Tag Archives: university research

An Artificial Nerve Networks

When neurons – brain nerve cells – are grown in culture, they don’t form complex ‘thinking’ networks. Moses, Feinerman and Rotem wondered whether the physical structure of the nerve network could be designed to be more brain-like. To simplify things, they grew a model nerve network in one dimension only – by getting the neurons to grow along a groove etched in a glass plate. The scientists found they could stimulate these nerve cells using a magnetic field (as opposed to other systems of lab-grown neurons that only react to electricity).

Experimenting further with the linear set-up, the group found that varying the width of the neuron stripe affected how well it would send signals. Nerve cells in the brain are connected to great numbers of other cells through their axons (long, thin extensions), and they must receive a minimum number of incoming signals before they fire one off in response. The researchers identified a threshold thickness, one that allowed the development of around 100 axons. Below this number, the chance of a response was iffy, while just a few over this number greatly raised the chance a signal would be passed on.

The scientists then took two thin stripes of around 100 axons each and created a logic gate similar to one in an electronic computer. Both of these ‘wires’ were connected to a small number of nerve cells. When the cells received a signal along just one of the ‘wires,’ the outcome was uncertain; but a signal sent along both ‘wires’ simultaneously was assured of a response. This type of structure is known as an AND gate. The next structure the team created was slightly more complex: Triangles fashioned from the neuron stripes were lined up in a row, point to rib, in a way that forced the axons to develop and send signals in one direction only. Several of these segmented shapes were then attached together in a loop to create a closed circuit. The regular relay of nerve signals around the circuit turned it into a sort of biological clock or pacemaker.

Moses: ‘We have been able to enforce simplicity on an inherently complicated system. Now we can ask, ‘What do nerve cells grown in culture require in order to be able to carry out complex calculations?’ As we find answers, we get closer to understanding the conditions needed for creating a synthetic, many-neuron ‘thinking’ apparatus.’

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Science Commons: Making Scientific Research Re-useful

Science Commons is a project of Creative Commons. Like other organizations trying to support the advancement of science with open access they deserve to be supported (PLoS and arXiv.org are other great organizations supporting science).

Science Commons has three interlocking initiatives designed to accelerate the research cycle – the continuous production and reuse of knowledge that is at the heart of the scientific method. Together, they form the building blocks of a new collaborative infrastructure to make scientific discovery easier by design.

Making scientific research re-useful, help people and organizations open and mark their research and data for reuse. Learn more.

Enabling one-click access to research materials, streamline the materials-transfer process so researchers can easily replicate, verify and extend research. Learn more.

Integrating fragmented information sources, help researchers find, analyze and use data from disparate sources by marking and integrating the information with a common, computer-readable language. Learn more.

NeuroCommons, is their proof-of-concept project within the field of neuroscience. The NeuroCommons is a beta open source knowledge management system for biomedical research that anyone can use, and anyone can build on.

Fast Fitness Forecast is False, it Takes Time

Fitness Isn’t an Overnight Sensation

“To make a change in how you look, you are talking about a significant period of training,” Dr. Kraemer said. “In our studies it takes six months to a year.” And, he added, that is with regular strength-training workouts, using the appropriate weights and with a carefully designed individualized program. “That is what the reality is,” he said.

And genetic differences among individuals mean some people respond much better to exercise than others
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Now, said Mr. Antane, who runs with a group in Princeton on Thursday nights, “everything changed — my outlook on life, who I hung out with, how I felt about myself.”

Our bodies evolved under conditions with much more exercise than we currently get if we sit in an office all day. And we had less food. It is no surprise with more food and less exercise that we gain weight. And given that the benefit of fat was to help us survive when we had little food out bodies don’t change overnight. If they did then our ancestors would have had much more difficulty surviving – the whole point was to provide a resource to tap in bad times. If that resource dissipated quickly it would not have helped much.

Moving Closer to Robots Swimming Through Bloodsteam

Pretty cool. Tiny motor allows robots to swim through human body

James Friend, of Monash University, said that such devices could enter previously unreachable brain areas, unblocking blood clots, cleaning vessels or sending back images to surgeons. “The first complete device we want to build would have a camera,” Professor Friend said.
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Professor Friend said they had shown the motor, which is a quarter of a millimetre wide, had enough power to navigate this type of nanorobot through the bloodstream of a human artery. Tests of their prototype device in a liquid as viscous as blood were also promising. “It swam.”
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The team plans to conduct animal tests of a nanorobot driven by their motor later this year or early next year. But Professor Friend cautioned that many technical hurdles needed to be overcome.

Their miniature motor was connected to an electricity supply and a way would need to be found to power it remotely. The construction of the flagella also needed refinement.

Making Magnificent Mirrors with Math

At Drexel, he designs amazing mirrors

Could math provide the path to better reflection? Perline asked.

Indeed it could. Eight years and numerous calculations later, Hicks is now testing a prototype mirror – for a car, not a bike – and he is in talks with a foreign manufacturer. As with the bike mirror, the rounded surface provides a wide field of view – so wide that it eliminates the dreaded, driver-side “blind spot” – yet the subtle mathematics of his design result in little or no distortion.

He didn’t stop there. The 42-year-old mathematician went on to design half a dozen other reflective surfaces for various applications – a few of them in collaboration with Perline – and they are like nothing you’d ever see on the bathroom wall.

Panoramic mirrors. Mirrors for use with high-tech surveillance cameras. Mirrors with odd, undulating surfaces that are fashioned with a computer-guided milling machine. And one wacky mirror that doesn’t yield a mirror image at all. If you raise one hand while looking into the curved surface, your reflection appears to be raising the opposite hand.

It’s not clear what use that one will have, beyond entertainment – Perline calls it “the vampire mirror” – but with his driver-side prototype, Hicks may be onto something.

New Family of Antibacterial Agents Discovered

Bacteria continue to gain resistance to commonly used antibiotics. In this week’s JBC, one potential new antibotic has been found in the tiny freshwater animal Hydra.

The protein identified by Joachim GrÃ¶tzinger, Thomas Bosch and colleagues at the University of Kiel (Germany), hydramacin-1, is unusual (and also clinically valuable) as it shares virtually no similarity with any other known antibacterial proteins except for two antimicrobials found in another ancient animal, the leech.

Hydramacin proved to be extremely effective though; in a series of laboratory experiments, this protein could kill a wide range of both Gram-positive and Gram-negative bacteria, including clinically-isolated drug-resistant strains like Klebsiella oxytoca (a common cause of nosocomial infections). Hydramacin works by sticking to the bacterial surface, promoting the clumping of nearby bacteria, then disrupting the bacterial membrane.

GrÃ¶tzinger and his team also determined the 3-D shape of hydramacin-1, which revealed that it most closely resembled a superfamily of proteins found in scorpion venom; within this large group, they propose that hydramacin and the two leech proteins are members of a newly designated family called the macins.

Source: American Society for Biochemistry and Molecular Biology

Soil Mineral Degrades the Nearly Indestructible Prion

Warped pathogens that lack both DNA and RNA, prions are believed to cause such fatal brain ailments as chronic wasting disease (CWD) in deer and moose, mad cow disease in cattle, scrapie in sheep and Creutzfeldt-Jakob disease in humans. In addition to being perhaps the weirdest infectious agent know to science, the prion is also the most durable. It resists almost every method of destruction from fire and ionizing radiation to chemical disinfectants and autoclaving, which reduce prion infectivity but fail to completely eliminate it.

Other studies have shown that prions can survive in the soil for at least three years, and that soil is a plausible route of transmission for some animals, says Joel Pedersen, a UW-Madison environmental chemist. “We know that environmental contamination occurs in deer and sheep at least,” he notes.

Prion reservoirs in the soil, Pedersen explains, are likely critical links in the chain of infection because the agent does not appear to depend on vectors — intermediate organisms like mosquitoes or ticks — to spread from animal to animal.

That the birnessite family of minerals possessed the capacity to degrade prions was a surprise, Pedersen says. Manganese oxides like birnessite are commonly used in such things as batteries and are among the most potent oxidants occurring naturally in soils, capable of chemically transforming a substance by adding oxygen atoms and stripping away electrons. The mineral is most abundant in soils that are seasonally waterlogged or poorly drained.

full press release

Tiny $10 Microscope

Researchers at Caltech, who developed the revolutionary imaging system, say that the devices could be mass-produced at a cost of $10 each and incorporated into large arrays, enabling high-throughput imaging in biology labs. The device could also broaden access to imaging technology: incorporated into PDA-size devices, for example, the microscopes could enable rural doctors to carry sophisticated imaging systems in their pockets.

The Caltech device uses a system of tiny fluid channels called microfluidics to direct cells and even microscopic animals over a light-sensing chip. The chip, an off-the-shelf sensor identical to those found in digital cameras, is covered with a thin layer of metal that blocks out most of the pixels. A few hundred tiny apertures punched in the metal along the fluid channel let light in. As the sample flows through the microscope, each aperture captures an image. One version of the microscope uses gravity to control the flow of the sample across the apertures. Another version, which allows for much better control, uses an electrical potential to drive the flow of cells.

$100 Million to Tackle Energy Issues

Stanford launches $100 million initiative to tackle energy issues

The $100 million in new funds will enable the hiring of additional faculty and support new graduate students, in addition to the more than $30 million in yearly funding now spent on energy research.
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Precourt holds bachelor’s and master’s degrees in petroleum engineering from Stanford and an MBA from Harvard University. He has spent his career in the energy industry, holding president and/or CEO positions at Hamilton Oil Co.; Tejas Gas Corporation, subsequently a Shell Oil Co. subsidiary; and ScissorTail Energy and Hermes Consolidated, gatherers, transporters and processors of natural gas, crude oil and refined products.

He is convinced that Stanford research can influence national energy policy for the better. “The wonderful resources that are available at Stanford, and the multidisciplinary approach they have to developing working solutions, are really attractive in terms of making things happen,” he said.

On a personal level, Precourt said, “Stanford made a huge impact on my life, as I look back on it. It was a superb education and I made some wonderful friends that I’ve taken with me for my lifetime.” Precourt donated $50 million to the energy institute that bears his name.

A $40 million gift from Steyer and Taylor will create a new research center as part of the institute, the TomKat Center for Sustainable Energy.

Moth Jams Bat Sonar

Superloud moth jams bat sonar

A gray moth with orange highlights called Bertholdia trigona “goes berserk,” making lots of noise above the range of human hearing when a hunting bat approaches, says William Conner of Wake Forest University in Winston-Salem, N.C. Bats rely on their natural sonar to locate flying moths in the dark, but in a lab setup, the bats rarely managed to nab a loud moth.

When researchers disabled the moth’s noisemaking organs, though, bats caught the moths in midair with ease, Conner reported at the annual meeting of the Society for Integrative and Comparative Biology.

Conner says the work is “the first example of any prey item that jams biological sonar.” Conference attendee David Yager of the University of Maryland in College Park says Conner’s experimental paradigm is “very strong, and I do think he has documented jamming by a species of moth.”

Insect-hunting bats and their moth prey have become a classic in the study of evolutionary arms races, Conner says. “This is warfare … The first counter-adaptation is that the insects developed ears.”
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Jamming isn’t the only possible explanation for moth noises, he said. An explosive clicking sound coming back out of the night might startle a bat just a split-second long enough for the moth to get away.