Tag Archives: human health

Honda U3-X Personal Transport

Honda and Toyota continue to develop personal transport and personal robotics assistance products. While other car companies can barely stay in business Honda and Toyota not only are doing well (even if Toyota will lose money this year) they are investing in the future and pushing strong engineering programs. I must say the personal transportation devices seem less than awesome to me though this video does make the Honda U3-X seem reasonable – better than the Toyota Winglet looked.

Honda unveiled U3-X, a compact experimental device that fits comfortably between the rider’s legs, to provide free movement in all directions – forward, backward, side-to-side, and diagonally. Honda will continue research and development of the device including experiments in a real-world environment to verify the practicality of the device.

This new personal mobility device makes it possible to adjust speed and move, turn and stop in all directions when the rider leans the upper body to shift body weight. This was achieved through application of advanced technologies including Honda’s balance control technology, which was developed through the robotics research of ASIMO, Honda’s bipedal humanoid robot, and the world’s first omni-directional driving wheel system (Honda Omni Traction Drive System, or HOT Drive System), which enables movement in all directions, including not only forward and backward, but also directly to the right and left and diagonally. In addition, this compact size and one-wheel-drive personal mobility device was designed to be friendly to the user and people around it by making it easier for the rider to reach the ground from the footrest and placing the rider on roughly the same eye level as other people or pedestrians.

2009 Nobel Prize in Physiology or Medicine

This year’s Nobel Prize in Physiology or Medicine is awarded to three scientists who have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes – the telomeres – and in an enzyme that forms them – telomerase.

The long, thread-like DNA molecules that carry our genes are packed into chromosomes, the telomeres being the caps on their ends. Elizabeth Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation. Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.

If the telomeres are shortened, cells age. Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed. This is the case in cancer cells, which can be considered to have eternal life. Certain inherited diseases, in contrast, are characterized by a defective telomerase, resulting in damaged cells. The award of the Nobel Prize recognizes the discovery of a fundamental mechanism in the cell, a discovery that has stimulated the development of new therapeutic strategies.

Scientists began to investigate what roles the telomere might play in the cell. Szostak’s group identified yeast cells with mutations that led to a gradual shortening of the telomeres. Such cells grew poorly and eventually stopped dividing. Blackburn and her co-workers made mutations in the RNA of the telomerase and observed similar effects in Tetrahymena. In both cases, this led to premature cellular ageing – senescence. In contrast, functional telomeres instead prevent chromosomal damage and delay cellular senescence. Later on, Greider’s group showed that the senescence of human cells is also delayed by telomerase. Research in this area has been intense and it is now known that the DNA sequence in the telomere attracts proteins that form a protective cap around the fragile ends of the DNA strands.

Many scientists speculated that telomere shortening could be the reason for ageing, not only in the individual cells but also in the organism as a whole. But the ageing process has turned out to be complex and it is now thought to depend on several different factors, the telomere being one of them. Research in this area remains intense.

The 3 awardees are citizens of the USA; two were born elsewhere.
Read more about their research at the Nobel Prize web site.

Molecular biologist Elizabeth Blackburn–one of Time magazine’s 100 “Most Influential People in the World” in 2007–made headlines in 2004 when she was dismissed from the President’s Council on Bioethics after objecting to the council’s call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report.

Webcast of Dr. Elizabeth Blackburn speaking at Google:
Continue reading →

Movie Aims to Inspire College Students With Tales of Successful Minority Scientists

African American women are still rare in many science professions, despite their increasing representation in undergraduate science classes. The documentary – Roots to STEM: Spelman Women in Science—seeks to explore how these women were able to succeed and to hold them up as role models.

Tarsha Ward remembers begging her mother for a stethoscope so she could be the star of career day at her kindergarten class in Charleston, S.C. Her mother presented her with something that proved more prophetic: a white lab coat.

“For me that was the beginning of a career,” said Ward, who is working toward her doctorate in biomedical sciences at Morehouse School of Medicine in Atlanta, Ga., focused on cancer research. “Ever since then everything was about science.”

“If you get into a bind you have to think it out yourself,” she said. “A Ph.D. has really taught me to think on my own. You’re here thinking in the midnight hours and there’s no book to tell you what’s right. You just have to see if it works.”

Such struggles have already paid off. “In seven months, I published my first paper. I worked on it day and night,” said Ward, a 2004 Spelman graduate. “I (loved) the fact that I could find something no one else could find and actually publish it.”

Read the full press release

Smokers with High Blood Pressure and High Cholesterol Lose 10 Years

By examining data from the Whitehall Study researchers have found smokers with high blood pressure and high cholesterol in middle age died 10 years earlier than the others after reaching age 50. This is independent of changes after later in life (quiting smoking, etc.). Life expectancy in relation to cardiovascular risk factors: 38 year follow-up of 19,000 men in the Whitehall study

At entry, 42% of the men were current smokers, 39% had high blood pressure, and 51% had high cholesterol. At the re-examination, about two thirds of the previously “current” smokers had quit smoking shortly after entry and the mean differences in levels of those with high and low levels of blood pressure and cholesterol were attenuated by two thirds. Compared with men without any baseline risk factors, the presence of all three risk factors at entry was associated with a 10 year shorter life expectancy from age 50 (23.7 v 33.3 years). Compared with men in the lowest 5% of a risk score based on smoking, diabetes, employment grade, and continuous levels of blood pressure, cholesterol concentration, and body mass index (BMI), men in the highest 5% had a 15 year shorter life expectancy from age 50 (20.2 v 35.4 years).

Conclusion Despite substantial changes in these risk factors over time, baseline differences in risk factors were associated with 10 to 15 year shorter life expectancy from age 50.

Another conclusion: if you don’t want to live a shorter life, don’t smoke. Not a new idea but given how many people continue to smoke it seems some don’t understand this conclusion.

How to Stay Healthy: Avoiding the Flu

It is no secret that washing your hands is a great strategy to stay healthy. Still few people take care to wash their hands thoroughly frequently during each day. The H1N1 Flu is just the latest sickness that washing your hands protects you from.

The CDC recommends you take these everyday steps to protect your health to protect yourself from the flu:

Wash your hands often with soap and water, especially after you cough or sneeze. Alcohol-based hand cleaners are also effective. Though the scientific evidence is not as extensive as that on hand washing and alcohol-based sanitizers, other hand sanitizers that do not contain alcohol may be useful for killing flu germs on hands.
Avoid touching your eyes, nose or mouth. Germs spread this way.
Try to avoid close contact with sick people.

And to keep others healthy you should

Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it. [others also suggest coughing into you elbow instead of your hands, again to reduce the spread of germs.]
If you are sick with flu-like illness, CDC recommends that you stay home for at least 24 hours after your fever is gone except to get medical care or for other necessities. (Your fever should be gone without the use of a fever-reducing medicine.) Keep away from others as much as possible to keep from making others sick.

The spread of this 2009 H1N1 flu is thought to be happening in the same way that seasonal flu spreads. Flu viruses are spread mainly from person to person through coughing or sneezing of people with influenza. Sometimes people may become infected by touching something with flu viruses on it and then touching their mouth or nose.

The incidence of H1N1flu is likely to be high this flu season based on results in the Southern Hemishpere. Symptoms are those of the flu: fever, cough, sore throat, runny or stuffy nose, body aches, headache, chills and fatigue; can include diarrhea and vomiting.

The CDC includes weekly flu statistics on their web site. Since mid-April to August 30, 2009, a total of 9,079 hospitalizations and 593 deaths associated with 2009 influenza A (H1N1) viruses have been reported to CDC an increase from 8,843 hospitalizations and 556 deaths from the prior week.

Scientific Illiteracy Leaves Many at Risk in Making Health Care Judgements

Scientific literacy is important for many reasons and that importance has increased greatly over the last century. Medical research is often difficult to interpret. Often various studies seem to contradict each other. Often the conclusions that are drawn are far too broad (especially as the research conclusions are passed on and people hear of them overly simplified ways).

Many health care options are not obviously all good, or all bad, but instead a mix of benefits and risks, both of which include interactions with the individuals makeup. So we often see contradictory (and seemingly contradictory) advice. Without a level of scientific literacy it is very difficult for people to know how to react to medical advice.

We have numerous posts on the scientific inquiry process showing that acquiring scientific knowledge is complex and can be quite confusing in many instances. While understanding things are often less clear cut than they are presented it is still true that most often strategies for healthy living have far better practices that will provide far better results than alternatives.

The scientific illiteracy that has some think because their are risks no matter what is done that means there is no evidence some alternatives are far superior is very dangerous. As you can see in action now with those that risk their and others lives and health by doing things like not vaccinating their children, or driving when drunk, or driving when talking on a cell phone.

Without a scientifically literate society even completely obvious measures like not using antibiotics on viral infections are ignored.

4 and 8 Year Old Sisters Impress with Squeak

Young programmers win big

XtremeApps is a competition based in Singapore where competitors program computer applications from scratch.

Armed with just the basics in the Squeak programming language, as well as encouragement – but no help – from mum and dad, the Chan sisters came up with an application called Health Fairies.

It is an interactive, educational story with an anti-smoking message: The main protaganist is a beautiful young girl who loses her youth, and good looks, because she puffs away like there’s no tomorrow.

The sisters took the bulk of the June holidays to complete their entry. They had to come up with the storyline, draw the characters, and write programs that animated the characters, among other things.

Their effort paid off: Health Fairies landed a merit award in the junior category of the contest, beating 68 other contestants, mostly 11 and 12 year olds.

The Calorie Delusion

The calorie delusion: Why food labels are wrong

Nutritionists are well aware that our bodies don’t incinerate food, they digest it. And digestion – from chewing food to moving it through the gut and chemically breaking it down along the way – takes a different amount of energy for different foods. According to Geoffrey Livesey, an independent nutritionist based in Norfolk, UK, this can lower the number of calories your body extracts from a meal by anywhere between 5 and 25 per cent depending on the food eaten.
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Dietary fibre is one example. As well as being more resistant to mechanical and chemical digestion than other forms of carbohydrate, dietary fibre provides energy for gut microbes, and they take their cut before we get our share. Livesey has calculated that all these factors reduce the energy derived from dietary fibre by 25 per cent
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“Cooking gives food energy,” says Wrangham. It alters the structure of the food at the molecular level, making it easier for our body to break it up and extract the nutrients.

In plants, for example, much of the energy from starch is stored as amylopectin, which is semi-crystalline, does not dissolve in water, and cannot be easily digested. Heat starchy foods with water, though, and the crystalline forms begin to melt. The starch granules absorb water, swell, and eventually burst. The amylopectin is shattered into short starch molecules called amylose, which are easily digested by the enzyme amylase.

It seems pretty obvious, just looking around, as you walk around in any city that people are much fatter, on average, than we were 20 years ago. And the data shows people were much larger (taller, but also fatter) 20 years ago than they were 100 years ago. And we know obesity causes many human health issues. The failure to address the obesity problem in the USA is another example of the failed “health care” system. Instead of a working health care system we just manage diseases that result for unhealthy living. We should be do better at providing information to people on healthy eating (including more accurate calorie counts as it concerns food we eat) and healthy lifestyle choices.

Toyota Develops Thought-controlled Wheelchair

Toyota has developed a thought-controlled wheelchair (along with Japanese government research institute, RIKEN, and Genesis Research Institute). Honda has also developed a system that allows a person to control a robot through thoughts. Both companies continue to invest in innovation and science and engineering. The story of a bad economy and bad sales for a year or two is what you read in most newspapers. The story of why Toyota and Honda will be dominant companies 20 years from now is their superior management and focus on long term success instead of short term quarterly results.

The BSI-Toyota Collaboration Center, has succeeded in developing a system which utilizes one of the fastest technologies in the world, controlling a wheelchair using brain waves in as little as 125 milliseconds (one millisecond, or ms, is equal to 1/1000 seconds.

Plans are underway to utilize this technology in a wide range of applications centered on medicine and nursing care management. R&D under consideration includes increasing the number of commands given and developing more efficient dry electrodes. So far the research has centered on brain waves related to imaginary hand and foot control. However, through further measurement and analysis it is anticipated that this system may be applied to other types of brain waves generated by various mental states and emotions.

Teen diagnoses her own disease in science class

Her doctors, no matter how hard they tried, couldn’t figure out the cause of Jessica’s abdominal distress. Then one day in January, Terry, 18, figured it out on her own.

In her Advanced Placement high school science class, she was looking under the microscope at slides of her own intestinal tissue — slides her pathologist had said were completely normal — and spotted an area of inflamed tissue called a granuloma, a clear indication that she had Crohn’s disease.

“It’s weird I had to solve my own medical problem,” Terry told CNN affiliate KOMO in Seattle, Washington. “There were just no answers anywhere. … I was always sick.”
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Crohn’s disease is often misdiagnosed or diagnosed very late, says Dr. Corey Siegel, director of the Inflammatory Bowel Disease Center at Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire. “Granulomas are oftentimes very hard to find and not always even present at all,” Siegel said. “I commend Jessica for her meticulous work.”