Tag Archives: university research

Parrots Given “Names” by Their Parents and Use Them Throughout Their Lives

Parrots learn their ‘names’ from their parents

Parrots, which have long amused us for their ability to imitate our vocal patterns, actually learn to caw their “names” from their parents, says a new Cornell study. The research offers the first evidence that parrots learn their unique signature calls from their parents and shows that vocal signaling in wild parrots is a socially acquired rather than a genetically wired trait.
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Previous research had shown that all wild parrots use unique “contact calls” that not only distinguish each bird individually, but also communicate their gender, and the mate and larger group they belong to.
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“Parrots can have extremely long periods [leading up] to independence, and this is thought to be related to their large brains,” explained Berg. The same goes for primates, he said, with humans in particular being “off the charts” when it comes to a lengthy stage of child dependence.

More research is required, to better understand the evolution of and interaction between these physical and behavioral traits, he said. “We still don’t have good explanations of how these behaviors help wild individuals survive and reproduce in nature,” he said.

The paper offers some possible explanations: Perhaps the parrots’ far-ranging journeys to “communal foraging sights” are what impress upon each parent the need to have their fledglings’ names sorted out — not unlike human parents’ need to call for their children by name at a crowded fair.

I enjoy learning more fun and cool stuff about the animals we share the world with. They are quite an interesting bunch of creatures.

Key Indicator for Malignant Melanoma Found

Skin cancer detection breakthrough

The researchers found that certain biochemical elements in the DNA of normal pigment-producing skin cells and benign mole cells are absent in melanoma cells. Loss of these methyl groups — known as 5-hmC — in skin cells serves as a key indicator for malignant melanoma. Loss corresponded to more-advanced stages of melanoma as well as clinical outcome.

Strikingly, researchers were able to reverse melanoma growth in preclinical studies. When the researchers introduced enzymes responsible for 5-hmC formation to melanoma cells lacking the biochemical element, they saw that the cells stopped growing.

“It is difficult to repair the mutations in the actual DNA sequence that are believed to cause cancer,” said Christine Lian, a physician-scientist in the Department of Pathology at BWH and one of the lead authors. “So having discovered that we can reverse tumor cell growth by potentially repairing a biochemical defect that exists — not within the sequence but just outside of it on the DNA structure — provides a promising new melanoma treatment approach for the medical community to explore.”

Because cancer is traditionally regarded as a genetic disease involving permanent defects that directly affect the DNA sequence, this new finding of a potentially reversible abnormality that surrounds the DNA (thus termed “epigenetic”) is a hot topic in cancer research, according to the researchers.

In the United States, melanoma is the fifth most common type of new cancer diagnosis in men and the seventh most common type in women. The National Cancer Institute estimates that in 2012 there will be 76,250 new cases and 9,180 deaths in the United States owing to melanoma.

Thankfully scientists keep making great progress in understanding and finding potential clues to treating cancer. And big gains have been made in treating some cancers over the last few decades. But the research successes remain difficult to turn into effective solutions in treating patients.

I am thankful we have so many scientists doing good work in this difficult and important area (cancer).

Antibiotics fuel obesity by creating microbe upheavals

We aren’t single individuals, but colonies of trillions. Our bodies, and our guts in particular, are home to vast swarms of bacteria and other microbes. This “microbiota” helps us to harvest energy from our food by breaking down the complex molecules that our own cells cannot cope with. They build vitamins that we cannot manufacture. They ‘talk to’ our immune system to ensure that it develops correctly, and they prevent invasions from other more harmful microbes. They’re our partners in life.

What happens when we kill them?

Farmers have been doing that experiment in animals for more than 50 years. By feeding low doses of antibiotics to healthy farm animals, they’ve found that they could fatten up their livestock by as much as 15 percent.
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Ilseung Cho from the New York University School of Medicine has confirmed that hypothesis. By feeding antibiotics to young mice, he has shown that the drugs drastically change the microscopic communities within their guts, and increase the amount of calories they harvest from food. The result: they became fatter.

I continue to believe we are far to quick to medicate. We tremendously overuse anti-biotis and those costs are huge. They often are delays and systemic and given our current behavior we tend to ignore delayed and systemic problems.

The link between the extremely rapid rise in obesity and the overuse of anti-biotics is in need of much more study. It seems a possible contributing factor but there is much more data needed to confirm such a link. And other factors still seem dominant to me: increase in caloric intake and decrease in physical activity.

Virus Kills Breast Cancer Cells in Laboratory

Some very exciting and good news from Penn State. Researchers have found a virus that kills breast cancer cells. It is great to read about research breakthroughs like this. Of course, most of these announcements never become practical solutions, unfortunately. And if they do it is many many years later and almost always in much less exciting ways than the headlines. Still, the percentage that do make it through the process into workable solutions provide us great benefits.

Virus kills breast cancer cells in laboratory

Adeno-associated virus type 2 (AAV2) is a virus that regularly infects humans but causes no disease. Past studies by the same researchers show that it promotes tumor cell death in cervical cancer cells infected with human papillomavirus. Researchers used an unaltered, naturally occurring version of AAV2 on human breast cancer cells.

“Breast cancer is the most prevalent cancer in the world and is the leading cause of cancer-related death in women,” said Samina Alam, research associate in microbiology and immunology. “It is also complex to treat.”
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“We can see the virus is killing the cancer cells, but how is it doing it?” Alam said. “If we can determine which viral genes are being used, we may be able to introduce those genes into a therapeutic. If we can determine which pathways the virus is triggering, we can then screen new drugs that target those pathways. Or we may simply be able to use the virus itself.”
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AAV2 does not affect healthy cells. However, if AAV2 were used in humans, the potential exists that the body’s immune system would fight to remove it from the body. Therefore, by learning how AAV2 targets the death pathways, researchers potentially can find ways to treat the cancer without using the actual virus.

In ongoing studies, the Penn State researchers also have shown AAV2 can kill cells derived from prostate cancer, mesothelioma, squamous cell carcinoma, and melanoma. A fourth line of breast cancer cells — representing the most aggressive form of the disease — also was studied in a mouse breast tumor model, followed by treatment with AAV2. Preliminary results show the destruction of the tumors in the mice, and researchers will report the findings of those mouse studies soon.

The fight against cancer has many promising breakthroughs. We have made some great progress. Still the fight is extremely difficult and we have many more frustrations than successes.

An Apple a Day is Good Advice

Apples really are healthy food. They provide fiber and nutrients without a large amount of calories. Including them in your diet can contribute to a healthy lifestyle.

How apples can make you skinnier & 4 more health benefits of apples

Packing in quite a bit of soluble fiber (4 grams per medium apple) for a modest amount of calories (95) makes apples a filling, sweet snack. Plus, a medium apple counts as 1 cup of fruit, so after eating one you’re well on your way to meeting your daily fruit quota (around 2 cups for adults on a 2,000-calorie diet). They also are a good source of immune-boosting vitamin C (providing 14% of the Daily Value).
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a survey of eating and health habits, found that people who had eaten apples in any form over the past day were 27 percent less likely to have symptoms of metabolic syndrome than those who didn’t. The apple eaters also had lower levels of C-reactive protein, a marker of inflammation whose presence in the blood suggests an increased risk for heart disease and diabetes.

“Our study suggests that ursolic acid increases skeletal muscle and brown fat leading to increased calorie burning, which in turn protects against diet-induced obesity, pre-diabetes and fatty liver disease,” Christopher Adams, M.D., Ph.D., UI associate professor of internal medicine at the University of Iowa.

Until quite recently, researchers believed that only infants had brown fat, which then disappeared during childhood. However, improved imaging techniques have shown that adults do retain a very small amount of the substance mostly in the neck and between the shoulder blades. Some studies have linked increased levels of brown fat with lower levels of obesity and healthier levels of blood sugar and blood lipid, leading to the suggestion that brown fat may be helpful in preventing obesity and diabetes.

Scientific Inquiry Process Finds More Evidence Supporting Einstein’s Theory

As scientists have been able to see farther and deeper into the universe, the laws that govern its expansion have been revealed to be under the influence of an unexplained force.

In a paper on the arXiv, Astrophysical Tests of Modified Gravity: Constraints from Distance Indicators in the Nearby Universe, are a vindication of Einstein’s theory of gravity. Having survived several decades of tests in the solar system, it has passed this new test in galaxies beyond our own as well.

In 1998, astrophysicists made an observation that turned gravity on its ear: the universe’s rate of expansion is speeding up. If gravity acts the same everywhere, stars and galaxies propelled outward by the Big Bang should continuously slow down, like objects thrown from an explosion do here on Earth.

This observation used distant supernovae to show that the expansion of the universe was speeding up rather than slowing down. This indicated that something was missing from physicists’ understanding of how the universe responds to gravity, which is described by Einstein’s theory of general relativity. Two branches of theories have sprung up, each trying to fill its gaps in a different way.

One branch — dark energy — suggests that the vacuum of space has an energy associated with it and that energy causes the observed acceleration. The other falls under the umbrella of “scalar-tensor” gravity theories, which effectively posits a fifth force (beyond gravity, electromagnetism and the strong and weak nuclear forces) that alters gravity on cosmologically large scales.

“These two possibilities are both radical in their own way,” University of Pennsylvania astrophysicist Bhuvnesh Jain said. “One is saying that general relativity is correct, but we have this strange new form of energy. The other is saying we don’t have a new form of energy, but gravity is not described by general relativity everywhere.”

Jain’s research is focused on the latter possibility; he is attempting to characterize the properties of this fifth force that disrupts the predictions general relativity makes outside our own galaxy, on cosmic length scales. Jain’s recent breakthrough came about when he and his colleagues realized they could use the troves of data on a special property of a common type of star as an exquisite test of gravity.

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Using Nanocomposites to Improve Dental Filling Performance

After a dentist drills out a decayed tooth, the cavity still contains residual bacteria. Professor Huakun (Hockin) Xu says it is not possible for a dentist to remove all the damaged tissue, so it’s important to neutralize the harmful effects of the bacteria, which is just what the new nanocomposites are able to do.

Rather than just limiting decay with conventional fillings, the new composite he has developed is a revolutionary dental weapon to control harmful bacteria, which co-exist in the natural colony of microorganisms in the mouth.

“Tooth decay means that the mineral content in the tooth has been dissolved by the organic acids secreted by bacteria residing in biofilms or plaques on the tooth surface. These organisms convert carbohydrates to acids that decrease the minerals in the tooth structure,” says Xu, director of the Division of Biomaterials and Tissue Engineering in the School’s Department of Endodontics, Prosthodontics and Operative Dentistry.

The researchers also have built antibacterial agents into primer used first by dentists to prepare a drilled-out cavity and into adhesives that dentists spread into the cavity to make a filling stick tight to the tissue of the tooth. “The reason we want to get the antibacterial agents also into primers and adhesives is that these are the first things that cover the internal surfaces of the tooth cavity and flow into tiny dental tubules inside the tooth,” says Xu.

The main reason for failures in tooth restorations, says Xu, is secondary caries or decay at the restoration margins. Applying the new primer and adhesive will kill the residual bacteria, he says.

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Lean Science: Using Cheap Robots to Aid Research

Fun video showing how scientists use Lego Mindstorm robots to aid research into creating artificial bones. Lego Mindstorm robots are useful at a very reasonable price.

The webcast also includes this practical quote from Michelle Oyen, lecturer in the Department of Engineering at Cambridge University: “without your bones you would be a pile of goo lying on the floor.”

The thinking discussed in the webcast echos the lean manufacturing principles discussed in the Curious Cat Management Improvement Blog: finding good solutions to aid people in doing their jobs. The type of custom solutions they discuss here are great.

This type of use of technology is great. One of the problems we often see with technology solutions though is when they are imposed on the workplace in a way that doesn’t aid people. There is a big difference between what Toyota does (using robots to make people’s jobs easier) and what others do in trying to copy Toyota (using robots to eliminate jobs). Lean manufacturing stressed the importance of using brainpower people bring to work every day. You want to use technology to enable people. These scientists understand that. Unfortunately many managers don’t.

Potential Antibiotic Alternative to Treat Infection Without Resistance

Researchers at the University of Michigan have found a potential alternative to conventional antibiotics that could fight infection with a reduced risk of antibiotic resistance. Sadly Michigan is another school that is allowing work of those paid for by the citizens of Michigan to be lock away, only due to the wishes of an outdated journal business model instead of supporting open science. The Big Ten seems much more interested in athletic riches than in promoting science. The Big Ten should be ashamed of such anti knowledge behavior and require open science for their schools if they indeed value knowledge.

By using high-throughput screening of a library of small molecules, the team identified a class of compounds that significantly reduced the spread and severity of group A Streptococcus (GAS) bacteria in mice. Their work suggests that the compounds might have therapeutic value in the treatment of strep and similar infections in humans.

“The widespread occurrence of antibiotic resistance among human pathogens is a major public health problem,” said David Ginsburg, a faculty member at LSI, a professor of internal medicine, human genetics, and pediatrics at the U-M Medical School and a Howard Hughes Medical Institute investigator.

Ginsburg led a team that included Scott Larsen, research professor of medicinal chemistry and co-director of the Vahlteich Medicinal Chemistry Core at U-M’s College of Pharmacy, and Hongmin Sun, assistant professor of medicine at the University of Missouri School of Medicine.

Work on this project is continuing at U-M and the University of Missouri, including the preparation of new compounds with improved potency and the filing of patents, Larsen said. Large research schools are also very interested in patents. That is ok, though seems to cloud the pursuit of knowledge too often when too large a focus is on dollars at many schools. But, it seems to put the schools primary focus on dollars; education seems to start to be a minor activity at some of these large schools.

Current antibiotics interfere with critical biological processes in the pathogen to kill it or stop its growth. But at the same time, stronger strains of the harmful bacteria can sometimes resist the treatment and flourish.

An alternate approach is to suppress the virulence of the infection but still allow the bacteria to grow, which means there is no strong selection for strains that are resistant to antibiotics. In a similar experiment at Harvard University, an anti-virulence strategy was successful in protecting mice from cholera.

About 700 million people have symptomatic group A Streptococcus infections around the world each year, and the infection can be fatal. Most doctors prescribe penicillin. The newly identified compounds could work with conventional antibiotics and result in more effective treatment.

Microbiologist Develops Mouthwash That Targets Only Harmful Cavity Causing Bacteria

A new mouthwash developed by a microbiologist at the UCLA School of Dentistry is highly successful in targeting the harmful Streptococcus mutans bacteria that is the principal cause tooth decay and cavities.

In a recent clinical study, 12 subjects who rinsed just one time with the experimental mouthwash experienced a nearly complete elimination of the S. mutans bacteria over the entire four-day testing period.

Dental caries, commonly known as tooth decay or cavities, is one of the most common and costly infectious diseases in the United States, affecting more than 50 percent of children and the vast majority of adults aged 18 and older. Americans spend more than $70 billion each year on dental services, with the majority of that amount going toward the treatment of dental caries.

This new mouthwash is the product of nearly a decade of research conducted by Wenyuan Shi, chair of the oral biology section at the UCLA School of Dentistry. Shi developed a new antimicrobial technology called STAMP (specifically targeted anti-microbial peptides) with support from Colgate-Palmolive and from C3-Jian Inc., a company he founded around patent rights he developed at UCLA; the patents were exclusively licensed by UCLA to C3-Jian.

The human body is home to millions of different bacteria, some of which cause diseases such as dental caries but many of which are vital for optimum health. Most common broad-spectrum antibiotics, like conventional mouthwash, indiscriminately kill both benign and harmful pathogenic organisms and only do so for a 12-hour time period.

The overuse of broad-spectrum antibiotics can seriously disrupt the body’s normal ecological balance, rendering humans more susceptible to bacterial, yeast and parasitic infections.

Shi’s Sm STAMP C16G2 investigational drug, tested in the clinical study, acts as a sort of “smart bomb,” eliminating only the harmful bacteria and remaining effective for an extended period.

“With this new antimicrobial technology, we have the prospect of actually wiping out tooth decay in our lifetime,” said Shi, who noted that this work may lay the foundation for developing additional target-specific “smart bomb” antimicrobials to combat other diseases.