Tag Archives: Research

Parasitic Worms Reduce Hay Fever Symptoms

Parasitic worms reduce hay fever symptoms

Researchers are seeking to use the ability of the hookworm, Necator americanus, to suppress immune system responses that occur in conditions including Crohn’s disease, multiple sclerosis, asthma and other allergies. Recently-completed studies suggest giving worms to people with hay fever is safe, and potentially beneficial.
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Scientists have suggested a lack of such intestinal parasites has left those in the developed world more vulnerable to diseases caused an overactive immune system.

Parasite Rex is an excellent book exploring similar ideas and more on the interaction of parasites with hosts. And from Good Germs Bad Germs, page 100:

in 1999 the Dutch biologist Maria Yazdanbakhsh found that eliminating intestinal worms from infected children in African villages immediately predisposed them to allergies.”

Surprising New Diabetes Data

But these measures are only surrogates for disease. And in many cases, the connection between “better” numbers and better health is tenuous. In the case of cholesterol, many people won’t see a health benefit from lower numbers.

Now comes yet another sobering reminder that lowering a surrogate marker doesn’t necessarily bring better health. On Feb. 6, the National Institutes of Health announced it was halting a key trial for diabetes. Researchers had hoped the trial, dubbed ACCORD (Action to Control Cardiovascular Risk in Diabetes), would show that more aggressive lowering of blood sugar would significantly reduce deaths. Instead, the opposite happened. More people in the intensive treatment group died than in the group getting standard care. “A thorough review of the data shows that the medical treatment strategy of intensively reducing blood sugar below current clinical guidelines causes harm in these…patients,” says Dr. Elizabeth Nabel, director of the National Heart, Lung & Blood Institute.

Scientific study often results in less than clear conclusions, especially in complex systems. There is great difficulty understanding what is actually going on, what interactions are present, what factors are significant, etc.. One of the great problems with the low level of scientific literacy in the USA is so many people think science is about simple absolute truth.

Scientific inquiry, especially related to health care, must attempt to gain insights from confusing signals. To gain scientific literacy one must understand basics concepts, like data is a proxy for what you aim to understand. To understand yourself you need to accept that science is not math. For a long time we are going to have to do our best to build up our understanding of human health (and other complex systems) as best we can. We need to be able to sort out what are solid conclusion, what are guesses, what seem like reasonable explanation and what level of confidence we can have in statements.

It is not enough to learn facts we need to be able to think scientifically and comprehend the subtleties surrounding the advances in scientific understanding. Some criticize newspapers and popular science for providing too simplistic a view of new scientific knowledge. While this can be a problem I really see the problem much more serious if people read obviously overly simplistic articles and don’t understand that it is just scratching the surface. The reader needs to take responsibility too. I enjoy many great articles that gloss over many of the details but provide a quick view of intriguing new breakthroughs.

Country H-index Rank for Science Publications

The SCImago Journal and Country Rank provides journal and country scientific indicators developed from the information contained in the Scopus database. As stated in previous posts these types of rankings have limitations but they are also interesting (such as the best research universities 2007). The table shows the top 6 countries by h-index and then some others I chose to list.

Country	h-index	% of World Population	% of World GDP	total Cites	% Top 500 Schools
USA	793	4.6%	27.4%	43,436,526	33%
United Kingdom	465	0.9	4.9	9,895,817	8
Germany	408	1.3	6.0	8,377,298	8
France	376	0.9	4.6	5,795,531	4
Japan	372	2.0	9.0	7,167,200	6
Canada	370	0.5	2.6	4,728,874	4
Additional countries of interest
20) China	161	20.1	5.5	1,629,993	3
20) South Korea	161	.7	1.8	1,018,532	2
24) Brazil	148	2.9	2.2	752,658	1
25) India	146	17.0	1.9	994.561	.4

Read more about the h-index (Hirsh index). Country population and GDP data taken World Development Indicators 2007, by the World Bank.

via: Stat freaks, are you ready to play with the SCImago Journal & Country Rank?

Computer Science PhD Overview

A nice overview by Mor Harchol-Balter at Carnegie Mellon University on Applying to Ph.D. Programs in Computer Science:

A Ph.D. is a long, in depth research exploration of one topic. By long we’re typically talking about 6 years. By in depth we mean that at the end of the Ph.D. you will be the world expert or close to it in your particular area.
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In contrast, a Ph.D. program typically requires typically less than 10 courses during the entire 6
years (at CMU there are 5 required “core” courses, and 3 required “electives”). The emphasis in the
Ph.D. is not on classes, but rather on research.
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If you choose to be a professor at a research university, your life will consist of the following
tasks: (i) doing research on anything you like, (ii) working with graduate students, (iii) teaching
classes, (iv) applying for grants, (v) flying around to work with other researchers and to give talks
on your research, (vi) doing service for your department and school (like giving this talk). Note that
I say “your life” rather than your job, because for new faculty, your life becomes your job. It’s a
fantastic job/life for me because I love these activities, so I’m happy to work hard at all of them, but
it’s not right for everyone.

The document also offers a list of fellowships including: the NSF Graduate Research Fellowship and NDSEG Graduate Fellowship (disclosure: I work for ASEE administering part of the process for these, and other, fellowships – this blog is my own and not associated with ASEE).

Cool Crow Research

photo of crow vending machine

Very cool project – A Vending Machine for Crows

The goal of this project is to create a device that will autonomously train crows. Initially we’re training them to deposit dropped coins they find on the ground in exchange for peanuts, but eventually we hope to be able to train them to search and rescue, or to collect garbage, or who knows!
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This is the highest-risk segment of the machine’s operation. At this point coins alone are made available whenever the bird lands on the perch. However, should a bird peck or sweep coins off the tray and cause a coin to fall down the funnel, the device then produces some peanuts. This stage is designed to cement in the crows’ mind the relationship between coins going down the funnel and peanuts being made available.
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Finally we shift the device into its intended, and long-term state of only providing peanuts when coins go down the funnel. Nothing is otherwise provided aside from coins scattered around the device at the beginning of the project.

Joshua Klein Thesis presentation definitely watch this! (the webcast takes like 30 seconds before the talk starts – it is worth the wait). Watch a video from the University of Ithaca site (with Dr. Kevin McGowan).

Other sites that also are mentioned as possible sites: Dr. Anne Clark, University of Binghamton (with a captive population of crows); Dr. Natalie Jeremijenko (seed podcast), Dr. Carolee Caffrey, Harvard and Dr. James Ha, University of Washington. Read the Paper by Joshua Klein about the plans for the experiment.

Nanotechnology Breakthroughs for Computer Chips

Nano On Off Switch

Photo: Actual scanning tunneling microscopy images of the naphthalocyanine molecule in the “on” and the “off” state. More images

IBM Unveils Two Major Nanotechnology Breakthroughs as Building Blocks for Atomic Structures and Devices

IBM scientists have made major progress in probing a property called magnetic anisotropy in individual atoms. This fundamental measurement has important technological consequences because it determines an atom’s ability to store information. Previously, nobody had been able to measure the magnetic anisotropy of a single atom.

With further work it may be possible to build structures consisting of small clusters of atoms, or even individual atoms, that could reliably store magnetic information. Such a storage capability would enable nearly 30,000 feature length movies or the entire contents of YouTube – millions of videos estimated to be more than 1,000 trillion bits of data – to fit in a device the size of an iPod. Perhaps more importantly, the breakthrough could lead to new kinds of structures and devices that are so small they could be applied to entire new fields and disciplines beyond traditional computing.

In the second report, IBM researchers unveiled the first single-molecule switch that can operate flawlessly without disrupting the molecule’s outer frame — a significant step toward building computing elements at the molecular scale that are vastly smaller, faster and use less energy than today’s computer chips and memory devices.

In addition to switching within a single molecule, the researchers also demonstrated that atoms inside one molecule can be used to switch atoms in an adjacent molecule, representing a rudimentary logic element. This is made possible partly because the molecular framework is not disturbed.

Best Research University Rankings – 2007

There are several rankings of universities. They can be interesting but also have obvious limitations. I find Shanghai’s Jiao Tong University’s the most interesting (especially the international nature of it). Their real focus seems to be in providing a way for China to get a feel for how they are progressing toward developing world class universities (interesting slide presentation on their efforts). The methodology values publications and faculty awards and is provides a better ranking of research (rather than teaching). Results from the 2007 rankings of Top 500 Universities worldwide showing country representation of the top schools:

location	Top 101	% of World Population	% of World GDP	% of top 500
USA	54	4.6%	27.4%	32.7%
United Kingdom	11	0.9	4.9	8.3
Germany	6	1.3	6.0	8.1
Japan	6	2.0	9.0	6.3
Canada	4	0.5	2.6	4.3
France	4	0.9	4.6	4.3
Sweden	4	0.1	0.8	2.2
Switzerland	3	0.1	0.8	1.6
Australia	2	0.3	1.6	3.3
Netherlands	2	0.3	1.4	2.4
Israel	1	0.1	0.3	1.4
Finland	1	0.1	0.4	1.0
Norway	1	0.1	0.6	0.8
Denmark	1	0.1	0.6	0.8
Russia	1	2.2	2.0	0.4
China		20.1	5.5	2.8
India		17.0	1.9	0.4

China has 1 ranked in the 151-202 range as do Taiwan, Korea and Brazil. Singapore has one in the 102-151 range. The other country without any in the top 101 with representation in the next 101 is Italy with 3 schools in the 102-151 range and 2 in the 152-202 range. India has 2 in the 305-401 range.

Top 10 schools (same schools as last year, Cambridge moved from 2nd to 4th):

Harvard University
Stanford University
University of California at Berkeley
Cambridge University
Massachusetts Institute of Technology(MIT)
California Institute of Technology
Columbia University
Princeton University
University Chicago
Oxford University

University of Wisconsin – Madison is 17th 🙂 My father taught there while I grew up.
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Why do We Sleep?

Study puts us one step closer to understanding the purpose of sleep:

Sleep remains one of the big mysteries in biology. All animals sleep, and people who are deprived of sleep suffer physically, emotionally and intellectually. But nobody knows how sleep restores the brain.
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Although an electronic power-napper sounds like a product whose time has come, Tononi is chasing a larger quarry: learning why sleep is necessary in the first place. If all animals sleep, he says, it must play a critical role in survival, but that role remains elusive.

Based on the fact that sleep seems to “consolidate” memories, many neuroscientists believe that sleeping lets us rehearse the day’s events.

Tononi agrees that sleep improves memory, but he thinks this happens through a different process, one that involves a reduction in brain overload. During sleep, he suggests, the synapses (connections between nerve cells) that were formed by the day’s learning can relax a little.

Asia: Rising Stars of Science and Engineering

Great report – The Atlas of Ideas: How Asian innovation can benefit us all by Charles Leadbeater and James Wilsdon:

Each country will develop differently. In South Korea strong government support has created a world-class information infrastructure.
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China is mobilising massive resources for innovation through ambitious long-term plans, funded by rapid economic growth. Beijing’s university district produces as many engineers as all of western Europe. China is developing world-class universities and attracting multinational innovation centres.
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India’s elite, trained at the Indian Institutes of Technology, are second to none. New institutions like the National Science and Engineering Foundation could energise a disjointed innovation system. Yet India’s innovation elite may face a rural backlash. Its infrastructure is in poor repair and cities like Bengalooru are congested. Even the much-vaunted IITs do not, unlike their US counterparts, animate innovation clusters.

Percentage of world share of scientific publications

Year	China	France	Germany	Japan	Korea	UK	US	EU-15
1995	2.05	6.09	7.62	8.65	0.79	8.88	33.54	34.36
1998	2.90	6.48	8.82	9.42	1.41	9.08	31.63	36.85
2001	4.30	6.33	8.68	9.52	2.01	8.90	31.01	36.55
2004	6.52	5.84	8.14	8.84	2.70	8.33	30.48	35.18

Excellent reading, the report is full of useful information I have not been able to obsorb yet.
Related: Diplomacy and Science Research – The World’s Best Research Universities – Engineering the Future Economy – Worldwide Science and Engineering Doctoral Degree Data – USA Under-counting Engineering Graduates – Increasing American Fellowship Support for Scientists and Engineers
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$75.3 Million for 5 New Engineering Research Centers

Photo: Claire Gmachl, associate professor of electrical engineering at Princeton, the MIRTHE center director.

NSF Awards $75.3 Million for Five New Engineering Research Centers including the Mid-Infrared Technologies for Health and the Environment (MIRTHE):

The goal of the research is to produce devices that are so low in cost and easy to use that they transform aspects of the way doctors care for patients, local agencies monitor air quality, governments guard against attack and scientists understand the evolution of greenhouse gases in the atmosphere.
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will combine the work of about 40 faculty members, 30 graduate students and 30 undergraduates from the six universities. The center also is collaborating with dozens of industrial partners to turn the technology into commercial products, and is working with several educational outreach partners, which will use MIRTHE’s research as a vehicle for improving science and engineering education.