Tag Archives: MIT

2008 Lemelson-MIT Prize for Invention

photo of Joseph Desimone

The Lemelson-MIT Prize awards $500,000 to mid-career inventors dedicated to improving our world through technological invention and innovation. Joseph M. DeSimone received the 2008 award.

His exposure to polymer science led him to pursue a Ph.D. in chemistry from Virginia Polytechnic Institute and State University in Blacksburg, Va. At the age of 25, DeSimone joined the University of North Carolina at Chapel Hill (UNC) as an assistant professor in chemistry and launched the university’s polymer program with his mentor Dr. Edward Samulski. He resides there today as the Chancellor’s Eminent Professor of Chemistry at UNC, in addition to serving as the William R. Kenan, Jr. Distinguished Professor of Chemical Engineering at North Carolina State University.

Among DeSimone’s notable inventions is an environmentally friendly manufacturing process that relies on supercritical carbon dioxide instead of water and bio-persistent surfactants (detergents) for the creation of fluoropolymers or high-performance plastics, such as TeflonÂ®. More recently, he worked on a team to design a polymer-based, fully bioabsorbable, drug-eluting stent, which helps keep a blocked blood vessel open after a balloon-angioplasty and is absorbed by the body within 18 months.

DeSimone’s newest invention is PRINTÂ® (Particle Replication in Non-wetting Templates) technology, used to manufacture nanocarriers in medicine. At present, DeSimone’s Lab is vested in a variety of projects that also extend beyond medicine, including potential applications for more efficient solar cells and morphable robots. In 2004, DeSimone co-founded Liquidia Technologies with a team of researchers from UNC to make the technology available in the market. Liquidia is using the PRINT technology to develop precisely engineered nanocarriers for highly targeted delivery of biological and small molecule therapeutics to treat cancer and other diseases. DeSimone’s proposed applications for cancer treatment with the PRINT platform was instrumental in UNC landing a grant of $24 million from the National Cancer Institute to establish the Carolina Center for Cancer Nanotechnology Excellence.

“You can do all the innovating you want in the laboratory, but if you can’t get it out of the university walls you do no one any good,” said DeSimone. He instills an entrepreneurial spirit in his students that focuses on the importance of commercializing technology and scientific inventions. One of DeSimone’s greatest accomplishments is his mentorship of more than 45 postdoctoral research associates, 52 Ph.D. candidates, six M.S. theses and 21 undergraduate researchers. Furthermore, he speaks to groups of high school students about the inventive process and encourages them to learn and explore areas that are less familiar to them to broaden their exposure to other disciplines.

A prolific inventor, DeSimone holds more than 115 issued patents with more than 70 new patent applications pending, and he has published more than 240 peer-reviewed scientific articles.

Cost Efficient Solar Dish by Students

Solar Energy Dish

Low-cost system could revolutionize global energy production

A team led by MIT students this week successfully tested a prototype of what may be the most cost-efficient solar power system in the world – one team members believe has the potential to revolutionize global energy production.

The system consists of a 12-foot-wide mirrored dish that team members have spent the last several weeks assembling. The dish, made from a lightweight frame of thin, inexpensive aluminum tubing and strips of mirror, concentrates sunlight by a factor of 1,000 – creating heat so intense it could melt a bar of steel.

To demonstrate the system’s power, Spencer Ahrens, who just received his master’s in mechanical engineering from MIT, stood in a grassy field on the edge of the campus this week holding a long plank. Slowly, he eased it into position in front of the dish. Almost instantly there was a big puff of smoke, and flames erupted from the wood. Success!

Burning sticks is not what this dish is really for, of course. Attached to the end of a 12-foot-long aluminum tube rising from the center of the dish is a black-painted coil of tubing that has water running through it. When the dish is pointing directly at the sun, the water in the coil flashes immediately into steam.

Someday soon, Ahrens hopes, the company he and his teammates have founded, called RawSolar, will produce such dishes by the thousands. They could be set up in huge arrays to provide steam for industrial processing, or for heating or cooling buildings, as well as to hook up to steam turbines and generate electricity. Once in mass production, such arrays should pay for themselves within a couple of years with the energy they produce.

“This is actually the most efficient solar collector in existence, and it was just completed,” says Doug Wood, an inventor based in Washington state who patented key parts of the dish’s design–the rights to which he has signed over to the student team.

Great job students. Good luck with RawSolar. Photo (by David Chandler): Matt Ritter shows steam coming from the return hose after passing through the coil above the solar dish.

$1 Billion for Life Sciences in Massachusetts

Petri dish for economic growth

So far, the signs are good. The bill commits $500 million for research facilities, infrastructure improvements, and other capital projects; $250 million for tax credits; and $250 million for research grants. The plan is flexible enough to support research at private institutions while making major investments at public universities. Patrick and legislators fended off the most flagrant attempts to divert money into political pet projects with little direct relevance to the biotech industry, such as $49.5 million for a science building at a state college with no graduate science programs.

As I have mentioned many times the centers of scientific excellence are important for economic success. Massachusetts has some great advantages with MIT, Harvard, many biotech companies… but still must continue to focus on staying a center of excellence.

Engineering Sports at MIT

Making sports an exact science by Shira Springer

“It’s all about finding your passion,” said Vasquez, the group leader and a Material Science and Engineering major. “All the guys on the [project] team love sports. It’s more fun than what you typically think of with an MIT research project.

“There are very few sports companies that put value in good engineering, in terms of projects that make engineering sense rather than just marketing sense. When you get to see how your research can actually be used, it’s pretty cool.”
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The MIT Sports Innovation program, though, was designed to give undergraduates hands-on research experience away from textbooks and classrooms. Working in a Building 17 laboratory cluttered with experiments, where the hum of the wind tunnel can make conversation difficult, the undergraduates brainstorm and build different components of the test setup.

Inside the laboratory and Aero/Astro hangar, the MIT baseball research project looks like a combination of shop class and horror flick: Power tools, quick-drying cement, PVC pipe, handsaws, and mannequin parts are scattered around.

Gecko-inspired Bandage

MIT creates gecko-inspired bandage

Drawing on some of the principles that make gecko feet unique, the surface of the bandage has the same kind of nanoscale hills and valleys that allow the lizards to cling to walls and ceilings. Layered over this landscape is a thin coating of glue that helps the bandage stick in wet environments, such as to heart, bladder or lung tissue. And because the bandage is biodegradable, it dissolves over time and does not have to be removed.
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Gecko-like dry adhesives have been around since about 2001 but there have been significant challenges to adapt this technology for medical applications given the strict design criteria required. For use in the body, they must be adapted to stick in a wet environment and be constructed from materials customized for medical applications. Such materials must be biocompatible, meaning they do not cause inflammation; biodegradable, meaning they dissolve over time without producing toxins; and elastic, so that they can conform to and stretch with the body’s tissues.
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When tested against the intestinal tissue samples from pigs, the nanopatterned adhesive bonds were twice as strong as unpatterned adhesives. In tests of the new adhesive in living rats, the glue-coated nanopatterned adhesive showed over a 100 percent increase in adhesive strength compared to the same material without the glue. Moreover, the rats showed only a mild inflammatory response to the adhesive, a minor reaction that does not need to be overcome for clinical use.

Among other advantages, the adhesive could be infused with drugs designed to release as the biorubber degrades. Further, the elasticity and degradation rate of the biorubber are tunable, as is the pillared landscape. This means that the new adhesives can be customized to have the right elasticity, resilience and grip for different medical applications.

Study challenges notion of ‘pandemic’ flu

Peter Doshi, a graduate student in the History, Anthropology, and Science, Technology and Society Program at MIT, based his study on an analysis of more than a century of influenza mortality data. He found that the peak monthly death rates in the 1957-1958 and 1968-1969 pandemic seasons were no higher than–and were sometimes exceeded by–those for severe nonpandemic seasons.

Doshi says the pandemic-equals-extreme-mortality concept appears to be a generalization of a single data point: the 1918 season, a period in which “doctors lacked intensive care units, respirators, antiviral agents and antibiotics.” He argues that “had no other aspect of modern medicine but antibiotics been available in 1918, there seems good reason to believe that the severity of this pandemic would have been far reduced.”

As may be expected given improvements in living conditions, nutrition and other public health measures, influenza death rates substantially declined across the 20th century. Doshi calculates an 18-fold decrease in influenza deaths between the 1940s and 1990s, a trend that began far before the introduction of widespread vaccination.

Secrets of Spider Silk’s Strength

The strength of a biological material like spider silk lies in the specific geometric configuration of structural proteins, which have small clusters of weak hydrogen bonds that work cooperatively to resist force and dissipate energy, researchers in Civil and Environmental Engineering have revealed.

This structure makes the lightweight natural material as strong as steel, even though the “glue” of hydrogen bonds that hold spider silk together at the molecular level is 100 to 1,000 times weaker than the powerful glue of steel’s metallic bonds or even Kevlar’s covalent bonds.
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“Using only one or two hydrogen bonds in building a protein provides no or very little mechanical resistance, because the bonds are very weak and break almost without provocation,” said Buehler, the Esther and Harold E. Edgerton Assistant Professor in the Department of Civil and Environmental Engineering. “But using three or four bonds leads to a resistance that actually exceeds that of many metals. Using more than four bonds leads to a much-reduced resistance. The strength is maximized at three or four bonds.”

Drug Price Crisis

I don’t think the suggestion below really solves the drug price crisis. But I do think it is an example of an educational and research institution actually proposing sensible role for themselves. As I have said too many universities now act like they are for-profit drug or research companies: Funding Medical Research. For some background on drug prices read my post on the Curious Cat Management blog from 2005.

Solving the drug price crisis

The mounting U.S. drug price crisis can be contained and eventually reversed by separating drug discovery from drug marketing and by establishing a non-profit company to oversee funding for new medicines, according to two MIT experts on the pharmaceutical industry.
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Following the utility model, Finkelstein and Temin propose establishing an independent, public, non-profit Drug Development Corporation (DDC), which would act as an intermediary between the two new industry segments — just as the electric grid acts as an intermediary between energy generators and distributors.

The DDC also would serve as a mechanism for prioritizing drugs for development, noted Finkelstein. “It is a two-level program in which scientists and other experts would recommend to decision-makers which kinds of drugs to fund the most. This would insulate development decisions from the political winds,” he said.

Book – Reasonable Rx: Solving the Drug Price Crisis by Stan Finkelstein and Peter Temin

Easy File Sync Over the Internet

Dropbox aims to simplifying file backup, sync, and sharing for the world. Like other Y Combinator startups it is small and focused – 3 MIT computer science alums. Watch a web presentation that shows a very useful looking service. It is in private beta now – you can register to be notified when it is open for public launch.

Y Combinator: “We care more about how smart you are than how old you are, and more about the quality of your ideas than whether you have a formal business plan.” You have until April 2nd to apply for funding for the current cycle.

Great Physics Webcast Lectures

One great example of MIT’s Open Course Ware initiative is Physics I: Classical Mechanics. This course features lecture notes, problem sets with solutions, exams with solutions, links to related resources, and a complete set of videotaped lectures. The 35 video lectures by Professor Lewin, were recorded on the MIT campus during the Fall of 1999. These are some great lectures by a entertainer and educator. Some lecture topics: Newton’s Laws, Momentum – Conservation of Momentum – Center of Mass, Doppler Effect – Binary Stars – Neutron Stars and Black Holes, The Wonderful Quantum World – Breakdown of Classical Mechanics. What a wonderful web it is.