Tag Archives: virus

Potential Viral Therapy for Difficult Cancers

Potential viral therapy weapon for difficult cancers is safe and effective in study

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice. This new finding may add to the growing arsenal of so called oncolytic viruses under development as novel cancer treatments, especially for difficult, inoperable tumors
…
“Based on these findings and other preclinical studies, we expect oncolytic viral therapy will be one additional treatment modality available in the future for oncologists,” Dr. Cripe said. “The challenge over the next decade will be determining which viruses work best for which cancers, at what doses, schedules, routes of administration, and in what combinations with other treatments.”

Viruses Eating Bacteria

All the World’s a Phage by John Travis:

“Believe it or not, nobody had looked before,” says Suttle. “On average, there are 50 million viruses per milliliter in seawater. The question is, What the heck they’re doing there?” Microbiologists then documented similar, and even higher, concentrations of phages in soil samples. This led to estimates of 10³¹ bacteriophages worldwide, a staggeringly large number that many scientists initially dismissed. “We can’t wrap our brains around it,” says Pedulla. “If phages were the size of a beetle, they would cover the Earth and be many miles deep.”
…
According to estimates put forth by Suttle, phages destroy up to 40 percent of the bacteria in Earth’s oceans each day.
…
The students collected soil from barnyards, gardens, and even the monkey pit at the Bronx Zoo. The scientists then taught the students how to isolate a bacteriophage from the soil by growing the viruses in Mycobacterium smegmatis, a harmless bacterial relative of the microbe that causes tuberculosis. “We guarantee them that the bacteriophage they find will never have been discovered before. We know that because the diversity is so high, and we’ve never isolated the same bacteriophage twice,” says Hatfull.

In the April 18 Cell, Hatfull and his professional and teenage collaborators describe the genomes of 10 soil-dwelling bacteriophages that they had isolated. Of the more than 1,600 genes that the team identified, about half are novel, that is, they don’t match any previously described genes in any other organism.

Science is full of amazing new frontiers. Some other amazing stuff: Thinking Slime Moulds – Tracking the Ecosystem Within Us – Retroviruses – Energy Efficiency of Digestion – One Species’ DNA Discovered Inside Another’s

Secret Life of Microbes

New Window Opens on the Secret Life of Microbes: Scientists Develop First Microbial Profiles of Ecosystems

Nowhere is the principle of “strength in numbers” more apparent than in the collective power of microbes: despite their simplicity, these one-cell organisms–which number about 5 million trillion trillion strong (no, that is not a typo) on Earth–affect virtually every ecological process, from the decay of organic material to the production of oxygen.

But even though microbes essentially rule the Earth, scientists have never before been able to conduct comprehensive studies of microbes and their interactions with one another in their natural habitats.
…
Because microbes are an ecosystem’s first-responders, by monitoring changes in an ecosystem’s microbial capabilities, scientists can detect ecological responses to stresses earlier than would otherwise be possible–even before such responses might be visibly apparent in plants or animals, Rohwer said.

Evidence that viruses–which are known to be ten times more abundant than even microbes–serve as gene banks for ecosystems. This evidence includes observations that viruses in the nine ecosystems carried large loads of DNA without using such DNA themselves. Rohwer believes that the viruses probably transfer such excess DNA to bacteria during infections, and thereby pass on “new genetic tricks” to their microbial hosts. The study also indicates that by transporting the DNA to new locations, viruses may serve as important agents in the evolution of microbes.

Virus Engineered To Kill Deadly Brain Tumors

Yale Lab Engineers Virus That Can Kill Deadly Brain Tumors

A laboratory-engineered virus that can find its way through the vascular system and kill deadly brain tumors has been developed by Yale School of Medicine researchers, it was reported this week in the Journal of Neuroscience.

Each year 200,000 people in the United States are diagnosed with a brain tumor, and metastatic tumors and glioblastomas make up a large part of these tumors. There currently is no cure for these types of tumors, and they generally result in death within months.
…
“Three days after inoculation, the tumors were completely or almost completely infected with the virus and the tumor cells were dying or dead,” van den Pol said. “We were able to target different types of cancer cells. Within the same time frame, normal mouse brain cells or normal human brain cells transplanted into mice were spared. This underlines the virus’ potential therapeutic value against multiple types of brain cancers.”

Pretty cool. Too bad these press releases never quite live up to the initial promise. Still this one is very cool, if it can succeed in helping even a small percentage of people it will be a great breakthrough. It is also just cool – using a virus to kill tumors – how cool is that?

Swimmers’ Sunscreen Killing Off Coral

Swimmers’ Sunscreen Killing Off Coral Ker Than for National Geographic News:

Four commonly found sunscreen ingredients can awaken dormant viruses in the symbiotic algae called zooxanthellae that live inside reef-building coral species. The chemicals cause the viruses to replicate until their algae hosts explode, spilling viruses into the surrounding seawater, where they can infect neighboring coral communities.

Zooxanthellae provide coral with food energy through photosynthesis and contribute to the organisms’ vibrant color. Without them, the coral “bleaches”—turns white—and dies. “The algae that live in the coral tissue and feed these animals explode or are just released by the tissue, thus leaving naked the skeleton of the coral,” said study leader Roberto Danovaro of the Polytechnic University of Marche in Italy.

The researchers estimate that 4,000 to 6,000 metric tons of sunscreen wash off swimmers annually in oceans worldwide, and that up to 10 percent of coral reefs are threatened by sunscreen-induced bleaching.

Amazing Science: Retroviruses

One of the great things about writing this blog is I find myself more focused on reading about interesting science. Retroviruses are very interesting and frankly amazing. Darwin’s Surprise by Michael Specter, The New Yorker:

A retrovirus stores its genetic information in a single-stranded molecule of RNA, instead of the more common double-stranded DNA. When it infects a cell, the virus deploys a special enzyme, called reverse transcriptase, that enables it to copy itself and then paste its own genes into the new cell’s DNA. It then becomes part of that cell forever; when the cell divides, the virus goes with it. Scientists have long suspected that if a retrovirus happens to infect a human sperm cell or egg, which is rare, and if that embryo survives – which is rarer still – the retrovirus could take its place in the blueprint of our species, passed from mother to child, and from one generation to the next, much like a gene for eye color or asthma.

When the sequence of the human genome was fully mapped, in 2003, researchers also discovered something they had not anticipated: our bodies are littered with the shards of such retroviruses, fragments of the chemical code from which all genetic material is made. It takes less than two per cent of our genome to create all the proteins necessary for us to live. Eight per cent, however, is composed of broken and disabled retroviruses, which, millions of years ago, managed to embed themselves in the DNA of our ancestors. They are called endogenous retroviruses, because once they infect the DNA of a species they become part of that species. One by one, though, after molecular battles that raged for thousands of generations, they have been defeated by evolution. Like dinosaur bones, these viral fragments are fossils. Instead of having been buried in sand, they reside within each of us, carrying a record that goes back millions of years. Because they no longer seem to serve a purpose or cause harm, these remnants have often been referred to as “junk DNA.” Many still manage to generate proteins, but scientists have never found one that functions properly in humans or that could make us sick.

How amazing is that? I mean really think about it: it is incredible. The whole article is great. Related: Old Viruses Resurrected Through DNA – DNA for once species found in another species’ Genes – New Understanding of Human DNA – Retrovirus overview (Tulane) – Cancer-Killing Virus
Continue reading →

Virus Found to be One Likely Factor in Bee Colony Collapse Disorder

Photo of a bee bu Justin Hunter

Scientists say a virus appears to be a factor in honeybee colony collapse by Andrew C. Revkin:

Scientists sifting genetic material from thriving and ailing bee colonies say a virus appears to be a prime suspect – but is unlikely to be the only culprit – in the mass die-offs of honeybees reported last autumn and winter.

Very well stated. The virus while seeming to be a factor in the deaths appears to cause death in colonies that are stressed which seem to be highly correlated with colonies that are moved from place to place by commercial beekeepers to pollinate various crops. Bees that are kept by hobbiest, wild bees… don’t seem to be dying off. The impact of CCD is growing economically as prices for renting bees to pollinate crops increases and in some cases there are not enough bees available. Honey prices are increasing and prices for food pollinated by bees are too.

The Department of Agriculture states: The only pathogen found in almost all samples from honey bee colonies with CCD, but not in non-CCD colonies, was the Israeli acute paralysis virus (IAPV), a dicistrovirus that can be transmitted by the varroa mite. It was found in 96.1 percent of the CCD-bee samples. This does not identify IAPV as the cause of CCD,” said Pettis. “What we have found is strictly a strong correlation of the appearance of IAPV and CCD together. We have not proven a cause-and-effect connection.”

Related: Bee researchers close in on Colony Collapse Disorder, Penn State (Penn State broke the link so it was removed) – Bye Bye Bees – Bee Colony Collapse Disorder CCD – More on Disappearing Honeybees – Colony Collapse Disorder and Pollinator Decline

Using Viruses to Construct Electrodes and More

She harnesses viruses to make things

Manufacturing was once the province of human hands, then of machines. Angela Belcher, professor of materials science and engineering and biological engineering at MIT, has pushed manufacturing in another, much smaller, direction: Her lab has genetically engineered viruses that can construct useful objects like electrodes and wires.
…
Her lab employed this method to form an electrode that can be used in a lithium ion battery like the rechargeable ones used in electronics. The result looks like an innocuous length of celluloid tape, the sort you could use to wrap a package.

“It’s self-assembled,” says Belcher. “The viruses make these materials at room temperature.” So there’s little pollution.
…
Belcher hopes to be making prototypes within the next two years. “Actual devices are five to 10 years off.”

Microbes

photo of T4 bacteriophage

Photo: T4 bacteriophage, middle, is a virus that invades bacterial cells. Courtesy of the MicrobeLibrary.org

The MicrobeWorld web site includes an introduction to microbes – Microbes: what they are and what they do:

Microbes are single-cell organisms so tiny that millions can fit into the eye of a needle.

They are the oldest form of life on earth. Microbe fossils date back more than 3.5 billion years to a time when the Earth was covered with oceans that regularly reached the boiling point, hundreds of millions of years before dinosaurs roamed the earth.

Microbes types:

Archaea
These bacteria look-alikes are living fossils that are providing clues to the earliest forms of life on Earth.

Bacteria
Often dismissed as “germs” that cause illness, bacteria help us do an amazing array of useful things, like make vitamins, break down some types of garbage, and maintain our atmosphere.

Fungi
From a single-celled yeast to a 3.5-mile-wide mushroom, fungi do everything from helping to bake bread to recycling to decomposing waste.

Protista
Plant-like algae produce much of the oxygen we breathe; animal-like protozoa (including the famous amoeba) help maintain the balance of microbial life.

Viruses
Unable to do much of anything on their own, viruses go into host cells to reproduce, often wreaking havoc and causing disease. Their ability to move genetic information from one cell to another makes them useful for cloning DNA and could provide a way to deliver gene therapy.