Tag Archives: open access paper

Treated Mosquito Nets Prevent Malaria

WHO Backs Free, Treated Mosquito Nets to Prevent Malaria

Long-lasting, insecticide-treated mosquito nets should be distributed free, rapidly and widely in malaria-endemic areas, World Health Organization officials said here Thursday, setting new guidelines for fighting the mosquito-borne disease around the globe.
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The WHO announcement was paired with what Kochi called “impressive” findings by Kenyan health authorities that widespread, free distribution of mosquito nets can effectively save children’s lives.

After several years of using a combination of free distribution and sales, the Kenyan government last year conducted a massive, almost military-style campaign to distribute without charge 3.4 million insecticide-treated mosquito nets over three days in 46 malaria-endemic districts across the country.

Among a monitored group of 3,500 children in four of those districts, the number sleeping under the nets increased nearly tenfold from 2004 to 2006, WHO said, citing Kenyan government figures. The result was 44 percent fewer deaths than among children not sleeping under nets. Insecticide-treated mosquito nets kill mosquitoes on contact. If enough nets are distributed and used, they can have a kind of collective impact of eradicating mosquitoes in a given area.

PLoS Medicine open access article: Increasing Coverage and Decreasing Inequity in Insecticide-Treated Bed Net Use among Rural Kenyan Children

Who Killed the Software Engineer?

Computer Science Education: Where Are the Software Engineers of Tomorrow? by Dr. Robert B.K. Dewar and Dr. Edmond Schonberg

Over the last few years we have noticed worrisome trends in CS education. The following represents a summary of those trends:
1. Mathematics requirements in CS programs are shrinking.
2. The development of programming skills in several languages is giving way to cookbook approaches using large libraries and special-purpose packages.
3. The resulting set of skills is insufficient for today’s software industry (in particular for safety and security purposes) and, unfortunately, matches well what the outsourcing industry can offer. We are training easily replaceable professionals.
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As faculty members at New York University for decades, we have regretted the introduction of Java as a first language of instruction for most computer science majors. We have seen how this choice has weakened the formation of our students, as reflected in their performance in systems and architecture courses.
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Every programmer must be comfortable with functional programming and with the important notion of referential transparency. Even though most programmers find imperative programming more intuitive, they must recognize that in many contexts that a functional, stateless style is clear, natural, easy to understand, and efficient to boot.

An additional benefit of the practice of Lisp is that the program is written in what amounts to abstract syntax, namely the internal representation that most compilers use between parsing and code generation. Knowing Lisp is thus an excellent preparation for any software work that involves language processing.

This is an excellent article: any CS students or those considering careers as programmers definitely should read this. Also read: Computer Science Education.

via: Who Killed the Software Engineer?

Dewar, a professor emeritus of computer science at New York University, believes that U.S. colleges are turning out programmers who are – there’s no nice way to say this – essentially incompetent.

DNA Seen Through the Eyes of a Coder

Great paper looking at DNA from the perspective of a computer programmer. DNA seen through the eyes of a coder by Bert Hubert:

The language of DNA is digital, but not binary. Where binary encoding has 0 and 1 to work with (2 – hence the ‘bi’nary), DNA has 4 positions, T, C, G and A. Whereas a digital byte is mostly 8 binary digits, a DNA ‘byte’ (called a ‘codon’) has three digits. Because each digit can have 4 values instead of 2, an DNA codon has 64 possible values, compared to a binary byte which has 256.

A typical example of a DNA codon is ‘GCC’, which encodes the amino acid Alanine. A larger number of these amino acids combined are called a ‘polypeptide’ or ‘protein’, and these are chemically active in making a living being.
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Furthermore, 97% of your DNA is commented out. DNA is linear and read from start to end. The parts that should not be decoded are marked very clearly, much like C comments. The 3% that is used directly form the so called ‘exons’. The comments, that come ‘inbetween’ are called ‘introns’.

Bdelloid Rotifers Abandoned Sex 100 Million Years Ago

Who Needs Sex (or Males) Anyway? by Liza Gross:

If you own a birdbath, chances are you’re hosting one of evolutionary biology’s most puzzling enigmas: bdelloid rotifers. These microscopic invertebrates—widely distributed in mosses, creeks, ponds, and other freshwater repositories—abandoned sex perhaps 100 million years ago, yet have apparently diverged into nearly 400 species. Bdelloids (the “b” is silent) reproduce through parthenogenesis, which generates offspring with essentially the same genome as their mother from unfertilized eggs.

Scientists stumped by 100m years of chastity

Bdelloid rotifers are egg laying microscopic invertebrates — widely distributed in mosses, streams and ponds — which have managed to diverge into nearly 400 species without a scintilla of sex… Now a new study, published today in the journal PLoS biology, has confirmed the worst fears of scientists: the rotifers do indeed present a major challenge to the assumption that sex is necessary for organisms to diversify into species.
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Rather than mixing up DNA, creatures like the bdelloid rotifers can evolve solely through the build-up of mutations that occur in the ‘cloning’ process when a new rotifer is born. The new study proves that these differences are not random and can help rotifers adapt to a different environment, such as the legs or chest of a water louse. Bdelloids can be found happily swimming around in a puddle in your garden, hot springs or in freezing ponds in the Antarctic.

Evolution of Antibiotic Resistance

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance from the Public Library of Science Biology Journal:

The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders pathogenic Escherichia coli unable to evolve resistance in vivo to ciprofloxacin or rifampicin, important quinolone and rifamycin antibiotics. We show in vitro that LexA cleavage is induced during RecBC-mediated repair of ciprofloxacin-mediated DNA damage and that this results in the derepression of the SOS-regulated polymerases Pol II, Pol IV and Pol V, which collaborate to induce resistance-conferring mutations. Our findings indicate that the inhibition of mutation could serve as a novel therapeutic strategy to combat the evolution of antibiotic resistance.