Tag Archives: university research

Common Cold Alters the Activity of Genes

Scientists Come Closer to Unlocking Secrets of Common Cold

Canadian and U.S. researchers have found that the human rhinovirus, long blamed for causing the common cold, doesn’t actually cause those annoying sniffles, sneezes, and coughs.

Instead, the ubiquitous virus alters the activity of genes in the body, which then results in the misery that afflicts most people every year or so, according to a study in the first November issue of the American Journal of Respiratory and Critical Care Medicine.
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Human rhinovirus (HRV) causes some 30 percent to 50 percent of common colds and can also worsen more serious conditions, such as asthma.
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A “microarray analysis” of DNA showed no genetic changes eight hours after infection. But, after two days, about 6,500 genes had been affected, either with heightened activity or dampened activity.

The genes most affected by the presence of the virus were ones that make antiviral proteins and pro-inflammatory chemicals that contribute to airway inflammation, the researchers said.

Read: Learning How Viruses Evade the Immune System – Gene Carnival – Black Raspberries Alter Hundreds of Genes Slowing Cancer – Study Finds No Measurable Benefit to Flu Shots

Waste from Gut Bacteria Helps Host Control Weight

A single molecule in the intestinal wall, activated by the waste products from gut bacteria, plays a large role in controlling whether the host animals are lean or fatty, a research team, including scientists from UT Southwestern Medical Center, has found in a mouse study.

When activated, the molecule slows the movement of food through the intestine, allowing the animal to absorb more nutrients and thus gain weight. Without this signal, the animals weigh less.

The study shows that the host can use bacterial byproducts not only as a source of nutrients, but also as chemical signals to regulate body functions. It also points the way to a potential method of controlling weight, the researchers said.

“It’s quite possible that blocking this receptor molecule in the intestine might fight a certain kind of obesity by blocking absorption of energy from the gut,” said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and a senior co-author of the study, Proceedings of the National Academy of Sciences, open access: Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.

Humans, like other animals, have a large and varied population of beneficial bacteria that live in the intestines. The bacteria break up large molecules that the host cannot digest. The host in turn absorbs many of the resulting small molecules for energy and nutrients.

In the Big Fat Lie I mentioned some related ideas:

It also makes perfect sense that our bodies evolved to store energy for worse times (and some of us have bodies better at doing that). Now we are in a new environment where (at least for many people alive today) finding enough calories is not going to be a problem so it would be nice if we could tell our bodies to get less efficient at storing fat

This research seems to be looking for a similar way to attack the obesity epidemic: reduce the efficiency of our bodies converting potential energy in the food we eat to energy we use or store. If we can make that part of the solution that will be nice. So far the reduction in our activity and increase in food intake have not been getting good results. And efforts to increase (from our current low levels) activity and reduce food intake have not been very effective.
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Plants can Signal Microbial Friends for Help

When under attack, plants can signal microbial friends for help

Researchers at the University of Delaware have discovered that when the leaf of a plant is under attack by a pathogen, it can send out an S.O.S. to the roots for help, and the roots will respond by secreting an acid that brings beneficial bacteria to the rescue.
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In a series of laboratory experiments, the scientists infected the leaves of the small flowering plant Arabidopsis thaliana with a pathogenic bacterium, Pseudomonas syringae. Within a few days, the leaves of the infected plants began yellowing and showing other symptoms of disease.

However, the infected plants whose roots had been inoculated with the beneficial microbe Bacillus subtilis were perfectly healthy. Farmers often add B. subtilis to the soil to boost plant immunity. It forms a protective biofilm around plant roots and also has antimicrobial properties, according to Bais.

Using molecular biological tools, the scientists detected the transmission of a long-distance signal, a “call for help,” from the leaves to the roots in the plants that had Bacillus in the soil. The roots responded by secreting a carbon-rich chemical–malic acid.

All plants biosynthesize malic acid, Bais explains, but only under specific conditions and for a specific purpose–in this case, the chemical was actively secreted to attract Bacillus. Magnified images of the roots and leaves showed the ratcheted-up defense response provided by the beneficial microorganisms.
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“Plants can’t move from where they are, so the only way they can accrue good neighbors is through chemistry,” Bais notes.

High-School Social Skills Predict Better Earnings than Test Scores

High-School Social Skills Predict Better Earnings than Test Scores

Ten years after graduation, high-school students who had been rated as conscientious and cooperative by their teachers were earning more than classmates who had similar test scores but fewer social skills, said a new University of Illinois study.

The study’s findings challenge the idea that racial, ethnic, and socioeconomic gaps in educational attainment and earnings can be narrowed solely by emphasizing cognitive skills, said Christy Lleras, a University of Illinois assistant professor of human and community development.

“It’s important to note that good schools do more than teach reading, writing, and math. They socialize students and provide the kinds of learning opportunities that help them to become good citizens and to be successful in the labor market,” she said.

“Unless we address the differences in school climates and curriculum that foster good work habits and other social skills, we’re doing a huge disservice to low-income kids who may be entering the labor market right after high school, especially in our increasingly service-oriented economy,” Lleras added.

The University of Illinois study analyzed data from the National Educational Longitudinal Study, which followed a diverse group of 11,000 tenth graders for 10 years, tracking not only their scores on standard achievement tests but teacher appraisals of such qualities as the students’ work habits, their ability to relate well to peers, and their participation in extracurricular activities, a proxy for the ability to interact well with both students and adults.

The teachers’ assessments were then compared with the students’ self-reported educational attainments and earnings 10 years after high-school graduation. Even after controlling for students’ achievement test scores, family socioeconomic status, and educational attainment, Lleras found that such social skills as conscientiousness, cooperativeness, and motivation were as important as test scores for success in the workplace.

Silk E.coli Sensors

“Edible Optics” Could Make Food Safer

Scientists at Tufts University’s School of Engineering have demonstrated for the first time that it is possible to design such “living” optical elements that could enable an entirely new class of sensors. These sensors would combine sophisticated nanoscale optics with biological readout functions, be biocompatible and biodegradable, and be manufactured and stored at room temperatures without use of toxic chemicals. The Tufts team used fibers from silkworms to develop the platform devices.
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The possibility of integrating optical readout and biological function in a single biocompatible device unconstrained by these limitations is tantalizing. Silk optics has captured the interest of the Defense Department, which has funded and been instrumental in enabling rapid progress on the topic. The Defense Advanced Research Projects Agency (DARPA) awarded Tufts a research contract in 2007 and is funding Tufts and others on groundbreaking projects that could someday result in biodegradable optical sensing communications technology.
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To form the devices, Tufts scientists boiled cocoons of the Bombyx mori silkworm in a water solution and extracted the glue-like sericin proteins. The purified silk protein solution was ultimately poured onto negative molds of ruled and holographic diffraction gratings with spacing as fine as 3600 grooves/mm.
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The Tufts team embedded three very different biological agents in the silk solution: a protein (hemoglobin), an enzyme (horseradish peroxidase) and an organic pH indicator (phenol red). In the hardened silk optical element, all three agents maintained their activity for long periods when simply stored on a shelf. “We have optical devices embedded with enzymes that are still active after almost a year of storage at room temperature.

The Nobel Prize in Chemistry 2008

The Nobel Prize in Chemistry 2008 is evenly shared by Osamu Shimomura, Boston University Medical School, USA; Martin Chalfie, Columbia University, New York, USA and Roger Y. Tsien, University of California, San Diego, USA for discovery and work with glowing green fluorescent protein.

The remarkable brightly glowing green fluorescent protein, GFP, was first observed in the beautiful jellyfish, Aequorea victoria in 1962. Since then, this protein has become one of the most important tools used in contemporary bioscience. With the aid of GFP, researchers have developed ways to watch processes that were previously invisible, such as the development of nerve cells in the brain or how cancer cells spread.

Tens of thousands of different proteins reside in a living organism, controlling important chemical processes in minute detail. If this protein machinery malfunctions, illness and disease often follow. That is why it has been imperative for bioscience to map the role of different proteins in the body.

This year’s Nobel Prize in Chemistry rewards the initial discovery of GFP and a series of important developments which have led to its use as a tagging tool in bioscience. By using DNA technology, researchers can now connect GFP to other interesting, but otherwise invisible, proteins. This glowing marker allows them to watch the movements, positions and interactions of the tagged proteins.

Researchers can also follow the fate of various cells with the help of GFP: nerve cell damage during Alzheimer’s disease or how insulin-producing beta cells are created in the pancreas of a growing embryo. In one spectacular experiment, researchers succeeded in tagging different nerve cells in the brain of a mouse with a kaleidoscope of colors.

Osamu Shimomura, a Japanese citizen, was born 1928 in Kyoto, Japan. He received his Ph.D. in organic chemistry 1960 from Nagoya University, Japan. first isolated GFP from the jellyfish Aequorea victoria, which drifts with the currents off the west coast of North America. He discovered that this protein glowed bright green under ultraviolet light.

Martin Chalfie demonstrated the value of GFP as a luminous genetic tag for various biological phenomena. In one of his first experiments, he coloured six individual cells in the transparent roundworm Caenorhabditis elegans with the aid of GFP.

Roger Y. Tsien contributed to our general understanding of how GFP fluoresces. He also extended the colour palette beyond green allowing researchers to give various proteins and cells different colours. This enables scientists to follow several different biological processes at the same time.

Stanford Gets $75 Million for Stem Cell Center

Stanford gets $75 million for stem cell center

With today’s announcement, Lokey more than doubles his commitment. School officials say he is the lead contributor for a $200 million stem cell research building that will break ground Oct. 27 and be finished in the summer of 2010. In a statement released by the medical school, Lokey said stem cells would be “as significant as the silicon chip that created Silicon Valley,” producing treatments for disease and saving lives.

He said he was driven to fund research after President Bush, in August 2001, forbid the use of federal funds for stem cell research that involved the destruction of human embryos. “It’s very narrow-minded,” Lokey said of the position. “This is about lives being saved.”
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Some 350 scientists will work in the 200,000-square-foot Lorry I. Lokey Stem Cell Research Building, the school said. The center is also getting a $43.6 million grant from the California Institute for Regenerative Medicine. The institute, the state’s $3 billion stem cell funding unit, was created by a 2004 state initiative from research advocates opposed to Bush’s restrictions.

$92 Million for Engineering Research Centers

photo of Alex Huabg

NSF Launches Third Generation of Engineering Research Centers with Awards Totaling $92.5 Million. Each of the 5 sites will receive will use $18.5 million over five-years. Each center has international university partners and partners in industry.

The NSF Engineering Research Center for Biorenewable Chemicals (CBiRC), based at Iowa State University, seeks to transform the existing petrochemical-based chemical industry to one based on renewable materials.

The NSF Engineering Research Center for Future Renewable Electric Energy Delivery and Management (FREEDM) Systems, based at North Carolina State University, will conduct research to transform the nation’s power grid into an efficient network that integrates alternative energy generation and new storage methods with existing power sources.

The NSF ERC for Integrated Access Networks (CIAN), based at the University of Arizona, will conduct research to create transformative technologies for optical access networks that offer dramatically improved performance and expanded capabilities.

The NSF ERC for Revolutionizing Metallic Biomaterials, based at North Carolina Agricultural and Technical State University, aims to transform current medial and surgical treatments by creating “smart” implants for craniofacial, dental, orthopedic and cardiovascular interventions.

The NSF Smart Lighting ERC, based at Rensselaer Polytechnic Institute, aims to create new solid-state lighting technologies to enable rapid biological imaging, novel modes of communication, efficient displays and safer transportation.

Photo: Alex Huang will lead direct the research of ways to integrate renewable energy sources into the nation’s power grid at North Carolina State University.

Holographic Television on the Way

Ok, there really isn’t much new since I posted that holographic TV is getting closer. But won’t it be cool when I can have one in my house? And you might need to plan for it in your new house addition 🙂 Also, with the economic news lately a good distraction might be useful – Holographic television to become reality

The reason for renewed optimism in three-dimensional technology is a breakthrough in rewritable and erasable holographic systems made earlier this year by researchers at the University of Arizona.

Dr Nasser Peyghambarian, chair of photonics and lasers at the university’s Optical Sciences department, told CNN that scientists have broken a barrier by making the first updatable three-dimensional displays with memory.

“This is a prerequisite for any type of moving holographic technology. The way it works presently is not suitable for 3-D images,” he said. The researchers produced displays that can be erased and rewritten in a matter of minutes.
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According to Peyghambarian, they could be constructed as a screen on the wall (like flat panel displays) that shows 3-D images, with all the image writing lasers behind the wall; or it could be like a horizontal panel on a table with holographic writing apparatus underneath.
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Peyghambarian is also optimistic that the technology could reach the market within five to ten years. He said progress towards a final product should be made much more quickly now that a rewriting method had been found.

However, it is fair to say not everyone is as positive about this prospect as Peyghambarian. Justin Lawrence, a lecturer in Electronic Engineering at Bangor University in Wales, told CNN that small steps are being made on technology like 3-D holograms, but, he can’t see it being ready for the market in the next ten years.

I would have to say I am with those that think this might take a bit longer to be in place. But I would be glad to be wrong.

$400 Million More for Harvard and MIT

$400 million endowment for the Broad Institute of Harvard and MIT

“Today the Broad Institute is the world’s leading genomics and biomedical institute, and we’re now making a $600 million bet that the Broad will be the place where the greatest scientific discoveries take place,” Eli Broad said at today’s ceremony.
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In its short history, the Broad Institute’s accomplishments include cataloging and identifying genetic risk factors for diseases such as type 2 diabetes and autism; discovering new therapeutic targets for cancer, malaria, and other diseases; and applying genomic tools to better understand and treat human pathogens like tuberculosis.
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The Broads’ gift is the largest to support biomedical research at a university anywhere in the world. The Broads initially invested $100 million in 2003 as a way to test the institute’s new approach to biomedical research. By 2005, the Broad Institute had already made significant accomplishments and progress, and the Broads invested a second $100 million. Their endowment of $400 million today will allow the Broad Institute to transition to a permanent, non-profit 501(c)(3) organization with both Harvard and MIT still at the heart of it, continuing to help govern the institute.

Many countries would love to create a world class center of biomedical research. And several are trying. Boston sure seems to be staking a claim that it will be one of those centers of excellence. The economic benefits of that to Boston will be huge.