Tag Archives: Madison

Nobel Laureate Initiates Symposia for Student Scientists

The video shows a portion of Oliver Smithies’ Nobel acceptance lecture. See the rest of the speech, and more info, on the Nobel Prize site.

As an undergraduate student at Oxford University in the 1940s, Oliver Smithies attended a series of lectures by Linus Pauling, one of the most influential chemists of the 20th century. It was a powerful experience, one that sparked the young scientist’s ambitions and helped launch his own eminent career.

“It was tremendously inspiring,” says Smithies, one of three scientists who shared the Nobel Prize in Medicine in 2007. “People were sitting in the aisles to listen to him.”

Now Smithies, who was a genetics professor at the University of Wisconsin-Madison from 1960-88, is taking it upon himself to expose a new generation of undergraduates to this sort of experience. Using the prize money that came with his Nobel Prize, Smithies is funding symposia at all four universities he has been affiliated with throughout his scientific career: Oxford, the University of Toronto, UW-Madison and the University of North Carolina, where he is currently the Excellence Professor of Pathology and Laboratory Medicine. Each university will receive about $130,000 to get things started.

“He wants the symposium to be a day when we bring the very best in biology to campus to interact with the students,” says geneticist Fred Blattner, who is in charge of organizing the symposium at UW-Madison and who collaborated with Smithies when their careers paths overlapped in Wisconsin.

The first of two speakers at the UW-Madison’s inaugural Oliver Smithies Symposium will be Leroy Hood, director of the Institute for Systems Biology, located in Seattle. Hood is a pioneer of high-throughput technologies and was instrumental in developing the technology used to sequence the human genome. More recently, Hood has focused his efforts on systems biology, the field of science in which researchers create computer models to describe complex biological processes, such as the development of cancer in the body. He is also at the forefront of efforts to use computer models to help doctors tailor drugs and dosages to an individual’s genetic makeup.
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Playing Dice and Children’s Numeracy

My father, Willaim Hunter, a professor of statistics and of Chemical Engineering at the University of Wisconsin, was a guest speaker for my second grade class (I think it was 2nd) to teach us about numbers – using dice. He gave every kid a die. I remember he asked all the kids what number do you think will show up when you roll the die. 6 was the answer from about 80% of them (which I knew was wrong – so I was feeling very smart).

Then he had the kids roll the die and he stood up at the front to create a frequency distribution of what was actually rolled. He was all ready for them to see how wrong they were and learn it was just as likely for any of the numbers on the die to be rolled. But as he asked each kid about what they rolled something like 5 out of the first 6 said they rolled a 6. He then modified the exercise a bit and had the kid come up to the front and roll the die on the teachers desk. Then my Dad read the number off the die and wrote on the chart 🙂

This nice blog post, reminded me of that story: Kids’ misconceptions about numbers — and how they fix them

in the real study, conducted by John Opfer and Rober Siegler, the kids used lines with just 0 and 1000 labeled. They were then given numbers within that range and asked to draw a vertical line through the number line where each number fell (they used a new, blank number line each time). The figure above represents (in red) the average results for a few of the numbers used in the study. As you can see, the second graders are way off, especially for lower numbers. They typically placed the number 150 almost halfway across the number line! Fourth graders perform nearly as well as adults on the task, putting all the numbers in just about the right spot.

But there’s a pattern to the second-graders’ responses. Nearly all the kids (93 were tested) understood that 750 was a larger number than 366; they just squeezed too many large numbers on the far-right side of the number line. In fact, their results show more of a logarithmic pattern than the proper linear pattern.

Disrupting the Replication of Bacteria

UW-Madison researchers develop novel method to find new antibiotics:

Filutowicz’s approach involves looking for new drugs that render bacteria harmless by blocking the replication of—and thus eliminating—some of their DNA.

Bacterial DNA comes in two forms: chromosomal DNA, which is required for life, and plasmid DNA, which is not. The nonessential plasmid DNA contains many undesirable bacterial genes, including those that confer antibiotic resistance or lead to the production of toxins.

Filutowicz is seeking antibiotics that would selectively disrupt the replication of plasmid DNA, so that when bacteria reproduce, they would produce plasmid-free offspring that are harmless or susceptible to traditional antibiotics. Such compounds could dramatically alter the character of some of our nastiest microbial adversaries.

Top degree for S&P 500 CEOs? Engineering

See more recent post with data from 2005-2009: S&P 500 CEO’s: Engineers Stay at the Top

The most common undergraduate degree for CEO’s of Fortune 500 companies is Engineering: with 20% of all CEOs (from 2005 CEO Study: A Statistical Snapshot of Leading CEOs

Another interesting point from the report (at least to those of us who grew up in Madison with a father who taught at the University of Wisconsin (teaching Chemical Engineering, Industrial Engineering and Statistics, in my father’s case, by the way):

For the second year in a row, the University of Wisconsin joins Harvard as the most common undergraduate university attended by S&P 500 CEOs. Prior to 2004, Harvard alone was the most common school attended.

Concentrating Solar Collector wins UW-Madison Engineering Innovation Award

Solar Collector

An inexpensive, modular solar-energy technology that could be used to heat water and generate electricity (see photo) won $12,500 and took first place in both the Schoofs Prize for Creativity and Tong Prototype Prize competitions, held Feb. 9 and 10 during Innovation Days on the UW-Madison College of Engineering campus.

In a package about the size of a small computer desk, the winning system uses a flat Fresnel lens to collect the sun’s energy and focus it onto a copper block. Then a unique spray system removes the energy from the copper block and converts it into steam, says inventor Angie Franzke, an engineering mechanics and astronautics senior from Omro, Wisconsin. The steam either heats water for household use or powers a turbine to generate electricity.

Other 2006 Schoofs Prize for Creativity winners include:

* Second place and $7,000 — William Gregory Knowles, for the OmniPresent Community-Based Response Network, a personal, business or industrial security system that draws on networked users and devices to more efficiently verify burglar alarms, fire alarms or medical emergencies.
* Third place and $4,000 — Garret Fitzpatrick, Jon Oiler, Angie Franzke, Peter Kohlhepp and Greg Hoell for the Self-Leveling Wheelchair Tray, a stowable working surface for wheelchairs that self-levels, even when the wheelchair is tilted or reclined up to a 45-degree angle.

Symbiotic relationship between ants and bacteria

Study reveals classic symbiotic relationship between ants, bacteria

Ants that tend and harvest gardens of fungus have a secret weapon against the parasites that invade their crops: antibiotic-producing bacteria that the insects harbor on their bodies.

“Every ant species [that we have examined] has different, highly modified structures to support different types of bacteria,” says Currie. “This indicates the ants have rapidly adapted to maintain the bacteria. It also indicates that the co-evolution between the bacteria and the ants, as well as the fungus and parasites, has been occurring since very early on, apparently for tens of millions of years.”

Furthermore, Currie says, the fact that the species have coexisted for so long means there might be a mechanism in place to decrease the rate of antibiotic resistance – which could help address a significant problem facing modern medicine. “We can learn a lot about our own use of antibiotics from this system,” he says.

Read more about the overuse of antibiotics