Tag Archives: university research

North American Fish Threatened

Nearly 40 percent of fish species in North America are imperiled, according to a new survey by fish experts, the U. S. Geological Survey, and the American Fisheries Society, up 92 percent from the last survey done in 1989.
…
No single cause explains the ongoing fish losses, Taylor and others agree. Habitat loss, invasive species, diseases, dams, and water contaminants all contribute.

“Fish are kind of canaries in the coal mine,” said Howard Jelks of the USGS and lead author of the report, published in Fisheries. “If you change the water to something that’s not able to support these fish, it’s also not going to be as high quality for recreating, for eating the fish out of these streams, for drawing water that’s ultimately used for drinking, or for other things.”

Active Amish Avoid Obesity

Lessons from the Amish: We’re not doomed to obesity

Four years ago we discovered that the Amish maintained super-low obesity levels despite eating a diet high in fat, calories and refined sugar. They key was their level of physical activity — men averaged 18,000 steps a day, women 14,000. That’s monumental compared to the paltry couple of thousand or so most of us eke out in a day.
…
A recent study revealed even more about the Old Order Amish: They maintain low obesity levels despite having a gene variation that makes them susceptible to obesity. The secret here? You guessed it — lots of physical activity.

Study Conclusions: “Our results strongly suggest that the increased risk of obesity owing to genetic susceptibility by FTO variants can be blunted through physical activity. These findings emphasize the important role of physical activity in public health efforts to combat obesity, particularly in genetically susceptible individuals.”

Sometimes the simple explanation is worth paying attention to. Add lack of activity to eating more (Obesity Epidemic Explained – Kind Of: 1970 Americans ate an average of 2170 calories per day in 2000 they ate an average of 2700) and it seems like it is logical we would gain weight due to these two factors.

Best Research University Rankings – 2008

The annual ranking of research Universities are available from Shanghai’s Jiao Tong University. The methodology values publications and faculty awards which provides a better ranking of research (rather than teaching). Results from the 2008 rankings of Top 500 Universities worldwide, country representation of the top schools:

location	Top 100	% of World Population	% of World GDP	% of top 500
USA	54	4.6%	27.2%	31.6%
United Kingdom	11	0.9	4.9	8.3
Germany	6	1.3	6.0	8.0
Japan	4	2.0	9.0	6.2
Canada	4	0.5	2.6	4.2
Sweden	4	0.1	0.8	2.2
France	3	0.8	4.6	4.6
Switzerland	3	0.1	0.8	1.6
Australia	3	0.3	1.6	3.0
Netherlands	2	0.2	1.4	2.4
Denmark	2	0.1	0.6	0.8
Finland	1	0.1	0.4	1.2
Norway	1	0.1	0.7	0.8
Israel	1	0.1	0.3	1.2
Russia	1	2.2	2.0	0.4
China		20.5	6.6	6.0
India		17.0	1.9	0.4

There is little change in most of the data from last year, which I think is a good sign, it wouldn’t make much sense to have radical shifts over a year in these rankings. Japan lost 2 schools in the top 100, France lost 1. Denmark (Aarhus University) and Australia (University of Sydney) gained 1. Last year there was a tie so there were 101 schools in the top 100.

The most dramatic data I noticed is China’s number of top 500 schools went from 14 to 30, which made me a bit skeptical of what caused that quick change. Looking more closely last year they reported the China top 500 totals as (China 14, China-Taiwan 6 and China-Hong Kong 5). That still gives them an impressive gain of 5 schools.

Singapore has 1 in the 102-151 range. Taiwan has 1 ranked in the 152-200 range, as do Mexico, Korea and Brazil. China has 9 in the 201-302 range (including 3 in Hong Kong). India has 2 in the 303-401 range.

University of Wisconsin – Madison is 17th again 🙂 My father taught there while I grew up.
Continue reading →

Autonomous Helicopters Teach Themselves to Fly

photo of Stanford Autonomous Learning Helicopters

Stanford’s “autonomous” helicopters teach themselves to fly

Stanford computer scientists have developed an artificial intelligence system that enables robotic helicopters to teach themselves to fly difficult stunts by watching other helicopters perform the same maneuvers.
…
The dazzling airshow is an important demonstration of “apprenticeship learning,” in which robots learn by observing an expert, rather than by having software engineers peck away at their keyboards in an attempt to write instructions from scratch.
…
It might seem that an autonomous helicopter could fly stunts by simply replaying the exact finger movements of an expert pilot using the joy sticks on the helicopter’s remote controller. That approach, however, is doomed to failure because of uncontrollable variables such as gusting winds.

Saving Lives with Smarter Hurricane Evacuations

A sign indicating a hurricane evacuation route near Boca Raton, Florida. Photo / Wikimedia Commons

Software developed by a MIT student is aiding emergency officials as they decide on evacuation plans:
Saving lives through smarter hurricane evacuations

Michael Metzger’s software tool, created as part of the research for his PhD dissertation, could allow emergency managers to better decide early on whether and when to order evacuations — and, crucially, to do so more efficiently by clearing out people in stages. The tool could also help planners optimize the location of relief supplies before a hurricane hits.
…
“All in all, this is a complex balancing act,” Metzger says.

The concept of evacuating an area in stages — focusing on different categories of people rather than different geographical locations — is one of the major innovations to come out of Metzger’s work, since congestion on evacuation routes has been a significant problem in some cases, such as hurricanes Katrina and Rita. Metzger suggests that, for example, the elderly might be evacuated first, followed by tourists, families with children, and then the remaining population. The determination of the specific categories and their sequence could be determined based on the demographics of the particular area.

By spacing out the evacuation of different groups over a period of about two days, he says, the process would be more efficient, while many traditional systems of evacuating a given location all at once can and have caused serious congestion problems.
….
Other factors that could help to make evacuations more effective, he says, include better planning in the preparation of places for evacuees to go to, making sure buses and other transportation are ready to transport people, and preparing supplies in advance at those locations.

Black Raspberries Alter Hundreds of Genes Slowing Cancer

Black Raspberries Slow Cancer by Alter Hundreds of Genes

Researchers at the Ohio State University Comprehensive Cancer Center examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer
…
“We have clearly shown that berries, which contain a variety of anticancer compounds, have a genome-wide effect on the expression of genes involved in cancer development,” says principal investigator Gary D. Stoner
…
Stoner notes that black raspberries have vitamins, minerals, phenols and phytosterols, many of which individually are known to prevent cancer in animals. “Freeze drying the berries concentrates these elements about ten times, giving us a power pack of chemoprevention agents that can influence the different signaling pathways that are deregulated in cancer,” he says.
…
Their analyses included measuring the activity, or expression levels, of 41,000 genes. In the carcinogen-treated animals, 2,261 of these genes showed changes in activity of 50 percent or higher.

Pretty cool stuff.

Using Spice-based Compound To Kill Cancer Cells

Synthetic molecules, derived from curcumin, a naturally occurring compound found in the spice turmeric have been killed cancer cells, in lab settings. Centuries of anecdotal evidence and recent scientific research suggest curcumin has multiple disease-fighting features, including anti-tumor properties. However, when eaten, curcumin is not absorbed well by the body. Instead, most ingested curcumin in food or supplement form remains in the gastrointestinal system and is eliminated before it is able to enter the bloodstream or tissues.

James Fuchs, assistant professor of medicinal chemistry and pharmacognosy at Ohio State University and principal investigator on the project, and colleagues are continuing to refine compounds that are best structured to interact with a few overactive proteins that are associated with cell activity in breast and prostate cancers. Blocking these molecular targets can initiate cell death or stop cell migration in the cancers.

A major component of their strategy is called structure-based, computer-aided design, a relatively new technology in the drug discovery field. Before ever working with an actual compound, the scientists can make manipulations to computer-designed molecules and observe simulated interactions between molecules and proteins to predict which structural changes will make the most sense to pursue.

“Most of the interaction between our compound and the overactive protein comes from what are called hot spots on the protein’s surface,” said Chenglong Li, assistant professor of medicinal chemistry and pharmacognosy at Ohio State and an expert in computational chemistry. “For each spot, we can design small chemical fragments and link them together to make a molecule. This is what computer-aided design and modeling can do.”

Some of the most effective compounds have been tested for their effectiveness against human cancer cell lines – as well as whether they might be toxic to healthy cells. So far, the molecule favored by the researchers has a nearly 100-fold difference in toxicity to cancer cells vs. healthy cells, meaning it takes 100 times more of the compound to kill a healthy cell than it does to kill a cancer cell.

Dolphin Kick Gives Swimmers Edge

photo of Michael Phelps diving

Dolphin Kick Gives Swimmers Edge

Rajat Mittal, a professor of mechanical and aerospace engineering at the George Washington University, was studying dolphins for the U.S. Navy five years ago. “We were asked to understand how fish swim so efficiently,” Mittal says, “and it seemed like a natural extension to apply this to human swimming.”
…
They decided to “essentially compare these swimmers to the dolphin, assuming that the dolphin is the ultimate swimmer,” Mittal says. “And the thing that we found is that Michael [Phelps] is able to use his body in a way that is very, very different from the other athletes, and also seems to be much closer to dolphins than we have seen for any other swimmer.”

The dolphin kick first hit Olympic swimming big-time 20 years ago, after Harvard backstroker David Berkoff figured out something fundamental. “It seemed pretty obvious to me that kicking underwater seemed to be a lot faster than swimming on the surface,” Berkoff says.

That’s because there’s turbulence and air on the surface of the water, and they create resistance. The “Berkoff Blastoff,” as it was called, was used at the start and after turns, with long stretches of that underwater undulating kick.

Follow the link for a video of Michael Phelps demonstrating the technique and more interesting details. Photo by A. Dawson shows Michael Phelps diving into the water at the 2008 U.S. Olympic Swimming Trials.

The PI lacks the experience with the proposed methodology…

A nice post from ScienceWoman: The PI lacks the experience with the proposed methodology…

Well, no kidding. I’m 3000 miles from my old stomping grounds. I’m trying to start an independent research program in a place where the geology/climate are not at all the same. I’m applying for $ for that are specific to Mystery State. Damn straight I’m going to need to learn a few new techniques. (And we’re not talking rocket science here.) But was there nothing in the proposal to suggest that I didn’t understand the techniques or wasn’t properly applying them. Just a lack of a publication record that explicitly used those techniques or occurred in this part of the country.

I suspect that this is a criticism that I’m going to see a few more times before tenure. And I suspect that it’s a criticism that’s not uniquely being leveled at me.
…
In this case, this criticism isn’t the reason the proposal wasn’t funded. But it’s the one reviewer critique that I can’t surmount on the resubmission. It’s like that itch I can’t scratch. So I guess the resubmitted proposal is just going to have to be so kick-ass in all other respects that there’s no way they can deny me these funds. Better get to work.

Invisibility Cloak Closer

Invisibility shields one step closer with new metamaterials that bend light backwards

Applications for a metamaterial entail altering how light normally behaves. In the case of invisibility cloaks or shields, the material would need to curve light waves completely around the object like a river flowing around a rock. For optical microscopes to discern individual, living viruses or DNA molecules, the resolution of the microscope must be smaller than the wavelength of light.

The common thread in such metamaterials is negative refraction. In contrast, all materials found in nature have a positive refractive index, a measure of how much electromagnetic waves are bent when moving from one medium to another.

In a classic illustration of how refraction works, the submerged part of a pole inserted into water will appear as if it is bent up towards the water’s surface. If water exhibited negative refraction, the submerged portion of the pole would instead appear to jut out from the water’s surface.
…
For a metamaterial to achieve negative refraction, its structural array must be smaller than the electromagnetic wavelength being used. Not surprisingly, there has been more success in manipulating wavelengths in the longer microwave band, which can measure 1 millimeter up to 30 centimeters long.