Tag Archives: medical research

Howard Hughes Medical Institute Takes Big Open Access Step

HHMI Announces New Policy for Publication of Research Articles that will require

its scientists to publish their original research articles in scientific journals that allow the articles and supplementary materials to be made freely accessible in a public repository within six months of publication.

Great news. Some, including me, would prefer a shorter time but this is the limit on the slowest time that will be acceptable not a goal. I don’t know but I wouldn’t be surprised if HHMI is the largest source of research funds outside of the federal government in the USA. This is one more sign the tactics of the old school journals are failing.

HHMI and Public Access Publishing policy

The Howard Hughes Medical Institute has long viewed the sharing of research materials and tools as a fundamental responsibility of scientific authorship. That principle also extends to ensuring that original, peer-reviewed research publications and supplemental materials are freely accessible within six months of publication

Well put; it is amazing how out of touch with the basic concepts of advancing scientific ideas the old style journals are.

How The Brain Rewires Itself

How The Brain Rewires Itself:

The finding was in line with a growing number of discoveries at the time showing that greater use of a particular muscle causes the brain to devote more cortical real estate to it. But Pascual-Leone did not stop there. He extended the experiment by having another group of volunteers merely think about practicing the piano exercise. They played the simple piece of music in their head, holding their hands still while imagining how they would move their fingers. Then they too sat beneath the TMS coil.

When the scientists compared the TMS data on the two groups–those who actually tickled the ivories and those who only imagined doing so–they glimpsed a revolutionary idea about the brain: the ability of mere thought to alter the physical structure and function of our gray matter.

Self-Assembling Cubes Could Deliver Medicine

Nanocubes photos

Tiny Self-Assembling Cubes Could Carry Medicine, Cell Therapy – News Release from Johns Hopkins (pdf format)

Details of photos: “Scanning electron microscopy images of image of (A) a hollow, open surfaced, biocontainer, and (B) a device loaded with glass microbeads. (C) Fluorescence microscopy images of a biocontainer loaded with cell-ECM-agarose with the cell viability stain, Calcein-AM. (D) Release of viable cells from the biocontainer.”

Johns Hopkins researchers have devised a self- assembling cube-shaped perforated container, no larger than a dust speck, that could serve as a delivery system for medications and cell therapy.

When the process is completed, they form a perforated cube. When the solution is cooled, the solder hardens again, and the containers remain in their box-like shape.

“To make sure it folds itself exactly into a cube, we have to engineer the hinges very precisely,” Gracias said. “The self-assembly technique allows us to make a large number of these microcontainers at the same time and at a relatively low cost.”

Gracias and his colleagues used micropipettes to insert into the cubes a suspension containing microbeads that are commonly used in cell therapy. The lab team showed that these beads could be released from the cubes through agitation. The researchers also inserted human cells, similar to the type used in medical therapy, into the cubes. A positive stain test showed that these cells remained alive in the microcontainers and could easily be released.

And they are “always on the lookout for exceptional and highly creative undergraduate, graduate students and post-doctoral candidates” – maybe you.