Tag Archives: MIT

$400 Million More for Harvard and MIT

$400 million endowment for the Broad Institute of Harvard and MIT

“Today the Broad Institute is the world’s leading genomics and biomedical institute, and we’re now making a $600 million bet that the Broad will be the place where the greatest scientific discoveries take place,” Eli Broad said at today’s ceremony.
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In its short history, the Broad Institute’s accomplishments include cataloging and identifying genetic risk factors for diseases such as type 2 diabetes and autism; discovering new therapeutic targets for cancer, malaria, and other diseases; and applying genomic tools to better understand and treat human pathogens like tuberculosis.
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The Broads’ gift is the largest to support biomedical research at a university anywhere in the world. The Broads initially invested $100 million in 2003 as a way to test the institute’s new approach to biomedical research. By 2005, the Broad Institute had already made significant accomplishments and progress, and the Broads invested a second $100 million. Their endowment of $400 million today will allow the Broad Institute to transition to a permanent, non-profit 501(c)(3) organization with both Harvard and MIT still at the heart of it, continuing to help govern the institute.

Many countries would love to create a world class center of biomedical research. And several are trying. Boston sure seems to be staking a claim that it will be one of those centers of excellence. The economic benefits of that to Boston will be huge.

MIT International Science and Technology Initiatives

MIT is providing seed funding to faculty to encourage global research. The seed funds cover a variety of expenses, including exploratory field research, workshop materials and instrument costs. Each proposal is eligible for up to $20,000 in funding. Research and collaboration can take place anywhere in the world on any topic. For all projects, up to $10,000 in additional funding is available for undergraduate and graduate student participation.

MISTI country programs also offer five country-specific seed funds for collaborative research involving France, India, Italy, Japan or Spain.

This is a good use of their huge endowment. So is the Open Courseware initiative. As is their elimination of tuition for those with families earning less than $75,000. Good for MIT.

Do Dolphins Sleep?

Do dolphins sleep?, MIT:

Dolphins do sleep, but not quite in the same way that people do. They sleep with one half of the brain at a time and with one eye closed. Dolphins rest this way on and off throughout the day, switching which side of the brain they shut down. During these periods, everything inside the dolphin slows down, and the mammal moves very little.

Saving Lives with Smarter Hurricane Evacuations

A sign indicating a hurricane evacuation route near Boca Raton, Florida. Photo / Wikimedia Commons

Software developed by a MIT student is aiding emergency officials as they decide on evacuation plans:
Saving lives through smarter hurricane evacuations

Michael Metzger’s software tool, created as part of the research for his PhD dissertation, could allow emergency managers to better decide early on whether and when to order evacuations — and, crucially, to do so more efficiently by clearing out people in stages. The tool could also help planners optimize the location of relief supplies before a hurricane hits.
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“All in all, this is a complex balancing act,” Metzger says.

The concept of evacuating an area in stages — focusing on different categories of people rather than different geographical locations — is one of the major innovations to come out of Metzger’s work, since congestion on evacuation routes has been a significant problem in some cases, such as hurricanes Katrina and Rita. Metzger suggests that, for example, the elderly might be evacuated first, followed by tourists, families with children, and then the remaining population. The determination of the specific categories and their sequence could be determined based on the demographics of the particular area.

By spacing out the evacuation of different groups over a period of about two days, he says, the process would be more efficient, while many traditional systems of evacuating a given location all at once can and have caused serious congestion problems.
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Other factors that could help to make evacuations more effective, he says, include better planning in the preparation of places for evacuees to go to, making sure buses and other transportation are ready to transport people, and preparing supplies in advance at those locations.

Wireless Power

An end to spaghetti power cables by Maggie Shiels, BBC News

Mr Rattner envisaged a scenario where a laptop’s battery could be recharged when the machine gets within several feet of a transmit resonator which could be embedded in tables, work surfaces, picture frames and even behind walls.

Intel’s technology relies on an idea called magnetic induction. It is a principle similar to the way a trained singer can shatter a glass using their voice; the glass absorbs acoustic energy at its natural frequency. At the wall socket, power is put into magnetic fields at a transmitting resonator – basically an antenna. The receiving resonator is tuned to efficiently absorb energy from the magnetic field, whereas nearby objects do not.

Intel’s demonstration has built on work done originally by Marin Soljacic, a physicist at Massachusetts Institute of Technology (MIT). At the Intel Developer Forum in San Francisco, researcher Alanson Sample showed how to make a 60-watt light bulb glow from an energy source three feet away. This was achieved with relatively high efficiency, only losing a quarter of the energy it started with.

Don’t expect to see this available commercially this year, they estimate it is at least 5 years away. Though this is not university and business collaboration in the sense they are working together, it is in the sense that Intel is building upon the work MIT did. See other posts on university and business collaboration.

Life in a bubble

Hundreds of insect species spend much of their time underwater, where food may be more plentiful. MIT mathematicians have now figured out exactly how those insects breathe underwater.

By virtue of their rough, water-repellent coat, when submerged these insects trap a thin layer of air on their bodies. These bubbles not only serve as a finite oxygen store, but also allow the insects to absorb oxygen from the surrounding water.

“Some insects have adapted to life underwater by using this bubble as an external lung,” said John Bush, associate professor of applied mathematics, a co-author of the recent study.

Thanks to those air bubbles, insects can stay below the surface indefinitely and dive as deep as about 30 meters, according to the study co-authored by Bush and Morris Flynn, former applied mathematics instructor. Some species, such as Neoplea striola, which are native to New England, hibernate underwater all winter long.

Pseudogap and Superconductivity

MIT physicists shed light on key superconductivity riddle

Hudson’s team is focusing on the state of matter that exists at temperatures just above the temperature at which materials start to superconduct. This state, known as the pseudogap, is poorly understood, but physicists have long believed that characterizing the pseudogap is important to understanding superconductivity.

In their latest work, published online on July 6 in Nature Physics, they suggest that the pseudogap is not a precursor to superconductivity, as has been theorized, but a competing state. If that is true, it could completely change the way physicists look at superconductivity, said Hudson.

“Now, if you want to explain high-temperature superconductivity and you believe the pseudogap is a precursor, you need to explain both. If it turns out that it is a competing state, you can instead focus more on superconductivity,” he said.

Fixing the World on $2 a Day

MIT’s Guru of Low-Tech Engineering Fixes the World on $2 a Day

The charcoal project is the responsibility of Mary Hong, a 19-year-old branching out beyond her aerospace major this semester. She and the other students, coincidentally all women, are enrolled in Smith’s D-Lab, a course that is becoming quietly famous beyond the MIT campus in Cambridge, Mass. The D is for development, design and dissemination; last fall, more than 100 students applied for about 30 slots. To prepare for their field work, D-Lab students live for a week in Cambridge on $2 per day. (Smith joins in.) Right now, eight more D-Lab teams are plying jungle rivers, hiking goat trails and hailing chicken buses in seven additional countries—Brazil, Honduras, Ghana, Tanzania, Zambia, India and China. In Smith’s view, even harsh aspects of Third World travel have their benefits. “If you get a good bout of diarrhea from a waterborne disease,” she says, “you really understand what it means to have access to clean drinking water.”
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Despite their simplicity, Smith’s creations made her a minor celebrity at MIT, and in 2000 she became the first woman to win the $30,000 Lemelson-MIT Student Prize. The same year, she began teaching full time at the university. It was nearly 30 years since German economist E.F. Schumacher had published Small is Beautiful: Economics as if People Mattered, the book credited with launching the appropriate technology movement. Schumacher argued that many of the infrastructure projects funded by the World Bank and other organizations hadn’t improved lives on the village level. “He rightly and aptly pointed out that big solutions don’t fit for villages. You have to make it small,”

Measuring Protein Bond Strength with Optical Tweezers

Using a light touch to measure protein bonds

MIT researchers have developed a novel technique to measure the strength of the bonds between two protein molecules important in cell machinery: Gently tugging them apart with light beams. “It’s really giving us a molecular-level picture of what’s going on,” said Matthew Lang, an assistant professor of biological and mechanical engineering
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The researchers studied the interactions between the proteins by pinning one actin filament to a surface and controlling the motion of the second one with a beam of light. As the researchers tug on a bead attached to the second filament, the bond mediated by the actin-binding protein eventually breaks.

With this technique, the researchers can get a precise measurement of the force holding the proteins together, which is on the order of piconewtons (10^-12 newtons).

Exploring the Signaling Pathways of Cells

New probe may help untangle cells’ signaling pathways

MIT researchers have designed a new type of probe that can image thousands of interactions between proteins inside a living cell, giving them a tool to untangle the web of signaling pathways that control most of a cell’s activities.

“We can use this to identify new protein partners or to characterize existing interactions. We can identify what signaling pathway the proteins are involved in and during which phase of the cell cycle the interaction occurs,” said Alice Ting, the Pfizer-Laubach Career Development Assistant Professor of Chemistry and senior author of a paper describing the probe published online June 27 by the Journal of the American Chemical Society.

The new technique allows researchers to tag proteins with probes that link together like puzzle pieces if the proteins interact inside a cell. The probes are derived from an enzyme and its peptide substrate. If the probe-linked proteins interact, the enzyme and substrate also interact, which can be easily detected.

To create the probes, the researchers used the enzyme biotin ligase and its target, a 12-amino-acid peptide.