest level of funding for this round were systems and infrastructure, human computer interaction, multimedia and security. In this round, 26 percent of the funding was awarded to universities outside the U.S.

Some examples

Erik Brynjolfsson, Massachusetts Institute of Technology. The Future of Prediction – How Google Searches Foreshadow Housing Prices and Quantities (Economics and market algortihms): How data from search engines like Google provide a highly accurate but simple way to predict future business activities.
John Quinn, Makerere University, Uganda. Mobile Crop Surveillance in the Developing World (Multimedia search and audio/video processing): A computer vision system using camera-enabled mobile devices to monitor the spread of viral disease among staple crops.
Ronojoy Adhikari, The Institute of Mathematical Sciences, India (probably this is the person, why doesn’t google include a link to these people’s sites?). Machine Learning of Syntax in Undeciphered Scripts (Machine learning): Devise algorithms that would learn to search for evidence of semantics in datasets such as the Indus script.
Jennifer Rexford, Princeton. Rethinking Wide-Area Traffic Management (Software and hardware systems infrastructure): Drawing on mature techniques from optimization theory, design new traffic-management solutions where the hosts, routers, and management system cooperate in a more effective way.

Smart companies realize great research is done in universities that should be adlopted by companies. Many companies listen to fools that talk of academic research as not “real world.” Companies like Google do well for many reasons but one is they pay more attention to scientific research than wall street research. More companies would benefit from adopting this leadership style from Google. Google also continues to fund and support research.

USA Science And Engineering Kavli Video Contest

Do you think Science is cool? Do you want to share your passion for science with others? Here is your chance to inspire thousands of people to be more curious, and to care about science & engineering the way you do: create a short video that explores the question “Why is Science Cool?”

We are seeking videos that are creative, surprising, and “contagious” in terms of spreading your enthusiasm about science to others. Videos might explore a scientific concept, show us the wonders of nature, give us a glimpse into the future, show us what scientific discovery has done for us in the past or will do for us in the future, introduce us to a great scientist or engineer, tell us why you think science is so cool or simply show us why we should care about science and/or engineering.

1st prize: $1,000 (to the school or science club); plus $500 electronics gift certificate for the student (or student group); plus a travel stipend to travel to Washington DC for the Expo!

In addition, the winning videos will be screened during the USA Science & Engineering Festival Expo on the National Mall in Washington DC on October 23 and 24, 2010 and at other key Festival events.

Find out how to submit a video.

Green Technology Innovation by College Engineering Students

With prizes totaling more than $100,000 in value, this year’s Climate Leadership Challenge is believed to be the most lucrative college or university competition of its kind in the country. The contest was open to all UW-Madison students.

A device that would help provide electricity efficiently and at low cost in rural areas of developing countries took the top prize – $50,000 – this week in a student competition at the University of Wisconsin-Madison for innovative ideas to counteract climate change.

The “microformer” is the brainchild of Jonathan Lee, Dan Ludois, and Patricio Mendoza, all graduate students in electrical engineering. Besides the cash prize, they will receive a promotional trip worth $5,000 and an option for a free one-year lease in the University Research Park’s new Metro Innovation Center on Madison’s east side.

“We really want to see implementation of the best ideas offered,” said Tracey Holloway, director of the Nelson Institute Center for Sustainability and the Global Environment at UW-Madison, which staged the contest for the second year in a row. “The purpose of this competition is to make an impact on climate change.”

The runner-up for the “most action-ready idea” was a proposal to promote the use of oil from Jatropha curcas plants to fuel special cooking stoves in places like Haiti. UW-Madison seniors Eyleen Chou (mechanical engineering), Jason Lohr (electrical engineering), Tyler Lark (biomedical engineering/mathematics) won $10,000 for their scheme to reduce deforestation by lowering demand for wood charcoal as a cooking fuel.

CORE Concept, a technology that would cut emissions from internal combustion engines by using a greater variety of fuels, won mechanical engineering doctoral students Sage Kokjohn, Derek Splitter, and Reed Hanson $15,000 as the “most innovative technical solution.”

SnowShoe, a smart phone application that would enable shoppers to check the carbon footprint of any item in a grocery store by scanning its bar code, won $15,000 as the “most innovative non-technical solution.” Graduate students Claus Moberg (atmospheric and oceanic science), Jami Morton (environment and resources), and Matt Leudtke (civil and environmental engineering) submitted the idea.

Other finalists were REDCASH, a plan to recycle desalination wastewater for carbon sequestration and hydrogen fuel production, by doctoral student Eric Downes (biophysics) and senior Ian Olson (physics/engineering physics); and Switch, an energy management system that integrates feedback and incentives into social gaming to reduce personal energy use, by doctoral students David Zaks (environment and resources) and Elizabeth Bagley (environment and resources/educational psychology).

University of Wisconsin-Stout Wins 2010 Rube Goldberg Contest

University of Wisconsin-Stout wins 2010 Rube Goldberg contest

The team’s machine was called “Valley of the Kings” and had an Egyptian theme, telling a tale of events following the death of King Tut.

The task for the Rube Goldberg machines this year was to dispense sanitizer into a hand. Wisconsin-Stout’s machine dispensed the sanitizer into a mummy’s hand. The Rube Goldberg competition, sponsored by Phi Chapter of Theta Tau fraternity, rewards machines that most effectively combine creativity with inefficiency and complexity.

Machines must use at least 20 steps to complete the task in no more than two minutes. Teams have three tries to complete two runs. Points are deducted if students have to assist the machine once it has started. The Wisconsin-Stout machine has 120 steps. The team completed two perfect runs with no interventions in about a minute and a half each.
…
St. Olaf’ College of Northfield, Minn., last year’s national winner, took second place with a medieval-themed machine. Pennsylvania State University placed third with an “Indiana Jones” theme.

$100,000 Lemelson-MIT Award for Sustainability

[Sadly the video was made private so I removed it. It is disappointing how often people fail to follow decade old usability advice to make internet urls permanent]

According to the United Nations, more than 40 percent of Africans live in poverty, subsisting on less than US$1 a day. As co-founder and CEO of the nonprofit social enterprise KickStart, Fisher develops and markets moneymaking tools such as low-cost, human-powered irrigation pumps that improve the lives of small-scale rural farmers – the majority of the poor in sub-Saharan Africa.

“These poor rural farmers have one asset: a small plot of land; and one basic skill: farming. The best business they can pursue is irrigated farming,” Fisher explained. “Once they employ irrigation, the farmers can grow and sell high-value crops, like fruits and vegetables. They can grow year-round and reap four or five harvests, instead of waiting for the rain to grow a staple crop once or twice a year.”

Presidential Science Teaching and Mentoring Awards

Remarks by President Obama on the “Educate to Innovate” Campaign and Science Teaching and Mentoring Awards, January 6, 2010

To all the teachers who are here, as President, I am just thrilled to welcome you, teachers and mentors, to the White House, because I believe so strongly in the work that you do. And as I mentioned to some of you, because I’ve got two girls upstairs with math tests coming up, I figure that a little extra help from the best of the best couldn’t hurt. So you’re going to have assignments after this. (Laughter.) These awards were not free. (Laughter.)

photo of President Obama with science teachers at the White House

President Barack Obama with Presidential Awards for Excellence in Mathematics and Science Teaching winners in the State Dining of the White House January 6, 2010. (Official White House photo by Chuck Kennedy)

We are here today to honor teachers and mentors like Barb who are upholding their responsibility not just to the young people who they teach but to our country by inspiring and educating a new generation in math and science. But we’re also here because this responsibility can’t be theirs alone. All of us have a role to play in building an education system that is worthy of our children and ready to help us seize the opportunities and meet the challenges of the 21st century.

Whether it’s improving our health or harnessing clean energy, protecting our security or succeeding in the global economy, our future depends on reaffirming America’s role as the world’s engine of scientific discovery and technological innovation. And that leadership tomorrow depends on how we educate our students today, especially in math, science, technology, and engineering.

But despite the importance of education in these subjects, we have to admit we are right now being outpaced by our competitors. One assessment shows American 15-year-olds now ranked 21st in science and 25th in math when compared to their peers around the world. Think about that — 21st and 25th. That’s not acceptable. And year after year the gap between the number of teachers we have and the number of teachers we need in these areas is widening. The shortfall is projected to climb past a quarter of a million teachers in the next five years — and that gap is most pronounced in predominately poor and minority schools.

And meanwhile, other nations are stepping up — a fact that was plain to see when I visited Asia at the end of last year. The President of South Korea and I were having lunch, and I asked him, what’s the biggest education challenge that you have? He told me his biggest challenge in education wasn’t budget holes, it wasn’t crumbling schools — it was that the parents were too demanding. (Laughter.) He’s had to import thousands of foreign teachers because parents insisted on English language training in elementary school. The mayor of Shanghai, China — a city of over 20 million people — told me that even in such a large city, they had no problem recruiting teachers in whatever subject, but particularly math and science, because teaching is revered and the pay scales are comparable to professions like doctors.
Continue reading →

President Obama Speaks on Getting Students Excited About Science and Engineering

The President announces the “Educate to Innovate” initiative, a campaign to get students excited about pursuing careers in science, technology, engineering and mathematics. Quotes from President Obama from his speech – (see webcast above):

“As President, I believe that robotics can inspire young people to pursue science and engineering.”

“Now the hard truth is that for decades we’ve been losing ground. One assessment shows American 15-year-olds now rank 21st in science and 25th in math when compared to their peers around the world.”

“And today, I’m announcing that we’re going to have an annual science fair at the White House with the winners of national competitions in science and technology. If you win the NCAA championship, you come to the White House. Well, if you’re a young person and you’ve produced the best experiment or design, the best hardware or software, you ought to be recognized for that achievement, too. Scientists and engineers ought to stand side by side with athletes and entertainers as role models, and here at the White House we’re going to lead by example. We’re going to show young people how cool science can be.”

“improving education in math and science is about producing engineers and researchers and scientists and innovators who are going to help transform our economy and our lives for the better.”