Tag Archives: innovation

Printing Bone, Muscle and More

A Pittsburgh-based research team has created and used an innovative ink-jet system to print “bio-ink” patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells.

The custom-built ink-jet printer, developed at Carnegie Mellon’s Robotics Institute, can deposit and immobilize growth factors in virtually any design, pattern or concentration, laying down patterns on native extracellular matrix-coated slides (such as fibrin). These slides are then placed in culture dishes and topped with muscle-derived stem cells (MDSCs). Based on pattern, dose or factor printed by the ink-jet, the MDSCs can be directed to differentiate down various cell-fate differentiation pathways (e.g. bone- or muscle-like).

“This system provides an unprecedented means to engineer replacement tissues derived from muscle stem cells,” said Johnny Huard, professor of orthopedic surgery at the University of Pittsburgh School of Medicine and director of the Stem Cell Research Center at Children’s Hospital of UPMC. Huard has long-standing research findings that show how muscle-derived stem cells (MDSCs) from mice can repair muscle in a model for Duchenne Muscular Dystrophy, improve cardiac function following heart failure, and heal large bone and articular cartilage defects.

Weiss and Campbell, along with graduate student Eric Miller, previously demonstrated the use of ink-jet printing to pattern growth factor “bio-inks” to control cell fates. For their current research, they teamed with Phillippi, Huard and biologists of the Stem Cell Research Center at Children’s Hospital to gain experience in using growth factors to control differentiation in populations of MDSCs from mice.

The team envisions the ink-jet technology as potentially useful for engineering stem cell-based therapies for repairing defects where multiple tissues are involved, such as joints where bone, tendon, cartilage and muscle interface. Patients afflicted with conditions like osteoarthritis might benefit from these therapies, which incorporate the needs of multiple tissues and may improve post-treatment clinical outcomes.

The long-term promise of this new technology could be the tailoring of tissue-engineered regenerative therapies. In preparation for preclinical studies, the Pittsburgh researchers are combining the versatile ink-jet system with advanced real-time live cell image analysis developed at the Robotics Institute and Molecular Biosensor and Imaging Center to further understand how stem cells differentiate into bone, muscle and other cell types.

Engineering a Better Football

The football (soccer ball) for the 2010 FIFA World Cup features completely new, ground-breaking technology. Eight 3-D spherically formed panels are moulded together, harmoniously enveloping the inner carcass. The result is an energetic unit combined with perfect roundness.

Aero grooves create the clearly visible profile on the ball’s surface. The Grip’n’Groove profile circles around the entire ball in an optimal aerodynamic way. The integrated grooves provide unmatched flight characteristics, making this the most stable and most accurate Adidas football. The ground breaking performance features have been confirmed in comprehensive comparison tests at Loughborough University in England and countless checks in wind tunnel and the Adidas football laboratory in Scheinfeld, Germany.

The process, shown in the video, for manufacturing the footballs is way more complicate than I thought it would be.

Bionic Vision

Micro Machines and Opto-Electronics on a Contact Lense

Fiction now meets reality with prototype contact lenses developed by Babak Parviz at the University of Washington, in Seattle. Dr. Parviz’s prototype lenses can be used as biosensors to display body chemistry or as a heads up display (HUD). Powered by radio waves and 330 microwatts of power from a loop antenna that picks up power beamed from nearby radio sources, future versions will also be able to harvest power from a cell phone.

In his early 2008 lab tests, rabbits safely wore contact lenses with metal connectors for electronic circuits. The prototype lenses contained an electric circuit as well as red light-emitting diodes for a display. The lenses were tested on rabbits for up to 20 minutes and the animals showed no adverse effects.
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Contact lenses as replacements for smart phone displays — even to monitor blood glucose levels — might best be done while not operating heavy equipment. “The true promise of this research is not just the actual system we end up making, whether it’s a display, a biosensor, or both,” comments Dr. Parviz. “We already see a future in which the humble contact lens becomes a real platform, like the iPhone is today, with lots of developers contributing their ideas and inventions. As far as we’re concerned, the possibilities extend as far as the eye can see, and beyond.”

Teenage Engineer’s Company Launches Safety Stair

Young engineer launches stair aid by Geoff Adams-Spink

A young woman from Sheffield has turned a GCSE coursework project into an award-winning stair-climbing device for older and disabled people. Ruth Amos has launched her StairSteady handrail at Naidex 2008 – the annual disability exhibition in Birmingham.

She told BBC News that she was inspired to create the device for the father of one of her teachers who had had a stroke. She won an award for her idea and has now set up a company to sell it. The StairSteady is a horizontal rail at 90 degrees to the wall or banister that people can hold on to as they go up or down stairs.
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The invention was then entered for the Young Engineer for Britain competition and won first prize.

Great stuff. Innovation doesn’t have to be amazing technology. Finding solutions that make people’s lives better is the key. And then showing some entrepreneurship is great, Ruth setup her company when she was 16. I wish her luck.

Engineering: Cellphone Microscope

UCLA Professor Aydogan Ozcan‘s invention (LUCAS) enables rapid counting and imaging of cells without using any lenses even within a working cell phone device. He placed cells directly on the imaging sensor of a cell phone. The imaging sensor captures a holographic image of the cells containing more information than a conventional microscope. The CelloPhone received a Wireless Innovations Award from Vodafone

a wireless health monitoring technology that runs on a regular cell-phone would significantly impact the global fight against infectious diseases in resource poor settings such as in Africa, parts of India, South-East Asia and South America.

The CelloPhone Project aims to develop a transformative solution to these global challenges by providing a revolutionary optical imaging platform that will be used to specifically analyze bodily fluids within a regular cell phone. Through wide-spread use of this innovative technology, the health care services in the developing countries will significantly be improved making a real impact in the life quality and life expectancy of millions.
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For most bio-medical imaging applications, directly seeing the structure of the object is of paramount importance. This conventional way of thinking has been the driving motivation for the last few decades to build better microscopes with more powerful lenses or other advanced imaging apparatus. However, for imaging and monitoring of discrete particles such as cells or bacteria, there is a much better way of imaging that relies on detection of their shadow signatures. Technically, the shadow of a micro-object can be thought as a hologram that is based on interference of diffracted beams interacting with each cell. Quite contrary to the dark shadows that we are used to seeing in the macro-world (such as our own shadow on the wall), micro-scale shadows (or transmission holograms) contain an extremely rich source of quantified information regarding the spatial features of the micro-object of interest.

By making use of this new way of thinking, unlike conventional lens based imaging approaches, LUCAS does not utilize any lenses, microscope-objectives or other bulk optical components, and it can immediately monitor an ultra-large field of view by detecting the holographic shadow of cells or bacteria of interest on a chip. The holographic diffraction pattern of each cell, when imaged under special conditions, is extremely rich in terms of spatial information related to the state of the cell or bacteria. Through advanced signal processing tools that are running at a central computer station, the unique texture of these cell/bacteria holograms will enable highly specific and accurate medical diagnostics to be performed even in resource poor settings by utilizing the existing wireless networks.

This is another great example of engineers creating technologically appropriate solutions.

Researching Direct Brain Interfaces for Text Entry

Adam Wilson posted a status update on the social networking Web site Twitter — just by thinking about it. A UW-Madison biomedical engineering doctoral student, Wilson is among a growing group of researchers worldwide who aim to perfect a communication system for users whose bodies do not work, but whose brains function normally. Among those are people who have amyotrophic lateral sclerosis (ALS), brain-stem stroke or high spinal cord injury.

The interface consists, essentially, of a keyboard displayed on a computer screen. “The way this works is that all the letters come up, and each one of them flashes individually,” says Williams. “And what your brain does is, if you’re looking at the ‘R’ on the screen and all the other letters are flashing, nothing happens. But when the ‘R’ flashes, your brain says, ‘Hey, wait a minute. Something’s different about what I was just paying attention to.’ And you see a momentary change in brain activity.”

The system still is not very quick. However, as with texting, users improve as they practice using the interface. “I’ve seen people do up to eight characters per minute,” says Wilson.

Read full press release

Honda U3-X Personal Transport

Honda and Toyota continue to develop personal transport and personal robotics assistance products. While other car companies can barely stay in business Honda and Toyota not only are doing well (even if Toyota will lose money this year) they are investing in the future and pushing strong engineering programs. I must say the personal transportation devices seem less than awesome to me though this video does make the Honda U3-X seem reasonable – better than the Toyota Winglet looked.

Honda unveiled U3-X, a compact experimental device that fits comfortably between the rider’s legs, to provide free movement in all directions – forward, backward, side-to-side, and diagonally. Honda will continue research and development of the device including experiments in a real-world environment to verify the practicality of the device.

This new personal mobility device makes it possible to adjust speed and move, turn and stop in all directions when the rider leans the upper body to shift body weight. This was achieved through application of advanced technologies including Honda’s balance control technology, which was developed through the robotics research of ASIMO, Honda’s bipedal humanoid robot, and the world’s first omni-directional driving wheel system (Honda Omni Traction Drive System, or HOT Drive System), which enables movement in all directions, including not only forward and backward, but also directly to the right and left and diagonally. In addition, this compact size and one-wheel-drive personal mobility device was designed to be friendly to the user and people around it by making it easier for the rider to reach the ground from the footrest and placing the rider on roughly the same eye level as other people or pedestrians.

Volkswagen Fun Theory: Piano Staircase

Volkswagen built this piano stairway in Stockholm, Sweden as part of their fun theory project, which aims to change people’s behavior for the better through fun. That is a great strategy.

Engineer Tried to Save His Sister and Invented a Breakthrough Medical Device

Here is another remarkable example of the great benefit engineers provide society.

How a software engineer tried to save his sister and invented a breakthrough medical device

I wanted to help my sister as much as I could. I went to Medline, where there are hundreds of thousands of documents describing clinical studies, to see what I could find.

There are billions of dollars spent every year on clinical studies. I was surprised to discover that there were sometimes clinical studies of treatments for which there were no clinical applications. The trials would show successful results but no clinical applications.

I found a 1987 Italian funded set of clinical studies that showed successful treatment of tumors by the application of chemotherapy directly into the tumors. But I could find nothing since then.
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It took us two years to do the engineering. And it has taken the FDA seven years and two months to approve the product for sale. We were able to shorten the FDA process a little by saying that it was similar to other devices that had already been approved.

Great stuff.

Atomic Force Microscopy Image of a Molecule

The delicate inner structure of a pentacene molecule imaged with an atomic force microscope. For the first time, scientists achieved a resolution that revealed the chemical structure of a molecule. The hexagonal shapes of the five carbon rings in the pentacene molecule are clearly resolved. Even the positions of the hydrogen atoms around the carbon rings can be deduced from the image. (Pixels correspond to actual data points). Image courtesy of IBM Research – Zurich

IBM scientists have been able to image the “anatomy” — or chemical structure — inside a molecule with unprecedented resolution. “Though not an exact comparison, if you think about how a doctor uses an x-ray to image bones and organs inside the human body, we are using the atomic force microscope to image the atomic structures that are the backbones of individual molecules,” said IBM Researcher Gerhard Meyer. “Scanning probe techniques offer amazing potential for prototyping complex functional structures and for tailoring and studying their electronic and chemical properties on the atomic scale.”

The AFM uses a sharp metal tip to measure the tiny forces between the tip and the sample, such as a molecule, to create an image. In the present experiments, the molecule investigated was pentacene. Pentacene is an oblong organic molecule consisting of 22 carbon atoms and 14 hydrogen atoms measuring 1.4 nanometers in length. The spacing between neighboring carbon atoms is only 0.14 nanometers—roughly 1 million times smaller then the diameter of a grain of sand. In the experimental image, the hexagonal shapes of the five carbon rings as well as the carbon atoms in the molecule are clearly resolved. Even the positions of the hydrogen atoms of the molecule can be deduced from the image.

Read full press release: IBM Scientists First to Image the “Anatomy” of a Molecule
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